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国际医学放射学杂志 2022年第3期 353-354页

作者： b.siewert S.Swedeen O.R.brook R.L.Eisenberg L.Sokol-Hessner J.b.Kruskal 马永红

摘要医疗保健中的情绪伤害事件可能导致失去信任和不良后果。然而，针对放射科情绪危害的调查仍然不足。目的更好地了解放射科可能发生情绪伤害的促成因素和临床场

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分次团注射能谱多层CT评价胰腺:评估辐射剂量和肿瘤显示率

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国际医学放射学杂志 2013年第6期 583-584页

作者： O.R.brook S.Gourtsoyianni A.brook b.siewert T.Kent V.Raptopoulos 李亮 Department of Radiology Beth Israel Deaconess Medical Center 330 Brookline AveBoston MA 02215

摘要目的采用分次团注能谱CT研究胰腺癌,探究一种既能减少放射剂量又能提高肿瘤显示率的检查方法。材料与方法本研究经机构审查委员会批准并符合HIPAA。免除

关键词：显示率团注能谱辐射剂量胰腺 CT

CT上偶发性脾肿块是否需要进一步处理:一项观察研究

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国际医学放射学杂志 2018年第3期 354-354页

作者： b.siewert N.Z.Millo K.Sahi R.G.Sheiman O.R.brook M.R.M.Sun 高月 Department of Radiology Beth Israel Deaconess Medical Center

摘要目的评估腹部CT中偶然发现的脾肿块是否需要进一步的影像检查。材料与方法本回顾性研究经机构伦理委员会批准并符合HIPAA,检索2002年—2008年期间CT

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偶然发现胆囊息肉是否需要随访?——346例临床与超声的长期分析

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国际医学放射学杂志 2011年第2期 175-175页

作者： M.T.Corwin b.siewert R.G.Sheiman R.A.Kane 唐光健 Department of Radiology Beth Israel Deaconess Medical Center

目的确定超声(US)偶然发现的胆囊息肉的自然史并根据息肉大小对此类病变提出处理指南。材料与方法学院委员会批准了此项符合HIPAA要求的研究,免除知情

关键词：胆囊息肉胆囊隆起性病变超声恶性病变

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胰腺手术:多学科评价手术中超声的应用价值

国际医学放射学杂志 2013年第3期 271-271页

作者： J.M.Ni Mhuircheartaigh M.R.Sun M.P.Callery b.siewert C.M.Vollmer R.A.Kane 尹学青 Department of Radiology Beth Israel Deaconess Medical Center

目的为了综合评价不同类型胰腺手术中超声应用的价值。材料与方法本研究是经伦理审查委员会批准并符合HIPAA,免签病人知情同意书的回顾性分析。研究对象为单个医疗中心10年内胰腺手术中应用超声或腹腔镜超声者,放射科医生与胰腺外科医... 详细信息

目的为了综合评价不同类型胰腺手术中超声应用的价值。材料与方法本研究是经伦理审查委员会批准并符合HIPAA,免签病人知情同意书的回顾性分析。研究对象为单个医疗中心10年内胰腺手术中应用超声或腹腔镜超声者,放射科医生与胰腺外科医生共同收集每例病人的手术记录、影像学资料及术后临床过程中的病例资料,并记录最初诊断、手术方式及最终的病理结果。将术中超声及腹腔镜超声的应用价值分为0～3分共4个等级,建立一个相对价值评分体系。对比相同得分组内的手术方式和病理结果。分类变量采用χ2检验或Fisher检验。结果 189例手术中进行了193次术中超声或术中腹腔镜超声检查。102例男性,87例女性。平均年龄57.8岁(18～86岁)。所有术中或腹腔镜超声检查价值得分情况如下:0分,3.6%;1分,11.9%;2分,31.1%;3分,53.4%。较高的得分(3分,60次)最常见的作用是能促使手术方案的改变。较高的得分与胰腺炎手术相关性最大(P<0.01)。手术结果表明,术中胰腺肿瘤分期通常导致低价值得分。所有得0分的病例均为胰腺恶性肿瘤腹腔镜手术(分期或胰腺活检)。结论术中超声或腹腔镜超声可作为在多种胰腺相关手术过程中的有效手段,不同的手术类型中可显示各自的价值。

关键词：手术中超声得分应用价值胰腺

Taq1b CETP Polymorphism and Cardiovascular Risk in an Endogamous Pop-ulation of Diabetic Men: A Study in Santa Rosa Del Conlara, San Luis, Argentina

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Journal of Diabetes Mellitus 2015年第2期5卷 123-134页

作者： Susana siewert Irma Gonzalez Sergio Filipuzzi Dario C. Ramirez Marta S. Ojeda Laboratory of Diabetes Department of Biochemistry and Biological Sciences School of Chemistry Biochemistry and Pharmacy National University of San Luis San Luis Argentina Hospital of Santa Rosa Government of the Province of San Luis Santa Rosa del Conlara Argentina Laboratory of Experimental Medicine and Therapeutics IMIBIO-SL-National Bureau of Science and Technology (CONICET) & National University of San Luis San Luis Argentina

Objectives: Type 2 diabetes mellitus (T2DM) patients are at increased risk of cardiovascular diseases (CVDs). Several polymorphisms in the cholesterol ester transfer protein (CETP) gene have been reported. The aim of this study was to determine the distribution and effect of the Taq1b polymorphism in the CETP gene on clinical and biochemical indicators of CVD risk in a population of endogamous-T2DM men. Methods: 102 men (57.5 ± 9.3 years old) inhabitants of Santa Rosa del Conlara, San Luis, Argentina, were recruited and assigned into two groups (22 control and 80 T2DM). Further, these two groups were subdivided according to their Taq1b CETP gene genotypes (i.e., b1b1, b1b2 and b2b2). Clinical and fasting-plasma biochemical indicators of CVD risk were measured and their association with the b1 allele was determined. Results: Compared to control, T2DM men had more central obesity, hypertension, atherogenic index, insulin resistance and poorly controlled diabetes. Compared to T2DM men having the b2 allele, those T2DM men having the b1 allele have increased risk of CVD as assessed by systolic blood pressure (156 ± 16.0 vs 135.8 ± 19.2, p = 0.015), atherogenic index (6.15 ± 1.3 vs 4.4 ± 0.7, p = 0.0008), HDL-c levels (38.9 ± 5.3 vs 64.4 ± 8.2, p ± 3.0 vs 2.4 ± 0.78, p = 0.004). Interestingly, only body mass index (r = ﹣0.559, p = 0.01) and HDL-c concentration (r = ﹣0.492, p = 0.02) negatively correlated with CVD risk in the endogamous population of b1b1 and b1b2 T2DM men. Conclusion: The b1 allele of the CETP gene predicts cardiovascular complications in an endogamous population of T2DM men.

关键词： Cholesteryl Ester Transfer Protein Taq1b Polymorphism Endogamous Type 2 Diabetic Men Cardiovascular Disease Risk Santa Rosa del Conlara-San Luis-Argentina

Hyperglycemia promotes overexpression of SR-bII isoform of the scavenger receptor class b type I in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina

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Journal of Diabetes Mellitus 2013年第4期3卷 172-183页

作者： Gisela V. Mendoza Susana siewert Irma González María C. Della Vedova Gustavo Fernandez Marta S. Ojeda Laboratory of Diabetes Department of Biochemistry and Biological Sciences School of Chemistry Biochemistry and Pharmacy National University of San Luis San Luis Argentina

The scavenger receptor class b type I (SR-bI) is a high-density lipoprotein (HDL) receptor involved in reverse cholesterol transport. Some studies reported the association to be stronger in the presence of diabetes. The full length gene encoding SR-bI is comprised in 13 exons that are alternatively spliced to produce two major transcripts: the full length SR-bI and the splice variant SR-bII, in which exon 12 is skipped. Considering that type 2 diabetes status is characterized by changes in the concentration of plasma lipids, modifications in lipoprotein size and composition, which may be important modulators of the SR-bI expression;the aims of the study were to examine the influence of SR-bI polymorphism (rs838895) on lipid profile and SR-bI mRNA expression in a population of diabetic patients living in Juana Koslay City. blood samples were drawn from controls (n = 40) and Type 2 diabetic patients (n = 66) and DNA and total RNA were obtained. SR-bI mRNA expression was measured by RT-PCR and SR-bI polymorphism was detected by Tetra Primer ARMSPCR. Compared to controls, diabetic patients had higher fasting serum glucose, glycated hemoglobin, triglycerides, total cholesterol, lowdensity lipoprotein cholesterol, and lower highdensity lipoprotein cholesterol. SR-bI mRNA expression was lower in T2DM when compared to controls, suggesting that the hyperglycemia presents in T2DM patients down-regulates SR-bI mRNA expression. Interestingly, we found that decreased SR-bI expression resulted in markedly increased plasma LDL concentrations in T2DM subjects, and the overexpression of SRbII isoform is responsible for the markedly increased plasma LDL-c concentrations. The polymorphism (rs838895) did not modify the mRNA level of SR-bI in leucocytes from control and diabetic patients. This study provides novel evidence suggesting that hyperglycemia may affect reverse cholesterol transport by controlling SRbI expression in diabetic patients. LDL cholesterol levels are associated with

关键词： Type 2 Diabetes Mellitus Hyperglycemia Scavenger Receptor Class b Type I and Polymorphism

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腹腔镜胆囊切除术的失误和危险

德国医学 1994年第3期11卷 170-171页

作者： J.R.siewert H.Feussner M.A.Scherer I.b.brune 张应天 Chirurgisehe Klinik und Poliklinik der TU Klinikum reehts der IsarIsmaninger Str.22D-81675 München 80Germany 武汉市第六医院

腹腔镜胆囊切除术(LC),热潮一度来势迅猛,使人没有时间对其详细评估而列为常规。资料虽多来自积极应用 LC 有经验的医院,然迄今报道中有'报喜不报忧'的情况。资料和方法收集比较国外文献1986～1992年 LC 共25 644例、1988～1992年剖腹... 详细信息

腹腔镜胆囊切除术(LC),热潮一度来势迅猛,使人没有时间对其详细评估而列为常规。资料虽多来自积极应用 LC 有经验的医院,然迄今报道中有'报喜不报忧'的情况。资料和方法收集比较国外文献1986～1992年 LC 共25 644例、1988～1992年剖腹胆囊切除术(OC)18 017例的并发症发生率和死亡率、德国(1990～1992年)

关键词：腹腔镜检胆囊切除失误危险

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