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Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet

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World Journal of Gastroenterology 2005年第42期11卷 6671-6675页

作者： Judit Bene Katalin Komlósi Beáta Gasztonyi Márk Juhász Zsolt Tulassay Béla Melegh Department of Medical Genetics and Child Development School of Medicine University of Pécs Hungary MTA PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs Hungary Department of Medical Genetics and Child Development School of Medicine University of Pécs Hungary 1st Department of Medicine School of Medicine University of Pécs Hungary 2nd Department of Medicine Semmelweis University Budapest Hungary

AIM： To determine the fasting plasma carnitine ester in patients with celiac disease. METHODS： We determined the fasting plasma carnitine ester profile using ESI triple quadrupol mass spectrometry in 33 adult patients with biopsy-confirmed maturity onset celiac disease maintained on long term gluten free diet. RESULTS： The level of free camibine did not differ as the celiac disease patients were compared with the healthy controls, whereas the acetylcarnitine level was markedly reduced （4.703± 0.205 vs 10.227 ± 0.368 nmol/mL, P〈0.01）. The level of propionylcarnitine was 61.5%, butyrylcarnitine 56.9%, hexanoylcarnitine 75%, octanoylcarnitine 71.1%, octenoylcarnitine 52.1%, decanoylcarnitine 73.1%, cecenoylcarnitine 58.3%, lauroylcarnitine 61.5%, miristoylcarnitine 66.7%, miristoleylcarnitine 62.5% and oleylcarnitine 81.1% in the celiac disease patients compared to the control values, respectively （P〈0.01）. CONCLUSION： The marked decrease of circulating acetylcarnitine with 50-80 % decrease of 11 other carnitine esters shows that the carnitine ester metabolism can be influenced even in clinically asymptomatic and well being adult celiac disease patients, and gluten withdrawal alone does not necessarily normalize all elements of the disturbed carnitine homeostasis.

关键词： Plasma carnitine ester profile Celiac disease

Novel Isatin-Schiff Base Cu (II) and Ni(II) Complexes. X-ray Crystal Structure of Bis[3-(4-hexylphenylimino)-1H-indol-2(3H)-one]-dichlorocopper(II) Complex

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Chinese Chemical Letters 2006年第2期17卷 243-246页

作者： Ayse ERCAG Sema Oztürk YILDIRIM Mehmet AKKURT Mahmure Ustün OZGUR Frank W. HEINEMANN Istanbul University Engineering Faculty Chemistry Department Avcilar Istanbul Turkey 34320 Department of Physics Faculty of Arts and Sciences Erciyes University Kayseri Turkey 38039 Yildiz Technical University Faculty of Arts and Sciences Chemistry Department Davutpasa Istanbul Turkey 34210 Institut für Inorganische Chemie UniversittErlangen-Nürnberg Egerlandstrasse 1 D-91058 Erlangen Germany

Schiff base ligand （HL） derived from 4-hexylaniline with isatin （1H-indole-2,3-dione） and its complexes with Cu（Ⅱ）, Ni（Ⅱ） were prepared and characterized by analytical, spectroscopic （IR, UV-Vis, Mass） techniques, electrical conductivity, magnetic and thermal measurements. The crystal and molecular structure of [Cu（HL）2Cl2] was determined by a single-crystal X-ray diffraction study. The molecular structure of the title compound has an inversion center on the Cu atom.

关键词： Mononuclear Cu(Ⅱ) and Ni(Ⅱ) complexes isatin-anilines Schiff base crystal structure.

Dental evaluation is helpful in the differentiation of functional heartburn and gastroesophageal reflux disease

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世界胃肠病学杂志:英文版 2023年第31期29卷 4774-4782页

作者： Krisztina Helle Anna ZsófiaÁrok Georgina Ollé Márk Antal András Rosztóczy Department of Internal Medicine Division of GastroenterologyUniversity of SzegedSzeged 6725Hungary Department of Operative and Esthetic Dentistry University of SzegedSzeged 6725Hungary

BACKGROUND Heartburn is identically the key symptom of both,gastroesophageal reflux disease(GERD)and functional heartburn(FHB),making the differential diagnosis *** manifestations of GERD can be easily examined;therefore,their exploration might be a cheap,widely available,and useful tool in the differentiation of GERD and *** To evaluate the prevalence of dental erosions(DE)and periodontal diseases(PD)in patients with heartburn and their association with GERD and *** A total of 116[M/F:51/65,mean age:54(17-80)years]consecutive patients with heartburn were enrolled for detailed esophageal function and orodental *** Dental disorders were detected in 89%(103/116).Patients with PD+DE had significantly more often pathologic reflux(90.0%vs 27.8%;P<0.05),higher esophagitis scores(1.8 vs 0.9;P<0.05),and a significantly different mean impedance curve(P=0.04)than those without any dental *** opposite approach established that patients with GERD had significantly higher prevalence of DE and PD,especially if both were present(28.9%vs 2.0%;P<0.01),more severe PD(1.5 vs 1.0;P<0.01),and longer history of heartburn(15 years vs 9 years;P<0.01)than those with *** The dental evaluation of patients with heartburn seems to be useful in the differential diagnosis of GERD and *** the studied parameters,the co-appearance of DE and PD seems to be the best predictor of GERD,whereas the absence of dental disorders was mostly observed in FHB.

关键词： Gastroesophageal reflux disease Gastric acid Heartburn Differential diagnosis Epidemiology Oral manifestations Prevalence Risk factors Dental erosion Periodontal diseases

Tackling boundaries of CCS in market deployment of second-generation oxy-fuel technology

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Clean Energy 2018年第1期2卷 72-81页

作者： Kalle Nuortimo Timo Eriksson Reijo Kuivalainen Janne Härkönen Harri Haapasalo Timo Hyppänen Sumitomo SHI FW Energia Oy P.O.Box 201 FI-78201 VarkausFinland Sumitomo SHI FW Energia Oy P.O.Box 7FI-02130 EspooFinland Industrial Engineering and Management University of OuluP.O.Box 4610FI-90014Finland LUT School of Energy Systems PL 2053851 LappeenrantaFinland

This article discusses the market potential estimation results at different stages of second-generation oxy-fuel technology for carbon capture and storage,where oxygen content is increased in order to increase efficiency and product life *** article highlights the challenges to commercializing an energy technology with long development lead *** related to external market environment,regulations and market price for carbon dioxide(CO_(2))also need to be *** study is based on a second-generation oxy-CFB technology evaluation,SWOT analysis and product life-cycle *** commercialization of second-generation oxy-fuel technology,estimated as a basis of oxy-CFB technology,is largely found to be dependent on technical,sociological and economical aspects related to the energy market *** CO_(2) price in European Union(EU)emissions trading is currently below 10€/ton,which does not favour investment in ***_(2) storage also faces public opposition and EU directive *** CO_(2) price needs to be in the range of 30€/ton by 2030,the estimated time of *** development or subsidies would also be required for the second-generation oxy-CFB power production concept to become *** is one of the critical factors in market deployment as the price development is influenced by several external factors,including the EU’s environmental policy,politics and public acceptance.

关键词： Second generation oxyfuel technology market deployment CFB technology tackling boundary of CCS

In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 993-1003页

作者： D. Burcu HAZER Ercan BAL Gülay NURLU Kemal BENLI Serdar BALCI Feral OZTrk Baki HAZER Department of Neurosurgery Faculty of MedicineMugla Sitki Kocman University Atatürk Research and Medical Center Neurosurgery ClinicMinistry of Health of the Republic of Turkey Department of Neurology Faculty of MedicineSchool of MedicineHacettepe University Department of Neurosurgery Faculty of MedicineSchool of MedicineHacettepe University Atatürk Research and Medical Center Department of PathologyYilditim Beyazit University Department of Histology and Embryology Faculty of MedicineMugla Sitki Kocman University Department of Chemistry Bülent Ecevit University

Objective:This study aims to investigate the degree of biocompatibility and neuroregeneration of a polymer tube,poly-3-hydroxyoctanoate(PHO)in nerve gap ***:Forty Wistar Albino male rats were randomized into two groups:autologous nerve gap repair group and PHO tube repair *** each group,a 10-mm right sciatic nerve defect was created and reconstructed *** was studied by sciatic function index(SFI),electromyography,and immunohistochemical studies on Days 7,21,45 and 60 of *** was analyzed by the capsule formation around the *** was analyzed by the molecular weight loss in ***:Electrophysiological and histomorphometric assessments demonstrated neuroregeneration in both groups over *** the experimental group,a straight alignment of the Schwann cells parallel to the axons was ***,autologous nerve graft seems to have a superior neuroregeneration compared to PHO *** biodegradation was observed in PHO conduit at the end of 60 ***:Although neuroregeneration is detected in PHO grafts with minor degradation in 60 d,autologous nerve graft is found to be superior in axonal regeneration compared to PHO nerve tube *** conduits were found to create minor inflammatory reaction in vivo,resulting in good soft tissue response.

关键词： Axonal spurting Biodegradable polymer Neuroregeneration Nerve grafting

In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 595-601页

作者： Mayank Gangwar Vijay C Verma Tryambak D Singh Sushil K Singh rk Goel Gopal Nath Department of Microbiology Institute of Medical Sciences Banaras Hindu University Department of Pharmacology Institute of Medical Sciences Banaras Hindu University Department of Medicinal Chemistry Institute of Medical Sciences Banaras Hindu University Department of Pharmaceutical Engineering Institute of Technology Banaras Hindu University

Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.

关键词： Protoscolicidal Echinococcus Hydatidosis Mallotus sp. Anti-helminthic agents Trypan blue

Synergistic effect of α-mangostin on antibacterial activity of tetracycline, erythromycin, and clindamycin against acne involved bacteria

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Chinese Herbal Medicines 2019年第4期11卷 412-416页

作者： Md Iftekhar Ahmad James E Keach Tapan behl Pharkphoom Panichayupakaranant Phytomedicine and Pharmaceutical Biotechnology Excellence Center Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-Yai 90112Thailand Department of Tropical Plant and Soil Sciences University of Hawai'i at MānoaKomohana Research and Extension CenterHiloHawai'i 96822USA Department of Pharmacology Chitkara College of PharmacyChitkara UniversityPunjab 140401India Department of Pharmacognosy and Pharmaceutical Botany Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-Yai 90112Thailand

Objective:To evaluate the synergistic effect ofα-mangostin with tetracycline,erythromycin,and clindamycin against bacteria involved in acne ***:A broth microdilution method was used to determine the minimum inhibitory concentration(MIC)ofα-mangostin and a range of *** effects on antibacterial activity were determined based on their own MIC,and then using a checkerboard method and a time-kill assay at 37°C for24 ***:α-Mangostin exhibited antibacterial activity against Propionibacterium acnes,Staphylococcus aureus,*** and *** with MIC values of 0.78,3.13,0.78,and 6.25μg/m L,*** results of the checkerboard assay showed thatα-mangostin produced synergistic effects with tetracycline,erythromycin,and clindamycin against all tested bacteria,with a fractional inhibitory concentration index(FICI)between 0.09 and ***,time-kill curve data indicated thatα-mangostin increased the antibacterial activity of tetracycline,erythromycin,and ***:These findings suggested thatα-mangostin may be used to enhance the antibacterial activity of some antibiotics against bacteria involved in acne production.

关键词： α-Mangostin acne clindamycin erythromycin synergistic tetracycline

Role of chloride on the instability of blue emitting mixed‑halide perovskites

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Frontiers of Optoelectronics 2023年第4期16卷 61-70页

作者： Max Karlsson Jiajun Qin Kaifeng Niu Xiyu Luo Johanna Rosen Jonas Björk Lian Duan Weidong Xu Feng Gao Department of Physics Chemistry and Biology(IFM)Linköping UniversityLinköpingSweden Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)Northwestern Polytechnical UniversityXi’an 710072China

Although perovskite light-emitting diodes(PeLEDs)have seen unprecedented development in device efciency over the past decade,they sufer signifcantly from poor operational *** is especially true for blue PeLEDs,whose operational lifetime remains orders of magnitude behind their green and red ***,we systematically investigate this efciency-stability discrepancy in a series of green-to blue-emitting PeLEDs based on mixed Br/*** fnd that chloride incorporation,while having only a limited impact on efciency,detrimentally afects device stability even in small *** lifetime drops exponentially with increasing Cl-content,accompanied by an increased rate of change in electrical properties during *** ascribe this phenomenon to an increased mobility of halogen ions in the mixed-halide lattice due to an increased chemically and structurally disordered landscape with reduced migration *** results indicate that the stability enhancement for PeLEDs might require diferent strategies from those used for improving efciency.

关键词： Ion migration Blue electroluminescence Mixed halide perovskites

Sclerotherapy as a primary or salvage procedure for aneurysmal bone cysts:A single-center experience

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世界骨科杂志:英文版 2023年第9期14卷 698-706页

作者： Kolja Sebastian Weber Claus Lindkær Jensen Michael Mørk Petersen Department of Orthopedic Surgery RigshospitaletCopenhagen 2100Denmark

BACKGROUND Aneurysmal bone cysts(ABC)are benign cystic bone tumors of an osteolytic and locally aggressive *** an alternative to the primary treatment of choice,which consists of curettage with bone grafting,alternative treatment methods with promising results have been *** our department,we have,in recent years,used percutaneous sclerotherapy with *** objective of this study was to identify the healing rate and safety of sclerotherapy with *** To identify the efficacy and safety of sclerotherapy with polidocanol in primary and recurrent *** Twenty-two consecutive patients(median age 12.5 years;range 1-27)with 23 ABCs treated with sclerotherapy with polidocanol from 2016-2021 were included *** patients(48%)had undergone different forms of previous treatment with *** general anesthesia and fluoroscopic guidance,repeated percutaneous injections of 4mg polidocanol/kg body weight were *** review of the electronic medical records,the following were identified:healing and recurrence rate,number of treatments,gender,age,comorbidity,location of the tumor and side effects/complications,as well as any previous surgery for *** median length of radiographic follow-up was 19.5 *** All ABCs except one(96%)showed healing or stable disease after a median of 4(range 1-8)*** clinical and radiographic healing was observed in 16 cysts(70%),while partial radiographic healing with resolution of pain was seen in 6 cases(26%)and considered as stable *** cyst that failed to heal had previously undergone curettage twice with *** patient with a large pelvic ABC experienced,right after two injections,a sudden drop in blood pressure,which could quickly be *** patient with a juxtaphyseal ABC in the femoral neck showed a minor limb length discrepancy because of *** that,no complications were *** Percutaneous sclerotherapy

关键词： Aneurysmal bone cyst Bone tumor Sclerotherapy Polidocanol Healing rate Complications