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Bibliometric and visualized analysis of research hotpots and future prospects in lacrimal duct obstruction disease(1900 to 2024)

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 526-540页

作者： Ming-Hai Chen fang bai Hai Tao Ophthalmology the Clinical College of General Hospital of Armed Police Forcesthe Fifth School of Clinical MedicineAnhui Medical UniversityHefei 230032Anhui ProvinceChina The Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100039China

AIM:To reveal the research hotspots,trends,and future prospects of lacrimal duct obstruction disease(LDOD)from 1900 to 2024 through the bibliometric and visualized analysis,providing a directional guidance for research in this ***:The Web of Science Core Collection database was used to retrieve relevant *** analysis and visualization were conducted using VOSviewer 1.6.20 and CiteSpace 6.3.1,including annual publication volume,trends,research areas,country/region and institution distribution,journal and co-cited journal analysis,author and co-cited author analysis,keyword and burst keyword analysis,***:The study included a total of 1481 articles,revealing an overall upward trend in research on LDOD,with ophthalmology being the predominant *** the United States previously led research efforts,India and China have emerged as key contributors since *** Javed Ali stands out as the most influential author in this research *** Plastic and Reconstructive Surgery has published the highest number of related articles,whereas Ophthalmology has the highest *** current focal points of research include minimally invasive and precise modifications to dacryocystorhinostomy,along with intubation,new materials for stents,and disease ***:LDOD research has garnered widely attention and exhibits a steady upward *** 1900,the United States,China,and India have been the leading contributors to this *** continue to be the primary driving force behind LDOD *** findings of this study suggest that at the forefront of LDOD research,our focus has long been on refining and innovating surgical *** minimally invasive and precise modification of lacrimal surgery,represented by dacryocystorhinostomy,is the ongoing developmental direction of this *** interdisciplinary integration and in-depth exploration of pathogenesis and allergic inflammation will lead to

关键词： lacrimal duct obstruction disease dacryocystorhinostomy lacrimal drainage system tear drainage system bibliometric analysis

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Stir-Fried Semen Armeniacae Amarum Suppresses Aristolochic AcidⅠ-Induced Nephrotoxicity and DNA Adducts

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Chinese Journal of Integrative Medicine 2025年第2期31卷 142-152页

作者： LI Cheng-xian XIAO Xiao-he LI Xin-yu XIAO Da-ke WANG Yin-kang WANG Xian-ling ZHANG Ping LI Yu-rong NIU Ming bai Zhao-fang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing(100102)China Department of Hepatology Military Institute of Chinese Materiathe Fifth Medical CentreGeneral Hospital of PLABeijing(100039)China National Key Laboratory of Kidney Beijing(100039)China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu(610075)China School of Traditional Chinese Medicine Capital Medical UniversityBeijing(100069)China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing(100039)China Department of Military Patient Management the Fifth Medical Center of PLA General HospitalBeijing(100039)China Department of Hematology the Fifth Medical Center of Chinese PLA General HospitalBeijing(100071)China

Objective:To investigate the protective effects of stir-fried Semen Armeniacae Amarum(SAA)against aristolochic acidⅠ(AAⅠ)-induced nephrotoxicity and DNA adducts and elucidate the underlying mechanism involved for ensuring the safe use of Asari Radix et ***:In vitro,HEK293T cells overexpressing Flag-tagged multidrug resistance-associated protein 3(MRP3)were constructed by Lentiviral transduction,and inhibitory effect of top 10 common pairs of medicinal herbs with Asari Radix et Rhizoma in clinic on MRP3 activity was verified using a self-constructed fluorescence screening *** m RNA,protein expressions,and enzyme activity levels of NAD(P)H quinone dehydrogenase 1(NQO1)and cytochrome P4501A2(CYP1A2)were measured in differentiated Hepa RG *** toxicity after inhibition of AAⅠmetabolite transport was detected using cell counting kit-8 *** vivo,C57BL/6 mice were randomly divided into 5 groups according to a random number table,including:control(1%sodium bicarbonate),AAⅠ(10 mg/kg),stir-fried SAA(1.75 g/kg)and AAⅠ+stir-fried SAA(1.75 and 8.75 g/kg)groups,6 mice in each *** 7 days of continuous gavage administration,liver and kidney damages were assessed,and the protein expressions and enzyme activity of liver metabolic enzymes NQO1 and CYP1A2 were determined ***:In vivo,combination of 1.75 g/kg SAA and 10 mg/kg AAⅠsuppressed AAⅠ-induced nephrotoxicity and reduced d A-ALI formation by 26.7%,and these detoxification effects in a dose-dependent manner(P<0.01).Mechanistically,SAA inhibited MRP3 transport in vitro,downregulated NQO1 expression in vivo,increased CYP1A2 expression and enzymatic activity in vitro and in vivo,respectively(P<0.05 or P<0.01).Notably,SAA also reduced AAⅠ-induced hepatotoxicity throughout the detoxification process,as indicated by a 41.3%reduction in the number of liver adducts(P<0.01).Conclusions:Stirfried SAA is a novel drug candidate for the suppression of AAⅠ-induced liver and kidney dam

关键词： aristolochic acidⅠ stir-fried Semen Armeniacae Amarum detoxification principles of compatibility metabolic enzymes transporters

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Kernel Estimators of the ROC Curve with Censored Data

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Acta Mathematicae Applicatae Sinica 2013年第1期29卷 43-54页

作者： fang-fang bai Yong Zhou Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Statistics and Management Shanghai University of Finance and Economics

Receiver operating characteristic （ROC） curves are often used to study the two sample problem in medical studies. However, most data in medical studies are censored. Usually a natural estimator is based on the Kaplan-Meier estimator. In this paper we propose a smoothed estimator based on kernel techniques for the ROC curve with censored data. The large sample properties of the smoothed estimator are established. Moreover, deficiency is considered in order to compare the proposed smoothed estimator of the ROC curve with the empirical one based on Kaplan-Meier estimator. It is shown that the smoothed estimator outperforms the direct empirical estimator based on the Kaplan-Meier estimator under the criterion of deficiency. A simulation study is also conducted and a real data is analyzed.

关键词： ROC curve smoothed estimator censored data Kaplan-Meier estimator deficiency

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AI enhances drug discovery and development

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National Science Review 2024年第3期11卷 52-54页

作者： fang bai Shiliang Li Honglin Li Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech University Lingang Laboratory Innovation Center for AI and Drug Discovery East China Normal University

The advent of the third wave of artificial intelligence(AI) heralds a new era in drug discovery. AI-powered techniques can be characteristic of identifying features that are difficult for humans to interpret from big ...

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Additive Maps Preserving Nilpotent Operators or Spectral Radius

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Acta Mathematica Sinica,English Series 2005年第5期21卷 1167-1182页

作者： Zhao fang bai Jin Chuan HOU School of Science Xi'an Jiaotong University Xi'an 710049 P. R. China Department of Mathematics Shanxi Teachers University Linfen 041004 P. R. China

Let X be a （real or complex） Banach space with dimension greater than 2 and let B0（X） be the subspace of B（X） spanned by all nilpotent operators on X. We get a complete classification of surjective additive maps Ф on B0（X） which preserve nilpotent operators in both directions. In particular, if X is infinite-dimensional, we prove that Ф has the form either Ф（T） = cATA^-1 or Ф（T） = cAT＇A^-1, where A is an invertible bounded linear or conjugate linear operator, c is a scalar, T＇ denotes the adjoint of T. As an application of these results, we show that every additive surjective map on B（X） preserving spectral radius has a similar form to the above with ｜c｜ = 1.

关键词： Additive preservers Nilpotent operators Spectral radius

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Microstructure and properties of the interlayer heat-affected zone in X80 pipeline girth welds

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Progress in Natural Science:Materials International 2020年第1期30卷 110-117页

作者： fang bai Hongsheng Ding Lige Tong Liqing Pan School of Mathematics and Physics University of Science and Technology Beijing Pipeline Institute China Petroleum Pipeline Engineering Co.Ltd. School of Energy and Environmental Engineering University of Science and Technology Beijing College of Science China Three Gorges University

The heat-affected zone between the layers of a weld metal is a sensitive and important component of girth welds in X80 ***,only a few studies have focused on the interlayer heat-afected zone(IHAZ).In this work,thermal simulation was conducted to investigate the relationship between IHAZ microstructure and *** showed that the toughness of the weld metal improved after a single welding thermal cycle but decreased after double welding thermal cycles,particularly when the weld metal was subjected to unaltered coarse grains of *** relationship between the microstructure and properties of IHAZ was established to present the correlation of toughness with granular bainite content,grain size,and high-angle grain boundary content.

关键词： Girth weld Interlayer heat-affected zone Thermal simulation Granular bainite Toughness

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Removal of chromium (Ⅵ) from aqueous solutions using quaternized chitosan microspheres

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Chinese Journal of Chemical Engineering 2017年第2期25卷 153-158页

作者： Chao Hua Runhu Zhang fang bai Ping Lu Xiangfeng Liang Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijng 100190China Hebei Collaborative Innovation Center of Modern Marine Chemical Technology Tianjin 300130China Department of Chemical Engineering Kunming Metallurgy CollegeKunming 650033China

In this study, quaternized chitosan microspheres （QCMS） were prepared and its Cr （VI） removal potential was investigated. Batch experiments were conducted to examine kinetics, adsorption isotherm, pH effect, and thermodynamic parameters. Equilibrium was attained within 50 rain and maximum removal of 97.34% was achieved under the optimum conditions at pH 5. Adsorption data for Cr （VI） uptake by the QCMS were analyzed according to Langmuir, Freundlich, and Temkin adsorption models. The maximum uptake of Cr （VI） was 39.1 mg.g-a. Thermodynamic parameters for the adsorption system were determinated at 293 K, 303 K, 313 K and 323 K. （AH° = 16.08 ***- 1;AG° = -5.84 to -8.08 ***1-1 and AS° = 74.81 J.K-1 .tool-l）. So the positive values of both A/-F and AS° suggest an endothermic reaction and increase in randomness at the solid-liquid interface during the adsorption. AG° values obtained were negative indicating a spontaneous adsorp- tion process. The kinetic process was described by a pseudo-second-order rate equation very well. The results of the present study indicated that the QCMS could he considered as a potential adsorbent for Cr （V1） in aqueous solutions.

关键词： Chromium (V1)AdsorptionQ uatemized chitosan microspheresIsothermsThermodynamics

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Structural insight into substrate specificity of human intestinal maltase-glucoamylase

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Protein & Cell 2011年第10期2卷 827-836页

作者： Limei Ren Xiaohong Qin Xiaofang Cao LeleWang fang bai Gang bai Yuequan Shen State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China College of Pharmacy Nankai UniversityTianjin 300071China College of Life Sciences Nankai UniversityTianjin 300071China

Human maltase-glucoamylase(MGAM)hydrolyzes linear alpha-1,4-linked oligosaccharide substrates,playing a crucial role in the production of glucose in the human lumen and acting as an efficient drug target for type 2 diabetes and *** amino-and carboxyl-terminal portions of MGAM(MGAM-N and MGAM-C)carry out the same catalytic reaction but have different substrate *** this study,we report crystal structures of MGAM-C alone at a resolution of 3.1Å,and in complex with its inhibitor acarbose at a resolution of 2.9Å.Structural studies,combined with biochemical analysis,revealed that a segment of 21 amino acids in the active site of MGAM-C forms additional sugar subsites(+2 and+3 subsites),accounting for the preference for longer substrates of MAGM-C compared with that of ***,we discovered that a single mutation of Trp1251 to tyrosine in MGAM-C imparts a novel catalytic ability to digest branched alpha-1,6-linked *** results provide important information for understanding the substrate specificity of alphaglucosidases during the process of terminal starch digestion,and for designing more efficient drugs to control type 2 diabetes or obesity.

关键词： MGAM C-terminal domain inhibitor crystal structure acarbose type 2 diabetes

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Preliminary study on the efficacy of lacrimal duct reconstruction with pedicled conjunctival flap in the treatment of severe lacrimal canalicular obstruction with conjunctivochalasis

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 539-546页

作者： Gao-Xiang Ouyang fang bai Hai Tao Department of Ophthalmology the Third People’s Hospital of DalianDalian 116033Liaoning ProvinceChina Lacrimal Center Senior Department of Ophthalmologythe Third Medical Center of Chinese PLA General HospitalBeijing 100039China

AIM:To determine the efficacy and safety of pedicled conjunctival lacrimal duct reconstruction in the treatment of severe obstruction of superior and inferior lacrimal canaliculi with ***:This study was per formed as a retrospective analysis of patients who received conjunctival dacryocystorhinostomy with pedicled conjunctival flap reconstruction combined with tube intubation due to severe superior and inferior lacrimal canalicular obstruction with conjunctivochalasis from January 2019 to October *** clinical data included the degree of preoperative epiphora and postoperative relief,preoperative examination of lacrimal duct computed tomography and ultrasound biomicroscopy,postoperative evaluation of lacrimal duct function by chloramphenicol taste and fluorescein dye disappearance test,*** was carried out to determine the reconstruction and patency of the lacrimal ***:All 9 patients(9 eyes)had severe canalicular obstruction with *** patients included 4 males and 5 females aged between 47–65y with an average age of 52.2±*** 3mo follow-up,the tube was removed and the patients were followed for a further *** tube removal,6 patients showed no *** patients also had positive chloramphenicol tastes and normal fluorescein dye disappearance test *** patientshad ***,syringing showed partial patency of the reconstructed lacrimal *** patient had no improvement in epiphora with negative chloramphenicol taste and fluorescein dye disappearance test results and obstruction of the reconstructed lacrimal *** total effective rate of the operation was 8/9,with no serious ***:Pedicled conjunctival lacrimal duct reconstruction conjunctival dacryocystorhinostomy is safe and effective for superior and inferior canalicular obstruction with conjunctivochalasis.

关键词： epiphora severe lacrimal canalicular obstruction conjunctival dacryocystorhinostomy pedicled conjunctival flap reconstruction conjunctivochalasis

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A Mn-Series of Oil-Quenched Super-Strength bainitic Steel With High Hardenability

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Journal of Iron and Steel Research International 2010年第5期17卷 38-43页

作者： ZHANG Han bai Bing-zhe fang Hong-sheng Laboratory of Advanced Materials Department of Materials Science and EngineeringTsinghua University Beijing 100084 China

A new Mn-series of oil-quenched super-strength bainitic steel was developed on the basis of the alloy system of the original Mn-series air cooled bainitic steel. The mechanical properties of the new steel are well combined while precious alloy elements and complicated technologies are not needed for its production. Experimental results show that bainite/martensite （B/M） dual phase microstructure can be obtained within a very wide cooling rate range and bainite microstructure exists even when the cooling rate reaches as fast as 60 ℃/s; the hardenability of the steel is better than that of 40CrNiMo and 42CrMo; the diameter of the round bar made of the steel is 250 mm, and the round bar tempered at 350 ℃ after oil quenching exhihits its central mechanical properties as follows： Rm = 1 550 MPa, Rp0.2 = 1 270 MPa, A=15%, aku=95 J/cm^2 （at room temperature）.

关键词： bainite oil quenching hardenahility mechanical property martensite

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