检索结果-南通市图书馆

High-temperature oxidation mechanism of ZrCoSb-based half-Heusler thermoelectric compounds

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第17期148卷 242-249页

作者： jinyu Gu Lei Wang Qingfeng Song Chao Wang Xugui Xia Jincheng Liao Yi-Yang Sun Lidong Chen Shengqiang bai State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

ZrCoSb-based half-Heusler(HH)compounds are among the most promising thermoelectric(TE)materials for high-temperature power generation.Oxidation resistance is one of the key issues for realizing the practical application of TE materials for long-term service in the ambient working environment.In this work,the oxidation behavior of Zr_(0.5)Hf_(0.5)CoSb_(0.8)Sn_(0.2)(ZHCSS)half-Heusler is systematically studied in the service temperature range from 873 to 1073 K.It is revealed that three typical layers of oxidation products tend to form on the surface of HH sample,namely,the dense oxide layer(DOL)composed of(Zr,Hf)O_(2) and CoSb,the alternate oxide layer(AOL)composed of repeated(Zr,Hf)O_(2) and CoSb_(2)O_(6)/Co_(3)O_(4),and the CoSb layer between the DOL and AOL.The mass gain during oxidation is mainly caused by the rapid growth of AOL,which is controlled by the outward diffusion of Zr/Hf and the inward diffusion of oxygen.The formation of a continuous CoSb layer and DOL is found beneficial to block the outward diffusion of Zr/Hf.Based on the analysis of the dominant factors on the outward and inward diffusions as well as the reaction activation energy,a simple approach is proposed to improve the oxidation resistance of Zr_(0.5)Hf_(0.5)CoSb_(0.8)Sn_(0.2)by pre-oxidizing the sample in low oxygen pressure to form the dense(Zr,Hf)O_(2) and CoSb layers as oxidation protecting and/or diffusion blocking layers.The oxidation test shows the effectiveness of such pre-oxidation on the formation and growth of the AOL and therefore on improving the service stability of Zr_(0.5)Hf_(0.5)CoSb_(0.8)Sn_(0.2)at high temperatures in the air.

关键词： Thermoelectric Half-Heusler compounds Oxidation mechanism

采用伪3D卷积网络的脑部MRI图像超分辨率重建

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计算机辅助设计与图形学学报 2022年第2期34卷 208-216页

作者：柏正尧陶劲宇云南大学信息学院昆明650500

针对现有深度学习医学图像超分辨率重建算法因网络参数量大导致计算复杂度过高、网络难以训练的问题,提出一种采用伪3D卷积的轻量级密集残差连接3D卷积神经网络(P3DSRNet)模型.首先利用密集残差块拓宽残差块中卷积层的通道,将更多的特... 详细信息

针对现有深度学习医学图像超分辨率重建算法因网络参数量大导致计算复杂度过高、网络难以训练的问题,提出一种采用伪3D卷积的轻量级密集残差连接3D卷积神经网络(P3DSRNet)模型.首先利用密集残差块拓宽残差块中卷积层的通道,将更多的特征信息传送到激活函数,使网络中浅层图像特征更容易地传播到高层,增强医学图像超分辨率的表达能力;然后采用伪3D可分离卷积策略训练网络,将标准3D卷积核分离成多个卷积核,分阶段进行训练,使网络训练收敛速度更快,解决标准3D卷积拓宽维数导致网络训练难度加大时参数急剧增加的问题.实验结果表明,对比传统的插值超分辨率算法和LRTV超分辨率算法,采用P3DSRNet模型重建的医学图像纹理细节更丰富,视觉效果更逼真,与采用卷积神经网络的超分辨率算法SRCNN3D和ReCNN相比, P3DSRNet模型网络参数大大减少,峰值信噪比分别提升了1.88 dB和0.30 dB,结构相似度分别提升了0.009 6和0.001 1, P3DSRNet模型不仅大大降低了参数量和计算复杂度,而且提高了医学图像的超分辨性能.

关键词：超分辨率磁共振成像伪3D卷积残差学习

Degradation-resistant implanted biomaterials establish an immunosuppressive microenvironment that induces T cell exhaustion by recruiting myeloid cells

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2022年第4期2卷 648-658页

作者： Qin Fan Huaxing Dai jinyu bai Jialu Xu Qingle Ma Ziying Fei Xiaozhong Zhou Kam W.Leong Chao Wang Institute of Functional Nano&Soft Materials Jjangsu Key Laboratory for Carbon-based Functional Materials and evices Soochow UniversitySuzhou 215123China Department of Orthopedics The Second Affliated Hospital of Soochow UniversitySuzhou 215004China Department f Biomedical Enginering Columbia UniversityNew YorkNY 10027USA

Implanted biomaterials have transformed healthcare and the treatment of injury and disease,but their infuence on the local immune landscape remains unclear.Here we discovered that degradation-resistant titanium-based implants establish an immunosuppressive microenvironment by recruiting myeloid cells,including monocytes,macrophages,neutrophils,and myeloid-lineage dendritic cells.Unlike normal tissues,the tissues nearby implants exhibit an chronic inflamed and immunosuppressive status characterised by myeloid-rich,T cell-exhaustion gene signature by single-cell RNA sequencing.Vitamin C treatment provides an effective strategy to rescue the immunosuppressive microenvironment,which can be used as a regular supplement to reduce the risk of malignant cell survival around the implants.

关键词： TiO_(2)nanoparicles Immune microenvironment Myeloid cells mplants Immunosuppressive

Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第11期6卷 4014-4026页

作者： Qin Fan jinyu bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma Xiaozhong Zhou Chao Wang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu215123China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu215004China Key Laboratory for Organic Electronics&Information Displays(KLOEID) Institute of Advanced Materials(IAM)and School of Materials Science and EngineeringNanjing University of Posts&TelecommunicationsNanjing210000China

The treatment of large-area bone defects still faces many difficulties and challenges.Here,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone regeneration.Blood clot gel platform as natural biomaterials can be engineered from autologous blood.Once implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different stages.Moreover,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and regeneration.We find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser treatment.We further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease models.Due to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation.

关键词： Blood clot BMP-2 Osteoimmunology Photothermal therapy Bone repair

Handheld Aptasensor for Sandwiched Detection of Chloramphenicol

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2020年第2期36卷 291-295页

作者： YU Mintong XIA Tian bai Wanchen JI jinyu WANG Huan HUANG Yaqi DENG Shengyuan MA Kefeng SU Yan WAN Ying School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094P.R.China Key Laboratory of New Membrane Materials Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and Technology/Nanjing 210094R R.China

Chloramphenicol(CAP)is an antifungal agent approved for use in aquarium.However,CAP residue imparts serious adverse effect on human health as well as the ecology.Thus,keeping track of CAP in aquatic products and its environmental metabolites are of great importance.Herein,we developed a novel and neat electrochemical aptasensor for the detection of simulated CAP residual in a sandwich fashion.The screen-printed carbon electrode was employed as the sensing platform and electrodeposited with peculiar nanogolds to enhance the electrochemical performance.For the specific recognition of such small target,a pair of chloramphenicol-binding aptamers,the primary Aptl and the secondary Apt2,were tailored as an artificial single-chained antibody couple,of which the thi-olated Aptl stood on the coated working substrate to capture the analyte,while the biotinylated Apt2 rallied the signal output.In the presence of CAP,Aptl at the lower place cooperated with the upper Apt2 pinched CAP together.After that,the reporter avidin-conjugated horseradish peroxidase associated atop the mounted biotin labels,resulting in an electrocatalytic amplification.In whole,this modular biosensing construction would set a paradigm not just for practicable checkpoint quarantine or point-of-care testing,but potentially adaptable for technological fusion with“Internet Plus”and“Internet of Things”.

关键词： Chloramphenicol Screen-printed carbon electrode Electrochemical aptasensor Electrochemical deposi tion Ufkimm

基于seer数据库关于甲状腺未分化癌的预后分析及Nomogram预测模型

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

包头医学院学报 2023年第8期39卷 37-43页

作者：白金钰王翠峰内蒙古科技大学包头医学院第一附属医院内蒙古包头014010

目的:基于seer数据库分析甲状腺未分化癌(anaplastic thyroid carcinoma,ATC)的预后,并建立Nomogram预测模型。方法:通过SEER*Stat软件收集数据库中于2004年至2015年间诊断为ATC的715例病例,运用单因素、多因素Cox回归分析、C-index评... 详细信息

目的:基于seer数据库分析甲状腺未分化癌(anaplastic thyroid carcinoma,ATC)的预后,并建立Nomogram预测模型。方法:通过SEER*Stat软件收集数据库中于2004年至2015年间诊断为ATC的715例病例,运用单因素、多因素Cox回归分析、C-index评价模型及Nomogram预测模型,并绘制ROC曲线评价模型,分析关于ATC患者预后的影响因素。结果:715例ATC病例中,女性438例(61.3%)、男性277例(38.7%),单因素分析显示年龄、AJCC分期、手术、放疗、化疗、综合治疗、切除淋巴结个数、阳性淋巴结个数、肿瘤大小是影响ATC患者生存预后的影响因素(P<0.05);多因素分析显示年龄≥45岁、T4b分期、M1分期、肿瘤≥65 mm及不切除淋巴结、肿瘤复发及为多发性恶性肿瘤为ATC患者预后不良的独立危险因素,接受手术、化疗、放疗治疗为独立保护因素(P<0.05);据KM生存分析可知ATC患者预后差,晚期ATC患者生存率极低,1年生存率约2%。结论:对于局限于甲状腺内的ATC患者,建议积极接受治疗,可延长生存期,但对于晚期ATC患者,目前治疗方案并不能有效延长生存期,因此对于此类患者重点考虑将支持性护理或临终关怀作为替代方案。

关键词：甲状腺未分化癌 SEER数据库预后分析 Cox回归分析 Nomogram预测模型

Economic Evaluation of the Comprehensive AIDS Prevention and Control Program—Tianjin Municipality,China,2011-2022

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2023年第48期5卷 1067-1072页

作者： Maohe Yu Jianping Wang Jinhua Zhao Yan Guo Jianyun bai Zhongquan Liu Hui Gong Tielin Ning Minna Zheng jinyu Hou Zhuang Cui STD&AIDS Control and Prevention Section Tianjin Centers for Disease Control and PreventionTianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjinChina

What is already known about this topic?Acquired immunodeficiency syndrome(AIDS)represents a significant public health challenge globally,not only inflicting harm on the health of individuals but also placing a considerable economic strain on society.What is added by this report?This study represents the inaugural report on the potential reduction in economic burden attributable to human immunodeficiency virus(HIV)prevention strategies in Tianjin.Between 2011 and 2022,it is estimated that effective measures could prevent 2,965 new HIV infections and avert 658 deaths,resulting in an economic benefit of approximately 14.437 billion Chinese Yuan.What are the implications for public health practice?The findings of this study offer valuable evidence to inform the development of localized HIV prevention and control strategies,as well as to guide public health policymaking.

关键词： prevention globally Tianjin

内部控制缺陷披露会导致企业内部控制执行成本增加吗?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南京审计大学学报 2019年第4期16卷 22-30页

作者：佘晓燕白瑾瑜云南财经大学会计学院

以我国A股上市公司2012—2016年披露的内部控制缺陷及审计费用的数据,深入研究我国强制执行内部控制审计之后内部控制缺陷披露对企业内部控制执行成本的影响。研究发现:首次强制执行内部控制审计以及后续年度里,企业披露内部控制缺陷均... 详细信息

以我国A股上市公司2012—2016年披露的内部控制缺陷及审计费用的数据,深入研究我国强制执行内部控制审计之后内部控制缺陷披露对企业内部控制执行成本的影响。研究发现:首次强制执行内部控制审计以及后续年度里,企业披露内部控制缺陷均导致企业内部控制执行成本的增加;同时,前期的内部控制缺陷披露也会增加企业当期内部控制执行成本。进一步的研究发现,内部控制缺陷披露严重程度与企业内部控制执行成本也显著正相关,企业披露的内部控制缺陷越严重,执行成本越高。但是,企业采取内部控制缺陷整改措施有助于降低企业内部控制执行成本。

关键词：内部控制审计内部控制缺陷披露企业内部控制执行成本自愿披露强制披露经营风险审计费用

在线全文

学校读者我要写书评

暂无评论

纤维混凝土及其在防护工程中的应用

空军工程大学学报（自然科学版） 2019年第4期20卷 1-11页

作者：许金余白二雷空军工程大学航空工程学院西安710038 西北工业大学力学与土木建筑学院西安710072

未来战场环境对防护工程的建设提出了更高的要求,建筑材料是影响防护工程综合防护能力的重要因素,作为防护工程建设的主要材料——传统的硅酸盐混凝土材料,存在着脆性大、抗拉强度低、抗冲击能力差、易开裂、功能单一等不足,难以适应实... 详细信息

未来战场环境对防护工程的建设提出了更高的要求,建筑材料是影响防护工程综合防护能力的重要因素,作为防护工程建设的主要材料——传统的硅酸盐混凝土材料,存在着脆性大、抗拉强度低、抗冲击能力差、易开裂、功能单一等不足,难以适应实际战场环境对防护工程的建设要求。纤维混凝土以其良好的性能在民用建筑工程以及防护工程领域得到了广泛的应用。介绍了纤维混凝土的发展历史、分类以及性能,重点以防护工程为应用背景阐述了纤维混凝土的力学性能、耐久性能、吸波性能以及耐高温性能等研究现状,分析了其发展动态,旨在为防护工程新材料的研究及应用提供参考。

关键词：纤维混凝土防护工程力学性能耐久性能吸波性能耐高温性能