检索结果-南通市图书馆

Induced Pluripotency for Translational Research

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2013年第5期11卷 288-293页

作者： Menghua Wu Guilai Chen baoyang Hu State Key Laboratory of Reproductive Biology and Key Laboratory of Translational Stem Cell Research Institute of ZoologyChinese Academy of Sciences

The advent of induced pluripotent stem cells （iPSCs） has revolutionized the concept of cellular reprogramming and potentially will solve the immunological compatibility issues that have so far hindered the application of human pluripotent stem cells in regenerative medicine. Recent findings showed that pluripotency is defined by a state of balanced lineage potency, which can be artificially instated through various procedures, including the conventional Yamanaka strategy. As a type of pluripotent stem cell, iPSCs are subject to the usual concerns over purity of differen- tiated derivatives and risks of tumor formation when used for cell-based therapy, though they pro- vide certain advantages in translational research, especially in the areas of personalized medicine, disease modeling and drug screening, iPSC-based technology, human embryonic stem cells （hESCs） and direct lineage conversion each will play distinct roles in specific aspects of translational medi- cine, and continue yielding surprises for scientists and the public.

关键词： iPSCs Pluripotency Cell fate decision Translational medicine

Photocatalytic syngas synthesis from CO_(2) and H_(2)O using ultrafine CeO_(2)-decorated layered double hydroxide nanosheets under visible-light up to 600 nm

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2021年第1期15卷 99-108页

作者： Ling Tan Kipkorir Peter Jing Ren baoyang Du Xiaojie Hao Yufei Zhao Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

The rational design of photocatalyst that can effectively reduce CO_(2) under visible light(l>400 nm),and simultaneously precise control of the products syngas(CO/H2)ratio is highly desirable for the Fischer-Tropsch *** this work,we synthesized a series of CeO_(2)-decorated layered double hydroxides(LDHs,Ce-x)samples for photocatalytic CO_(2) *** was found that the selectivity and productivity of CO and H_(2) from photoreduction of CO_(2) in conjunction with Ru-complex as photosensitizer performed an obvious“volcano-like”trend,with the highest point at Ce-0.15 and the CO/H_(2) ratio can be widely tunable from 1/7.7 to 1/***,compared with LDH,Ce-0.15 also drove photocatalytic CO_(2) to syngas under 600 nm *** implied that an optimum amount of CeO_(2) modifying LDH promoted the photoreduction of CO_(2) to *** report gives the way to fully utilize the rare earth elements and provides a promising route to enhance the photo-response ability and charge injection efficiency of LDH-based photocatalysts in the synthesis of syngas with a tunable ratio under visible light irradiation.

关键词： visible light catalysis CO_(2)conversion layered double hydroxide rare earth elements

Integrated analysis of multi-tissues lipidome and gut microbiome reveals microbiota-induced shifts on lipid metabolism in pigs

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2022年第3期10卷 280-293页

作者： Chunlin Xie Xiaoyan Zhu baoyang Xu Yaorong Niu Xuelei Zhang Libao Ma Xianghua Yan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhanHubei 430070China The Cooperative Innovation Center of Sustainable Pig Production WuhanHubei 430070China Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Technology WuhanHubei 430070China

Lipid metabolism is very important for meat quality in *** evidence shows that gut microbiota can contribute to this physiological ***,the gut microbiota that function in lipid metabolism and adipogenesis remains ***,we compared the characteristics of fat deposition and gut microbial community between Laiwu pigs and Duroc(LandraceYorkshire)(DLY)*** microbiota transplantation(FMT)was performed to determine the possible impact of gut microbiota on lipid metabolism in *** integrated analysis of the gut microbiome and lipidome of the small intestine,plasma,and liver was conducted to investigate the effects of FMT on host lipid *** comparative analysis of the gut microbiome showed higher abundance of Bacteroidetes(P=0.0018)while lower abundance of Firmicutes(P=0.012)in Laiwu pigs,and the microbial composition can be transferred from Laiwu pigs into DLY *** electron microscope and Oil red-O staining were performed to analyze the effects of FMT on lipid deposition in liver,the main target organ for lipid *** results showed that FMT significantly increased the number of lipid droplets(P=0.0035)and lipid accumulation(P=0.0026)in ***,integrated multi-tissues lipidome analysis demonstrated that the fatty acyls and glycerophospholipids were significantly increased(P<0.01)in intestine and liver,while glycerolipids and fatty acyls were reduced(P<0.01)in *** the small intestine,FMT increased(P<0.01)the relative abundance of polyketides and prenol lipids but reduced(P<0.01)the *** analysis revealed the potential interactions between microbiota and lipid ***,our results indicated that the gut microbiota may regulate the lipid metabolism and enhance the accumulation of lipid droplets in the liver of pigs.

关键词： Pig Gut microbiota Lipidome Fecal microbiota transplantation Lipid metabolism

Multi-omics analysis reveals gut microbiota-induced intramuscular fatdeposition via regulating expression of lipogenesis-associated genes

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2022年第2期9卷 84-99页

作者： Chunlin Xie Junyong Teng Xinkai Wang baoyang Xu Yaorong Niu Libao Ma Xianghua Yan State Key Laboratory of Agricultural Microbiology College of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhanHubei430070China Hubei Hongshan Laboratory WuhanHubei430070China The Cooperative Innovation Center of Sustainable Pig Production WuhanHubei430070China Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Technology WuhanHubei430070China

The gut microbiome has great effects on the digestion, absorption, and metabolism of lipids. However,the microbiota composition that can alter the fat deposition and the meat quality of pigs remains ***, we used Laiwu (LW) pigs (a native Chinese breed with higher intramuscular fat) compared withcommercial crossbreed Duroc×(Landrace×Yorkshire) (DLY) pigs to investigate the effects of microbiotaon meat quality, especially in intramuscular fat content. A total of 32 DLY piglets were randomly allottedto 4 groups and transplanted with fecal microbiota from healthy LW pigs. The results indicated that thehigh dose of fecal microbiota transplantation (HFMT) selectively enhanced fat deposition in longissimusdorsi (P < 0.05) but decreased backfat thickness (P < 0.05) compared with control group. HFMT significantlyaltered meat color and increased feed conversation ratio (P < 0.05). Furthermore, the multi-omicsanalysis revealed that Bacteroides uniformis, Sphaerochaeta globosa, Hydrogenoanaerobacterium saccharovorans,and Pyramidobacter piscolens are the core species which can regulate lipid deposition. A total of140 male SPF C57BL/6j mice were randomly allotted into 7 groups and administrated with these 4 microbesalone or consortium to validate the relationships between microbiota and lipid *** the bacterial consortium into mice increased intramuscular fat content (P < 0.05) comparedwith control mice. Increased expressions of lipogenesis-associated genes including cluster of differentiation36 (Cd36), diacylglycerol O-acyltransferase 2 (Dgat2), and fatty acid synthase (FASN) wereobserved in skeletal muscle in the mice with mixed bacteria compared with control mice. Together, ourresults suggest that the gut microbiota may play an important role in regulating the lipid deposition in the muscle of pigs and mice.

关键词： Gut microbiota Lipid deposition Intramuscular fat Meat quality Fecal microbiota transplantation

Multi‑omics analysis reveals gut microbiota‑ovary axis contributed to the follicular development difference between Meishan and Landrace×Yorkshire sows

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2023年第5期14卷 1954-1968页

作者： baoyang Xu Wenxia Qin Yuwen Chen Yimei Tang Shuyi Zhou Juncheng Huang Libao Ma Xianghua Yan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070HubeiChina Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Wuhan 430070HubeiChina

Background The mechanism by which Meishan(MS)sows are superior to white crossbred sows in ovarian follicle development remains *** gut microbiota could regulate female ovarian function and reproductive capacity,this study aimed to determine the role of gut microbiota-ovary axis on follicular development in *** We compared the ovarian follicular development,gut microbiota,plasma metabolome,and follicular fluid metabolome between MS and Landrace×Yorkshire(L×Y)sows.A H_(2)O_(2)-induced cell apoptosis model was used to evaluate the effects of multi-omics identified metabolites on the apoptosis of porcine ovarian granulosa cells in *** Compared with L×Y sows,MS sows have greater ovary weight and improved follicular development,including the greater counts of large follicles of diameter≥5 mm,secondary follicles,and antral follicles,but lesser atretic *** ovarian granulosa cells in MS sows had alleviated apoptosis,which was indicated by the increased BCL-2,decreased caspases-3,and decreased cleaved caspases-3 than in L×Y *** ovarian follicular fluid of MS sows had higher concentrations of estradiol,progesterone,follicle-stimulating hormone,luteinizing hormone,and insulin like growth factor 1 than L×Y *** microbiota of MS sows formed a distinct cluster and had improved alpha diversity,including increased Shannon and decreased Simpson than those of L×Y *** to the enhanced function of carbohydrate metabolism and elevated short-chain fatty acids(SCFAs)in feces,the differential metabolites in plasma between MS and L×Y sows are also mainly enriched in pathways of fatty acid *** were significant correlations among SCFAs with follicular development,ovarian granulosa cells apoptosis,and follicular fluid hormones,***,compared with L×Y sows,MS sows had higher follicular fluid SCFAs concentrations which could ameliorate H_(2)O_(2)-induced porcine granulosa cells apoptosis in ***

关键词： Follicular development Granulosa cells apoptosis Gut microbiota Short-chain fatty acids Sows

The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2014年第6期7卷 63-69页

作者： Lian Li baoyang Ding Qi Yang Shang Chen Huaying Ren Jinfeng Wang Hengchang Zang Fengshan Wang Lixuan Zang School of Pharmaceutical Sciences and National Glycoengineering Research Center Shandong University No.44 Wenhuaxi Road Jinan 250012P.R.China School of Chemistry and Chemical Engineering Shandong University No.27 Shandanan Road Jinan 250010P.R.China

Near infrared spectroscopy(NIRS)is based on molecular overtone and combination *** is difficult to assign specific features under complicated *** it is necessary to find the relevance between NIRS and target *** this purpose,the chondroitin sulfate(CS)ethanol precipitation process was selected as the research model,and 90 samples of 5 different batches were collected and the content of CS was determined by modifed carbazole *** relevance between NIRS and CS was studied throughout optical pathlength,pretreat ment methods and variables selection *** conclusion,the first derivative with Savitzky--Golay(SG)smoothing was selected as the best pretreatment,and the best spectral region was selected using interval partial least squares(iPLS)method under 1 mm optical cell.A multivariate cali-bration model was established using PLS algorithm for determining the content of CS,and the root mean square error of prediction(RMSEP)is *** method will have great potential in process analytical technology in the future.

关键词： Chondroitin sulfate near infrared spectroscopy variable selection pathlength

Gut microbiota contributes to the development of endometrial glands in gilts during the ovary-dependent period

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2021年第4期12卷 1610-1622页

作者： baoyang Xu Wenxia Qin Yiqin Yan Yimei Tang Shuyi Zhou Juncheng Huang Chunlin Xie Libao Ma Xianghua Yan State Key Laboratory of Agricultural Microbiology College of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070HubeiChina Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Technology Wuhan 430070HubeiChina

Background:The hyper-prolificacy Meishan gilts achieved a superior endometrial gland development(EGD)than white crossbred gilts during the ovary-independent period(before 60 d of age).Then,the EGD continues under the management of ovary-derived steroid hormones that regulated by gut microbiota(after 60 d of age).However,whether Meishan gilts’superiority in EGD lasting to the ovary-dependent period(after 60 d of age)and the role of gut microbiota in this period both remain ***:Meishan gilts and Landrace x Yorkshire(LxY)gilts were raised under the same housing and feeding conditions until sexual maturity and then we compared their EGD and gut ***,we transplanted fecal microbiota from Meishan gilts to L×Y gilts to explore the role of gut microbiota in *** sampled plasma every 3 weeks and collected the uterus,ovary,liver,and rectal feces after the *** then determined the hormone concentrations and expressions of the EGD-related *** also profiled the gut microbiota using 16S rDNA sequencing and metabolites of plasma and liver tissue using untargeted ***,the correlation analysis and significant test was conducted between FMT-shifted gut microbes and EGD-related ***:Meishan gilts have larger endometrial gland area(P<0.001),longer uterine horn length(P<0.01)but lighter uterine horn weight(P<0.05),a distinctive gut microbiota compared with L×Y *** microbiota transplantation(FMT)increased endometrial gland area(P<0.01).FMT markedly shifted the metabolite profiles of both liver and plasma,and these differential metabolites enriched in steroid hormone biosynthesis *** increased estradiol and insulin-like growth factor 1 but decreased progesterone *** also increased the expression of the EGD-related genes estrogen receptor 1 gene,epithelial cadherin,and forkhead box protein *** is a significant correlation between FMT-shifted gut microbes and EGD-related ***

关键词： Endometrial gland Fecal microbiota transplantation Gut microbiota Meishan gilts Steroid hormones Untargeted metabolomics Uterus

Optimal Design of Electrical Machines Assisted by Hybrid Surrogate Model Based Algorithm

在线全文

学校读者我要写书评

暂无评论

CES Transactions on Electrical Machines and Systems 2020年第1期4卷 13-19页

作者： Ziyan Ren Yuan Sun baoyang Peng Bin Xia Xia Li School of Electrical Engineering in Shenyang University of Technology Shenyang110870 China Shenyang University of Technology Shenyang 110870 China Inner Mongolia Power(Group)Co. Ltd China Department of Information Engineering China Jiliang UniversityHangzhouZhejiang 310018 China

In this paper,for design of large-scale electromagnetic problems,a novel robust global optimization algorithm based on surrogate models is *** proposed algorithm can automatically select a proper meta-model technique among multiple *** this paper,three representative meta-modeling techniques including ordinary Kriging,universal Kriging,and response surface method with multi-quadratic radial basis functions are *** each optimization iteration,the above three models are used for parallel *** proposed hybrid surrogate model optimization algorithm synthesizes advantages of these different *** verification of a specific meta-model,a suitable one for the engineering problem to be analyzed is automatically ***,the proposed algorithm intends to make a better trade-off between numerical efficiency and searching accuracy for solving engineering problems,which are characterized by stronger non-linearity,higher complexity,non-convex feasible region,and expensive performance analysis.

关键词： Electromagnetic problem global optimization hybrid surrogate model.

Rice bran oil supplementation protects swine weanlings against diarrhea and lipopolysaccharide challenge

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 430-441页

作者： Juncheng HUANG Wenxia QIN baoyang XU Haihui SUN Fanghua JING Yunzheng XU Jianan ZHAO Yuwen CHEN Libao MA Xianghua YAN State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070China Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Wuhan 430070China Yichun Dahaigui Life Science Co. Ltd.Yichun 336000China

Early weaned piglets suffer from oxidative stress and enteral infection,which usually results in gut microbial dysbiosis,serve diarrhea,and even *** bran oil(RBO),a polyphenol-enriched by-product of rice processing,has been shown to have antioxidant and anti-inflammatory properties both in vivo and in ***,we ascertained the proper RBO supplementation level,and subsequently determined its effects on lipopolysaccharide(LPS)-induced intestinal dysfunction in weaned piglets.A total of 168 piglets were randomly allocated into four groups of seven replicates(42 piglets each group,(21±1)d of age,body weight(7.60±0.04)kg,and half males and half females)and were given basal diet(Ctrl)or basal diet supplemented with 0.01%(mass fraction)RBO(RBO1),0.02%RBO(RBO2),or 0.03%RBO(RBO3)for 21 ***,seven piglets from the Ctrl and the RBO were treated with LPS(100μg/kg body weight(BW))as LPS group and RBO+LPS group,***,seven piglets from the Ctrl were treated with the saline vehicle(Ctrl group).Four hours later,all treated piglets were sacrificed for taking samples of plasma,jejunum tissues,and *** results showed that 0.02%was the optimal dose of dietary RBO supplementation based on diarrhea,average daily gain,and average daily feed intake indices in early weaning ***,RBO protected piglets against LPS-induced jejunal epithelium damage,which was indicated by the increases in villus height,villus height/crypt depth ratio,and Claudin-1 levels,as well as a decreased level of jejunal epithelium *** also improved the antioxidant ability of LPS-challenged piglets,which was indicated by the elevated concentrations of catalase and superoxide dismutase,and increased total antioxidant capacity,as well as the decreased concentrations of diamine oxidase and malondialdehyde in ***,RBO improved the immune function of LPS-challenged weaned piglets,which was indicated by elevated immunoglobulin A(IgA),IgM,β-defensin-1,and ly

关键词： Rice bran oil Gut microbiota Weaned piglets Oxidative stress Lipopolysaccharide