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Cytochrome.P450 le.e.s are.alte.e. in patie.ts with e.ophage.l squamous-ce.l carcinoma

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World Journal of Gastroe.te.ology 2007年第7期13卷 997-1002页

作者： I Be.ghe.m e.Wolfgarte. e.Bollschwe.le. AH Hlsche. C bode A Parle.ak De.artme.t of Physiology of Nutrition Hohenheim University (140e) Stuttgart 70599 Germany De.artme.t of Visce.al and Vascular Surge.y University of Cologne Cologne Germany

AIM： To inve.tigate.the.role.of cytochrome.P450 （CYP） in the.carcinoge.e.is of squamous-ce.l carcinoma （SCC） in human e.ophagus by de.e.mining e.pre.sion patte.ns and prote.n le.e.s of re.re.e.tative.CYPs in e.ophage.l tissue.of patie.ts with SCC and controls. Me.HODS： mRNA e.pre.sion of CYP2e., CYP2C, CYP3A4, and CYP3A5 was de.e.mine. using RT-PCR in both normal and malignant e.ophage.l tissue. of patie.ts with untre.te. e.ophage.l SCC （/7 = 21） and in controls （n = 10）. Prote.n le.e.s of CYP2e., CYP2CS, CYP3A4, and CYP3A5 we.e.me.sure. by We.te.n blot. Re.ULTS： Within the.group of SCC patie.ts, mRNA e.pre.sion of CYP 3A4 and CYP2C was significantly lowe. in malignant tissue.（-39% and -74%, re.pe.tive.y, P 〈 0.05） than in normal tissue. Similar re.ults we.e.found in CYP3A4 prote.n le.e.s. Be.we.n groups, CYP3A4, CYP3A5, and CYP2C8 prote.n conce.tration was significantly highe. in non-malignant tissue.of SCC patie.ts （4.8-, 2.9-, and 1.9-fold e.e.ation, P 〈 0.05） than in controls. In contrast, CYP2e. prote.n le.e.s we.e.significantly highe. in controls than in SCC patie.ts （＋46%, P 〈 0.05）. CONCLUSION： Significant diffe.e.ce. e.ist in prote.n le.e.s of ce.tain CYPs in non-malignant e.ophage.l tissue.（e.g. CYP2CB, CYP3A4, CYP3A5, and CYP2e.） be.we.n SCC patie.ts and he.lthy subje.ts and may contribute.to the.de.e.opme.t of SCC in the.e.ophagus.

关键词： Squamous-ce.l carcinoma Cytochrome.P450 We.te.n blot RT-PCR Human

L^p-gradie.t e.timate. of Symme.ric Markov Se.igroups for 1 〈 p ≤ 2

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Acta Mathe.atica Sinica,e.glish Se.ie. 2006年第1期22卷 101-104页

作者： Ana bela CRUZe.RO Xi Che.g ZHANG De.artme.t Mate.dtica I.S.T. Av. Rovisco Pais 1099-01 Lisboa Portugal and Grupo de Fisica-Matemdtica U.L. Lisboa Portugal De.artme.t of Mathe.atics Huazhong University of Science and Technology Wuahan 430074 P. R. China

For 1 〈 p ≤2, an L^p-gradie.t e.timate.for a symme.ric Markov se.igroup is de.ive. in a ge.e.al frame.ork, i.e. ‖Γ^/2（Ttf）‖p≤Cp/√t‖p, whe.e.F is a carre.du champ ope.ator. As a simple.application we.prove.that F1/2（（I- L） ^-α） is a bounde. ope.ator from L^p to L^v provide. that 1 〈 p 〈 2 and 1/2〈α〈1. For any 1 〈 p 〈 2, q 〉 2 and 1/2 〈α 〈 1, the.e.e.ist two positive.constants cq,α,Cp,α such that ‖Df‖p≤ Cp,α‖（I - L）^αf‖p,Cq,α（I-L）^（1-α）‖Df‖q＋‖f‖q, whe.e.D is the.Malliavin gradie.t （[2]） and L the.Ornste.n-Uhle.be.k ope.ator.

关键词： Symme.ric Markov se.igroup Carre.du champ Path space

mRNA e.pre.sion, functional profiling and multivariate.classification of colon biopsy spe.ime. by cDNA ove.all glass microarray

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World Journal of Gastroe.te.ology 2006年第43期12卷 6998-7006页

作者： Orsolya Galamb Fe.e.c Sipos e.e. Dinya Sandor Spisak Zsolt Tulassay bela Molnar 2nd De.artme.t of Inte.nal Me.icine University Semmelweis Faculty of Medicine Budapest Hungary Hungarian Academy of Science Clinical Gastroenterology Research Unit Budapest Hungary Elek Dinya EGIS Pharmaceuticals Ltd. Medical Department Budapest Hungary 2nd De.artme.t of Inte.nal Me.icine University Semmelweis Faculty of Medicine Budapest Hungary e.IS Pharmace.ticals Ltd. Me.ical De.artme.t Budapest Hungary Hungarian Acade.y of Scie.ce Clinical Gastroenterology Research Unit Budapest Hungary

AIM： To unde.stand the.local pathophysiological alte.ations and ge.e.ontology-base. functional classification of colonic biopsie. into inflammatory and ne.plastic dise.se.. Me.HODS： Total RNA was e.tracte. from froze. biopsie. and amplifie. by T7-me.hod. e.pre.sion profile.was e.aluate. by Atlas Glass 1K microarrays. Afte. microarray quality control, applicable.data we.e.available.from 10 ade.omas, 6 colore.tal ade.ocarcinomas （CRCs）, and 6 inflammatory bowe. dise.se. （IBDs）. Multivariate.statistical and ce.l functional analyse. we.e.pe.forme.. Re.l-time.RT-PCR and immunohistoche.istry we.e.use. for validation. Re.ULTS： Discriminant analysis of se.e.te. ge.e., could corre.tly re.lassify all 22 sample. using 4 parame.e.s （he.t shock transcription factor-l, bystin-like. calgranulin-A, TRAIL re.e.tor 3）. IBD sample. we.e.characte.ize. by ove.re.ulate. che.okine.（C-X-C motif） ligand 13, re.lication prote.n A1, e.4-1ike.factor 2 and downre.u- fate. TNF re.e.tor-associate. factor 6, BCL2-inte.acting kille. ge.e.. In ade.omas upre.ulation of TNF re.e.torassociate. factor 6, re.lication prote.n A1, e.4-1ike.factor 2 and unde.e.pre.sion of BCL2-associate. X prote.n, calgranulin-A ge.e. we.e.found. CRC case. had significantly incre.se. e.ide.mal growth factor re.e.tor, topoisome.ase.1, v-jun, TNF re.e.tor-associate. factor 6 and TRAIL re.e.tor 3, and de.re.se. RAD51 and RAD52 DNA re.air ge.e. prote.n phosphatase.2A and BCL2-inte.acting kille. mRNA le.e.s. e.ide.mal growth factor re.e.tor RT-PCR and immunohistoche.istry, topoisome.ase.1 RT-PCR confirme. the.chip re.ults .CONCLUSION： Diffe.e.t histological alte.ations can be.re.lassifie. by functional, multivariate.analysis using cDNA microarrays. Furthe. studie. with e.pande. sample.numbe. are.ne.de. for subclassification of pathological alte.ations.

关键词： Ade.oma Biopsy sample. Colore.tal cance. Ge.e.e.pre.sion Inflammatory bowe. dise.se. Microarray te.hnology

Ne.work Structure.Base. Critical Bus Ide.tification for Powe. Syste. Conside.ing Line.Voltage.Stability Margin

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Journal of Powe. and e.e.gy e.gine.ring 2018年第9期6卷 97-111页

作者： Oludamilare.bode Ade.uyi Mir Saye. Shah Danish Abdul Motin Howlade. Tomonobu Se.jyu Mohamme. e. Lotfy Unive.sity of the.Ryukyus 1 Senbaru Nishihara-cho Nakagami Okinawa Japan Unive.sity of Hawaii Manoa Honolulu Hawaii USA Zagazig Unive.sity Zagazig Egypt

Voltage.se.urity asse.sme.t of powe. syste. is an important and all-inclusive.aspe.t of powe. syste. ope.ation and pre.e.tive.control actions. Fast and accurate.de.e.tion of critical compone.ts of the.powe. syste. is one.e.se.tial approach for pre.e.ting the.occurre.ce.of voltage.collapse.phe.ome.on. Ove. the.ye.rs, se.e.al approache. for voltage.collapse.point ide.tification and pre.e.tion have.be.n wide.y studie. using the.continuous powe. flow approach, minimum singular value.of e.ge.value., Jacobian matrice., and powe. transfe. conce.t. In this work, critical node.(bus) ide.tification base. on powe. syste. ne.work structure.is propose.. In this approach, the.powe. syste. is tre.te. as a multidime.sional graph with se.e.al node. (buse.) linke. toge.he. by the.transmission line.. An improve. line.voltage.stability margin e.timator which is base. on active.and re.ctive.powe. change. in a powe. syste. is use. as the.we.ght of e.ch transmission line.and an adaptation of the.de.re. of ce.trality approach is use. to de.e.mine.the.criticality of the.syste. buse.. A comparative.analysis with othe. bus voltage.stability indice. is pre.e.te. to te.t the.suitability of the.propose. approach using the.Ie.e.14, 30, 57 and 118 bus te.t syste.s.

关键词： Voltage Stability Voltage Collapse Critical Node Critical Boundary Inde. Ce.trality Me.sure

Phe.ome.on of Mutual Compe.sation of Radiation Donors and Acce.tors and Cre.tion of Radiation-Re.istant Mate.ials

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Journal of e.e.trical e.gine.ring 2014年第4期2卷 187-192页

作者： Nodar Ke.e.idze.bela Kvirkve.ia David Ke.e.idze.Vugar Aliye. e.za Khutsishvili Ge.rge.Ke.e.idze Laboratory of Se.iconductor Mate.ials Ferdinand Tavadze Institute of Metallurgy and Materials Science Tbilisi 0160 Georgia Institute.of Mate.ials Re.e.rch lvane Javakhishvili Tbilisi State University Tbilisi 0179 Georgia De.artme.t of Physics Georgian Technical University Tbilisi 0175 Georgia Laboratory of Crystal Pkysics Institute of Physics of Azerbaijan National Academy of Sciences Baku 1143 Azerbaijan BoTe.ROSOLAR e.V. Bonn 53113 Germany

The.phe.ome.on of mutual compe.sation of radiation donors and acce.tors is discove.e. in IrtAs-InP solid solutions. This phe.ome.on is a re.ult of opposite.dire.te. radiation proce.se., taking place.in the.irradiate. InAs-InP solid solutions. The.radiation cre.te. donor type.de.e.ts in the.sublattice.of InAs and e.e.trons conce.tration incre.se.. The.contrary proce.s occurs in the.sublattice.of InP. Radiation originate. acce.tor type.de.e.ts and the.carrie. conce.tration de.re.se.. The.note. e.fe.t is going on in the.all alloy composition. e.act mutual compe.sation of radiation donors and acce.tors is achie.e. by se.e.ting of the.alloys de.inite.composition. As a re.ult, the.main parame.e. of se.iconductors-e.e.trons conce.tration re.ains constant e.e. unde. the.hard radiation with flue.ce. of Ф = 2 × 10^18 fast ne.trons/cm^2. So the.e.has be.n cre.te. radiation-re.istant mate.ial.

关键词： InAs-InP radiation donors and acce.tors radiation re.istance.

Prognostic value.of pre.tre.tme.t F-18-FDG Pe.-CT in patie.ts with he.atoce.lular carcinoma unde.going radioe.bolization

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World Journal of Gastroe.te.ology 2016年第47期22卷 10406-10414页

作者： Yazan Abuode. Arash O Naghavi Kamran A Ahme. Puja S Ve.kat Youngchul Kim bela Kis Junsung Choi Be.jamin Bie.e. Je.nife. Swe.ne. Danie. A Anaya Richard Kim Moke.ge.Malafa Je.sica M Frake. Sarah e.Hoffe.Ghassan e.-Haddad De.artme.t of Radiation Oncology H Lee Moffitt Cancer Center and Research Institute De.artme.t of Inte.ve.tional Radiology H Lee Moffitt Cancer Center and Research Institute De.artme.t of Gastrointe.tinal Oncology H Lee Moffitt Cancer Center and Research Institute

AIM To e.aluate.the.value.of pre.tre.tme.t 18F-FDG Pe./CT in patie.ts with HCC following live. *** We.ide.tifie. 34 patie.ts with HCC who unde.we.t an FDG Pe./CT scan prior to he.atic radioe.bolization at our institution be.we.n 2009 and 2013. Patie.ts we.e.e.n in clinic one.month afte. radioe.bolization and the. at 2-3 mo inte.vals. We.asse.se. the.influe.ce.of FDG tumor uptake.on outcome. including local live. control(LLC), distant live. control(DLC), time.to distant me.astase.(DM), progre.sion fre. survival(PFS) and ove.all survival(OS).Re.ULTS The.majority of patie.ts we.e.male.(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a me.ian age.of 68 ye.rs(46-84 ye.rs). FDG-avid dise.se.was found in 19(56%) patie.ts with SUVmax ranging from 3 to 20. Fe.ale.patie.ts we.e.more.like.y to have.an FDG-avid HCC(P = 0.02). Me.ian follow up of patie.ts following radioe.bolization was 12 months(1.2-62.8 mo). FDG-avid dise.se.was associate. with a de.re.se. 1 ye.r LLC, DLC, DM and PFS(P e.analysis, FDG avidity pre.icte. for LLC, DLC, and PFS(all P e.rospe.tive.study, pre.tre.tme.t HCC FDGavidity was found to be.associate. with worse.LLC, DLC, and PFS following radioe.bolization. Large. studie. are.ne.de. to validate.our initial findings to asse.s the.role.of F-18-FDG Pe./CT scans as biomarke. for patie.ts with HCC following radioe.bolization.

关键词： F-18 fluorode.xyglucose.Pe. He.atoce.lular carcinoma Radioe.bolization Prognosis Biomarke.

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废气涡轮增压器与高增压四冲程柴油机的匹配

国外内燃机车 1988年第4期 33-37页

作者： e.bode 李明海

0.前言为了确保高增压柴油机与废气涡轮增压器的最佳匹配,要认真而精确地选择废气流道及整个系统管路的参数。它既涉及到通流部件的基本几何尺寸,也涉及到通流结构的最佳化设计问题。这些工作对于废气涡轮增压器是非常重要的。若匹配点... 详细信息

0.前言为了确保高增压柴油机与废气涡轮增压器的最佳匹配,要认真而精确地选择废气流道及整个系统管路的参数。它既涉及到通流部件的基本几何尺寸,也涉及到通流结构的最佳化设计问题。这些工作对于废气涡轮增压器是非常重要的。若匹配点(压比)接近音速,并从经济性考虑,应采用一级废气涡轮增压。在发动机工作时,增压器应有尽可能高的总效率,以便使燃油消耗率有最大的降低,这是一个重要的任务。

关键词：压气机喷嘴环压缩机临界压比废气涡轮增压器涡轮增压器轴流式涡轮轴流式透平亚临界流动流体流动气流角反动度大型柴油机扩压器叶栅

Dige.e.n parasite. of the.marine.gastropods Littorina littore. and Gibbula umbilicalis in the.Northe.n Portugue.e.Atlantic coast,with a re.ie. of dige.e.ns infe.ting the.two gastropod ge.e.a

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Journal of Coastal Life.Me.icine 2016年第5期4卷 345-352页

作者： Graça Costa Sónia Soare. Fe.nando Carvalho João bela e.tação de.Biologia Marinha do Funchal Universidade da MadeiraPromenade Orla Marítima do FunchalMadeiraPortugal Instituto de.Ciências Biomédicas Abe. Salazar Universidade do PortoRua Jorge ViterboPortoPortugal CON-AQUA Rua Mário SacramentoAveiroPortugal

Obje.tive.To study the.dige.e.n parasite. of the.prosobranch gastropods,Littorina littore.(***)and Gibbula umbilicalis(***)from rocky shore. of the.Northe.n Atlantic coast of ***:A total of 413 *** and 2603 *** we.e.colle.te. from rocky shore.,at Ave.ro e.tuary,Aguda Be.ch,and Foz Be.ch at Porto(Northe.n Atlantic coast of Portugal)from January to July 2014 and Fe.ruary 2014 to January 2015,*** and dige.tive.glands of the.gastropods we.e.e.amine. unde. light microscopy for the.pre.e.ce.of *** gonads of *** we.e.pre.are. for histological obse.vation,whe.e.s dige.e.ns found in *** we.e.studie. and ide.tifie. with the.aid of light and scanning e.e.tron ***:Two spe.ie. of dige.e.ns we.e.found infe.ting the.dige.tive.gland and gonads of ***,name.y,Cainocre.dium labracis and Le.ithochirium furcolabiatum with a combine. pre.ale.ce.of 3%.Histological obse.vations of gonads of *** re.e.le. the.infe.tion with dige.e.ns,with conside.able.re.lace.e.t of gonadal *** dige.e.ns we.e.not ide.tifie. to spe.ie. *** pre.ale.ce.of dige.e.ns in this snail host was 0.7%.Conclusions:The.pre.e.t study adds *** as anothe. first inte.me.iate.host for Cainocre.dium labracis and e.te.ds its ge.graphical range.to the.Portugue.e.Atlantic *** of Le.ithochirium furcolabiatum we.e.pre.iously re.orte. from ***.A lite.ature.re.ie. of dige.e.ns occurring in the.gastropod ge.e.a Gibbula and Littorina is give..

关键词： Littorina littore. Gibbula umbilicalis Dige.e.ns Se. snails Atlantic Oce.n Portugal

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美国地面施药技术和器械的研究

农药译丛 1982年第1期 42-46页

作者： B.J.Butle. L.e.bode 王君奎美国伊里诺斯大学美国伊里诺斯大学教授副教授

前言本文试图总结美国施用农药方面的工程技术的研究工作,不包括飞机施药,但包括各州农业试验站和美国农业部的工作以及所知的私营企业的研究和开发工作.在美国病虫草害防治是一项发达的事业,其中农业上防治占其大部分.几乎所有的作物... 详细信息

前言本文试图总结美国施用农药方面的工程技术的研究工作,不包括飞机施药,但包括各州农业试验站和美国农业部的工作以及所知的私营企业的研究和开发工作.在美国病虫草害防治是一项发达的事业,其中农业上防治占其大部分.几乎所有的作物种植面积至少进行一次除草,玉米和棉花往往用杀虫剂处理一次或多次,大多数果树和蔬菜要施用多次杀虫剂和杀菌剂.施用农药是美国农民的一项重要开支,仅就伊里诺斯州而言,农民每年花费于施用农药的钱就超过1亿美元.由于这样大的花费,因而一致要求农药使用量不应超过作物生长的需要,而且喷到和保留在作物上的农药已经引起人们重新关心更精确地施用农药.能源费用的增加也使得地面常规施药和飞机施药人员同样关心降低喷药量.

关键词：施药量美国农业部佐治亚州防治效果喷液施药人员雾滴谱喷雾机喷雾器植保机具低压喷头器械