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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu jia-bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Improving inherent soil productivity underpins agricultural sustainability

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Pedosphere 2023年第1期33卷 3-5页

作者： jia bao ZHANG State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China)

There is now increasing attention to how to raise global food production and security due to the expanding population *** and high yield of crops depends on soil quality improvement,which relies on inherent soil productivity *** in inherent soil productivity can provide a range of benefits for soil structure,microorganisms,nutrient cycling,and carbon *** underlying mechanisms related to inherent soil productivity improvement under different agricultural management practices on large scales need to be further ***,to achieve agricultural sustainability,efforts need to focus on developing technologies related to straw return,tillage management,and cover cropping and understanding their relationships with inherent soil productivity improvement.

关键词： soil crops return

Interpretation of the Galactic gamma-ray excess with the dark matter indicated by ^(8)Be and ^(4)He anomalous transitions

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Chinese Physics C 2021年第6期45卷 15-22页

作者： Lian-bao jia Tong Li School of Science Southwest University of Science and TechnologyMianyang 621010China School of Physics Nankai UniversityTianjin 300071China

The long-standing Galactic center gamma-ray excess could be explained by GeV dark matter(DM)annihilation,but the DM interpretation seems to conflict with recent joint limits from different astronomical scale observations such as dwarf spheroidal galaxies,the Milky Way halo,and galaxy groups/*** by ^(8)Be and ^(4)He anomalous transitions with possible new interactions mediated by a vector boson X,we consider a small fraction of DM mainly annihilating into a pair of on-shell vector bosons followed by in this *** Galactic center gamma-ray excess is explained by this DM cascade *** gamma rays are mainly from inverse Compton scattering emission,and the DM cascade annihilation could be compatible with joint astrophysical limits and meanwhile be allowed by AMS-02 positron *** direct detection of this model is also discussed.

关键词： Galactic center gamma-ray excess Atomki anomalies dark matter

Interpretation of XENON1T excess with MeV boosted dark matter

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Chinese Physics C 2022年第8期46卷 149-154页

作者： Lian-bao jia Tong Li School of Science Southwest University of Science and TechnologyMianyang 621010China School of Physics Nankai UniversityTianjin 300071China

The XENON IT excess of keV electron recoil events may be induced by the scattering of electrons and long-lived particles with an MeV mass and high *** consider a tangible model composed of two scalar MeV dark matter(DM) particles,S_(A) and S_(B),to interpret the XENON IT keV excess via boosted S_(B).A small mass splitting m_(S_(A))-m_(S_(B))>0 is introduced,and the boosted S_(B) can be produced using the dark annihilation process of S_(A)S_(A)^(■)→φ→S_(B)S_(B)^(■) via a resonant scalar φ.S_(B)-electron scattering is intermediated by a vector boson *** the constraints from Big Bang nucleosynthesis,cosmic microwave background(CMB),and low-energy experiments set the X-mediated S_(B)-electron scattering cross section to be≤10^(-35)cm^(2),the MeV scale DM with a resonance enhanced dark annihilation today can still provide sufficient boosted S_(B) and induce the XENON1 T keV *** relic density of S_(B) is significantly reduced by the s-wave process S_(B)S_(B)^(■)→XX,which is permitted by the constraints from CMB and 21-cm absorption.A very small relic fraction of S_(B) is compatible with the stringent bounds on un-boosted S_(B)-electron scattering in DM direct detection,and the S_(A)-electron scattering is also allowed.

关键词： boosted dark matter XENON1T excess dark matter direct detection

A novel blind deconvolution algorithm using single frequency bin

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1271-1276页

作者： ZHANG Gui-bao LI jia-wen LI Cong-xin National Die ＆ Mold CAD Engineering Research Center Shanghai Jiao Tong University Shanghai 200030 China

Former frequency-domain blind devolution algorithms need to consider a large number of frequency bins and recover the sources in different orders and with different amplitudes in each frequency bin,so they suffer from permutation and amplitude indeterminacy troubles. Based on sliding discrete Fourier transform,the presented deconvolution algorithm can directly recover time-domain sources from frequency-domain convolutive model using single frequency bin. It only needs to execute blind sepa-ration of instantaneous mixture once there are no permutation and amplitude indeterminacy troubles. Compared with former algorithms,the algorithm greatly reduces the computation cost as only one frequency bin is considered. Its good and robust per-formance is demonstrated by simulations when the signal-to-noise-ratio is high.

关键词： Blind deconvolution Single frequency bin Convolutive mixture

Maneuvering target tracking by adaptive statistics model

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The Journal of China Universities of Posts and Telecommunications 2013年第1期20卷 108-114页

作者： JIN Xue-bo DU Jing-jing bao jia College of Computer and Information Engineering Beijing Technology and Business University College of Informatics Zhejiang Sci-Tech University

A good model can extract useful information about the target＇s state from observations effectively. There are many models used to tracking a, maneuvering target such as constant-velocity （CV） model, Singer acceleration model （zero-mean first-order Markov model） and current model （mean-adaptive acceleration model）, etc. While due to the complexity of maneuvering target, to seek the target model which can get better performance is still a subject worthy of study. Based on statistics relation between the autocormlation function and the covariance of Markov random processing, this paper develops a model which can adaptively adjust system parameters on line. Simulations show the good estimation performance get by the model developed here, and comparing CV, Singer and current models, the model can adaptively get the model parameter while tracking the trajectory and needn＇t doing several tests to obtain a priori parameter.

关键词： maneuvering target target model statistics relation state estimation

Optimization of the processing technology of Fructus Arctii by response surface methodology

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Chinese Journal of Natural Medicines 2015年第3期13卷 222-231页

作者： LIU Qi-Di QIN Kun-Ming SHEN bao-jia CAI Hao CAI bao-Chang Engineering Center of State Ministry of Education for Chinese Medicine Processing Nanjing University of Chinese Medicine Nanjing Haichang Chinese Medicine Group Co Ltd Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing

The present study was designed to optimize the processing of Fructus Arctii by response surface methodology （RSM）. Based on single factor studies, a three-variable, three-level Box-Behnken design （BBD） was used to monitor the effects of independent variables, including processing temperature and time, on the dependent variables. Response surfaces and contour plots of the contents of total lignans, chlorogenic acid, arctiin, and aretigenin were obtained through ultraviolet and visible （UV-Vis） monitoring and high performance liquid chromatography （HPLC）. Fructus Arctii should be processed under heating in a pot at 311℃, medicine at 119℃ for 123s with flipping frequently. The experimental values under the optimized processing technology were consistent with the predicted values. In conclusion, RSM is an effective method to optimize the processing of traditional Chinese medicine （TCM）.

关键词： Fructus Arctii Processing technology Response surface methodology (RSM)

Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage

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Chinese Journal of Integrative Medicine 2022年第3期28卷 272-280页

作者： jiaNG Yu-hang HE jia-kai LI Ran CHEN Ze-hao jia bao-hui Department of Acupuncture Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China

Alzheimer's disease(AD)is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80%of all *** pathogenesis of AD is complicated and enigmatic thus *** mitochondrial cascade hypothesis assumes that mitochondrial damage may mediate,drive,or contribute to a variety of AD pathologies and may be the main factor in late-onset ***,there are no widely recognized drugs able to attenuate mitochondrial damage in ***,increasing evidence supports the efficacy of acupuncture for improving the mitochondrial structure and protecting mitochondrial functions in *** review reports the mechanisms by which acupuncture regulates mitochondrial dynamics,energy metabolism,calcium homeostasis and *** conclusion,these findings suggest that AD mitochondrial dysfunction represents a reasonable therapeutic target and acupuncture could play a significant role in preventing and treating AD.

关键词： acupuncture Alzheimer's disease mitochondrial damage review

Effect of Annealing on the Morphology,Structure and Photoelectric Properties of AZO/Pt/FTO Trilayer Films

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 281-288页

作者： Li-Jing Huang Nai-Fei Ren bao-jia Li Ming Zhou School of Materials Science and Engineering Jiangsu University jiangsu Provincial Key Laboratory of Center for Photon Manufacturing Science and Technology Jiangsu University School of Mechanical Engineering Jiangsu University

Aluminum-doped zinc oxide/platinum/fluorine-doped tin oxide（AZO/Pt/FTO） trilayer films were prepared by sputtering 5-nm-thick Pt layers and 150-nm-thick AZO layers in sequence on commercial FTO *** effects of onestep annealing and layer-by-layer annealing on the morphology,structure and photoelectric properties of the AZO/Pt/FTO trilayer films were comparatively *** is found that the both annealing approaches increased the grain size and improved the crystallinity of the films,leading to enhancement in transmittance and ***,layer-by-layer annealing led to the formation of quasi-continuous or continuous AZO layers,different from the sparsely distributed AZO particles brought about by one-step annealing,resulting in excellent optical and electrical ***,after layer-by-layer annealing at 400 ℃ for both Pt and AZO layers,the AZO/Pt/FTO trilayer film showed an increase in average transmittance from 71.3% to 85.3% and a decrease in sheet resistance from 7.5 to 5.6 Ω/□,leading to the highest figure of merit of 3.64 × 10^（-2） Ω^（-1）.

关键词： Annealing Magnetron sputtering Optical property Electrical property AZO/Pt/FTO trilayer film