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Helmholtz decomposition with a scalar Poisson equation in elastic anisotropic media

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Petroleum Science 2024年第3期21卷 1597-1610页

作者： Xin-Yu Fang Gang yao Qing-Qing Zheng Ping-Min Zhang Di Wu Feng-Lin Niu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Unconventional Petroleum Research Institute China University of Petroleum(Beijing)Beijing102249China Department of Mathematics College of ScienceChina University of Petroleum(Beijing)Beijing102249China College of Geophysics China University of Petroleum(Beijing)Beijing102249China Department of Earth Environmental and Planetary SciencesRice UniversityHoustonTX77005UA

P-and S-wave separation plays an important role in elastic reverse-time *** can reduce the artifacts caused by crosstalk between different modes and improve image *** addition,P-and Swave separation can also be used to better understand and distinguish wave types in complex *** present,the methods for separating wave modes in anisotropic media mainly include spatial nonstationary filtering,low-rank approximation,and vector Poisson *** of these methods require multiple Fourier transforms or the calculation of large matrices,which require high computational costs for problems with large *** this paper,an efficient method is proposed to separate the wave mode for anisotropic media by using a scalar anisotropic Poisson operator in the spatial *** 2D problems,the computational complexity required by this method is 1/2 of the methods based on solving a vector Poisson ***,compared with existing methods based on pseudoHelmholtz decomposition operators,this method can significantly reduce the computational *** examples also show that the P and S waves decomposed by this method not only have the correct amplitude and phase relative to the input wavefield but also can reduce the computational complexity significantly.

关键词： Anisotropic media Scalar anisotropic Poisson equation Improved elastic wavefield decomposition

Fangchinoline induces antiviral response by suppressing STING degradation

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Journal of Pharmaceutical Analysis 2024年第6期14卷 902-913页

作者： Jinyong Wang Fang Xie Xin Jia Xuejiao Wang Lingdong Kong Yiying Li b Xue Liang Meiqi Zhang Yuting He Wandi Feng Tong Luo yao Wang Anlong Xu School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing100029China School of Life Science Beijing University of Chinese MedicineBeijing100029China beijing Key Laboratory of Drug Target Identification and New Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

The stimulator of interferon genes(STING),an integral adaptor protein in the DNA-sensing pathway,plays a pivotal role in the innate immune response against ***,it presents a valuable therapeutic target for infectious diseases and *** observed that fangchinoline(Fan),a bis-benzylisoquinoline alkaloid(bbA),effectively impedes the replication of vesicular stomatitis virus(VSV),encephalomyocarditis virus(EMCV),influenza A virus(H1N1),and herpes simplex virus-1(HSV-1)in *** treatment significantly reduced the viral load,attenuated tissue inflammation,and improved survival in a viral sepsis mouse ***,Fan activates the antiviral response in a STING-dependent manner,leading to increased expression of interferon(IFN)and interferon-stimulated genes(ISGs)for potent antiviral effects in vivo and in ***,Fan interacts with STING,preventing its degradation and thereby extending the activation of IFN-based antiviral ***,our findings highlight the potential of Fan,which elicits antiviral immunity by suppressing STING degradation,as a promising candidate for antiviral therapy.

关键词： Fangchinoline Virus Type I interferons Stimulator of interferon genes Protein degradation

Targeting the Warburg effect:A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

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Acta Pharmaceutica Sinica b 2024年第3期14卷 953-1008页

作者： Minru Liao Dahong yao Lifeng Wu Chaodan Luo Zhiwen Wang Jin Zhang bo Liu Department of biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China School of Pharmaceutical Sciences Shenzhen Technology UniversityShenzhen 518118China School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China Department of Psychology University of Southern CaliforniaLos AngelesCA 90089USA

Cancer reprogramming is an important facilitator of cancer development and survival,with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation,even under sufficient oxygen supply *** metabolic alteration,known as the Warburg effect,serves as a significant indicator of malignant tumor *** Warburg effect primarily impacts cancer occurrence by influencing the aerobic glycolysis pathway in cancer *** enzymes involved in this process include glucose transporters(GLUTs),HKs,PFKs,LDHs,and ***,the expression of transcriptional regulatory factors and proteins,such as FOXM1,p53,NF-κb,HIF1a,and c-Myc,can also influence cancer ***,lncRNAs,miRNAs,and circular RNAs play a vital role in directly regulating the Warburg ***,gene mutations,tumor microenvironment remodeling,and immune system interactions are closely associated with the Warburg ***,the development of drugs targeting the Warburg effect has exhibited promising potential in tumor *** comprehensive review presents novel directions and approaches for the early diagnosis and treatment of cancer patients by conducting in-depth research and summarizing the bright prospects of targeting the Warburg effect in cancer.

关键词： Warburg effect Cancer Regulatory factor LncRNAs miRNAs Traditional Chinese medicine Small-molecule drug Drug resistance

blast damage zone strength reduction method for deep cavern excavation and its application

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 236-251页

作者： Tianzhi yao Zuguo MO Li QIAN Yunpeng GAO Jianhai ZHANG Xianglin XING Enlong LIU Ru ZHANG State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resources and HydropowerSichuan UniversityChengdu 610065China Power China Chengdu Engineering Corporation Limited Chengdu 610072China

The drill and blast(D&b)method is widely used to excavate underground spaces,but explosions generally cause damage to the ***,no blast simulation method can provide computational accuracy and *** this paper,a blast equivalent simulation method called the blast damage zone strength reduction(bDZSR)method is *** method first calculates the range of the blast-induced damage zone(bDZ)by formulae,then reduces the strength and deformation parameters of the rock within the bDZ ahead of excavation,and finally calculates the excavation damage zone(EDZ)for the D&b method by numerical *** method combines stress wave attenuation,rock damage criteria and stress path variation to derive the bDZ depth calculation *** formulae consider the initial geo-stress,and the reliability is verified by numerical *** calculation of bDZ depth with these formulae allows the corresponding numerical simulation to avoid the time-consuming dynamic calculation process,thus greatly enhancing the calculation *** method was applied to the excavation in Jinping Class II hydropower station to verify its *** results show that the bDZSR method can be applied to blast simulation of underground caverns and provide a new way to study blast-induced damage.

关键词： attenuation of stress wave deep-buried underground building drill and blast in situ stress

Activation of the wnt/β-catenin/CYP1b1 pathway alleviates oxidative stress and protects the blood-brain barrier under cerebral ischemia/reperfusion conditions

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Neural Regeneration Research 2024年第7期19卷 1541-1547页

作者： Xingyong Chen Nannan yao Yanguang Mao Dongyun Xiao Yiyi Huang Xu Zhang Yinzhou Wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Cangzhou Central HospitalCangzhouHebei ProvinceChina Fujian Academy of Medical Science FuzhouFujian ProvinceChina Key Testing Laboratory of Fujian Province FuzhouFujian ProvinceChina

Accumulating evidence suggests that oxidative stress and the Wnt/β-catenin pathway participate in stroke-induced disruption of the blood-brain ***,the potential links between them following ischemic stroke remain largely *** present study found that cerebral ischemia leads to oxidative stress and repression of the Wnt/β-catenin ***,Wnt/β-catenin pathway activation by the pharmacological inhibito r,TWS119,relieved oxidative stress,increased the levels of cytochrome P4501b1(CYP1b1)and tight junction-associated proteins(zonula occludens-1[ZO-1],occludin and claudin-5),as well as brain microvascular density in cerebral ischemia *** r,rat brain microvascular endothelial cells that underwent oxygen glucose deprivation/reoxygenation displayed intense oxidative stress,suppression of the Wnt/β-catenin pathway,aggravated cell apoptosis,downregulated CYP1b1and tight junction protein levels,and inhibited cell prolife ration and *** ofβ-catenin or knockdown ofβ-catenin and CYP1b1 genes in rat brain mic rovascular endothelial cells at least partly ameliorated or exacerbated these effects,*** addition,small interfering RNA-mediatedβ-catenin silencing decreased CYP1b1 expression,whereas CYP1b1 knoc kdown did not change the levels of glycogen synthase kinase 3β,Wnt-3a,andβ-catenin proteins in rat brain microvascular endothelial cells after oxygen glucose deprivatio n/***,the data suggest that CYP1b1 can be regulated by Wnt/β-catenin signaling,and activation of the Wnt/β-catenin/CYP1b1 pathway contributes to alleviation of oxidative stress,increased tight junction levels,and protection of the blood-brain barrier against ischemia/hypoxia-induced injury.

关键词： blood-brain barrier CYP1b1 oxidative stress oxygen glucose deprivation/reoxygenation tight junction vascular endothelial cells Wnt/β-catenin pathway β-catenin

Mitochondrial dysfunction: A promising therapeutic target for liver diseases

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Genes & Diseases 2024年第3期11卷 324-337页

作者： Ping Chen Lichao yao Mengqin Yuan Zheng Wang Qiuling Zhang Yingan Jiang Lanjuan Li Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhanHubei 430060China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China

The liver is an important metabolic and detoxification organ and hence demands a large amount of energy,which is mainly produced by the *** tissues of pa-tients with alcohol-related or non-alcohol-related liver diseases contain ultrastructural mito-chondrial lesions,mitochondrial DNA damage,disturbed mitochondrial dynamics,and compromised ATP *** of mitochondrial reactive oxygen species in-duces oxidative damage to mitochondrial proteins and mitochondrial DNA,decreases mito-chondrial membrane potential,triggers hepatocyte inflammation,and promotes programmed cell death,all of which impair liver *** DNA may be a poten-tial novel non-invasive biomarker of the risk of progression to liver cirrhosis and hepatocellular carcinoma in patients infected with the hepatitis b *** herein present a review of the mechanisms of mitochondrial dysfunction in the development of acute liver injury and chronic liver diseases,such as hepatocellular carcinoma,viral hepatitis,drug-induced liver injury,alcoholic liver disease,and non-alcoholic fatty liver *** review also discusses mito-chondrion-centric therapies for treating liver diseases.

关键词： Chronic diseases Liverdamage Mesenchymalstem cell Mitochondrial dysfunction Oxidativestress

Review on article of preoperative prediction in chronic hepatitis b virus patients using spectral computed tomography and machine learning

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World Journal of Gastroenterology 2024年第38期30卷 4239-4241页

作者： yao-Qian Yuan Qian-Qian Chen Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

This letter comments on the article that developed and tested a machine learning model that predicts lymphovascular invasion/perineural invasion status by combining clinical indications and spectral computed tomography characteristics *** review the research content,methodology,conclusions,strengths and weaknesses of the study,and introduce follow-up research to this work.

关键词： Gastric cancer Spectral computed tomography Perineural invasion Lympho-vascular invasion Machine learning

Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs

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Journal of Animal Science and biotechnology 2024年第5期15卷 1866-1880页

作者： Zhen Wang bangmin Song Jianyu yao Xingzheng Li Yan Zhang Zhonglin Tang Guoqiang Yi Shenzhen branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Livestock and Poultry Multi‑Omics of MARAAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China Kunpeng Institute of Modern Agriculture at Foshan Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesFoshan 528226China School of Life Sciences Henan UniversityKaifeng 475004China Shenzhen Research Institute of Henan University Shenzhen 518000China State Key Laboratory of Pharmaceutical biotechnology The University of Hong KongHong Kong SARChina Key Laboratory of Tropical Animal breeding and Disease Research Institute of Animal Science and Veterinary MedicineHainan Academy of Agricultural SciencesHaikou 571100China bama yao Autonomous County Rural Revitalization Research Institute Bama 547500China

background Long-term natural and artificial selection has resulted in many genetic footprints within the genomes of pig breeds across distinct agroecological ***,the mechanisms by which these signatures contribute to phenotypic diversity and facilitate environmental adaptation remain *** Here,we leveraged whole-genome sequencing data from 82 individuals from 6 domestic pig breeds originating in tropical,high-altitude,and frigid *** genetic analysis suggested that habitat isolation significantly shaped the genetic diversity and contributed to population stratification in local Chinese pig *** of selection signals revealed regions under selection for adaptation in tropical(55.5 Mb),high-altitude(43.6 Mb),and frigid(17.72 Mb)*** potential functions of the selective sweep regions were linked to certain complex traits that might play critical roles in different geographic environments,including fat coverage in frigid environments and blood indicators in tropical and high-altitude *** genes under selection were significantly enriched in biological pathways involved in environmental *** pathways included blood circulation,protein degradation,and inflammation for adaptation to tropical environments;heart and lung development,hypoxia response,and DNA damage repair for high-altitude adaptation;and thermogenesis,cold-induced vasodilation(CIVD),and the cell cycle for adaptation to frigid *** examining the chromatin state of the selection signatures,we identified the lung and ileum as two candidate functional tissues for environmental ***,we identified a mutation(chr1:G246,175,129A)in the cis-regulatory region of AbCA1 as a plausible promising variant for adaptation to tropical *** In this study,we conducted a genome-wide exploration of the genetic mechanisms underlying the adaptability of local Chinese pig breeds to tropical,high-altitude

关键词： Environmental adaptation Local Chinese breeds Pig Population genetics Selection signals Whole-genome resequencing

Anti-OX40 Antibody Combined with Hbc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model

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biomedical and Environmental Sciences 2024年第2期37卷 187-195页

作者： LIU Jia Jia SU Qiu Dong YI yao SHEN Li Ping bI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic *** this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis b core viruslike particles(Hbc VLPs)therapy using a mouse colon cancer *** Humanized b-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with Hbc VLPs+anti-h OX40 *** growth was *** cytometric analysis was performed to evaluate the populations of T cell subsets in the *** The combination of anti-OX40 with Hbc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination *** studies revealed that Hbc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with Hbc *** Combination therapy of anti-h OX40 and Hbc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.

关键词： Anti-OX40 antibody Hepatitis b core virus-like particles Tumor Combination therapy