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Ethnobotanical studies of plants of Charkotli Hills, Batkhela District, Malakand, Pakistan

Frontiers in Biology 2009年第4期4卷 539-548页

作者： barkatullah Muhammad IBRAR Farrukh HUSSAIN Pharmacognosy Lab Department of BotanyUniversity of PeshawarPeshawarPakistan Center of Plant Biodiversity University of PeshawarPeshawarPakistan

A survey was conducted with the aim to document the indigenous information of Charkotli Hills,Batkhela District,Malakand,*** area has rich vegetation and a high potential for ethnobotanical *** was collected on various traditional uses of 100 plants distributed over 49 families,of which 43 families were of dicot,2 of monocot,2 of pteridophyta,and 1 of *** plants have more than one local ***-six plants were found to be medicinal species,21 fruit and edible seed species,11 furniture species,18 fodder or forage species,12 vegetable species,12 fuel species,11 thatching and building species,5 hedge or fencing species,5 timber wood species,5 poisonous plants,3 species used in ketchup,2 fixed oil yielding species,2 miswak species,2 species for making sticks for cattle and defense purposes,2 species cultivated for ornamental purposes,2 species used as mehindi by girls,1 irritant species,1 species for the making of Salai(a little stick for applying‘surma’to the eyes),1 species for tanning,1 species used as refresher in milk pots,1 species giving gum used as chewing gum,and 1 species used as insect *** area is under heavy pressure of deforestation and overgrazing,which have reduced the regeneration of woody *** ecological manage-ment is required to protect the wildlife and ethnobotanical resources for the coming generations.

关键词： ethnobotanical information Charkotli Hills deforestation ecological management

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Synthesis of silver and gold nanoparticles from leaf of Litchi chinensis and its biological activities

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Asian Pacific Journal of Tropical Biomedicine 2018年第3期8卷 142-149页

作者： Uzma Murad barkatullah Shafqat Ali Khan Muhammad Ibrar Sami Ullah Umbreen Khattak Department of Botany Faculty of Biological Sciences Islamia College Department of Botany Faculty of Biological Sciences University of Peshawar

Objective: To synthesize and isolate silver and gold nanoparticles from Litchi chinensis leaf methanolic extract, and to evaluate its comparative biological activities including muscles relaxant, analgesic, anti-inflammatory and antidiarrheal. Methods: The gold and silver nanoparticles were synthesized by dissolving methanolic extract in gold chloride and silver nitrate solution separately which were confirmed by colour change and UV-Vis spectroscopy, and pellets were collected through centrifugation. Biological activities of the extract were conducted on BALB/c mice through various standard methods and the data were subjected to One-way ANOVA. Results: The colorless gold chloride solution changed to purple soon after the addition of plant extract, demonstrating that the reaction took place and gold ions were reduced to gold nanoparticles, while colorless silver nitrate solution changed to light and dark brown that was indicative of silver nanoparticles. The muscles relaxant activity showed that silver nanoparticles were more effective than gold nanoparticles and methanolic extract in traction test. The analgesic activity showed that silver and gold nanoparticles showed highest percentage decrease in acetic acid induced writhing at the doses of 50, 100 and 150 mg/kg b.w. The highest anti-inflammatory activity was produced by gold nanoparticles followed by silver nanoparticles, while low activity was observed in methanolic leaf extract. Only the crude methanolic extract showed significant antidiarrheal activity as compared to the standard drug atropine sulphate, while antidiarrheal activities of gold and silver nanoparticles were non-significant. Conclusions: The present work concludes that isolated silver and gold nanoparticles from leaf methanolic extract shows strong muscles relaxant, analgesic and anti-inflammatory activities while crude methanolic extract possesses good antidiarrheal activity.

关键词： Litchi chinensis Methanolic extract Silver and gold nanoparticles Muscles relaxant Analgesic Anti-inflammatory Antidiarrheal activities

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In vivo screening of essential oils of Skimmia laureola leaves for antinociceptive and antipyretic activity

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Asian Pacific Journal of Tropical Biomedicine 2013年第3期3卷 202-206页

作者： Naveed Muhammad barkatullah Muhammad Ibrar Haroon Khan Muhammad Saeed Amir Zada Khan Waqar Ahmad Kaleem Department of Pharmacy.University of Peshawar-25120 Department of Pharmacy University of Peshawar-25120 Gandhara College of Pharmacy Gandhara University

Objective:To study the screening of essential oils of Skimmia laureola leaves(SLO)for acute toxicity,antinociceptive,antipyretic and anticonvulsant activities in various animal ***:SLO were extracted using modified Clevenger type *** toxicity test was used in mice to observe its safety *** activity of SLO was evaluated in acetic acid induced writhing and hot plate *** induced hyperthermic mice and pentylenetetrazole induced convulsive mice were used for the assessment of its antipyretic and anticonvulsant profile ***:Substantial safety was observed for SLO in acute toxicity *** showed a high significant activity in acetic acid induced writhing test in a dose dependent manner with maximum pain attenuation of 68.48%at 200 mg/kg ***,it did not produce any relief in thermal induced pain at test *** challenged against pyrexia evoked by yeast,SLO manifested marked amelioration in hyperthermic mice,dose *** anti-hyperthermic activity(75%)was observed at 200 mg/kg *** 4 h of drug ***,SLO had no effect on seizures control and mortality caused by ***:In vivo studies of SLO showed prominent antinociceptive and antipyretic activities with ample safety profile and thus provided pharmacological base for the traditional uses of the plant in various painful conditions and *** detail studies are required to ascertain its clinical application.

关键词： Skimmia laureola leaves Essential oils Antinociceptive Antipyretic activity

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