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Dihydroartemisinin is an inhibitor of ovarian cancer cell growth

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Acta Pharmacologica Sinica 2007年第7期28卷 1045-1056页

作者： Yang JIAO~2,Chun-min GE~3,Qing-hui MENG~3,jian-ping CAO~2,jian TONG~2,Sai-jun FAN~(2,3,4)~2 School of Radiology and Public Health,Soochow University,Suzhou 215123,China ~3 Department of Oncology,Lombardi ComprehensiveCancer Center,Georgetown University,Washington DC 20057,USA School of Radiology and Public Health Soochow University Suzhou China Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA

Aim:To investigate the anticancer activity of dihydroartemisinin （DHA）,a deriva-tive of antimalaria drug artemisinin in a panel of human ovarian cancer cell ***:Cell growth was determined by the MTT viability *** andcell cycle progression were evaluated by a DNA fragmentation gel electro-phoresis,flow cytometry assay,and TUNEL assay;protein and mRNA expression wereanalyzed by Western blotting and RT-PCR ***:Artemisinin and itsderivatives,including artesunate,arteether,artemether,arteannuin,and DHA,exhibit anticancer growth activities in human ovarian cancer *** them,DHA is the most effective in inhibiting cell *** cancer cell lines aremore sensitive （5-10-fold） to DHA treatment compared to normal ovarian *** at micromolar dose levels exhibits a dose-and time-dependent cyto-toxicity in ovarian cancer cell ***,DHA induced apoptosis and G2cell cycle arrest,accompanied by a decrease of Bcl-xLand Bcl-2 and an increase ofBax and ***:The promising results show for the first time that DHAinhibits the growth of human ovarian cancer *** selective inhibition ofovarian cancer cell growth,apoptosis induction,and G2arrest provide in vitroevidence for further studies of DHA as a possible anticancer drug in the clinicaltreatment of ovarian cancer.

关键词： dihydroartemisinin ovarian cancer cell growth

Analysis on vertical steering vibration of drum shearer cutting part

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Journal of Central South University 2018年第11期25卷 2722-2732页

作者： YANG Dao-long LI jian-ping WANG Yan-xiang jianG Hong-xiang School of Mechatronic Engineering Jiangsu Normal University School of Engineering China University of Mining and Technology

The impact of the load on the shearer is mainly transmitted through cutting *** this paper,in order to get the vertical steering vibration characteristics of the cutting part of the drum shearer,the working condition of coal mining machine is simplified.A simplified vertical steering model and the simplified vibration model of the whole cutting part of shearer are *** vertical steering vibration process of the cutting unit is simplified into a single freedom and one forced vibration system under harmonic *** dynamic response of the cutting part under sine excitation is obtained by using Matlab/Simulink for modeling and *** influence of the support rigidity and damping of the high oil cylinder on the vertical steering vibration characteristics of the cutting part is *** results show that the damping of the cylinder can reduce the vibration of the system and the stability of the swing process of cutting the part is improved.

关键词： drum shearer shearer cutting part vertical steering vibration Matlab/Simulink

Anti-tumor Immunity of Gene Vaccine with Nucleofection Technology

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Clinical oncology and cancer researeh 2011年第2期8卷 92-99页

作者： Tao GUAN Qiu XIE Xiao-ling YANG Guo-liang WANG Zhi-qiang ZHU jian-hua WANG bo NIU Department of Biochemistry and MolecularBiology Shanxi Medical University Taiyuan030001 Shanxi Province China. Capital Institute of Pediatrics Beijing100020 China.

OBJECTIVE To observe enhancement of anti-tumor immunity by gene vaccine using nucleofection technology METHODS The technique of nucleofection was used to transfer effectively plasmid DNA into immature dendritic cells （iDCs）; we studied immune responses regulated by DNA vaccine using real-time quantitative polymerase chain reaction （PCR） and western-blotting to optimize the follow-up lymphocyte activation. The anti-tumor capacity of lymphocytes primed by DCs was analyzed using lactate dehydrogenase with a non-radioactive cytotoxicity assay.

关键词： nucleofection technology gene vaccine immunity.

Wafer-Scale Gigahertz Graphene Field Effect Transistors on SiC Substrates

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Chinese Physics Letters 2011年第12期28卷 231-234页

作者： PAN Hong-Liang JIN Zhi MA Peng GUO jian-Nan LIU Xin-Yu YE Tian-Chun LI Jia DUN Shao-bo FENG Zhi-Hong Department of Microwave IC Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029 Science and Technology on ASIC Lab Hebei Semiconductor Research InstituteShijiazhuang 050051

Wafer-scale graphene field-effect transistors are fabricated using benzocyclobutene and atomic layer deposition Al_(2)O_(3) as the top−gate *** epitaxial-graphene layer is formed by graphitization of a 2-inch-diameter Si-face semi-insulating 6H-SiC *** graphene on the silicon carbide substrate is heavily n-doped and current saturation is not *** the intrinsic characteristic of this particular channel material,the devices cannot be switched *** cut-off frequencies of these graphene field-effect transistors,which have a gate length of 1µm,are larger than 800 *** largest one can reach 1.24 *** are greater than 95% active devices that can be successfully *** thus succeed in fabricating wafer-scale gigahertz graphene field-effect transistors,which paves the way for high-performance graphene devices and circuits.

关键词： switched effect carbide

Next generation sequencing reveals co-existence of hereditary spherocytosis and Dubin–Johnson syndrome in a Chinese gril: A case report

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World Journal of Clinical Cases 2019年第20期7卷 3303-3309页

作者： Yuan Li Yang Li Yang Yang Wen-Rui Yang jian-ping Li Guang-Xin Peng Lin Song Hui-Hui Fan Lei Ye You-Zhen Xiong Zhi-Jie Wu Kang Zhou Xin Zhao Li-ping Jing Feng-Kui Zhang Li Zhang Anemia Therapeutic Center Institute of Hematology and Blood Diseases HospitalCAMS and PUMC

BACKGROUND Hereditary spherocytosis(HS)is a hereditary disease of hemolytic anemia that occurs due to the erythrocyte membrane ***–Johnson syndrome(DJS),which commonly results in jaundice,is a benign hereditary disorder of bilirubin clearance that occurs only *** co-occurrence of HS and DJS is extremely *** recently diagnosed and treated a case of co-occurring HS and *** SUMMARY A 21-year-old female patient presented to our department because of severe jaundice,severe splenomegaly,and mild anemia since *** eventually confirmed the diagnosis of co-occurring DJS and HS by next generation sequencing(NGS).The treatment of ursodeoxycholic acid in combination with phenobarbital successfully increased hemoglobin and reduced total bilirubin and direct *** The routine application of NGS can efficiently render a definite diagnosis when inherited disorders are suspected.

关键词： Hereditary spherocytosis Dubin–Johnson syndrome Hemolytic anemia Jaundice Next generation sequencing ABCC2 SPTB Case report

基于多特征融合及能量分布的图像篡改检测方法

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兰州理工大学学报 2018年第4期44卷 96-102页

作者：钱建波淮安信息职业技术学院江苏淮安223001 江苏省电子产品装备制造工程技术研究研发中心江苏淮安223001

针对最常见的一种图像篡改方式——拼接,采取了特征提取-分类判别的技术手段,对图像的真假属性进行鉴别.首先,从多通道(亮度通道与色度通道)、多变换域(空间域与频率域)的角度建立了多特征融合的图像篡改检测模型,克服了以往特征提取算... 详细信息

针对最常见的一种图像篡改方式——拼接,采取了特征提取-分类判别的技术手段,对图像的真假属性进行鉴别.首先,从多通道(亮度通道与色度通道)、多变换域(空间域与频率域)的角度建立了多特征融合的图像篡改检测模型,克服了以往特征提取算法采用马尔科夫等单一性特征的缺陷.其次,通过分析不同通道不同变换域的能量分布,在亮度通道对能量做基准化处理,从而对马尔科夫转移状态的阈值做出修正;在色度通道,根据能量的集中性,对马尔科夫的转移进行状态细分.由此对模型进一步改进,并在最新的彩色图像库上进行实验验证.实验表明,多特征融合的图像篡改检测方法将检测准确率由单一特征的67.2%提高至85.5%,基于能量分布的改进模型将检测准确率进一步提升至87.1%,从而证实了算法的有效性和高效性.

关键词：图像篡改检测马尔科夫多特征融合能量分布

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基于生物入侵的特征选择算法

计算机工程 2024年第9期50卷 46-53页

作者：张健张博武汉大学计算机学院湖北武汉430072

在自然界中,生物入侵以其发展的迅速和巨大的生态影响而受到关注,所引入种群对合适栖息地的寻找过程往往有其内在的逻辑,种群之间的交流和种群的扩张也在这个过程中起到了重要作用。通过探究种群对适宜栖息地的寻找原理,提出一种基于生... 详细信息

在自然界中,生物入侵以其发展的迅速和巨大的生态影响而受到关注,所引入种群对合适栖息地的寻找过程往往有其内在的逻辑,种群之间的交流和种群的扩张也在这个过程中起到了重要作用。通过探究种群对适宜栖息地的寻找原理,提出一种基于生物入侵的特征选择(BIAFS)算法。在BIAFS算法中,生物入侵过程分为种群建立、种群迁移、种群交流和扩张、种群发展4个阶段。在实验验证过程中,在9个数据集上将BIAFS算法与8种高性能算法进行实验比较。实验结果显示,BIAFS算法在7个数据集上的分类准确率(CA)和降维(DR)率均超过了对比算法。此外,适应度标准偏差的比较实验也证实了BIAFS算法的高稳定性,表明其在多个数据集上能更加稳健地寻找最优解。上述实验结果证明了BIAFS算法在特征选择任务中的有效性和优越性。

关键词：生物入侵特征选择入侵动态差分进化精英策略

Surface evolution of Al-Si-Cu alloy in thermal shock under different heating speeds

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Journal of Central South University 2021年第10期28卷 2988-2998页

作者： LIU Lei ZHANG Hai-jun LI bo-yan YANG Zhong BAO Tong LI jian-ping GUO Yong-chun XIA Feng YANGWei LI Hai-ying School of Materials and Chemical Engineering Xi'an Technological UniversityXi'an 710021China China North Engine Research Institute(Tianjin) Tianjin 300400China

In order to understand the initial surface damage of Al piston in unsteady thermal environment like knock combustion,T6 heat treated cast Al-Si-Cu alloy was thermal shocked under different heating speeds between room temperature and 450°C by adjusting the environmental *** surface evolution was mainly characterized in view of roughness,hardness,morphology,texture,phase and element *** indicated that both the roughness and hardness went up to the maximum and then decreased with rising heating ***-structure and phase analysis suggested that the interactions of solid phase transition and oxidation with enhancing thermal stress took responsible for the surface evolution.

关键词： Al alloy piston thermal shock heating speed surface roughness

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静电除尘高压供电设备控制器的开发

北京工业大学学报 2005年第1期31卷 25-28页

作者：闫博徐萍萍陈文楷北京工业大学电子信息与控制工程学院北京100022

介绍了静电除尘用高压供电设备控制器的主要设计方案,此方案的特点是能自动跟踪最高运行电压, 具有电场短路、电场开路、偏励磁和油温超限等保护功能.通过实践证明该方案稳定、可靠.

关键词：静电除尘高压供电控制器