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Multiple primary cancers with gastrointestinal malignant tumors as the first manifestation:Three case reports and review of literature

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World Journal of Gastroenterology 2025年第8期31卷 130-139页

作者： Xin-ran bi Shuang-Yan Zhao Yu-Qi Ma Xiao-Yu Duan Ting-Ting Hu Lian-Zhu bi Hong-Yi Cai The First Clinical Medical College of Gansu University of Traditional Chinese Medicine Lanzhou 730000Gansu ProvinceChina Department of Radiotherapy Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Gastrointestinal Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Neurology Hospital of Fengnan DistrictTangshan 063300Hebei ProvinceChina

BACKGROUND The incidence of malignant gastrointestinal(GI)tumors is increasing,and advancements in medical care have significantly improved patient survival *** a result,the number of cases involving multiple primary cancers(MPC)has also *** rarity of MPC and the absence of sensitive and specific dia-gnostic markers often lead to missed or incorrect *** is,therefore,of vital importance to improve the vigilance of clinicians and the accurate diagnosis of this *** with GI malignancies face a higher relative risk of deve-loping additional primary malignant tumors compared to those with other systemic *** monitoring and follow-up are crucial,especially for high-risk groups,which include older adults,men,those with addictions to alcohol and tobacco,those with a family history of tumors,and those who have undergone *** SUMMARY In this article,we report three cases of MPC,each involving malignant tumors of the GI tract as the initial primary carcinoma,offering insights that may aid in effectively managing similar *** Patients with GI malignancies face a higher MPC *** screening and follow-up protocols may enhance detection and treatment outcomes.

关键词： Multiple primary cancer Gastrointestinal tract Synchronous Metachronous Case report

An Optimal Content Caching Framework for Utility Maximization

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Tsinghua Science and Technology 2016年第4期21卷 374-384页

作者： ran bi Yingshu Li Xu Zheng Department of Computer Science Dalian University of Technology Department of Computer Science Georgia State University Department of Computer Science Harbin Institute of Technology

For desirable quality of service, content providers aim at covering content requests by large network caches. Content caching has been considered as a fundamental module in network architecture. There exist few studies on the optimization of content caching. Most existing works focus on the design of content measurement, and the cached content is replaced by a new one based on the given metric. Therefore, the performance for service provision with multiple levels is decreased. This paper investigates the problem of finding optimal timer for each content. According to the given timer, the caching policies determine whether to cache a content and which existing content should be replaced, when a content miss occurs. Aiming to maximize the aggregate utility with capacity constraint, this problem is formalized as an integer optimization problem. A linear programming based approximation algorithm is proposed, and the approximation ratio is proved. Furthermore, the problem of content caching with relaxed constraints is given. A Lagrange multiplier based approximation algorithm with polynomial time complexity is proposed. Experimental results show that the proposed algorithms have better performance.

关键词： content caching utility maximization integer optimization approximation algorithm

Utility Aware Offloading for Mobile-Edge Computing

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Tsinghua Science and Technology 2021年第2期26卷 239-250页

作者： ran bi Qian Liu Jiankang Ren Guozhen Tan School of Computer Science and Technology Dalian University of TechnologyDalian 116024China

Mobile-edge computing casts the computation-intensive and delay-sensitive applications of mobile devices onto network *** offloading incurs extra communication latency and energy cost,and extensive efforts have focused on offloading *** metrics of the system utility are defined to achieve satisfactory quality of ***,most existing works overlook the balance between throughput and *** study investigates the problem of finding an optimal offloading scheme in which the objective of optimization aims to maximize the system utility for leveraging between throughput and *** on Karush-Kuhn-Tucker condition,the expectation of time complexity is analyzed to derive the optimal scheme.A gradient-based approach for utility-aware task offloading is ***,we provide an increment-based greedy approximation algorithm with 1+1/(e-1)*** results show that the proposed algorithms can achieve effective performance in utility and accuracy.

关键词： utility approximation algorithm quality of experience mobile edge computing

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3D打印手性液晶智能材料研究进展

4D-printed snake-like biomimetic soft robots

液晶与显示 2025年第1期40卷 55-74页

作者：毕然刘源张璇杨言昭曹致隆封伟王玲天津大学材料科学与工程学院天津 300350 天津大学滨海工业研究院天津 300452

手性液晶材料是一种独特的光子材料,一般可以分为一维胆甾相液晶和三维蓝相液晶.得益于内部周期性排列的纳米结构,手性液晶不仅具有一般液晶所没有的光学性质,如选择性反射、旋光性和圆二色性等,还可以快速灵敏地协同响应外界环境条件,... 详细信息

手性液晶材料是一种独特的光子材料,一般可以分为一维胆甾相液晶和三维蓝相液晶.得益于内部周期性排列的纳米结构,手性液晶不仅具有一般液晶所没有的光学性质,如选择性反射、旋光性和圆二色性等,还可以快速灵敏地协同响应外界环境条件,这在先进显示、动态防伪、信息加密、智能织物等领域有广泛的应用.近年来,随着3D打印技术的蓬勃发展,研究人员开发了多种可打印的手性液晶墨水,制备了具有复杂几何结构、多功能、多刺激响应性的手性液晶材料,并深入研究了3D打印手性液晶的潜在应用价值.本文首先系统综述了基于3D打印技术的手性液晶的自组装机制,例如剪切诱导取向自组装、各向异性挥发自组装、临界胶体浓度自组装等,并重点介绍了基于3D打印技术的各种刺激响应性的手性液晶材料和具有荧光发光的手性液晶功能材料.最后总结了3D打印手性液晶材料的未来发展方向以及潜在的挑战.

关键词：手性液晶 3D打印结构色圆偏振发光刺激响应

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bio-Design and Manufacturing 2025年第1期8卷 55-67,I0018-I0038页

作者： Xingcheng Ou Jiaqi Huang Dantong Huang Xiaohong Li Guoliang Chen Yabin Yang ran bi Yu Sheng Shuang-Zhuang Guo Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices Guangdong Engineering Technology Research Centre for Functional BiomaterialsKey Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationState Key Laboratory of Optoelectronic Materials and TechnologiesSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China

Wireless millirobots engineered to infiltrate intricate vascular networks within living organisms,particularly within constricted and confined spaces,hold immense promise for the future of medical ***,with their multifaceted and intricate designs,some robots often grapple with motion and functionality issues when confronted with tight spaces characterized by small cross-sectional *** this study,drawing inspiration from the high aspect ratio and undulating swimming patterns of snakes,a millimeter-scale,snake-like robot was designed and fabricated via a combination of extrusion-based four-dimensional(4D)printing and magnetic-responsive intelligent functional inks.A sophisticated motion control strategy was also developed,which enables the robots to perform various dynamic movements,such as undulating swimming,precise turns,graceful circular motions,and coordinated cluster movements,under diverse magnetic field *** a potential application,the snake robot can navigate and release drugs in a model coronary intervention vessel with tortuous channels and fluid *** novel design and promising applications of this snake robot are invaluable tools in future medical surgeries and interventions.

关键词： 4D printing Magnetic-responsive ink Untethered medical soft robot Snake-like robot Drug delivery

Effect of dispersion and distribution of tungsten on W/HZSM-5 for selective catalytic reduction of NO by acetylene

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Journal of Natural Gas Chemistry 2008年第4期17卷 332-336页

作者： ran bi Xinping Wang Zhiguang Liu Jing Chen State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116024 Liaoning China

Catalytic performance of W/HZSM-5 in selective catalytic reduction of NO by acetylene was investigated in a reaction system with 1600 ppm of NO, 800 ppm of C2H2, and 9.95% of O2 in He. It was found that promotional effect of tungsten on the reaction is strongly affected by catalyst preparation conditions and Si/Al ratio of the parent zeolite. A better dispersion of tungsten on HZSM-5 and relatively more monomeric tungsten species were found on 8%W/HZSM-5 prepared by impregnation of the zeolite with lower SiO2/A1203 ratio （25） in ammonic ammonium tungstate solution and calcination of the resulting material at higher temperature （550 ℃）. The highest NO conversion to N2 of 86.3% in the reaction system was obtained at 350 ℃ over the catalyst thus prepared. The mechanism of monomeric tungsten species improving the C2H2-SCR can be attributed to accelerating the formation of active nitrate species.

关键词： nitric oxide selective catalytic reduction tungsten HZSM-5

Efficient synthesis of nigerose by a novel nigerose phosphorylase from Anaerosporobacter mobilis

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Systems Microbiology and biomanufacturing 2023年第3期3卷 498-508页

作者： ran bi Jing Wu Lingqia Su Wei Xia State Key Laboratory of Food Science and Technology Jiangnan University1800 Lihu AvenueWuxi 214122China School of biotechnology and Key Laboratory of Industrial biotechnology Ministry of Education Jiangnan University1800 Lihu AvenueWuxi 214122China International Joint Laboratory on Food Safety Jiangnan University1800 Lihu AvenueWuxi 214122China

Nigerose is a kind of rare disaccharide connected by anα-1,3 glucosidic bond,which is a potential probiotic due to its antidigestive properties and beneficial *** study identified and characterized a novel GH65 glycoside phosphorylase derived from Anaerosporobacter mobilis(AmNP).This new protein could specifically catalyze the phospholysis of nigerose to generate glucose and glucose-1-phosphate in the presence of phosphate,indicating it was a typical nigerose *** to the previously reported nigerose phosphorylases,AmNP exhibited lower affinity towards nigerose in phosphorolysis reaction and higher affinity towards glucose in reverse phosphorolysis reaction,which indicated that AmNP might be superior in the synthetic capability of *** AmNP was employed to synergize with maltose phosphorylase from Lactobacillus brevis(LbMP)to catalyze the synthesis of nigerose using maltose as the *** optimization of reaction conditions,the highest nigerose yield reached 132.0 g/L with a 66.3%conversion rate,which was higher than ever reported cases using the same reaction pathway to our *** findings on AmNP in this work were expected to provide a new candidate for large-scale enzymatic synthesis of nigerose and have important theoretical significance for studying nigerose phosphorylase.

关键词： Nigerose Nigerose phosphorylase Coupling reaction Enzymatic synthesis

High yield synthesis of nigerooligosaccharides by transglycosylation catalyzed by α-glucosidase TaAglA from Thermoplasma acidophilum

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Food bioscience 2022年第3期47卷 245-252页

作者： Wei Xia Yifan Wang ran bi Jing Wu State Key Laboratory of Food Science and Technology Jiangnan University1800 Lihu AvenueWuxi214122China School of biotechnology and Key Laboratory of Industrial biotechnology Ministry of Education Jiangnan University1800 Lihu AvenueWuxi214122China International Joint Laboratory on Food Safety Jiangnan University1800 Lihu AvenueWuxi214122China

Nigerooligosaccharides (NOS) is a new functional oligosaccharide containing α-1,3 glucosidic bond with good anti-digestive properties and intestinal *** catalyzed by α-glucosidase is an effective method for the preparation of ***,there are few reports on the enzymatic synthesis of nigerooligosaccharides by α-glucosidase at *** study was aimed to investigate the transglycosylation property of the GH31 α-glucosidase from Thermoplasma acidophilum,TaAglA,and also evaluate its application performance in the preparation of *** was found that TaAglA exhibited selectivity for α-1,3 and α-1,4 linkages when catalyzing hydrolysis,but for α-1,3 and α-1,6 linkages when catalyzing *** 10% glucose and 20% maltose as substrates,TaAglA yielded 88.5 g/L NOS under the condition of pH 6.0,80 ℃ and 1 U/mL enzyme addition,which was the highest level to our *** addition,components with higher polymerization degrees,*** and nigerosyl-glucose,occupied 53.6% proportion of the total NOS products,giving it better probiotic ***,after purification by glucoamylase digestion and yeast culture,the final yield of NOS was 26.1%,and the purity of the product was 93%.These findings on TaAglA were expected to provide a new candidate for large-scale enzymatic synthesis of NOS,and also have important theoretical significance for the study of GH31 α-glucosidase.

关键词： Nigerooligosaccharides α-glucosidase α-1,3 glucosidic bond Enzymatic synthesis Transglycosylation

Electrochemical and spectroscopic characteristics of dissolved organic matter in a forest soil profile

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Journal of Environmental Sciences 2013年第10期25卷 2093-2101页

作者： ran bi Qin Lu Tian Yuan Shungui Zhou Yong Yuan Yanfei Cai Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangdong Institute of Eco-Environmental and Soil Sciences College of Resources and Environment SouthChina Agricultural University

Dissolved organic matter （DOM） represents one of the most mobile and reactive organic compounds in ecosystem and plays an important role in the fate and transport of soil organic pollutants, nutrient cycling and more importantly global climate change. Electrochemical methods were first employed to evaluate DOM redox properties, and spectroscopic approaches were utilized to obtain information concerning its composition and structure. DOM was extracted from a forest soil profile with five horizons. Differential pulse voltammetry indicated that there were more redox-active moieties in the DOM from upper horizons than in that from lower horizons. Cyclic voltammetry further showed that these moieties were reversible in electron transfer. Chronoamperometry was employed to quantify the electron transfer capacity of DOM, including electron acceptor capacity and electron donor capacity, both of which decreased sharply with increasing depth. FT-IR, UV-Vis and fluorescence spectra results suggested that DOM from the upper horizons was enriched with aromatic and humic structures while that from the lower horizons was rich in aliphatic carbon, which supported the findings obtained by electrochemical approaches. Electrochemical approaches combined with spectroscopic methods were applied to evaluate the characteristics of DOM extracted along a forest soil profile. The electrochemical properties of DOM, which can be rapidly and simply obtained, provide insight into the migration and transformation of DOM along a soil profile and will aid in better understanding of the biogeochemical role of DOM in natural environments.

关键词： dissolved organic matter electrochemical characteristics soil profile spectroscopic characteristics