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Aspirin and pravastatin reduce lectin-like oxidized low density lipoprotein receptor-1 expression, adhesion molecules and oxidative stress in human coronary artery endothelial cells

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Chinese Medical Journal 2010年第12期123卷 1553-1560页

作者： CHEN Jia-wei ZHOU shi-bei TAN Zhi-ming Department of Anesthesiology Fudan University Shanghai Cancer Center Shanghai 200032 China

Background Oxidative stress and inflammation are important steps in the pathogenesis of atherosclerosis. We postulated that therapeutic concentrations of aspirin and pravastatin, especially in combination, may suppress oxidative stress and inflammation in endothelial cells, and this concept was examined in human coronary artery endothelial cells （HCAECs）. Methods Human coronary artery endothelial cells were cultured and treated with oxidized-low density lipoprotein （ox-LDL, 60 ug/ml for 24 hours） alone, or pre-treated with aspirin （1, 2 or 5 mmol/L）, pravastatin （1, 5 or 10 umol/L） or their combination （1 mmol/L aspirin and 5umol/L pravastatin）, followed by ox-LDL treatment. After respective treatment, superoxide anion production, p38 mitogen activated protein kinase and transcription factor NF-KB activation, protein expression of lectin-like ox-LDL receptor-1 （LOX-1） and adhesion molecules, and monocyte adhesion were measured. Results Ox-LDL treatment greatly elicited its receptor LOX-1 expression, superoxide anion production and inflammatory response, which were minimally affected by low concentration of aspirin （1 mmol/L） or pravastatin （5umol/L）, but were markedly decreased by their combination. Activation of p38 mitogen activated protein kinase and NF-KB, the expression of intercellular adhesion molecule-1 and monocyte chemotactic protein-I, which were only mildly affected by aspirin or pravastatin alone, were significantly attenuated by their combination. As a consequence, monocyte adhesion to endothelial cells was markedly attenuated by the combination of the two agents. Well-known anti-oxidants a-tocopherol and y-tocopherol had similar inhibitory effects on ox-LDL-mediated oxidative stress and LOX-1 expression as well as monocyte adhesion as did the combination of aspirin and pravastatin. Conclusions These studies point to a positive interaction between aspirin and pravastatin with regard to endothelial bioloqy. Anti-oxidant and subsequent anti-inflammatory

关键词： aspirin endothelial dysfunction HMG CoA reductase inhibitor inflammation oxidative stress

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Successful endoscopic sclerotherapy for bleeding gastric varices with combined cyanoacrylate and aethoxysklerol

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World Journal of Gastroenterology 2008年第22期14卷 3598-3601页

作者： bei shi Wei Wu Hui Zhu Yun-Lin Wu Department of Gastroenterology Ruijin Hospital Affiliated to Shanghai Jiaotong University Shanghai 200025 China Department of Radiology Ruijin Hospital Affiliated to Shanghai Jiaotong University Shanghai 200025 China

Two patients with liver cirrhosis and portal hyper-tension related to hepatitis infection were admitted to Shanghai Ruijin Hospital due to recurrent melena and hematemesis. Isolated gastric varices were observed in the gastric fundus during the retroflexion of gastroscope. We carried out endoscopic sclerotherapy successfully for bleeding gastric varices with combined cyanoacrylate and aethoxysklerol, which disappeared dramatically several months after two courses of sclerotherapy for each patient. No complication and clinical signs of gastrointestinal re-bleeding were observed during the 6-mo endoscopic follow-up. CT portal angiography (CTPA) has been widely used in the assessment of variceal treatment and improves the results of endoscopic injection therapy.

关键词： Endoscopic sclerotherapy Cyanoacrylate Aethoxysklerol Gastric varices CT portal angiography

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Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication

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Virologica Sinica 2024年第3期39卷 403-413页

作者： Xiu-Qing Li Meng-Pan Cai Ming-Yang Wang Bo-Wen shi Guo-Yu Yang Jiang Wang bei-bei Chu Sheng-Li Ming College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450046China Key Laboratory of Animal Biochemistry and Nutrition Ministry of Agriculture and Rural AffairsZhengzhou 450046China Key Laboratory of Veterinary Biotechnology of Henan Province Henan Agricultural UniversityZhengzhou 450046China Longhu Advanced Immunization Laboratory Zhengzhou 450046China International Joint Research Center of National Animal Immunology Henan Agricultural UniversityZhengzhou 450046China Ministry of Education Key Laboratory for Animal Pathogens and Biosafety Zhengzhou 450046China School of Basic Medicine Chongqing Medical UniversityChongqing 400016China

The pseudorabies virus(PRV)is identified as a double-helical DNA virus responsible for causing Aujeszky's disease,which results in considerable economic impacts *** enzyme tryptophanyl-tRNA synthetase 2(WARS2),a mitochondrial protein involved in protein synthesis,is recognized for its broad expression and vital role in the translation *** findings of our study showed an increase in both mRNA and protein levels of WARS2 following PRV infection in both cell cultures and animal *** WARS2 expression via RNA interference in PK-15 cells led to a reduction in PRV infection rates,whereas enhancing WARS2 expression resulted in increased infection ***,the activation of WARS2 in response to PRV was found to be reliant on the cGAS/STING/TBK1/IRF3 signaling pathway and the interferon-alpha receptor-1,highlighting its regulation via the type I interferon signaling *** analysis revealed that reducing WARS2 levels hindered PRV's ability to promote protein and lipid *** research provides novel evidence that WARS2 facilitates PRV infection through its management of protein and lipid levels,presenting new avenues for developing preventative and therapeutic measures against PRV infections.

关键词： Pseudorabies virus WARS2 Innate immunity Protein synthesis Lipid synthesis

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The Official Promotion Incentive： A New Re-Estimation and Re-Examination

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Journal of Modern Accounting and Auditing 2016年第10期12卷 530-535页

作者： Chen Feng Meng Qiu Rong Kang DongWang bei-bei shi University of New South Wales Sydney Australia Xi'an Jiaotong University Xi'an China Northwest University Xi'an China

Based on three major theories, the Chinese local officials＇ promotion incentive could be influenced by economic performances, political relationships, and financial performances. However, there were some researchers focusing on these promotion mechanisms and then they got different outcomes. This paper achieves the goal for exploring the influence factors of officials＇ promotion by using OLS empirical test. From collecting the data of Chinese local officials and cities＇ economic conditions, we find that economic performances and political relationships can have a significant effect on officials＇ promotion, but financial performances cannot have this effect. And the experiences and lesson of this research have some reference for exploration of Chinese local officials＇ promotion incentive.

关键词： officials' promotion incentive economic performance political relationships financial performances

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Comparison of growth structures for continuouswave electrically pumped 1.55 μm quantum dash lasers grown on(001) Si

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Photonics Research 2020年第12期8卷 1888-1894页

作者： WEI LUO YING XUE JIE HUANG LIYING LIN bei shi KEI MAY LAU Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Semiconductor lasers directly grown on silicon offer great potential as critical components in high-volume,lowcost integrated silicon photonics *** InAs/InP quantum dash(QDash)lasers on native InP substrate emitting at 1.5μm(C-band)have demonstrated notable performance,the growth of InAs/InP QDash lasers on silicon remains undeveloped because of the 8%lattice mismatch between InP and *** we report advances of growth techniques leading to the first C-band room-temperature continuous-wave electrically pumped QDash lasers on CMOS standard(001)silicon substrates by metalorganic chemical vapor deposition.A correlation between various material characterizations and device performance is analyzed for different QDash laser structures grown on planar nominal(001)*** the optimized QDash growth and improved fabrication process,the lowest threshold current density of 1.5 kA∕cm^(2) was determined on an 8μm×1.5 mmdevice on planar silicon with a single facet output power exceeding 14 *** device results illustrate the good material quality of the QDash lasers grown on silicon,suggesting potential applications for other active components of photonic integrated circuits,such as semiconductor optical amplifiers,modulators,and photodetectors.

关键词： pumped quantum wave

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Theoretical and experimental study on broadband terahertz atmospheric transmission characteristics

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Chinese Physics B 2017年第1期26卷 597-602页

作者： shi-bei Guo Kai Zhong Mao-Rong Wang Chu Liu Yong Xiao Wen-Peng Wang De-Gang Xu Jian-Quan Yao Institute of Laser and Opto-electronics College of Precision Instrument and Opto-electronics Engineering Tianjin University Tianjin 300072 China Key Laboratory of Opto-electronics Information Technology (Ministry of Education) Tianjin University Tianjin 300072 China National Key Laboratory of Science and Technology on Millimeter-wave Remote Sensing Beijing 100039 China

Broadband terahertz（THz） atmospheric transmission characteristics from 0 to 8 THz are theoretically simulated based on a standard Van Vleck–Weisskopf line shape, considering 1696 water absorption lines and 298 oxygen absorption *** influences of humidity, temperature, and pressure on the THz atmospheric absorption are analyzed and experimentally verified with a Fourier transform infrared spectrometer（FTIR） system, showing good consistency. The investigation and evaluation on high-frequency atmospheric windows are good supplements to existing data in the low-frequency range and lay the foundation for aircraft-based high-altitude applications of THz communication and radar.

关键词： terahertz atmospheric propagation line absorption continuum absorption

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