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Study of Digital Management System of Milking Process on Large-Sized Dairy Farm

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Agricultural Sciences in China 2008年第8期7卷 1022-1028页

作者： XIONG ben-hai LUO qing-yao Lǔ Jian-qiang YANG Liang State Key Laboratory of Animal Nutrition~Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China

This study was to supply the systemic and full milking process data to support the implementation of both dairy herd improvement （DHI） and digital feeding of dairy cattle. This study designed the relational structured database and developed a set of digital management information system on milking process of intensive dairy farm using Visual Basic 6.0, Access databases, and Crystal report combining the milking characteristics of a grown cow, such as quality and sanitation testing indexes of raw milk. The system supplies a series of convenient, intelligent input interfaces of crude datum, and can count, analyze, and graphically show milking datum based on different types and different parities of cows or herds in a specific duration, and can dynamically produce some important derived data, such as days of grown cow, daily average of milk production of grown cow, days of cow milk production, and daily average of milking cow production; and can carry out all-pervasive data mining. With the help of system analysis and software design techniques, it is possible to realize precision farming for a dairy cattle herd based on whole digital management of milking process and realtime prediction on nutrient requirements and ration of dairy cattle, as well as dairy herd improvement.

关键词： dairy farm dairy herd improvement (DHI) grown cow milking digital management

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-qing ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Multifunctional Cholesterol-modified Dendrimers for Targeted Drug Delivery to Cancer Cells Expressing Folate Receptors

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Chinese Journal of Polymer Science 2019年第2期37卷 129-135页

作者： Fan-Fan Fu ben-qing Zhou Zhi-Jun Ouyang Yi-Lun Wu Jing-Yi Zhu Ming-Wu Shen Jin-Dong Xia Xiang-Yang Shi Key Laboratory of Science & Technology of Eco-Textile Ministry of Education College of Chemistry Chemical Engineering and Biotechnology Donghua University Department of Radiology Shanghai Songjiang District Central Hospital

We present here the development of cholesterol(Chol)-modified dendrimer system for targeted chemotherapy of folate(FA)receptor-expressing cancer cells. In our study, poly(amidoamine)(PAMAM) dendrimers of generation 5(G5) were functionalized stepby-step with Chol, fluorescein isothiocyanate(FI), and FA via a poly(ethylene glycol)(PEG) spacer(PEG-FA), and then acetamide to shield their remaining surface amines. The synthesized ***-Chol-FI-PEG-FA(for short, G5-CFPF) dendrimers were utilized to encapsulate 10-hydroxycamptothecin(HCP), a hydrophobic anticancer drug. We find that each G5-CFPF dendrimer can encapsulate 13.8 HCP molecules. The complexes show a slower release profiles of HCP in a pH-dependent manner than the control complexes formed using the same dendrimers without Chol under the same conditions. Thanks to the targeting role played by FA, the complexes display a specific inhibition efficacy to FA receptor-expressing cervical cancer cells. The designed Chol-modified dendrimers may be adopted as a promising carrier for application in targeted cancer therapy.

关键词： PAMAM dendrimers Folate Cholesterol 10-Hydroxycamptothecin Targeted cancer therapy

Handmade tri-leaflet ePTFE conduits versus homografts for right ventricular outflow tract reconstruction

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World Journal of Pediatrics 2022年第3期18卷 206-213页

作者： Guan-Xi Wang Feng-Qun Mao Kai Ma Rui Liu Kun-Jing Pang Sen Zhang Yang Yang ben-qing Zhang Shou-Jun Li National Center for Cardiovascular Diseases Pediatric Cardiac CenterFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.167 Beilishi StreetXicheng DistrictBeijing 100037China Department of Echocardiography National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.167 Beilishi StreetXicheng DistrictBeijing 100037China Department of Pediatric Cardiac Surgery Fuwai HospitalChinese Academy of Medical SciencesPeking Union Medical College167 Beilishi RoadXicheng DistrictBeijing 100037China

Background This study aimed to investigate the performance of handmade tri-leaflet expanded polytetrafluoroethylene(ePTFE)conduits in the absence of a suitable *** Patients who underwent right ventricular outflow tract reconstruction with tri-leaflet ePTFE conduits or homografts between December 2016 and August 2020 were *** primary endpoint was the incidence of moderate or severe conduit stenosis(>36 mmHg)and/or moderate or severe *** secondary endpoint was the incidence of severe conduit stenosis(>64 mmHg)and/or severe *** There were 102 patients in the ePTFE group and 52 patients in the homograft *** median age was younger[34.5(interquartile range:20.8-62.8)vs.60.0(interquartile range:39.3-81.0)months,P=0.001]and the median weight was lower[13.5(10.0-19.0)vs.17.8(13.6-25.8)kg,P=0.003]in the ePTFE *** conduit size was smaller(17.9±2.2 vs.20.5±3.0 mm,P<0.001)and the conduit Z score was lower(1.48±1.04 vs.1.83±1.05,P—0.048)in the ePTFE *** was no significant difference in the primary endpoints(log rank,T3=0.33)and secondary endpoints(log rank,P=0.35).Multivariate analysis identified lower weight at surgery[P=0.01;hazard ratio:0.75;95%confidence interval(CI)0.59-0.94]and homograft conduit use(P=0.04;hazard ratio:8.43;95%CI 1.14—62.29)to be risk factors for moderate or severe conduit *** risk factors were found for moderate or severe conduit stenosis or conduit dysfunction on multivariate *** Handmade tri-leaflet ePTFE conduits showed acceptable early and midterm outcomes in the absence of a suitable homograft,but a longer follow-up is needed.

关键词： Expanded polytetrafluoroethylene conduit Homograft Right ventricular outflow tract reconstruction

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偏动式形状记忆合金驱动器系统建模与仿真

哈尔滨工业大学学报 2009年第1期41卷 58-61页

作者：任秉银陈本清哈尔滨工业大学机电工程学院哈尔滨150001

为了实现响应速度快、精度高的偏动式形状记忆合金驱动器控制系统,基于Kanaka-Liang提出的形状记忆合金材料一维本构关系建立了偏动式SMA驱动器的热动力学模型.针对形状记忆合金材料的非线性迟滞特性,结合PID控制和模糊控制各自的优点,... 详细信息

为了实现响应速度快、精度高的偏动式形状记忆合金驱动器控制系统,基于Kanaka-Liang提出的形状记忆合金材料一维本构关系建立了偏动式SMA驱动器的热动力学模型.针对形状记忆合金材料的非线性迟滞特性,结合PID控制和模糊控制各自的优点,设计了一种模糊增益自调整PID复合控制器方案,并对偏动式形状记忆合金驱动器的响应特性进行了仿真.仿真结果表明,与PID控制器和模糊控制器相比,模糊增益自调整PID复合控制器具有响应快、超调小、适应性好等优点.模糊增益自调整PID控制策略完全能满足偏动式形状记忆合金驱动器对控制精度的要求.

关键词：形状记忆合金驱动器迟滞模型模糊增益自调整PID控制仿真

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一种新型的层叠式介质埋藏贴片八木天线

电波科学学报 2009年第2期24卷 337-340,353页

作者：倪国旗高本庆北京理工大学北京100081 桂林空军学院广西桂林541003

为了解决平面式微带贴片八木天线的主波束不能与微带天线基片平面垂直的问题,运用微带天线耦合理论、八木天线原理和微带天线理论,借鉴八木天线设计经验和微带天线制作技术,研制出了一种新型的层叠式介质埋藏贴片八木天线,并提出在八木... 详细信息

为了解决平面式微带贴片八木天线的主波束不能与微带天线基片平面垂直的问题,运用微带天线耦合理论、八木天线原理和微带天线理论,借鉴八木天线设计经验和微带天线制作技术,研制出了一种新型的层叠式介质埋藏贴片八木天线,并提出在八木天线振子两旁增加"栅栏"的改进结构形式。经仿真计算和实物天线测试证明:这种天线性能优于平面式的微带贴片八木天线。

关键词：八木天线平面式微带八木天线层叠式介质埋藏贴片八木天线

Characterics of upper digestive tract diseasesin fishermen of the Bohai Bay

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World Journal of Gastroenterology 1997年第3期3卷 43-45页

作者： WANG Yuan ben 1, WANG Yuan Ping 1, ZOU Jing 1, BAI Bao Jie 2, REN Guo Chun 2 and CAI ben qing 2

AIM To study the characteristics of upper digestive tract diseases (UDTDs) in the fishermen of the Bohai Bay. METHODS An investigation was carried out in 1488 fishermen with symptoms of UDTDs except liver, biliary and pancreatic diseases during the period from December 1991 to February 1995, which included medical history inquiry, physical, gastroscopic and pathological examinations, detection of Helicobacter pylori ( H. pylori) infection, and nitrate content in their drinking water. RESULTS Among the 1488 subjects investigated, 1467 suffered from one or more diseases among 14 kinds of UDTDs, most of which were chronic atrophic gastritis (CAG, 1103 cases), peptic ulcer (268 cases), and cancer of the upper digestive tract (25 cases). CONCLUSION Incidence rate of UDTDs tends to be high among the fishermen, especially CAG, peptic ulcer and upper digestive tract cancer, and complicated state of illness due to their special life habits, and high nitrate content in their drinking water, etc, and UDTDs in fishermen is significantly different from that in inland residents in clinical manifestations.

关键词： digestive tract disease gastroscopy nitrate Helicobacter pylori gastritis, atrophic peptic ulcer digestive system neoplasms

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利用时域散射场进行目标方位探测研究

电波科学学报 2005年第6期20卷 741-744页

作者：刘波高本庆薛峰南京电子技术研究所江苏南京210013 北京理工大学电子工程系北京100081 西北工业大学电子信息学院陕西西安710072

为充分地开发电磁场时域响应数据中潜在的大量有用信息,提出一种新颖的仿真算法,将阵列信号处理技术应用到对电磁场时域响应的后处理中,可以确定目标的方位和距离,以及探测浸没在某种背景下的目标。通过时域有限差分法(FDTD)与MUSIC方... 详细信息

为充分地开发电磁场时域响应数据中潜在的大量有用信息,提出一种新颖的仿真算法,将阵列信号处理技术应用到对电磁场时域响应的后处理中,可以确定目标的方位和距离,以及探测浸没在某种背景下的目标。通过时域有限差分法(FDTD)与MUSIC方法相结合,实现了具体的数值模拟,从而证明利用阵列信号处理技术能够从电磁场时域响应当中获得潜在信息,同时两者结合可以构成更为完善的数值模拟。

关键词：时域数值方法阵列信号处理时域有限差分法 MUSIC

新生儿复苏培训中几个技术细节的再认识和探讨

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中国当代儿科杂志 2020年第6期22卷 555-560页

作者：朱小瑜吴本清南方医科大学附属深圳妇幼保健院新生儿科广东深圳518028 中国科学院大学深圳医院新生儿科广东深圳518107

作者在当前新生儿复苏培训课件的修订及其深入学习中,参照美国新生儿复苏原版教程,对少数几个技术细节或译词有些再认识,特提出来探讨,包括生后快速评估地点、时段、有关呼吸问项的表述,以及气管插管按压部位、复苏流程图中呼吸问项的... 详细信息

作者在当前新生儿复苏培训课件的修订及其深入学习中,参照美国新生儿复苏原版教程,对少数几个技术细节或译词有些再认识,特提出来探讨,包括生后快速评估地点、时段、有关呼吸问项的表述,以及气管插管按压部位、复苏流程图中呼吸问项的表述等。对以上这些进行准确理解和释义将有利于基层培训更准确有效地开展。

关键词：复苏培训课件翻译新生儿