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Prevention and treatment of gerbil hepatitis E using the programmable CRISPR-Cas13d system

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Genes & Diseases 2024年第4期11卷 94-97页

作者： Chengcheng Zhao Chong Lia Sa Li hanyu Wu Pengyao Ren Tianlong Liu Xiaoxiang Hu Ran Zhang State Key Laboratory of Animal Biotech Breeding College of Biological SciencesChina Agricultural UniversityBeijing 100193China Laboratory of Veterinary Pathology and Nanopathology College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China

In recent years,the global incidence of hepatitis E virus(HEV)has been rising,leading to increased morbidity and mortality associated with ***13,a CRISPR effector,shows promise as an antiviral agent against singlestranded RNA ***13d,a type VI-D effector,exhibits higher efficiency in suppressing RNA viruses compared to other type VI ***,its in vivo activity against RNA viruses in mammals remains unknown.

关键词： mortality hepatitis treatment

Ionic liquid driven nanostructure self-assembly in organic mixed ionic-electronic conductors

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Green Chemical Engineering 2024年第3期5卷 273-275页

作者： Xingyu Hu Ning Mao Dezhen Zhao Xu Liu Qingqing Sun Huige Yang Xuying Liu hanyu Jia School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China

As a type of three-terminal transistor,organic electrochemical transistors(OECTs)can effectively modulate their channel conductivity through ionic electrochemical doping across gate-electrolyte-channel routes,endowing their versatile applications in bioelectronics,low power logic circuit,and neuromorphic computing[1].In the concrete,free cations/anions in aqueous electrolytes driven by gate voltage can effectively penetrate into the bulk channel,then resulting in the volumetric n/p-doping of channel ***,the film thickness of the channel also involves the modulation of OECT performance owing to the polymer swelling and ion penetration,which is hardly occurred in other transistors working in field-effect mode.

关键词： doping ionic swelling

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Clathrate metal superhydrides under high-pressure conditions: enroute to room-temperature superconductivity

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National Science Review 2024年第07期 33-46页

作者： Ying Sun Xin Zhong hanyu Liu Yanming Ma Key Laboratory of Material Simulation Methods&Software of Ministry of Education College of Physics Jilin University State Key Laboratory of Superhard Materials College of PhysicsJilin University International Center of Future Science Jilin University

Room-temperature superconductivity has been a long-held dream of mankind and a focus of considerable interest in the research field of superconductivity. Significant progress has recently been achieved in hydrogen-based superconductors found in superhydrides（hydrides with unexpectedly high hydrogen contents） that are stabilized under high-pressure conditions and are not capturable at ambient *** particular interest is the discovery of a class of best-ever-known superconductors in clathrate metal superhydrides that hold the record for high superconductivity(e.g. Tc= 250–260 K for LaH10) among known superconductors and have great promise to be those that realize the long-sought room-temperature superconductivity. In these peculiar clathrate superhydrides, hydrogen forms unusual ‘clathrate’ cages containing encaged metal atoms, of which such a kind was first reported in a calcium hexa-superhydride（CaH6） showing a measured high Tcof 215 K under a pressure of 170 GPa. In this review, we aim to offer an overview of the current status of research progress on the clathrate metal superhydride superconductors,discuss the superconducting mechanism and highlight the key features（e.g. structure motifs, bonding features, electronic structure, etc.） that govern the high-temperature superconductivity. Future research direction along this line to find room-temperature superconductors will be discussed.

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Upgrading ethylene via renewable energy-driven electrocatalysis

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Science China Chemistry 2024年

作者： hanyu Wang Dunfeng Gao Guoxiong Wang Xinhe Bao State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

Ethylene oxide （EO） and ethylene glycol （EG） are two important commodity chemicals and are industrially produced from petroleum-derived ethylene via thermocatalytic processes. The overoxidation of ethylene and the implementation of high temperature and pressure lead to substantial CO2emission. Renewable energy-driven electrocatalysis provides a low-carbon route for upgrading ethylene under mild conditions, especially when it couples with ethylene electrosynthesis from CO2. In this minireview, we summarize recent achievements in the selective electrocatalytic oxidation of ethylene to EO and EG. Three main reaction routes including direct electrocatalytic oxidation with water, indirect electrocatalytic oxidation with halide mediators,and tandem electrocatalytic and thermocatalytic oxidation with hydrogen peroxide intermediate, are discussed. Some representative catalyst systems and reactor designs are exemplified. We discuss the existing scientific and technical challenges of electrocatalytic ethylene upgrading in terms of reaction rate, selectivity, and long-term stability, and propose future research directions and opportunities for pushing the process towards practical application.

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Analysis of GPS Technology in Surveying and Mapping Engineering Technology

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Journal of World Architecture 2024年第2期8卷 84-89页

作者： hanyu Zhao Institute of Geospatial Information Information Engineering UniversityZhengzhou 450001Henan ProvinceChina

With the rapid advancement of digital and information technology,global positioning system(GPS)technology has seen increasing utilization in surveying and mapping engineering,extending its application across land,ocean,and various other *** analyzing the technical means of GPS in surveying and mapping engineering,understanding the characteristics and key technologies in different application environments,and exploring the application process and key technical means,accurate control can be effectively *** on this,this paper mainly analyzes the specific application of GPS technology in surveying and mapping engineering technology for reference.

关键词： Surveying and mapping engineering technology GPS technology

Non-invasive Healthcare Analytical Platform Based on Organic Electrochemical Transistors

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 824-841页

作者： Hu, Xingyu Mao, Ning Yan, Xinwen Huang, Ling Liu, Xu Yang, Huige Sun, Qingqing Liu, Xuying Jia, hanyu Zhengzhou Univ Sch Mat & Engn Zhengzhou 450001 Peoples R China Longmen Lab Sci & Technol Innovat Ctr Adv Mat Intelligent Equi Luoyang 471000 Peoples R China South Cent Univ Nationalities Hubei R&D Ctr Hyperbranched Polymers Synth & Appli Key Lab Catalysis & Energy Mat Chem Minist Educ Wuhan 430074 Peoples R China South Cent Univ Nationalities Hubei R&D Ctr Hyperbranched Polymers Synth & Appli Hubei Key Lab Catalysis & Mat Sci Wuhan 430074 Peoples R China

Non-invasive bioelectronics, especially organic electrochemical transistors (OECTs), have drawn extensive attentions of academical and medical communities by virtue of their efficient bio-electronic interfacing, water-involved ionic transport, excellent ionic-electronic coupling, ultralow power consumption, wide detectable range, and outstanding detection sensitivity. Designable structure diversity, low-temperature solution processability, facile bio/chemical functionalization, and excellent biocompatibility of organic mixed ionic-electronic conductors (OMIECs) render OECTs particularly suitable for non-invasive or minimally invasive healthcare analytical platform. Here, we comprehensively review recent advances of the non-invasive analytical healthcare applications based on OECTs, especially on the detection of biomarkers or metabolites in the excretory biofluids, as well as the recording of electrophysiological signals. A brief introduction of OECT and its comparison with other organic thin-film transistors upon device configuration and working mechanism are firstly discussed. State-of-the-art non-invasive OECT-based biosensors are summarized on their detection of ionic and molecular biomarkers, following with circuit design strategies of OECTs for real-time and in-situ electrophysiological recording from skin surface. In conclusion, remaining barriers and future challenges of non-invasive OECT-based bioelectronics towards lower detection limit, more accurate quantitative relationship between analyte concentrations and measured parameters, more intimate device-tissue interface, and long-term operation stability are deeply analyzed with a critical outlook.

关键词： Organic electrochemical transistor Non-invasive Bioelectronics Ion-selective Electrophysiological monitoring SENSITIVITY ION DETECTION

Constraints Separation Based Evolutionary Multitasking for Constrained Multi-Objective Optimization Problems

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1819-1835页

作者： Kangjia Qiao Jing Liang Kunjie Yu Xuanxuan ban Caitong Yue Boyang Qu Ponnuthurai Nagaratnam Suganthan School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China School of Electrical Engineering and Automation Henan Institute of TechnologyXinxiang 453003China School of Electronic and Information Zhongyuan University of TechnologyZhengzhou 450007China KINDI Center for Computing Research College of EngineeringQatar UniversityDoha 999043Qatar

Constrained multi-objective optimization problems(CMOPs)generally contain multiple constraints,which not only form multiple discrete feasible regions but also reduce the size of optimal feasible regions,thus they propose serious challenges for *** all constraints,some constraints are highly correlated with optimal feasible regions;thus they can provide effective help to find feasible Pareto ***,most of the existing constrained multi-objective evolutionary algorithms tackle constraints by regarding all constraints as a whole or directly ignoring all constraints,and do not consider judging the relations among constraints and do not utilize the information from promising single ***,this paper attempts to identify promising single constraints and utilize them to help solve *** be specific,a CMOP is transformed into a multitasking optimization problem,where multiple auxiliary tasks are created to search for the Pareto fronts that only consider a single constraint ***,an auxiliary task priority method is designed to identify and retain some high-related auxiliary tasks according to the information of relative positions and dominance ***,an improved tentative method is designed to find and transfer useful knowledge among *** results on three benchmark test suites and 11 realworld problems with different numbers of constraints show better or competitive performance of the proposed method when compared with eight state-of-the-art peer methods.

关键词： Constrained multi-objective optimization(CMOPs) evolutionary multitasking knowledge transfer single constraint.

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Efficiency improvement by using metal–insulator‑semiconductor structure in InGaN/GaN micro‑light‑emitting diodes

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Frontiers of Optoelectronics 2024年第1期17卷 77-84页

作者： Jian Yin David Hwang Hossein Zamani Siboni Ehsanollah Fathi Reza Chaji Dayan ban Department of Electrical and Computer Engineering Waterloo Institute NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada Vuereal InC. 440 Philip StreetUnit 100WaterlooON N2L 5R9Canada

InGaN/GaN micro-light-emitting diodes(micro-LEDs)with a metal–insulator-semiconductor(MIS)structure on the sidewall are proposed to improve *** this MIS structure,a sidewall electrode is deposited on the insulating layer-coated sidewall of the device mesa between a cathode on the bottom and an anode on the ***(EL)measurements of fabricated devices with a mesa diameter of 10μm show that the application of negative biases on the sidewall electrode can increase the device external quantum efficiency(EQE).In contrast,the application of positive biases can decrease the *** band structure analysis reveals that the EQE is impacted because the application of sidewall electric fields manipulates the local surface electron density along the mesa sidewall and thus controls surface Shockley–Read–Hall(SRH)*** suggested strategies,reducing insulator layer thickness and exploring alternative materials,can be implemented to further improve the EQE of MIS micro-LEDs in future fabrication.

关键词： Micro-LED GaN EQE improvement Micro-fabrication

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A novel approach for assessing color harmony of historical buildings via street view image

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Frontiers of Architectural Research 2024年第4期13卷 764-775页

作者： Ruyi Yang Xinyan Deng hanyu Shi Zhuxuanzi Wang Haoyang He Jiaqi Xu Yang Xiao College of Architecture and Urban Planning Tongji UniversityShanghai 200092China

While new buildings continue to emerge in the process of urbanization,historical buildings,as valuable legacies carrying national historical memory,play an important role in the urban *** studies have shown that color harmony is a crucial factor in coordinating urban ***,the evaluation of color harmony in historic areas and buildings lacks effective quantitative standards,often overlooking factors such as complementary color harmony and the compatibility of analogous *** study aims to build a new method to evaluate the color harmony of historical buildings through street view technology,semantic segmentation algorithms,quantification of color harmony methods based on image property detection and classification,questionnaire verification,and takes Shanghai’s historical buildings as an example to *** study categorizes six types of color harmony indexes for Shanghai street-facing historic buildings into three levels,with the top tier serving as a benchmark for excellence and the lowest tier highlighting areas in need of urban environmental *** study uniquely considers color compatibility within hue ranges and expanded relationship types like complementary *** approach,applicable to cities globally,offers practical tools for urban planners and conservators in managing and preserving historic areas and buildings.

关键词： Historic buildings Historic area Color harmony Street view technology Computer vision