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Cytokine Profiles and Virological Marker Monitoring during 48 Weeks Peginterferon Alfa Treatment for HBeAg-Positive Chronic Hepatitis B

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biomedical and Environmental Sciences 2022年第4期35卷 312-321页

作者： LI Ming Hui SUN Fang Fang CHEN Feng Xin ZENG Zhan LIN Yan Jie bi xiao yue YANG Liu DENG Wen JIANG Ting Ting HUANG Rong Hai YI Wei XIE Yao Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Capital Medical University Beijing 100069China Department of Infectious Diseases Capital Medical UniversityBeijing 100015China Department of General Surgery Capital Medical UniversityBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective This study aimed to investigate whether cytokine profiles and virological markers might add value in monitoring the effects of peginterferon(PEG-IFN)therapy for hepatitis B e-antigen(HBeAg)positive chronic hepatitis B(CHB).Methods HBeAg positive patients with CHB were treated with PEG-IFN for 48 *** biochemical,and HBV serological indexes,as well as cytokines,were detected at baseline and every12 *** A total of 116 patients with CHB were enrolled in this study;100 patients completed the 48-week treatment and follow-up,of whom 38 achieved serum HBeAg disappearance,25 achieved HBeAg seroconversion,37 showed HBsAg decreases≥1 log10 IU/mL,9 showed HBsAg disappearance,and 8became HBsAb *** cytokine levels at baseline and during treatment were similar between the HBeAg disappearance group and non-disappearance *** disappearance of HBeAg was independently associated with HBeAg levels at weeks 12 and 24,and with the HBeAg decline at week 24(P<0.05).The HBsAg response was independently associated with HBsAg,the HBsAg decline,HBeAg,the HBeAg decline at week 12,and HBsAg at week 24(P<0.05).Conclusion There was no significant correlation between the response to interferon(IFN)and cytokines during PEG-IFN *** changes in virological markers predicted the response to IFN after 48 weeks.

关键词： Chronic hepatitis B Cytokine Peginterferon HBsAg HBeAg

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剪切形变下磷烯的力学和热学性能

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物理学报 2023年第12期72卷 214-222页

作者：李婷毕晓月孔婧文辽宁师范大学物理与电子技术学院大连116029

磷烯是一种新型的二维半导体材料,近年来得到了研究者们的广泛关注.通过分子动力学模拟对磷烯在剪切形变下的力学和热学性能进行了系统探究.磷烯的剪切力学呈现出各向同性的特点,沿扶手椅与锯齿方向的剪切模量均约为22 GPa.磷烯的断裂... 详细信息

磷烯是一种新型的二维半导体材料,近年来得到了研究者们的广泛关注.通过分子动力学模拟对磷烯在剪切形变下的力学和热学性能进行了系统探究.磷烯的剪切力学呈现出各向同性的特点,沿扶手椅与锯齿方向的剪切模量均约为22 GPa.磷烯的断裂强度和极限应变对温度十分敏感,高温会显著削弱磷烯抗剪切形变的能力.无应变时磷烯沿锯齿与扶手椅方向热导率的各向异性比为2.83.当对磷烯施加剪切应变时,磷烯沿扶手椅方向的热导率随着剪切应变的增大而减小,但是剪切应变对磷烯锯齿方向热导率的影响则相对较弱.通过对磷烯的声子态密度分析发现,剪切形变主要对其柔性声子模式的振动特性具有显著影响,使高频声子发生了红移.同时,剪切形变的存在会严重改变晶格的非简谐振动,继而在不同程度上对磷烯声子间的散射产生重要的影响.磷烯声子态密度的改变以及声子散射通道的变化共同决定了其在剪切形变下的导热特性.

关键词：磷烯剪切形变热导率分子动力学

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Combining Ability and Heterosis Between High Strength Lines and Transgenic Bt (Bacillus thuringiensis) Bollworm-Resistant Lines in Upland Cotton (Gossypium hirsutum L.)

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Agricultural Sciences in China 2003年第1期2卷 13-18页

作者： ZHANG Zheng-sheng, LI Xian-bi, xiao yue-hua, LUO Ming, LIU Da-jun, HUANG Shun-li and ZHANG Feng-xinSouthwest Agricultural University , Chongqing 400716 , P. R. China Southwest Agricultural University Chongqing 400716 P. R. China

To analyse the combining ability and heterosis between high-strength lines and transgenic Bt bollworm-resistant lines in upland cotton, 5 high-strength lines were crossed as female lines with 12 transgenic Bt bollworm-resistant lines according to NCII design. It was demonstrated that the compositions of variance in various traits were quite different. For seed cotton yield, lint yield, boll numbers per plant and boll weight, the dominant (special combining ability) effects were the major effects, accounting for 87.38, 84. 40, 80. 04 and 64. 46% of the total phenotypic variances, respectively, while for fibre strength and micronaire value, the additive (general combining ability) effects had the major effects, with a ratio of additive variance to phenotypic variance of 78.85 and 43.80%. As for lint percent and 2.5% span length, the dominant and additive variances had similar effects, in phenotypic variances (54.94 and 40.11% for lint percent, 45.76 and 42.49% for 2. 5% span length, respectively). The mid-parent heterosis (Hpm), surpassing parent heterosis (Hpb) and competitive heterosis (Hck) for seed cotton yield and lint yield were both extremely significant. For fibre properties, the Hck and Hpm of 2.5 % fibre span length were extremely significant, the Hck of fibre strength was significant, and the favorable negative Hck of micronaire was also extremely significant. The increments of hybrid over common variety were 17% for lint yield and fibre strength, 7% for fibre span length, and 4 % for fineness.

关键词： Cotton High fibre strength Transgenic Bt bollworm-resistance Combining ability Heterosis

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Physics based circuit compatible model for hybrid antiferroelectric random access memory

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Science China(Information Sciences) 2025年第1期68卷 396-397页

作者： Qiuxia WU yue PENG Wenwu xiao Wenxuan MA Shuo ZHANG Litao SUN Chunfu ZHANG xiaohua MA yue HAO School of Microelectronics Xidian University Xi'an Uni IC Semiconductors

Since the discovery of HfO2-based ferroelectric （FE） materials in 2011,considerable advancements have been made in material preparation,mechanism research,and device realization [1].Consequently,these materials are now regarded as leading candidates for embedded non-volatile memory（eNVM）.Beyond eNVM applications,recent studies have demonstrated that memory devices with antiferroelectric（AFE） films can achieve high response speeds,low latency,and reduced power consumption while maintaining excellent endurance characteristics [2,3].Additionally,the typical double hysteresis loops and multiple non-overlapping polarization current peaks of AFE films offer a novel approach to designing multistate ***,in order to further promote the application of high storage density AFE,an AFRAM electronic design automation （EDA） model must be developed,and it has yet to be proposed.

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藜芦醇和吐温80对白腐菌产木质素降解酶的影响及在偶氮染料脱色中的作用

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生物工程学报 2004年第2期20卷 302-305页

作者：荚荣汤必奎张晓宾何月梅安徽大学生命科学学院生物技术系合肥230039

担子菌PM2在限氮液体培养下 ,分泌木质素过氧化物酶和锰过氧化物酶 ;藜芦醇、吐温 80的补充 ,提高了该菌锰过氧化物酶的产生 ,获得的最大锰过氧化物酶Mnp酶活为 2 54 2u L、190 2u L ,分别是对照的 3 4倍和 2 5倍。选择三种偶氮染料 ... 详细信息

担子菌PM2在限氮液体培养下 ,分泌木质素过氧化物酶和锰过氧化物酶 ;藜芦醇、吐温 80的补充 ,提高了该菌锰过氧化物酶的产生 ,获得的最大锰过氧化物酶Mnp酶活为 2 54 2u L、190 2u L ,分别是对照的 3 4倍和 2 5倍。选择三种偶氮染料 ,在染料体系下 ,进一步分析藜芦醇、吐温 80对担子菌PM2产过氧化物酶及染料脱色的影响。结果表明 ,担子菌PM2分泌的锰过氧化物酶Mnp与染料脱色有关 ,脱色程度受其分子结构特征影响 ;吐温 80的补充 ,更有利于染料的脱色降解 ,48h后三种染料均可达到 80

关键词：藜芦醇吐温80 木质素过氧化物酶锰过氧化物酶偶氮染料脱色率白腐菌担子菌PM2

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： xiaoqin Li Jian Xiang Lu Qiu xiaohan Chen Yinkun Zhao Yujue Wang Qu yue Taotao Gao Wenlong Liu Dan xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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新型食品添加剂γ-聚谷氨酸合成酶基因的克隆及表达

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食品工业科技 2017年第3期38卷 127-132页

作者：王风青梁金钟毕明月肖玮哈尔滨商业大学食品工程学院黑龙江省高等学校食品科学与工程重点实验室黑龙江哈尔滨150076

γ-聚谷氨酸(γ-poly glutamic acid,γ-PGA)特殊的分子结构,使其具有很好的乳化、增稠、抗冻等特性,可作为添加剂广泛应用于食品当中。实验以枯草芽孢杆菌Bacillus subtilis 115基因组为模板,通过PCR技术成功克隆到γ-PGA合成酶系基因p... 详细信息

γ-聚谷氨酸(γ-poly glutamic acid,γ-PGA)特殊的分子结构,使其具有很好的乳化、增稠、抗冻等特性,可作为添加剂广泛应用于食品当中。实验以枯草芽孢杆菌Bacillus subtilis 115基因组为模板,通过PCR技术成功克隆到γ-PGA合成酶系基因pgs BCA,并进行测序,利用Ex PASy-Prot Param tool、Server 3.0 Signal P,TMHMM Server和Tmpred,PSORTB,Predict Protein,Swiss-Model Workspace软件,分别对蛋白质的生物信息进行了分析和预测,针对γ-PGA合成关键酶基因pgs B构建了表达体系,结果表明:pgs B,pgs C和pgs A基因分别含1182、450和1143个核苷酸,分别编码393、149和380个氨基酸,其对应蛋白均不存在信号肽,属于非分泌型蛋白;Pgs B、Pgs C和Pgs A分子量分别为44016.7、16302.9、42759.8 Da;Pgs B为亲水性不稳定的酸性蛋白质,二级结构以α-螺旋为主;Pgs C是疏水碱性的膜结合蛋白,存在4个强跨膜区;Pgs A为亲水稳定的碱性蛋白,在N端存在1个强跨膜区域。经聚丙烯酰胺凝胶电泳(SDS-PAGE)检测,pgs B基因被成功表达,目的蛋白相对分子质量约为45 k Da,与预测值基本相符。

关键词： Bacillus subtilis 115 γ-PGA pgsBCA基因克隆生物信息分析诱导表达

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Design high-performance narrowband emitters for blue light-emitting diodes through manipulating resonance structure of aromatic heterocycles

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Science China Chemistry 2025年

作者： yue Yu Lei Xu Wenle Tan Yuyu Pan Jiyin xiao Bohan Wang Guangjun Tian Yuguang Ma Lei Ying Institute of Polymer Optoelectronic Materials and Devices Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology School of Petrochemical Engineering Shenyang University of Technology Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University

Narrowband light-emitting materials play critical roles in improving the color gamut and energy consumption of electroluminescence. Herein we demonstrated that by regulating the ground state resonance structure form of emitters with polycyclic aromatic heterocycles, the high-energy vibration of the C–C bond can be effectively suppressed, resulting in narrow emission like classical cyanine dyes. The designed compounds consist of twist and planar conformation, while having differences in the orientation of the positioning electron-donating(nitrogen) and electron-accepting(carbonyl) groups in the polycyclic aromatic hydrocarbon skeleton. The resulting compound Ac-Ph-Ac with a dominated zwitterionic resonance structure exhibits a relatively wide electroluminescent profile with the full width at half maximum(FWHM) of 42 nm and moderate device performance. In contrast, the “soliton transition” of 2AcPh based on the cyanine limit character effectively suppresses C–C stretching vibration in the polycyclic aromatic heterocycle skeleton, leading to a narrow electroluminescent profile with FWHM of 30 nm(0.16 eV)associated with an impressively high external quantum efficiency of 28.52%, which is among the highest efficiencies of so far reported non-sensitized organic light-emitting diodes.

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三二饮治疗小儿急性支气管肺炎疗效观察

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湖南中医药大学学报 2009年第4期29卷 63-64,76页

作者：陈锡军肖碧跃蒋屏湖南中医药大学第一附属医院湖南长沙410007 湖南中医药大学湖南长沙410208

目的观察三二饮治疗小儿急性支气管肺炎的临床疗效。方法将166例小儿急性支气管肺炎患者随机分为治疗组和对照组各83例,治疗组以三二饮煎剂联用西药治疗,对照组用西药治疗,治疗7 d后观察疗效。结果治疗组主要症状和体征消失时间明显短... 详细信息

目的观察三二饮治疗小儿急性支气管肺炎的临床疗效。方法将166例小儿急性支气管肺炎患者随机分为治疗组和对照组各83例,治疗组以三二饮煎剂联用西药治疗,对照组用西药治疗,治疗7 d后观察疗效。结果治疗组主要症状和体征消失时间明显短于对照组,差异具有统计学意义(P<0.01);治疗组疗效优于对照组,差异亦具有统计学意义(P<0.05)。结论三二饮联合西药治疗小儿急性支气管肺炎疗效优于单纯西药治疗。

关键词：支气管肺炎小儿三二饮临床疗效麻黄杏仁半夏

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从《金匮要略》教学实例剖析PBL培养中医思维的作用点

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中国中医药现代远程教育 2015年第19期13卷 103-105页

作者：艾碧琛喻嵘肖碧跃易亚乔苏联军湖南中医药大学中医学院长沙410208

培养中医思维方法是《金匮要略》教学终极教学目的。传统的LBL教学法不利于形成学生中医临床思维,PBL教学法有利于培养学生自主学习的能力及形成解决问题的技能,对临床思维和技能的培养甚有意义。通过2012—2015《金匮要略》PBL教学实践... 详细信息

培养中医思维方法是《金匮要略》教学终极教学目的。传统的LBL教学法不利于形成学生中医临床思维,PBL教学法有利于培养学生自主学习的能力及形成解决问题的技能,对临床思维和技能的培养甚有意义。通过2012—2015《金匮要略》PBL教学实践,发现PBL教学能在辨病→辨证→确立治法→组方用药→治疗后病情变化分析及随证施治等多作用点促进中医思维的形成,是提高《金匮要略》教学效果的有效方法;但对合理运用四诊及提炼问诊资料的思维能力培养显欠缺,有待改良。

关键词：金匮要略 PBL教学中医思维

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