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Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： Seon Yeong ji Eunjin Bang hyun Hwangbo Min Yeong Kim Da Hye Kim Su hyun Hong Shin-hyung Park Chang-Young Kwon Gi-Young Kim You-jin Jeon Suengmok Cho Yung hyun Choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

Enhanced third-harmonic generation by manipulating the twist angle of bilayer graphene

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Light(Science & Applications) 2021年第2期10卷 176-185页

作者： Seongju Ha Nam Hun Park Hyeonkyeong Kim jiseon Shin Jungseok Choi Sungmin Park ji-Yun Moon Kwanbyung Chae Jeil Jung Jae-hyun Lee Youngdong Yoo ji-Yong Park Kwang Jun Ahn Dong-Il Yeom Department of Energy Systems Research Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Korea Research Institute of Standards and Science Daejeon 34113Republic of Korea Department of Physics University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Smart Cities University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Materials Science and Engineering Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Chemistry Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Physics Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea

Twisted bilayer graphene(tBLG)has received substantial attention in various research fields due to its unconventional physical properties originating from Moire *** electronic band structure in tBLG modified by interlayer interactions enables the emergence of low-energy van Hove singularities in the density of states,allowing the observation of intriguing features such as increased optical conductivity and photocurrent at visible or near-infrared ***,we show that the third-order optical nonlinearity can be considerably modified depending on the stacking angle in *** third-harmonic generation(THG)efficiency is found to significantly increase when the energy gap at the van Hove singularity matches the three-photon resonance of incident *** study on electrically tuneable optical nonlinearity reveals that the gate-controlled THG enhancement varies with the twist angle in tBLG,resulting in a THG enhanced up to 60 times compared to neutral monolayer *** results prove that the twist angle opens up a new way to control and increase the optical *** tBLG,,suggesting rotation-induced tuneable nonlinear optics in stacked two-dimensional material systems.

关键词： twist angle harmonic

Retreatment with peginterferon and ribavirin in chronic hepatitis C

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World Journal of Gastroenterology 2015年第6期21卷 1994-1999页

作者： Yong Min Jo Sung Wook Lee Sang Young Han Yang hyun baek Soo Young Kim Woo Jae Kim ji Hye Ahn ji Young Lee Department of Internal Medicine Dong-A University School of Medicine

The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis *** addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and ***,there are several challenges associated with the application of noveldrugs,such as new and more frequent adverse events,new drug interactions,and excessively high treatment *** additional concern is viral *** considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patients who are in need of *** retrospective study revealed that the sustained virologic response was not significantly reduced following peginterferon and ribavirin retreatment compared with the new *** suggest that patients who experience relapse shortly after completing treatment with peginterferon and ribavirin have a reasonable chance of achieving a sustained virologic response when retreated with these drugs alone.

关键词： Chronic hepatitis C Direct-acting antiviral agents

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

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Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim hyun-Ju Park Hyo Won Chang ji hyun Back Su jin Lee Yae Eun Park Eun Hye Kim Yeonsun Hong Gijung Kwak Ick Chan Kwon ji Eun Lee Yoon Se Lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

Microbiology and risk factors for gram-positive Cocci bacteremia in biliary infections

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 461-466页

作者： Ik hyun Jo Yeon-ji Kim Woo Chul Chung Jaeyoung Kim Seonhoo Kim Eun Sun Lim Honggeun Ahn Seong Yul Ryu Division of Gastroenterology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247Korea

Background:The rapid antibiotics treatment targeted to a specific pathogen can improve clinical outcomes of *** aimed to evaluate the clinical characteristics and outcomes of biliary septicemia caused by cholangitis or cholecystitis according to causative ***:We performed a retrospective cohort study in 151 patients diagnosed with cholangitis or cholecystitis with bacterial septicemia from January 2013 to December *** patients showed clinical evidence of biliary tract infection and had blood isolates that demonstrated ***:Gram-negative,gram-positive,and both types of bacteria caused 84.1%(127/151),13.2%(20/151),and 2.6%(4/151)episodes of septicemia,*** most common infecting organisms were Escherichia coli among gram-negative bacteria and Enterococcus species(Enterococcus casseliflavus and Enterococcus faecalis)among gram-positive *** were no differences in mortality,re-admission rate,and need for emergency decompression procedures between the gram-positive and gram-negative septicemia *** univariate analysis,previous gastrectomy history was associated with gram-positive *** analysis also showed that previous gastrectomy history was strongly associated with gram-positive septicemia(Odds ratio=5.47,95%CI:1.19–25.23;P=0.029).Conclusions:Previous gastrectomy history was related to biliary septicemia induced by gram-positive *** information would aid the choice of empirical antibiotics.

关键词： Cholangitis Cholecystitis Septicemia Gram-positive bacterial infections

Structural and Dielectric Properties of Dy-doped(Ba,Sr,Ca) TiO_3 Thick Films

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材料科学与工程学报 2007年第6期25卷 928-931页

作者： hyun-ji Noh Sung-Gap Lee Sang-Man Park Sang-Eun Yun Dept.of ceramic Engineering Eng.Res.Insti.Gyeongsang National University 900 GajwaJinju-siGyeongnam 660-701Korea

Preparation and electrocatalytic activities of Pt-TiO_2 nanotubes(Ba_ 0.57Sr_ 0.33Ca_ 0.10)TiO_3 powders,prepared by the sol-gel method,were doped MnCO_3 as acceptor and Dy_2O_3 as *** powder was mixed with an organic vehicle and BSCT thick films were fabricated by the screen-printing techniques on alumina *** structural and dielectric properties of BSCT thick films were investigated with variation of Dy_2O_3 *** a result of the differential thermal analysis(DTA),exothermic peak was observed at around 670℃ due to the formation of the polycrystalline perovskite *** the BSCT thick films showed the XRD patterns of a typical polycrystalline perovskite *** average grain size of BSCT thick films decreased with increasing amount of Dy_2O_*** relative dielectric constant and dielectric loss of the BSCT thick film doped Dy_2O_3 0.1mol% were 4637.4 and 1.6% at 1kHz,respectively.

关键词：介电性能结构性能镝厚膜丝网印刷术

A computational study of the chemokine receptor CXCR1 bound with interleukin-8

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Chinese Physics B 2018年第3期27卷 534-543页

作者： Yang Wang Cecylia Severin Lupala Ting Wang Xuanxuan Li ji-Hye Yun Jae-hyun Park Zeyu jin Weontae Lee Leihan Tan Haiguang Liu Complex Systems Division Beijing Computational Science Research Center Beijing 100193 China Genome Center University of California Davis 451 East Health Science Drive Davis CA 95616 USA Department of Engineering physics Tsinghua University Beijing 100086 China Department of Biochemistry College of Life Science ＆ Biotechnology Yonsei University Seou103722 South Korea Department of Physics and Institute of Computational and Theoretical Studies Hong Kong Baptist University Hong Kong China

CXCR1 is a G-protein coupled receptor, transducing signals from chemokines, in particular the interleukin-8 （1L8） molecules. This study combines homology modeling and molecular dynamics simulation methods to study the structure of CXCRI-IL8 complex. By using CXCR4-vMIP-II crystallography structure as the homologous template, CXCRI-IL8 complex structure was constructed, and then refined using all-atom molecular dynamics simulations. Through extensive simulations, CXCRI-IL8 binding poses were investigated in detail. Furthermore, the role of the N-terminal of CXCR1 receptor was studied by comparing four complex models differing in the N-terminal sequences. The results indicate that the receptor N-terminal affects the binding of IL8 significantly. With a shorter N-terminal domain, the binding of IL8 to CXCR1 becomes unstable. The homology modeling and simulations also reveal the key receptor-ligand residues involved in the electrostatic interactions known to be vital for complex formation.

关键词： CXCRI-IL8 complex homology modeling ligand binding molecular dynamics

Two-Terminal Lithium-Mediated Artificial Synapses with Enhanced Weight Modulation for Feasible Hardware Neural Networks

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Nano-Micro Letters 2023年第5期15卷 236-253页

作者： ji hyun baek Kyung Ju Kwak Seung Ju Kim Jaehyun Kim Jae Young Kim In Hyuk Im Sunyoung Lee Kisuk Kang Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Recently,artificial synapses involving an electrochemical reaction of Li-ion have been attributed to have remarkable synaptic ***-terminal synaptic transistors utilizing Li-ion intercalation exhibits reliable synaptic characteristics by exploiting the advantage of nondistributed weight updates owing to stable ion ***,the three-terminal configurations with large and complex structures impede the crossbar array implementation required for hardware neuromorphic ***,achieving adequate synaptic performances through effective Li-ion intercalation in vertical two-terminal synaptic devices for array integration remains ***,two-terminal Au/LixCoO_(2)/Pt artificial synapses are proposed with the potential for practical implementation of hardware neural *** Au/LixCoO_(2)/Pt devices demonstrated extraordinary neuromorphic behaviors based on a progressive dearth of Li in LixCoO_(2)*** intercalation and deintercalation of Li-ion inside the films are precisely controlled over the weight control spike,resulting in improved weight control *** types of synaptic plasticity were imitated and assessed in terms of key factors such as nonlinearity,symmetricity,and dynamic ***,the LixCoO_(2)-based neuromorphic system outperformed three-terminal synaptic transistors in simulations of convolutional neural networks and multilayer perceptrons due to the high linearity and low programming *** impressive performances suggest the vertical two-terminal Au/LixCoO_(2)/Pt artificial synapses as promising candidates for hardware neural networks.

关键词： Artificial synapse Neuromorphic Li-based Two-terminal Synaptic plasticity

How to improve patient satisfaction during midazolam sedation for gastrointestinal endoscopy?

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World Journal of Gastroenterology 2017年第6期23卷 1098-1105页

作者： Eun Hyo jin Kyoung Sup Hong Young Lee ji Yeon Seo ji Min Choi Jaeyoung Chun Sang Gyun Kim Joo Sung Kim hyun Chae Jung Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam Center Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Department of Biostatistics and Bioinformatics Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam Center

To determine the procedure-related factors that affect sedation satisfaction and to make a suggestion to improve *** prospectively enrolled a total of 456 patients who underwent outpatient endoscopy procedures with midazolam sedation between March 2014 and August 2014. All patients completed both pre- and post-endoscopy questionnaires about sedation expectations and *** study cohort included 167 (36.6%) patients who underwent esophagogastroduodenoscopy (EGD), 167 (36.6%) who underwent colonoscopy, and 122 (26.8%) who underwent a combined procedure (EGD and colonoscopy). Over 80% of all patients were satisfied with sedation using midazolam. In univariate and multivariate analyses, total procedure time in the EGD group, younger age (≤ 50 years), and longer colonoscopy withdrawal time in the colonoscopy group were related to decreased satisfaction with sedation. However, in active monitoring and intervention group, there was no decrease in grade of satisfaction despite longer procedure time due to more procedures during colonoscopy. Younger age (≤ 50 years), longer inter-procedure time gap, and colonoscopy withdrawal time were related to decreased satisfaction in the combined EGD and colonoscopy *** is still a safe and effective sedative for gastrointestinal endoscopy. Satisfaction with sedation depends on several factors including age (≤ 50 years) and procedure time duration. To improve patient satisfaction with sedation, active monitoring of sedation status by the endoscopist should be considered for patients who require long procedure time.

关键词： Conscious sedation Patient satisfaction Endoscopy Midazolam Surveys and questionnaires