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Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

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Protein & Cell 2024年第1期15卷 6-20页

作者： Ning Wu Ling Wei Zhipeng Zhu Qiang liu Kailong Li Fengbiao Mao {2. qiao Xiaolu Zhao State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyCenter for Reproductive MedicinePeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking university) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive technology Beijing 100191China Institute of Medical Innovation and Research Peking University Third HospitalBeijing 100191China Cancer Center Peking University Third HospitalBeijing 100191China department of biochemistry and biophysics Beijing Key Laboratory of Protein Posttranslational Modifications and Cell FunctionSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Beijing Advanced Innovation Center for Genomics Beijing 100191China Peking-Tsinghua Center for Life sciences Peking UniversityBeijing 100191China

Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular *** biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA,for which few detection methods are *** advances in high-throughput sequencing technologies have revealed that eccDNAs play crucial roles in tumor formation,evolution,and drug resistance as well as aging,genomic diversity,and other biological processes,bringing it back to the research *** mechanisms of eccDNA formation have been proposed,including the breakage-fusion-bridge(BFB)and translocation-deletion-amplification *** tumors and disorders of embryonic and fetal development are major threats to human reproductive *** roles of eccDNAs in these pathological processes have been partially elucidated since the first discovery of eccDNA in pig sperm and the double minutes in ovarian cancer *** present review summarized the research history,biogenesis,and currently available detection and analytical methods for eccDNAs and clarified their functions in gynecologic tumors and *** also proposed the application of eccDNAs as drug targets and liquid biopsy markers for prenatal diagnosis and the early detection,prognosis,and treatment of gynecologic *** review lays theoretical foundations for future investigations into the complex regulatory networks of eccDNAs in vital physiological and pathological processes.

关键词： extrachromosomal circular DNAs gynecologic tumors reproduction liquid biopsy non-invasive prena-tal testing

WTV2.0:A high-coverage plant volatilomics method with a comprehensive selective ion monitoring acquisition mode

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Molecular Plant 2024年第6期17卷 972-985页

作者： Honglun Yuan Yiding Jiangfang Zhenhuan liu Rongxiu Su qiao Li Chuanying Fang Sishu Huang Xianqing liu Alisdair R.Fernie jie Luo school of Breeding and Multiplication(Sanya Institute of Breeding and Multiplication)and College of Tropical Agriculture and Forestry Hainan UniversitySanya Hainan 572025China Yazhouwan National Laboratory(YNL) Sanya Hainan 572025China department of Molecular Physiology Max-Planck-Institute of Molecular Plant PhysiologyAm Mühlenberg 1Potsdam-Golm 14476Germany

Volatilomics is essential for understanding the biological functions and fragrance contributions of plant ***,the annotation coverage achieved using current untargeted and widely targeted volatomics(WTV)methods has been limited by low sensitivity and/or low acquisition ***,we introduce WTV 2.0,which enabled the construction of a high-coverage library containing 2.11 plant volatiles,and report the development of a comprehensive selective ion monitoring(cSIM)acquisition method,including the selection of characteristic qualitative ions with the minimal ion number for each compound and an optimized segmentation method,that can acquire the smallest but sufficient number of ions for most plant volatiles,as well as the automatic qualitative and semi-quantitative analysis of cSIM ***,the library and acquisition method we developed can be self-expanded by incorporating compounds not present in the library,utilizing the obtained cSIM *** showed that WTV 2.0 increases the median signal-to-noise ratio by 7.6-fold compared with the untargeted method,doubled the annotation coverage compared with the untargeted and WTV 1.0 methods in tomato fruit,and led to the discovery of menthofuran as a novel flavor compound in passion *** 2.0 is a Python library with a user-friendly interface and is applicable to profiling of volatiles and primary metabolites in any species.

关键词： volatilomics widely targeted methods GC-MS selective ion monitoring plant volatiles

A post-modification strategy to precisely construct dual-atom sites for oxygen reduction electrocatalysis

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Journal of Energy Chemistry 2024年第3期90卷 511-517,I0012页

作者： Juan Wang Xinyan liu Chang-Xin Zhao Yun-Wei Song Jia-Ning liu Xi-Yao Li Chen-Xi {2. Xin Wan Jianglan Shui Hong-jie Peng Bo-Quan Li Jia-Qi Huang school of Materials science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina school of Materials science and Engineering Beihang UniversityBeijing 100191China

Dual-atom catalysts(DACs) afford promising potential for oxygen reduction electrocatalysis due to their high atomic efficiency and high intrinsic ***,precise construction of dual-atom sites remains a *** this work,a post-modification strategy is proposed to precisely fabricate DACs for oxygen reduction ***,a secondary metal precursor is introduced to the primary single-atom sites to introduce direct metal-metal interaction,which ensures the formation of desired atom pair structure during the subsequent pyrolysis process and allows for successful construction of *** as-prepared FeCo-NC DAC exhibits superior oxygen reduction electrocatalytic activity with a half-wave potential of 0,91 V *** hydrogen ***-air batteries equipped with the FeCo-NC DAC demonstrate higher peak power density than those with the Pt/C *** importantly,this post-modification strategy is demonstrated universal to achieve a variety of dual-atom *** work presents an effective synthesis methodology for precise construction of catalytic materials and propels their applications in energy-related devices.

关键词： Dual-atom catalysts Electrocatalysis Oxygen reduction reaction Post-modification Zinc–air batteries

Chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor for neurotrophic keratopathy

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Neural Regeneration Research 2024年第3期19卷 680-686页

作者： jie Wu Yulei Huang Hanrui Yu Kaixiu Li Shifeng Zhang Guoqing qiao Xiao {2. Hongmei Duan Yifei Huang Kwok-Fai So Zhaoyang Yang Xiaoguang Li Liqiang Wang department of Ophthalmology the Third Medical CenterChinese PLA General HospitalBeijingChina The PLA Medical College Department of NephrologyChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanyaHainan ProvinceChina Medical school of Chinese PLA BeijingChina department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina department of Ophthalmology and State Key Laboratory of Brain and Cognitive sciences The University of Hong KongHong Kong Special Administrative RegionChina Center for Brain science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina school of Engineering Medicine Beijing Key Laboratory for Biomaterials and Neural RegenerationBeihang UniversityBeijingChina Beijing International Cooperation Bases for science and technology on {2.omaterials and Neural Regeneration Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang UniversityBeijingChina

Neurotrophic keratopathy is a persistent defect of the corneal epithelium,with or without stromal ulceration,due to corneal nerve deficiency caused by a variety of *** treatment options for neurotrophic keratopathy are *** this study,an ophthalmic solution was constructed from a chitosan-based thermosensitive hydrogel with long-term release of murine nerve growth factor(CTH-mNGF).Its effectiveness was evaluated in corneal denervation(CD)mice and patients with neurotrophic *** the preclinical setting,CTH-mNGF was assessed in a murine corneal denervation ***-mNGF was transparent,thermosensitive,and ensured sustained release of mNGF for over 2. hours on the ocular surface,maintaining the local mNGF concentration around 1300 pg/mL in *** denervation mice treated with CTH-mNGF for 10 days showed a significant increase in corneal nerve area and total corneal nerve length compared with non-treated and CTH treated mice.A subsequent clinical trial of CTH-mNGF was conducted in patients with stage 2.or 3 neurotrophic *** received topical CTH-mNGF twice daily for 8 *** sodium images,Schirmer’s test,intraocular pressure,Cochet-Bonnet corneal perception test,and best corrected visual acuity were *** total,six patients(total of seven eyes)diagnosed with neurotrophic keratopathy were *** 8 weeks of CTH-mNGF treatment,all participants showed a decreased area of corneal epithelial defect,as stained by ***,six out of seven eyes had fluorescence staining scores<***,best corrected visual acuity,intraocular pressure,Schirmer’s test and Cochet-Bonnet corneal perception test results showed no significant *** increase in corneal nerve density was observed by in vivo confocal microscopy after 8 weeks of CTH-mNGF treatment in three out of seven *** study demonstrates that CTH-mNGF is transparent,thermosensitive,and has sustained-release *** effecti

关键词： chitosan corneal reinnervation murine nerve growth factor neurotrophic keratopathy thermosensitive hydrogel

Low-modal-crosstalk doped-fiber amplifiers in few-mode-fiber-based systems

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Photonics Research 2024年第8期12卷 1768-1775页

作者： SHUAILUO HUANG LEI SHEN GANG qiao YUANPENG DING YUYANG GAO JIAN CUI BAOLONG ZHU SIYUAN liu MINGQING ZUO JINGLONG ZHU LEI ZHANG {2. LUO YONGQI HE ZHANGYUAN CHEN JUHAO LI State Key Laboratory of Advanced Optical Communication Systems and Networks Peking UniversityBeijing 100871China State Key Laboratory of Optical Fiber and Cable Manufacture technology Yangtze Optical Fibre and Cable Joint Stock Limited CompanyWuhan 430073China school of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China department of Networks China Mobile Communications Group Co.Ltd.Beijing 100033China department of Fundamental Network technology China Mobile Research InstituteBeijing 100053China Pengcheng Laboratory Shenzhen 518055China

Independent light propagation through one or multiple modes is commonly considered as a basic demand for mode manipulation in few-mode fiber(FMF)-or multimode fiber(MMF)-based optical systems such as transmission links,optical fiber lasers,or distributed optical fiber ***,the insertion of doped-fiber amplifiers always kills the entire effort by inducing significant modal *** this paper,we propose the design of doped-fiber amplifiers in FMF-based systems adopting identical multiple-ring-core(MRC)index profiles for both passive and doped fibers to achieve low modal *** develop the direct-glass-transition(DGT)modified chemical vapor deposition(MCVD)processing for precise fabrication of few-mode erbium-doped fibers(FM-EDFs)with MRC profiles of both refractive index and erbium-ion doping ***,a few-mode erbium-doped-fiber amplifier(FM-EDFA)with a maximum gain of 2..08 dB and differential modal gain(DMG)of 2.3 dB is realized based on fabricated FM-EDF matched with a transmission FMF supporting four linearly polarized(LP)*** the insertion of the FM-EDFA,60+60 km simultaneous LP_(01)∕LP_(11)∕LP_(2.)∕LP_(02.transmission without inter-modal multiple-input multiple-output digital signal processing(MIMO-DSP)is successfully *** proposed design of low-modal-crosstalk doped-fiber amplifiers provides,to our knowledge,new insights into mode manipulation methods in various applications.

关键词： fiber crosstalk amplifiers

Emerging WS_(2./WSe_(2.@graphene nanocomposites: synthesis and electrochemical energy storage applications

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Rare Metals 2024年第1期43卷 1-19页

作者： Yu-Meng Gao Yong liu Kai-Jia Feng Jun-Qing Ma Ying-jie Miao {2.n-Rui Xu Kun-Ming Pan Osaka Akiyoshi Guang-Xin Wang Ke-Ke Zhang qiao-Bao Zhang National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan Key Laboratory of Non-Ferrous Materials Science and Processing TechnologySchool of Materials Science and EngineeringHenan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-Construction of Collaborative school of Electrical Engineering Henan University of Science and TechnologyLuoyang 471023China biomaterials Laboratory Faculty of EngineeringOkayama UniversityTsushima-NakeOkayama-Shi 700-8530Japan department of Materials science and Engineering College of MaterialsXiamen UniversityXiamen 361005China Fujian Key Laboratory of Surface and Interface Engineering for High Performance Materials Xiamen UniversityXiamen 361005China

In recent years, tungsten disulfide(WS_(2.) and tungsten selenide(WSe_(2.) have emerged as favorable electrode materials because of their high theoretical capacity, large interlayer spacing, and high chemical activity;nevertheless, they have relatively low electronic conductivity and undergo large volume expansion during cycling, which greatly hinder them in practical applications. These drawbacks are addressed by combining a superior type of carbon material, graphene, with WS_(2. and WSe_(2. to form a WS_(2./WSe_(2.@graphene *** materials have received considerable attention in electro-chemical energy storage applications such as lithium-ion batteries(LIBs), sodium-ion batteries(SIBs),and supercapacitors. Considering the rapidly growing research enthusiasm on this topic over the past several years, here the recent progress of WS_(2./WSe_(2.@graphene nanocomposites in electrochemical energy storage applications is summarized. Furthermore, various methods for the synthesis of WS_(2./WSe_(2.@graphene nanocomposites are reported and the relationships among these methods, nano/microstructures, and electrochemical performance are systematically summarized and discussed. In addition, the challenges and prospects for the future study and application of WS_(2./WSe_(2.@graphene nanocomposites in electrochemical energy storage applications are proposed.

关键词： WS_(2./WSe_(2.@graphene nanocomposites Liion batteries(LIBs) Na-ion batteries(SIBs) Supercapacitors Electrochemical performance

Decoupling of temporal/spatial broadening effects in Doppler wind LiDAR by 2. spectral analysis

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Chinese physics B 2024年第3期33卷 447-452页

作者：刘珍张云鹏竹孝鹏刘继桥毕德仓陈卫标 Space Laser Engineering department Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Pulse echo accumulation is commonly employed in coherent Doppler wind LiDAR(light detection and ranging)under the assumption of steady ***,the measured spectral data are analyzed in the time dimension and frequency dimension to cope with the temporal wind shear and achieve the optimal accumulation time.A hardware-efficient algorithm combining the interpolation and cross-correlation is used to enhance the wind retrieval accuracy by reducing the frequency sampling interval and then reduce the spectral width calculation ***,the temporal broadening effect and spatial broadening effect are decoupled according to the strategy we developed.

关键词： Doppler wind LiDAR spectral analysis hardware efficiency spectrum broadening effects

Identification and Validation of SLC9A2.as A Potential Tumor Suppressor in Colorectal Cancer:Integrating bioinformatics Analysis with Experimental Confirmation

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Current Medical science 2024年第3期44卷 529-544页

作者： Yan-min liu Tie-cheng YANG Xiao-chang FANG Li-jie YANG Li-wen SHI Hua-{2. WANG Ting-ting DOU Lin SHU Tian-Liang CHEN Jun HU Xiao-ming YU Xuan-fei LI department of Gastroenterology the Central Hospital of WuhanKey Laboratory for Molecular Diagnosis of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Clinical Medical Research Center of Peritoneal Cancer of wuhan Wuhan430071China Hubei Provincial Clinical Research Center for Cancer Hubei Key Laboratory of Tumor Biological Behavi Wuhan430071China department of General Surgery Taihe HospitalHubei University of MedicineShiyan442000China department of Gastrointestinal Surgery Huangshi Central HospitalAffiliated Hospital of Hubei Polytechnic UniversityWuhan435001China

Objective To uncover the mechanisms underlying the development of colorectal cancer(CRC),we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and *** We performed Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis on differentially expressed genes(DEGs),constructed a protein-protein interaction(PPI)network to find the top 10 hub genes,and analyzed their expression in colon adenocarcinoma(COAD)and rectum adenocarcinoma(READ).We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2.in CRC tissues and cell lines using qRT-PCR and Western *** experiments were conducted in vitro to investigate the effects of SLC9A2.on tumor growth and *** We found 130 DEGs,with 45 up-regulated and 85 down-regulated in *** analysis indicated that these DEGs were primarily enriched in functions related to the regulation of cellular pH,zymogen granules,and transmembrane transporter *** pathway analysis revealed that the DEGs played pivotal roles in pancreatic secretion,rheumatoid arthritis,and the IL-17 signaling *** identified 10 hub genes:CXCL1,SLC2.A3,CXCL2.MMP7,MMP1,SLC9A2.SLC4A4,CLCA1,CLCA4,and *** enrichment analysis showed that these hub genes were predominantly involved in the positive regulation of *** expression analysis revealed that CXCL1,CXCL2.MMP1,and MMP7 were highly expressed in CRC,whereas CLCA1,CLCA4,SLC4A4,SLC9A2.SLC2.A3,and ZG16 were expressed at lower *** analysis revealed that 5 key genes were significantly associated with the prognosis of *** mRNA and protein expression levels of SLC9A2.were markedly reduced in CRC tissues and cell ***,SLC9A2.overexpression in SW480 cells led to a notable inhibition of cell proliferation,migration,and *** blotting analysis revealed tha

关键词： SLC9A2 colorectal cancer bioinformatic analysis biomarkers immune infiltrate

Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang jie Zheng Yi-Ming Lei Zhong-Yuan Chen Yi Guo Ya-jie Guo {2.ng-Qian Guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie Yi-Xuan liu Ting-Wei Jin {2.-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China school of Computer science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical bioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2.CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:162.5/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model