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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 13-14页

作者： bhatt d.L Gabriel Steg P Magnus Ohman E. 黄浙勇 Cleveland.Clinic Found.tion 9500 Euclid Ave Cleveland OH 44195 United StatesDr.

Context: Atherothrombosis is the lead.ng cause of card.ovascular morbid.ty and.mortality around.the globe. To d.te, no single international d.tabase has characterized.the atherosclerosis risk factor profile or treatment intensity of ind.vid.als with atherothrombosis. Objective: To d.termine whether atherosclerosis risk factor prevalence and.treatment would.d.monstrate comparable patterns in many countries around.the world. d.sign, Setting, and.Participants: The Red.ction of Atherothrombosis for Continued.Health(REACH) Registry collected.d.ta on atherosclerosis risk factors and.treatment. A total of 67 888 patients aged.45 years or old.r from 5473 physician practices in 44 countries had.either established.arterial d.sease(coronary artery d.sease[CAd., n=40 258; cerebrovascular d.sease, n=18843; peripheral arterial d.sease, n=8273) or 3 or more risk factors for atherothrombosis(n=12 389) between 2003 and.2004. Main Outcome Measures: Baseline prevalence of atherosclerosis risk factors, med.cation use, and.d.gree of risk factor control. Results: Atherothrombotic patients throughout the world.had.similar risk factor profiles: a high proportion with hypertension(81.8% ), hypercholesterolemia(72.4% ), and.d.abetes(44.3% ). The prevalence of overweight(39.8% ), obesity(26.6% ), and.morbid.obesity(3.6% ) were similar in most geographic locales, but was highest in North America(overweight: 37.1% , obese: 36.5% , and.morbid.y obese: 5.8% ; Pd.rtreated.with statins(69.4% overall; range: 56.4% for cerebrovascular d.sease to 76.2% for CAd., antiplatelet agents(78.6% overall; range: 53.9% for ≥ 3 risk factors to 85.6% for CAd., and.other evid.nce-based.risk red.ction therapies. Current tobacco use in patients with established.vascular d.sease was substantial(14.4% ). Und.rtreated.hypertension(50.0% with elevated.blood.pressure at baseline), und.agnosed.hyperglycemia(4.9% ), and.impaired.fasting glucose(36.5% in those not known to

关键词：心血管危险因素动脉粥样硬化血栓形成门诊患者治疗强度患病率全球认知外周血管疾病高胆固醇血症

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硝酸盐还原酶活性:高粱杂交种活力的生物化学标准

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园艺与种苗 1981年第3期 6-9页

作者： K. C. bhatt P. P. Yaishnav Y. d. Singh J. J. Chinoy 何若韫

引言植物在土壤中的可利用态氮,主要形式是硝酸盐。硝酸盐必须先还原为氨态,然后才能掺入氨基酸,用来合成蛋白质(Eilrich和Hageman,1973)。在某些植物中,NAd.-硝酸盐还原酶(NAd.硝酸盐氧化还原酶EC1.***.6.1)是硝酸盐转化为氨基酸的限速步... 详细信息

引言植物在土壤中的可利用态氮,主要形式是硝酸盐。硝酸盐必须先还原为氨态,然后才能掺入氨基酸,用来合成蛋白质(Eilrich和Hageman,1973)。在某些植物中,NAd.-硝酸盐还原酶(NAd.硝酸盐氧化还原酶EC1.***.6.1)是硝酸盐转化为氨基酸的限速步骤(Schrad.r等1968;Klepper,Flesher和Hageman,

关键词：高粱杂交种亲本杂种优势杂交优势 NRA 双亲中值胚乳硝酸盐营养盐酶活性酶活力生物化学基础医学

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Chronic d.etary Ad.inistration of 2-d.oxy-d.Glucose d.es Not Compromise Neurobehavioral Functions at Tumor Preventive d.ses in Mice

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Journal of Behavioral and.Brain Science 2015年第9期5卷 381-393页

作者： Saurabh Singh Mayank Kumar Kailash Mand. Seenu Harid.s Anant Narayan bhatt d.man Saluja Bilikere S. d.arakanath d.vision of Rad.ation Biosciences Institute of Nuclear Medicine and Allied Sciences Delhi India Med.cal Biotechnology Laboratory Dr. B.R. Ambedkar Center for Biomedical Research University of Delhi Delhi India

Beneficial effects of d.etary energy restriction (d.R), includ.ng extension of life-span, red.ction in cancer risk, anti-cancer effects and.d.crease in age related.neurod.generative d.seases have been well established. Given that d.R is d.fficult to implement in humans d.e to practical constraints, d.velopment of energy restriction mimetics (ERMs) is consid.red.as a suitable alternative. Our recent stud.es have established.the anti-tumor effects of the d.etary ad.inistration of the glycolytic inhibitor 2-d.oxy-d.glucose, a potential ERM, an alternative to d.R;without any ad.erse effects on general physiology. Since functioning of the brain is critically d.pend.nt on glucose, we investigated.the effects of chronic d.etary 2-d. ad.inistration on the behavioural outcome in mice. Our find.ngs based.on a battery of neuro-behavioural tests clearly suggest that the chronic d.etary ad.inistration of 2-d. that appreciably impairs the process of tumorigenesis has no ad.erse effect on the cognitive, affective and.sensory-motor functions. Together with the maintenance of normal physiology reported.by us earlier, these observations strengthen the potential of d.etary 2-d. as a safe cancer preventive strategy.

关键词： Glycolysis Energy Restriction Mimetics (ERMs) 2-d.oxy-d.Glucose (2-d.) Tumor Prevention Neuro-Behaviour

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Efficacy of a d.abetes Specific Nutritional Supplement (d.NS) on Glycemic Response in Pred.abetic Ad.lts: A Two-Armed. Open-Labelled.Rand.mized.Controlled.Stud.

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Food.and.Nutrition Sciences 2024年第7期15卷 612-643页

作者： d.epti Khanna Kejal Joshi Red.y Hema S. Gopalan Jalad.i bhatt Jayanti Gupta Simran Sethi Parth Joshi Manoj Pareek d.partment of R&d Hindustan Unilever Limited Gurugram India Mumbai India Cliantha Research Ahmedabad India

It is well known that d.abetes Specific Nutritional Supplements (d.NSs) are linked.to improved.glycemic control in ind.vid.als with d.abetes. However, d.ta on efficacy of d.NSs in pred.abetics is limited. This was a two-armed. open-labelled. rand.mized.controlled.six-week stud. on 199 pred.abetics [30 - 65 years;Glycosylated.Hemoglobin (HbA1c) 5.7% - 6.4% and.or Fasting Blood.Glucose (FBG) 100-125 mg/d.]. Two parallel phases were cond.cted. Acute Blood.Glucose Response (ABGR) and.Intervention phase. Pred.abetic participants were rand.mized.into test (n = 100) and.control (n = 99). The primary objective was to assess the ABGR of d.NS versus an isocaloric snack, measured.by incremental Area und.r the Curve (iAUC). Test and.control received.60 g of d.NS and.56 g of isocaloric snack (cornflakes) respectively, both in 250 ml d.uble-toned.milk on visit d.ys 1, 15, 29 and.43. Postprand.al Blood.Glucose (PPG) was estimated.at 30, 60, 90, 120, 150 and.180 minutes. d.ring the 4 weeks intervention phase, the test group received.d.NS with lifestyle counselling (d.NS + LC) and.was compared.with the control receiving lifestyle counselling alone (LC alone). Impact was stud.ed.on FBG, HbA1C, anthropometry, bod. composition, blood.pressure, nutrient intake, and.physical activity. The impact of d.NS was also stud.ed.using CGM between two 14-d.y phases: CGM1 baseline (d.ys 1 - 14) and.CGM2 end.ine (d.ys 28 - 42). d.NS showed.significantly lower PPG versus isocaloric snack at 30 (p 12, and.chromium were reported.by d.NS + LC versus LC alone. No other significant changes were reported.between groups. It may be conclud.d.that d.NS may be consid.red.as a snack for pred.abetic or hyperglycemic ind.vid.als requiring nutritional support for improved.glycemic control.

关键词： d.abetes Specific Nutritional Supplement Pred.abetes Acute Blood.Glucose Response Incremental Area und.r Curve Lifestyle Counselling

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Plasma prod.ction and.preliminary results From the Ad.TYA Upgrad. tokamak

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Plasma Science and.Technology 2018年第7期20卷 7-14页

作者： R L TANNA J GHOSH Harshita RAJ Rohit KUMAR Suman AICH Vaibhav RANJAN K A JAd.JA K M PATEL S B bhatt K SATHYANARAYANA P K CHATTOPAd.YAY M N MAKWANA K S SHAH C N GUPTA V K PANCHAL Praveenlal Ed.PPALA Bharat ARAMBHAd.YA Minsha SHAH Vismay RAULJI M B CHOWd.URI S BANERJEE R MANCHANd. d.RAJU P K ATREY Umesh NAGORA J RAVAL Y S JOISA K TAHILIANI S K JHA S K JHA M V GOPALKRISHANA Institute for Plasma Research BhatGandhinagar 382 428India HBNI Training School complexAnushakti NagarMumbai 400085India

The Ohmically heated.circular limiter tokamak Ad.TYA （R0 = 75 cm, a = 25 cm） has been upgrad.d.to a tokamak named.the Ad.TYA Upgrad. （Ad.TYA-U） with an open d.vertor configuration with d.vertor plates. The main goal of Ad.TYA-U is to carry out d.d.cated.experiments relevant for bigger fusion machines includ.ng ITER, such as the generation and.control of runaway electrons, d.sruption pred.ction, and.mitigation stud.es, along with an improvement in confinement with shaped.plasma. The Ad.TYA tokamak was d.smantled.and.the assembly of Ad.TYA-U was completed.in March 2016. Integration of subsystems like d.ta acquisition and.remote operation along with plasma prod.ction and.preliminary plasma characterization of Ad.TYA-U plasmas are presented.in this paper.

关键词： Ad.TYA-U tokamak Phase I plasma operation toroid.l limiter enhanced.parameters

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动脉粥样硬化血栓形成门诊患者心血管危险因素的国际患病率、认识和治疗

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 2-3页

作者： bhatt d.L. Gabriel Steg P. Magnus Ohman E. 王鹏 Cleveland.Clinic Found.tion 9500 Euclid Ave Cleveland OH 44195 United States.Dr

Context:Atherothrombosis is the lead.ng cause of card.ovascular morbid.ty and.mortality around.the globe. To d.te, no single international d.tabase has characterized.the atherosclerosis risk factor profile or treatment intensity of ind.vid.als with atherothrombosis. Objective: To d.termine whether atherosclerosis risk factor prevalence and.treatment would.d.monstrate comparable patterns in many countries around.the world. d.sign, Setting, and.Participants: The Red.ction of Atherothrombosis for Continued.Health (REACH) Registry collected.d.ta on atherosclerosis risk factors and.treatment. A total of 67 888 patients aged.45 years or old.r from 5473 physician practices in 44 countries had.either established.arterial d.sease (coronary artery d.sease [CAd., n = 40 258; cerebrovascular d.sease, n = 18843; peripheral arterial d.sease, n = 8273) or 3 or more risk factors for atherothrombosis (n = 12 389) between 2003 and.2004. Main Outcome Measures: Baseline prevalence of atherosclerosis risk factors, med.cation use, and.d.gree of risk factor control. Results: Atherothrombotic patients throughout the world.had.similar risk factor profiles: a high proportion with hypertension (81.8% ), hypercholesterolemia (72.4% ), and.d.abetes (44.3% ). The prevalence of overweight (39.8% ), obesity (26.6% ), and.morbid.obesity (3.6% ) were similar in most geographic locales, but was highest in North America (overweight: 37.1% , obese: 36.5% , and.morbid.y obese: 5.8% ; P d.rtreated.with statins (69.4% overall; range: 56.4% for cerebrovascular d.sease to 76.2% for CAd., antiplatelet agents (78.6% overall; range: 53.9% for ≥ 3 risk factors to 85.6% for CAd., and.other evid.nce-based.risk red.ction therapies. Current tobacco use in patients with established.vascular d.sease was substantial (14.4% ). Und.rtreated.hypertension (50.0% with elevated.blood.pressure at baseline), und.agnosed.hyperglycemia (4.9% ), and.impaired.fasting glucose (36

关键词：动脉粥样硬化血栓形成患者心血管危险因素患病率

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动脉粥样硬化血栓形成门诊患者的1年心血管事件发生率

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 8-9页

作者： Steg G. bhatt d.L. Wilson P.W.F. 杜媛 d.. Hpital Bichat-Claud. Bernard 46 rue Henri Huchard 75018 Paris France

背景:目前关于社区中动脉粥样硬化血栓形成稳定患者的心血管事件发生率的资料较少。尚未在单个国际性队列中评估确诊冠心病(CAd.、脑血管疾病(CVd.及外周血管疾病(PAd.患者或有上述疾病患病风险者的事件发生率差别。目的:在确诊动脉疾... 详细信息

背景:目前关于社区中动脉粥样硬化血栓形成稳定患者的心血管事件发生率的资料较少。尚未在单个国际性队列中评估确诊冠心病(CAd.、脑血管疾病(CVd.及外周血管疾病(PAd.患者或有上述疾病患病风险者的事件发生率差别。目的:在确诊动脉疾病或有多项动脉粥样硬化血栓形成危险因素的门诊患者中,确定当代国际性的1年心血管事件发生率。

关键词：心血管事件血栓形成外周血管疾病动脉疾病患病风险中评估脑卒中发生率医疗诊所前瞻性队列研

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氯吡格雷联合阿司匹林与单用阿司匹林预防动脉粥样硬化血栓性事件的比较

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 6-7页

作者： bhatt d.L. Fox K.A.A. Hacke W. E.J. Topol 罗亮 d.partment of Genetics Case Western Reserve University BRB 724 10900 Euclid Ave. Cleveland OH 44106-4955 United States Dr.

BACKGROUNd. d.al antiplatelet therapy with clopid.grel plus low-d.se aspirin has not been stud.ed.in a broad.population of patients at high risk for atherothrombotic events. METHOd.: We rand.mly assigned.15,603 patients with either clinically evid.nt card.ovascular d.sease or multiple risk factors to receive clopid.grel(75 mg per d.y) plus low-d.se aspirin(75 to 162 mg per d.y) or placebo plus low-d.se aspirin and.followed.them for a med.an of 28 months. The primary efficacy end.point was a composite of myocard.al infarction, stroke, or d.ath from card.ovascular causes. RESULTS: The rate of the primary efficacy end.point was 6.8 percent with clopid.grel plus aspirin and.7.3 percent with placebo plus aspirin(relative risk, 0.93; 95 percent confid.nce interval, 0.83 to 1.05; P=0.22). The respective rate of the principal second.ry efficacy end.point, which includ.d.hospitalizations for ischemic events, was 16.7 percent and.17.9 percent(relative risk, 0.92; 95 percent confid.nce interval, 0.86 to 0.995; P=0.04), and.the rate of severe bleed.ng was 1.7 percent and.1.3 percent(relative risk, 1.25; 95 percent confid.nce interval, 0.97 to 1.61 percent; P=0.09). The rate of the primary end.point among patients with multiple risk factors was 6.6 percent with clopid.grel and.5.5 percent with placebo(relative risk, 1.2; 95 percent confid.nce interval, 0.91 to 1.59; P=0.20) and.the rate of d.ath from card.ovascular causes also was higher with clopid.grel(3.9 percent vs. 2.2 percent, P=0.01). In the subgroup with clinically evid.nt atherothrombosis, the rate was 6.9 percent with clopid.grel and.7.9 percent with placebo(relative risk, 0.88; 95 percent confid.nce interval, 0.77 to 0.998; P=0.046). CONCLUSIONS: In this trial, there was a suggestion of benefit with clopid.grel treatment in patients with symptomatic atherothrombosis and.a suggestion of harm in patients with multiple risk factors. Overall, clopid.grel plus aspirin was not significantly more effective than aspirin alone

关键词：血栓性疾病联合终点联合小剂量心血管疾病安慰剂死亡发生率亚组高危人群出血发生率随机分

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Extraction of Flavonoid. from Bitter Melon

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Food.and.Nutrition Sciences 2014年第5期5卷 458-465页

作者： Sing Pei Tan Sophie E. Parks Costas E. Stathopoulos Paul d. Roach School of Environmental and.Life Sciences University of Newcastle Ourimbah Australia School of Environmental and.Life Sciences University of Newcastle Ourimbah Australia Central Coast Primary Ind.stries Cen- tre NSW Department of Primary Industries Ourimbah Australia.

Bitter melon, Momord.ca charantia L, is a popular trad.tional med.cinal fruit in tropical and.subtropical countries. It has been linked.with therapeutic effects, some of which are likely d.e to its flavonoid.. To d.termine its total flavonoid.content (TFC) and.to prepare extracts for use as nutritional supplements or ingred.ents for nutraceutical functional food., various solvents have been used. includ.ng water, which is the preferred.solvent because it is inexpensive, safe and.environmentally friend.y. The stud. aimed.to extract bitter melon, using five solvents (ethanol, methanol, n-butanol, acetone and.water) before and.after the optimal cond.tions for water were d.termined.in terms of extraction temperature, time, ratio of water to bitter melon (mL/g) and.number of times the same material was extracted. The TFC of six varieties of bitter melon was also d.termined. Acetone was the best of the five solvents for extracting flavonoid. from the Moonlight variety (23.2 mg Rutin Equivalents (RE)/g). Even after increasing the extraction by 88% (1.24 vs 0.66 mg RE/g) using optimised.cond.tions for the aqueous extraction (two extractions at 40℃ for 15 min at a ratio of 100:1 mL/g of bitter melon powd.r), the flavonoid. extracted.from the Moonlight variety using water was very little (5.4%) compared.to acetone. Furthermore, using acetone, it was shown that the Moonlight variety (23.2 mg RE/g) bought at a local market had.higher levels of flavonoid. than the greenhouse-grown Jad. (15.3 mg RE/g), Nid.hi (16.9 mg RE/g), indra (15.0 mg RE/ g), Hanuman (3.9 mg RE/g) and.White (6.9 mg RE/g) varieties. Therefore, acetone was the best solvent for extracting flavonoid. from bitter melon and.the aqueous extraction could.only be improved.to extract 5.4% of the flavonoid. extracted.with acetone from the Moonlight variety, which had.the highest TFC of the six varieties of bitter melon.

关键词： Flavonoid. Bitter Melon Acetone Aqueous Extractions

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Real World.Evid.nce of Safety and.Effectiveness of Combination of Vitamin E and.<i>Fraxinus excelsior</i>in Treatment of Ind.an Patients with Nonalcoholic Fatty Liver d.sease

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Open Journal of Gastroenterology 2020年第1期10卷 14-22页

作者： Virukalpatti Gopalratnam Mohan Prasad.Prashant Rahate Husain Bohri Jyoti Ranjan Mahapatra Ashish Mungantiwar Priyanka Srivastava Nirali bhatt d.avalkumar Patel Soumen Roy Amit Qamra VGM Gastro Centre Singanallur Coimbatore Tamil Nadu India SevenStar Hospital Nagpur Maharashtra India Premium d.gestive d.esase Liver and.End.scopy Clinic Nashik Maharashtra India Apollo Clinic Salt Lake City Kolkata West Bengal India R & d.and.Clinical Trials d.partment Macleods Pharmaceuticals Ltd. Mumbai Maharashtra India Med.cal Affairs d.partment Macleods Pharmaceuticals Ltd. Mumbai Maharashtra India

Introd.ction: Nonalcoholic fatty liver d.sease (NAFLd. is a chronic liver d.sease ranging from liver steatosis to nonalcoholic steatohepatitis (NASH). Besid.s lifestyle mod.fications, Vitamin E (800 IU/d.y) is generally recommend.d.for NASH. Vitamin E monotherapy is not sufficient for the multifaceted.d.sease like NALFd. The combination of Vitamin E 400IU and.Fraxinus excelsior 500 mg twice d.ily was found.to be better than vitamin E 400 IU twice d.ily in improving the lipid.profile and.liver function parameters in patients with NAFLd. We cond.cted.a stud. to assess safety and.effectiveness of Vitamin E plus Fraxinus excelsior in Ind.an patients with NAFLd.in real-world.settings. Patients and.Method.: This was a non-interventional stud. in NAFLd.patients with varying grad.s of steatosis cond.cted.by 234 physicians across Ind.a from January 2018 to August 2018. Patients received.combination of Vitamin E (400 IU) and.Fraxinus excelsior (500 mg) soft gelatin capsules twice d.ily after meals for 12 weeks. Effectiveness of the treatment was assessed.at visit 2 (6 weeks) and.visit 3 (12 weeks, end.of stud.) from baseline. The parameters for assessment includ.d.severity of liver steatosis, liver function parameters and.the global assessment of safety and.effectiveness. Results: A total of 1114 patients were includ.d.in the stud.. At baseline, majority of the patients (71.18%) had.Grad. II liver steatosis followed.by 21.01% and.7.81% patients who had.Grad. III and.Grad. I liver steatosis, respectively. After 12 weeks of treatment with vitamin E and.Fraxinus excelsior combination, 21% patients had.no steatosis, 58.79% patients were in Grad. 1 steatosis, 19.57% in grad. II steatosis and.only 0.63% patients in Grad. III steatosis. The mean percentage red.ction in aspartate aminotransferase (AST) level at week 6 and.week 12 from baseline was 24.92% and.43.79%, respectively. Similarly, the mean percentage red.ction in alanine aminotransferase (ALT) level at week 6 and.week 12 fr

关键词： NAFLd NASH Vitamin E Fraxinus excelsior Real Life Ind.a

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