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The sensitivity of numerical simulation to vertical mixing parameterization schemes: a case study for the Yellow Sea Cold Water Mass

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Journal of Oceanology and Limnology 2021年第1期39卷 64-78页

作者： congcong bi Zhigang YAO Xianwen BAO Cong ZHANG Yang DING Xihui LIU Junru GUO College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China Physical Oceanography Laboratory/CIMST Ocean University of China and Qingdao National Laboratory for Marine Science and TechnologyQingdao 266100China The First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266000China China National Environmental Monitoring Centre Beijing 100012China Operational Oceanography Institution Dalian Ocean UniversityDalian 116023China

The vertical mixing parameterization scheme,by providing the eff ects of some explicitly missed physical processes and more importantly closing the energy budgets,is a critical model component and therefore imposes signifi cant impacts on model *** Yellow Sea Cold Water Mass(YSCWM),as the most striking and unique phenomenon in the Yellow Sea during summer,is dramatically aff ected by vertical mixing process during its each stage and therefore seriously sensitive to the proper choice of parameterization *** this paper,a hindcast of YSCWM in winter of 2006 was implemented by using the Regional Ocean Modeling System(ROMS).Three popular parameterization schemes,including the level 2.5 Mellor-Yamada closure(M-Y 2.5),Generic Length Scale closure(GLS)and K-Profi le Parameterization(KPP),were tested and compared with each other by conducting a series of sensitivity model *** infl uence of diff erent parameterization schemes on modeling the YSCWM was then carefully examined and assessed based on these model *** reasonable thermal structure and its seasonal variation were well reproduced by all schemes,considerable diff erences could still be found among all experiments.A warmer and spatially smaller simulation of YSCWM,with very strong thermocline,appeared in M-Y 2.5 experiment,while a spatially larger YSCWM with shallow mixed layer was found in GLS and KPP *** all the experiments,the discrepancy,indicated by core temperature,appeared since spring,and grew gradually by the end of *** experiments also confi rmed that the increase of background diff usivity could eff ectively weaken the YSCWM,in either strength or *** wave,another contributor in upper layer,was found responsible for the shrinkage of YSCWM *** treatment of wave eff ect as an additional turbulence production term in prognostic equation was shown to be more superior to the strategy of directly increasing diff usivity fo

关键词： Yellow Sea Cold Water Mass(YSCWM) vertical mixing parameterizations thermocline background diff usivity surface wave induced mixing

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Observed characteristics of tidal currents and mean flow in the northern Yellow Sea

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Journal of Oceanology and Limnology 2019年第2期37卷 461-473页

作者： bi congcong BAO Xianwen DING Yang ZHANG Cong WANG Yu SHEN biao WAN Kai College of Oceanic and Atmospheric Sciences Ocean University of China Qingdao 266100 China Physical Oceanography Laboratory/CIMST Ocean University of China and Qingdao National Laboratory for Marine Science and Technology Qingdao 266100 China The First Institute of Oceanography State Oceanic Administration Qingdao 266061 China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and Technology Qingdao 266000 China National Marine Environmental Monitoring Center State Oceanic Administration Dalian 116023 China Beihai Off shore Engineering Survey Institute State Oceanic Administration Qingdao 266061 China

Several bottom-mounted Acoustic Doppler Current Profiler (ADCP) moorings were deployed in the northern Yellow Sea (NYS) during the four seasons of 2006–2007 and also the summertime of 2009. A synthesis analysis on the time-continuous records was performed to examine the characteristics and variations of tidal currents and mean flow over the observation period at these stations. Tidal currents accounted for ~75% of the total kinetic energy, with the absolute dominance of M2 constituent. Visible vertical variations of tidal flow were found on all sites, featured by the decrease of amplitude, increase of rotation rate as well as a decreasing trend of the phase for M2 component with depth. A notable exception was in the central NYS, where the maximum tidal currents occurred in the upper or middle layers (~20–40 m) instead of near the surface (<10 m). The observed mean flow was relatively weak, smaller than 15 cm/s. Velocity on the northern end of Yellow Sea Trough (YST) was characterized by low magnitude and an obvious layered structure vertically. In the Bohai Strait (BS) and the northern slope area, the currents weakened and the flow direction presented a major trend to deflect counterclockwise with depth in most observations. Summertime cyclonic circulation around the Yellow Sea Cold Water Mass (YSCWM), its intensification on the frontal zone and the Yellow Sea Warm Current (YSWC) for the winter season were all evident by our direct current measurements. However, the details of water exchange through the BS appeared partly diff erent from the traditionally-accepted pattern. The vertical diff erences of tidal and mean flow were larger in summer than that in winter, implying the influence of thermal structure to the local currents. Aff ected by the water stratification, mean flow usually reached its maximum near the thermocline in spring and summer, while showing a nearly uniform vertical distribution during winter.

关键词： northern Yellow Sea moored current measurements tidal currents mean flow thermal structure

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A numerical study of the South China Sea Warm Current during winter monsoon relaxation

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Journal of Oceanology and Limnology 2018年第2期36卷 216-229页

作者： ZHANG Cong DING Yang BAO Xianwen bi congcong LI Ruixiang ZHANG Cunjie SHEN bia WAN Kai College of Oceanic andAtmospheric Sciences Ocean University of China Qingdao 266100 China Key Laboratory of Physical Oceanography Ministry of Education Ocean University of China Qingdao 266100 China South China Sea Marine Survey and Technology Center State Ocean Administration Guangzhou 510310 China Beihai Offshore Engineering Survey Institute State Oceanic Administration Qingdao 266061 China

Using a Finite-Volume Community Ocean Model, we investigated the dynamic mechanism of the South China Sea Warm Current(SCSWC) in the northern South China Sea(NSCS) during winter monsoon relaxation. The model reproduces the mean surface circulation of the NSCS during winter, while model-simulated subtidal currents generally capture its current pattern. The model shows that the current over the continental shelf is generally southwestward, under a strong winter monsoon condition, but a northeastward counter-wind current usually develops between 50-and 100-m isobaths, when the monsoon relaxes. Model experiments, focusing on the wind relaxation process, show that sea level is elevated in the northwestern South China Sea(SCS), related to the persistent northeasterly monsoon. Following wind relaxation, a high sea level band builds up along the mid-shelf, and a northeastward current develops, having an obvious vertical barotropic structure. Momentum balance analysis indicates that an along-shelf pressure gradient provides the initial driving force for the SCSWC during the first few days following wind relaxation. The SCSWC subsequently reaches a steady quasi-geostrophic balance in the cross-shelf direction, mainly linked to sea level adjustment over the shelf. Lagrangian particle tracking experiments show that both the southwestward coastal current and slope current contribute to the northeastward movement of the SCSWC during winter monsoon relaxation.

关键词： northern South China Sea South China Sea Warm Current monsoon relaxation numerical model pressure gradient barotropic structure

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Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

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交联聚苯乙烯微球固载2,2,6,6-四甲基哌啶氮氧自由基的催化氧化性能与机理

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应用化学 2016年第9期33卷 1017-1025页

作者：董婷婷毕丛丛高保娇中北大学化学工程系太原030051

将交联聚苯乙烯(CPS)微球表面固载有2,2,6,6-四甲基哌啶氮氧自由基(TEMPO)的非均相催化剂微球(TEMPO/CPS)与过渡金属盐相结合,构成复合催化剂体系,用于分子氧对肉桂醇的氧化过程的研究。分别采用高价金属离子氧化性比硝酸根NO-3更弱和... 详细信息

将交联聚苯乙烯(CPS)微球表面固载有2,2,6,6-四甲基哌啶氮氧自由基(TEMPO)的非均相催化剂微球(TEMPO/CPS)与过渡金属盐相结合,构成复合催化剂体系,用于分子氧对肉桂醇的氧化过程的研究。分别采用高价金属离子氧化性比硝酸根NO-3更弱和更强的两类过渡金属盐为助催化剂,与微球TEMPO/CPS构成组合催化剂,深入探索研究了其催化性能与催化机理。研究结果表明,几种过渡金属盐(如Fe、Cu、Mn、Co盐)与微球TEMPO/CPS形成的复合催化剂,可有效地催化分子氧对肉桂醇的氧化过程,将其转化为唯一的产物肉桂醛。以过渡金属硝酸盐为助催化剂,当硝酸盐结构中对应的高价态(氧化态)金属离子的氧化性比NO-3离子弱时(如Fe(NO3)3与Cu(NO3)2),正负离子共同发挥助催化作用;当硝酸盐结构中对应的高价态(氧化态)金属离子的氧化性比NO-3离子强时,比如Co(NO3)2与Mn(NO3)2对应的Co(Ⅲ)与Mn(Ⅲ)离子,金属离子单独发挥助催化作用,NO-3离子不起作用。实验结果表明,对于肉桂醇的分子氧催化氧化,在几种过渡金属盐中,Fe(NO3)3作为最适宜的助催化剂,温和条件下(55℃、常压O2),可高效地将肉桂醇转化为肉桂醛,转化率为92%。

关键词：四甲基哌啶氮氧自由基非均相催化剂肉桂醇分子氧氧化催化氧化

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一种基于改进遗传算法的粗糙集属性约简算法

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计算机与数字工程 2014年第10期42卷 1831-1834页

作者：李玉龙张亚光毕聪聪东北石油大学计算机与信息技术学院大庆163318

为解决传统遗传算法在属性约简时会出现迭代次数多,收敛较慢的问题,论文提出了一种改进的遗传算法。该方法在适应函数上加入属性重要度因子,同时在交叉操作中有选择地保留子代个体,确保算法能够快速收敛。实验结果证明,改进之后的算法... 详细信息

为解决传统遗传算法在属性约简时会出现迭代次数多,收敛较慢的问题,论文提出了一种改进的遗传算法。该方法在适应函数上加入属性重要度因子,同时在交叉操作中有选择地保留子代个体,确保算法能够快速收敛。实验结果证明,改进之后的算法在保证属性约简的基础上,能够实现比传统遗传算法更快的迭代和收敛。

关键词：遗传算法粗糙集属性约简

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疼痛管理在老年骨折快速康复护理中的应用现状

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中华老年骨科与康复电子杂志 2017年第5期3卷 314-316页

作者：史冬立贺宇毕丛丛周东生山东大学附属省立医院骨科济南250021

随着社会结构逐渐老龄化,老年骨质疏松性骨折发病率日渐增多,并成为威胁老年人生活质量和生命健康的重要原因,与此相关的治疗与护理也引起医护工作者的关注。为了提高患者的生活质量和生存率,快速康复理念已经逐渐在临床上广泛开展。作... 详细信息

随着社会结构逐渐老龄化,老年骨质疏松性骨折发病率日渐增多,并成为威胁老年人生活质量和生命健康的重要原因,与此相关的治疗与护理也引起医护工作者的关注。为了提高患者的生活质量和生存率,快速康复理念已经逐渐在临床上广泛开展。作为快速康复护理的重要组成部分,疼痛管理在老年骨折患者中的应用具有重要意义,因此本文对老年骨折患者的疼痛管理、评估及管理策略等方面进行综述。

关键词：疼痛管理老年人骨折

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A stretchable triboelectric generator with coplanar integration design of energy harvesting and strain sensing

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Science China(Technological Sciences) 2022年第1期65卷 221-230页

作者： WU bin ZHANG ZengXing XUE Xiaobin HAO congcong ZHANG WenJun bi RuiYu WANG Qiang XUE ChenYang Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan 030051China

The rapid development of flexible triboelectric nanogenerators(TENGs)has become an alternative to batteries for wearable ***,multifunctional,and low-cost are the primary development directions for these wearable devices based on ***,a stretchable triboelectric generator with coplanar integration was designed for energy harvesting and force *** industrial conductive silicone and silicone were used to fabricate the TENG with a thickness of less than 0.9 *** the elongation was less than 150%,TENG exhibited excellent linear characteristics in the resistance-tensile strain correspondence,and the coefficient of determination was *** stretchable TENG with a sufficient contact area of 9 cm^(2) could generate a short-circuit current of 2μA when it was in contact with the ***,an intelligent tension monitoring wearable device that can effectively measure the tensile force was *** a stretchable,coplanar integration-based,and low-cost wearable device has excellent applicability in wearable electronics.

关键词： wearable device stretchable force monitoring multifunctional materials

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超重及肥胖2型糖尿病患者认知功能与脑结构影像的相关性研究

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中华糖尿病杂志 2024年第4期16卷 445-453页

作者：马雪琳张洲缪应雯徐湘丁群孙洁于从从陈诗桦杨东辉毕艳南京中医药大学鼓楼临床医学院南京鼓楼医院内分泌科南京210008 南京大学医学院附属鼓楼医院内分泌科南京210008

目的探讨超重及肥胖2型糖尿病(T2DM)患者认知功能与脑结构影像的相关性。方法为横断面研究。纳入2016年2月至2023年7月就诊于南京大学医学院附属鼓楼医院内分泌科的T2DM患者,并根据体重指数(BMI)将其分为正常体重T2DM组和超重及肥胖T2DM... 详细信息

目的探讨超重及肥胖2型糖尿病(T2DM)患者认知功能与脑结构影像的相关性。方法为横断面研究。纳入2016年2月至2023年7月就诊于南京大学医学院附属鼓楼医院内分泌科的T2DM患者,并根据体重指数(BMI)将其分为正常体重T2DM组和超重及肥胖T2DM组,招募同期就诊于南京大学医学院附属鼓楼医院健康管理中心年龄和受教育时间与其相匹配且18.5 kg/m^(2)≤BMI<24.0 kg/m^(2)的健康者作为健康对照组。收集3组研究对象的年龄、受教育时间、身高和体重并计算BMI,测量其Android区域脂肪含量,并计算脂肪质量指数(FMI),采用可重复的成套神经心理状态测量量表评估即刻记忆,测量其左右侧海马体积。采用独立样本t检验或单因素方差分析进行组间比较,采用协方差分析比较3组间认知功能、总脑及皮层下核团体积的差异,采用中介效应模型分析人体脂肪分布、脑结构、认知功能之间的关系。结果共纳入研究对象350例。其中,健康对照组50例,正常体重T2DM组100例,超重及肥胖T2DM组200例。与正常体重T2DM组相比,超重及肥胖T2DM组患者Android区域FMI更高(t=11.90,P<0.001)。协方差分析结果显示,与健康对照组和正常体重T2DM组相比,超重及肥胖T2DM组患者即刻记忆得分均更低(P值分别为0.048和0.041)、左右侧海马体积均更小(健康对照组和超重及肥胖T2DM组,正常体重T2DM组和超重及肥胖T2DM组左右侧海马体积比较,左侧P值分别为0.002和0.036,右侧P值分别为0.004和0.022)。中介效应模型分析结果显示,在T2DM患者中,左侧海马体积部分介导了Android区域FMI与即刻记忆得分之间的相关性(β=-0.313,95%CI-0.695~-0.076)。结论超重及肥胖T2DM患者相较正常体重T2DM患者认知功能损害及海马体积萎缩更为显著。T2DM患者腹部脂肪增加与认知功能损害和海马体积萎缩有关。

关键词：糖尿病,2型磁共振成像超重及肥胖认知功能人体成分分析

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山东地区1株牛病毒性腹泻病毒的分离鉴定及遗传进化分析

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中国畜牧兽医 2024年第10期51卷 4485-4499页

作者：毕峻铭董雅琴崔进沙洲顾丛丛郑辉魏荣孙福亮张锋张志宏延边大学农学院延吉136200 中国动物卫生与流行病学中心青岛266032 农业农村部动物生物安全风险预警及防控重点实验室(南方) 青岛266032 桓台县畜牧渔业服务中心淄博256400 陵城区临齐街道农业综合服务中心德州253500

【目的】了解并掌握山东地区牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)流行毒株的生物学特性和遗传变异情况,为BVDV防控提供理论依据和技术支持。【方法】采集养牛场疑似BVDV感染样品制备组织上清液,利用RT-PCR方法进行病原... 详细信息

【目的】了解并掌握山东地区牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)流行毒株的生物学特性和遗传变异情况,为BVDV防控提供理论依据和技术支持。【方法】采集养牛场疑似BVDV感染样品制备组织上清液,利用RT-PCR方法进行病原鉴定,接种MDBK细胞进行病毒分离培养,采用间接免疫荧光试验(IFA)和电镜观察对分离毒株进行鉴定,对分离毒株全基因组进行分段扩增、克隆和测序,并采用Lasergene等软件分别对全基因组序列、N^(pro)和E2基因进行比对和遗传演化分析。【结果】病料样品BVDV特异性引物RT-PCR扩增得到大小约504 bp的目的条带,与预期大小一致。IFA结果显示特异性绿色荧光;电镜下可见直径约50 nm的病毒粒子,表明分离到1株非致细胞病变型BVDV毒株,命名为SDNF9株。分离株基因组全长为12232 nt,与BVDV参考毒株的全基因组核苷酸相似性为79.1%~93.8%,其中,与中国分离毒株22AH-1和澳大利亚毒株Bega-like的相似性最高,为93.8%;N^(pro)和E2蛋白氨基酸存在多个位点变异;SDNF9分离毒株与BVDV2型毒株和BVDV3型毒株处于遗传演化的不同分支,而与BVDV 1型毒株处于同一分支,属于BVDV 1c基因型。【结论】本研究成功分离到1株BVDV 1c流行毒株,并进行基因组和遗传演化分析,与中国分离毒株22AH-1亲缘关系最近,为山东地区牛病毒性腹泻的防控和疫苗研制提供数据和材料支持。

关键词：牛病毒性腹泻病毒(BVDV) 分离鉴定序列分析遗传进化分析

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