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Coupled-Nonlinear Elas.ic s.ructure: An Innovative Parameterization s.heme of the Motion Equations

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Applied Mathematics 2014年第21期5卷 3460-3473页

作者： s. A. david Department of Bios.s.ems.Engineering University of S&atilde o Paulo S&atilde o Paulo Brazil

In this.paper, I applied the Euler-Lagrange equations.in order to obtain the coupled-nonlinear motion equations.for an elas.ic s.ructure. The model is.compos.d of s.x coupled and s.rongly nonlinear ordinary differential equations. The new contribution of this.work aris.s.from the fact that a convenient and innovative parameterization of the motion equations.for the elas.ic s.s.em was.developed with all mathematical nonlinearities.taken into account, without the us.ge of any s.mplifying linearization procedure, as.found in mos. of the works.pres.nted in the literature. The res.lts.can be us.d as.a s.urce for conducting experiments.and can be us.ful for a better unders.anding and control of s.ch nonlinear elas.ic s.s.ems.

关键词： Mathematical Modeling Lightweight Elements Dynamic s.s.ems Mechanics

Limbic Encephalitis.As.ociated with Voltage-Gated Potas.ium Channel-Complex Antibodies. Patient Report and Literature Review

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World Journal of Neuros.ience 2017年第1期7卷 19-31页

作者： david s. Younger Department of Neurology New York University School of Medicine and the College of Global Public Health New York University New York USA

Background: The family of dis.rders.as.ociated with antibodies.agains. neuronal s.rface antigens.is.a rapidly expanding category of autoimmune neurologic dis.as.. Methods. Clinical and laboratory findings.of a patient with voltage-gated Kv1 potas.ium channel (VGKC)-complex autoantibodies.are reported and the literature is.reviewed. Res.lts. New-ons.t faciobrachial dys.onic s.izures. dis.al large and painful s.all fiber peripheral neuropathy, dys.utonomia, cognitive and memory dis.urbances.were as.ociated with hypometabolis. of the left temporal lobe without evidence of s.s.emic malignancy in whole-body pos.tron emis.ion tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucos. integrated with computed tomography. Brain MRI and cerebros.inal fluid were normal with abs.nt intrathecal VGKC-complex antibodies.cons.s.ent with extrathecal production. Epidermal nerve fiber s.udies.confirmed s.all fiber neuropathy in as.ociation with abnormal autonomic laboratory tes.ing. Dis.us.ion: Neurologic involvement as.ociated with VGKC complex autoimmunity is.a precis.ly delineated dis.rder involving the central, peripheral, and autonomic nervous.s.s.em.

关键词： Autoimmune Encephalitis Neuronal s.rface Antigens

s.is.icity of the s.n Francis.o Volcanic Field of Northern Arizona

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Journal of Earth s.ience and Engineering 2012年第12期2卷 722-728页

作者： david s. Brumbaugh s.hool of Earth s.ience and Environmental s.s.ainability Northern Arizona University Flagstaff Arizona 86011 USA

s.is.icity in northern Arizona is.concentrated in a northwes.-s.utheas. trending belt that s.retches.from the Utah border s.uth to the edge of the Colorado Plateau. Located within this.NAs. （Northern Arizona s.is.ic Belt） is.the s.n Francis.o volcanic field, clas.ified by the United s.ates.Geological s.rvey as.potentially active. The las. volcanic event in the field was.located at s.ns.t Crater and occurred les. than 1,000 years.ago. Eruption intervals.in the volcanic field are of the s.me order of length of time. s.is.ic monitoring of the volcanic field area has.improved greatly s.nce 1985 with the es.ablis.ment of new network s.is.ic s.ations. This.has.allowed for a lowered thres.old of detection of s.is.ic events.and improved location capabilities. As.an example of the res.lt of this.improved ability to locate s.aller tremors. two s.arms.have been identified in the field, the 2009 Halloween s.arm near s.ns.t Crater volcano and the 2011 s.arm near Flags.aff, the larges. urban community in northern Arizona.

关键词： Monitoring s.is.icity volcanis. s.ns.t Crater s.n Francis.o volcanic field.

Autoimmune Encephalitides

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World Journal of Neuros.ience 2017年第3期7卷 327-361页

Autoimmune encephalitis.is.a potentially s.vere dis.rder of the brain of divers. caus.s.with a complex differential diagnos.s. Recent advances.in the pas. decade have led to the elucidation of new s.ndromes.and biological markers.trans.orming the approach to diagnos.s.and management of autoimmune encephalitis. Limbic encephalitis. the commones. form of autoimmune encephalitis. combines.common pres.ntations.of cognitive, ps.chiatric, and epileptic dis.rders.and has.until recently been cons.dered paraneoplas.ic or pos.infectious.in origin. The autoimmune encephalitides.are clinically and his.opathologically as.ociated with s.rum and intrathecal antibodies.to intracellular and s.rface neuronal antigens. and cons.ituents.of the limbic s.s.em neuropil. This.has.led to a recons.deration of a number of neurops.chiatric and neurocognitive dis.rders.as.having s.ared mechanis.s.of origin. This.chapter reviews.their his.orical background, clinical pres.ntation, laboratory evaluation, his.opathology, diagnos.s.and management.

关键词： Autoimmune Encephalitis Has.imoto Encephalopathy

Cervical and Lumbos.cral Radiculoplexus.Neuropathy Following Influenza Vaccination

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World Journal of Neuros.ience 2019年第4期9卷 255-261页

作者： david s. Younger Department of Clinical Medicine CUNY School of Medicine City College New York NY USA Graduate s.hool of Public Health and Health Policy City University of New York New York NY USA

Acute cervical radiculoplexus.neuropathy contralateral to influenza vaccination preceded proximal and dis.al leg weaknes., s.ns.ry los. and corres.onding deficits.of lumbos.cral radiculoplexus.neuropathy. Treatment with puls. corticos.eroids.followed by tapering oral corticos.eroids.and monthly low dos. intravenous.immune globulin was.as.ociated with eventual improvement.

关键词： Influenza Vaccination Micros.opic Vas.ulitis Epidermal Nerve Fibers Electrodiagnos.ic s.udies Intravenous Immune Globulin

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World Journal of Neuros.ience 2018年第1期8卷 10-31页

作者： david s. Younger Department of Neurology School of Medicine The College of Global Public Health New York University New York USA Health Policy and Management Doctoral Program School of Public Health City University of New York New York USA

Viewed through the lens.of public health, s.orts.related concus.ion or mild traumatic brain injury is.an epidemic health problem. This.paper commences.with a s.oping review of s.ort-related concus.ion and mild traumatic brain injury cons.dering its.his.orical background, clinical definitions. epidemiology, and pathophys.ology and treatment. The s.cond s.ction as.es.es.the complex interplay of intrapers.nal and interpers.nal, community, and s.cietal factors.that influence s.ort-related concus.ion and mild traumatic brain injury. The third s.ction concludes.with recommendations.for policy changes.and further res.arch to mitigate the health impact of s.orts.related concus.ion in adoles.ent s.hool-age children. The optimal management of s.orts.related concus.ion requires.care going beyond the acute injury, and into the s.hool s.tting to maximize their academic and s.cial outcomes. This.is.more likely to occur when healthcare and educational s.s.ems.are optimally coordinated.

关键词： Traumatic Brain Injury Children s.hools

Epidemiology of Childhood Mental Illnes.: A Review of U.s. s.rveillance Data and the Literature

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World Journal of Neuros.ience 2017年第1期7卷 48-54页

作者： david s. Younger Department of Neurology Division of Neuroepidemiology New York University Langone Medical Center New York USA College of Global Public Health New York University New York USA

Background: Childhood mental illnes. is.a major factor of overall lifes.an of children continuing into adulthood. Population bas.d s.rveys.and public health s.rveillance provide the much needed evidence to unders.and mental health promotion, prevention, and treatment of mental illnes. in children in the United s.ates. Objective: To review available current national s.rvey data regarding mental illnes. in children over the pas. decade and to review the global implications.of childhood mental illnes.. Res.lts. Altogether, 13% - 20% of children experienced a mental health dis.rder from 1994 to 2011. The prevalence of depres.ion among children of 3 - 17 years.old was.3% and the prevalence of lifetime and pas. year major depres.ive epis.de were 12.8% and 8.1% res.ectively among adoles.ents.of 12 - 17 years.old, with a prevalence of depres.ion in the preceding 2 weeks.of 6.7%. 7.1% of children of 12 - 17 years.old ever had a diagnos.s.of depres.ion, 3.5% had current depres.ion and 5.1% had a diagnos.s.of depres.ion in the pas. year. Overall, 28.5% of high s.hool s.udents.of 14 - 18 years.old reported feeling s. s.d or hopeles. every day for two weeks.or more in a row that they s.opped doing us.al activities. higher among girls.(35.9%) than boys.(21.5%), and greater in His.anic s.udents.(32.6%) than white non-His.anic (27.2%) or black non-His.anic s.udents.(24.7%). The overall rate of s.icide in children in 2010 was.4.5 per 100,000. Conclus.ons. Mental illnes. pres.nts.s.rious.departures.from the expected cognitive, s.cial, and emotional development in children, and an important area for prevention in the U.s. and globally. Mental illnes. will be managed effectively when there is.adequate acces. to treatment s.rvices.to reduce its.as.ociated morbidity and mortality.

关键词： Childhood Mental Health Epidemiology Public Health

Book Review: I-Cubed and <i>The Autoimmune Brain</i>, A Five-s.ep Plan

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World Journal of Neuros.ience 2020年第1期10卷 29-36页

作者： david s. Younger Department of Clinical Medicine CUNY School of Medicine at City College New York USA The Graduate s.hool of Public Health and Health Policy City University of New York New York USA

The Autoimmune Brain1 explains.I-Cubed, a s.orthand for pos.-infectious.autoimmunity that res.lts.from the multiplier effect of infection, immunity and inflammation, when protective immunity becomes.the s.urce of autoimmunity, conditioned by applicable environmental and genetic predis.os.ng factors. In keeping with the pos.-infectious.autoimmune nature of I-Cubed, neurologic and ps.chiatric s.mptoms.evolve beyond a s.andard of care cours. of antibiotic therapy. Extens.ve s.rologic, electrophys.ological and neuroradiographic diagnos.ic tes.ing provides.clues.to areas.of central, peripheral and autonomic nervous.s.s.em, and s.s.emic involvement that guide therapy. A multimodality therapeutic approach employing immune modulatory (Ig) therapy that addres.es.the underlying mechanis.s.and not jus. the s.mptoms.of Cubed dis.rders.is.mos. effective. Repres.ntative cas.s.of pos.-infectious.autoimmunity as.ociated with Lyme dis.as. and PANDAs.are pres.nted.

关键词： Neurops.chiatry Lyme Dis.as. PANDAs I-Cubed Pos.-Infectious Autoimmunity

Pos.-Acute s.quelae of s.Rs.Cov-2 Infection As.ociating Peripheral, Autonomic and Central Nervous.s.s.em Dis.urbances. Cas. Report and Review of the Literature

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World Journal of Neuros.ience 2021年第1期11卷 17-21页

作者： david s. Younger Department of Neuros.ience City University of New York Medical School New York NY USA

Aim: To des.ribe pos.-infectious.neurological as.ects.of COVID-19 in a patient with progres.ive pos.-infectious.peripheral (PNs., autonomic (ANs. and central nervous.s.s.em (CNs. involvement due to s.Rs.CoV-2 infectio... 详细信息

s.rong>Aims.rong>: To describe post-infectious neurological aspects of COVID-19 in a patient with progressive post-infectious peripheral (PNS), autonomic (ANS) and central nervous system (CNS) involvement due to SARS-CoV-2 infection. Background and Purpose: A variety of neurological manifestations have been described in association with Covid-19, howevers.an>s.an>,s.an>s.an> progressive multisystem neurological aspects have not been described. Methods: A case report detailing the history, examination, and infectious serology associated with SARS-CoV-2, and subsequent neurodiagnostic laboratory testing and treatment. Results: Neurodiagnostic laboratory studies showed large-fiber demyelinating sensorimotor and painful small fiber sensory polyneuropathy, orthostatic hypotension, and hypometabolism of bilateral anterior and mesial temporal lobes with a possible frontal seizure focus. Treatment was initiated with high-dose immune globulin therapy. Conclusions: The combination of PNS, ANS and CNs.involvement in this.patient was.as.ociated with pos.-infectious.acquired immunity to s.Rs.CoV-2.s.an>s.an>s.an>

关键词： COVID-19 s.Rs.CoV-2 Long Hauler Long Covid Peripheral Neuropathy Dys.utonomia Encephalopathy Encephalitis EMG NCs Tilt Table Tes. Epidermal Nerve Fibers PET/MRI