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在早期临床试验阶段利用动态增强磁共振成像评估血管功能

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国际医学放射学杂志 2012年第5期 495-495页

作者： M.O.Leach b.morgan P.S.Tofts D.L.buckley M.A.Horsfield 陈桂玲 Cancer Research UK and EPSRC Cancer Imaging Centre Institute of Cancer Research&Royal Marsden NHS Foundation TrustDowns RoadSuttonSurrey SM25PTUK

摘要很多治疗癌症的方法都直接或间接地影响肿瘤血管。动态对比增强MRI(DCE-MRI)已经成为临床前和临床实验早期阶段研究肿瘤血管的重要方法。对于这些临床实验,需保证测量过程(即图像采集和分析)的有效进行以及在各个研究中心之间的一... 详细信息

摘要很多治疗癌症的方法都直接或间接地影响肿瘤血管。动态对比增强MRI(DCE-MRI)已经成为临床前和临床实验早期阶段研究肿瘤血管的重要方法。对于这些临床实验,需保证测量过程(即图像采集和分析)的有效进行以及在各个研究中心之间的一致性。随着技术进步,不仅能够潜在改善敏感性和生理相关性,而且在改善研究中心之间的技术差异方面也具有很大空间。

关键词：动态对比增强磁共振成像肿瘤血管血管生成癌症早期临床试验

Design concerns of room and pillar retreat panels

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International Journal of Mining Science and Technology 2017年第1期27卷 29-35页

作者： Klemetti Ted M. Sears morgan M. Tulu Ihsan b. Mining Engineer Ground Control branch NIOSH Office of Mine Safety and Health ResearchPittsburghPAUSA

Why do some room and pillar retreat panels encounter abnormal conditions？ What factors deserve the most consideration during the planning and execution phases of mining and what can be done to mitigate those abnormal conditions when they are encountered7 To help answer these questions, and to determine some of the relevant factors influencing the conditions of room and pillar （R ＆ P） retreat min- ing entries, four consecutive R ＆ P retreat panels were evaluated. This evaluation was intended to rein- force the influence of topographic changes, depth of cover, multiple-seam interactions, geological conditions, and mining geometry. This paper details observations were made in four consecutive R ＆ P retreat panels and the data were collected from an instrumentation site during retreat mining. The pri- mary focus was on the differences observed among the four panels and within the panels themselves. The instrumentation study was initially planned to evaluate the interactions between primary and secondary support, but produced rather interesting results relating to the loading encountered under the current mining conditions. In addition to the obse^ation and ｜ll^trumentation, numerical modeling was per- formed to evaluate the stress condi~!ons. both the LaModel 3.0 and Rocscience Phase 2 programs were used to evaluate these four panels, The results of both models indicated a drastic reduction in the vertical stresses experienced in these panels due to the full extraction mining in overlying seams when compared to the full overburden load. both models showed a higher level of stress associated with the outside entries of the panels. These results agree quite well with the observations and instrumentation studies performed at the mine. These efforts provided two overarching conclusions concerning R ＆ P retreat mine planning and execution. The first was that there are four areas that should not be overlooked during R ＆ P retreat mining： topographic relief, multiple^seaPa str

关键词： Room and pillar Retreat mining Deep coverSafety Multiple seam

Skeletal muscle-directed gene therapy: hijacking the fusogenic properties of muscle cells

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4428-4430页

作者： Hildegard buning Michael morgan Axel Schambach Institute of Experimental Hematology Hannover Medical SchoolHannover30625Germany REbIRTH Research Center for Translational Regenerative Medicine Hannover Medical SchoolHannover30625Germany Division of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolBostonMA02115USA

A recent study published in Cell by the Millay lab reports on an elegant strategy to expand the repertoire of lentiviral(LV)vectors from being the main delivery tool for ex vivo gene therapy to an in vivo applicable viral vector that specifically transduces skeletal muscle.1 This very significant advance may result in novel therapeutics for patients suffering from various skeletal muscle diseases.

关键词： skeletal directed muscle

OPTICAL IMAGING AND SPECTROSCOPY OF SUPERFICIAL TISSUE

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 85-93页

作者： S.P.morgan I.M.STOCKFORD J.A.CROWE b.R.HAYES-GILL School of Electrical and Electronic Engineering University of Nottingham University Park Nottingham NG72RDUK

An overview of three techniques developed by our group for imaging superficial tissue is ***,a novel polarized light capillaroscope has been developed for imaging the *** capillaroscope has been used to make in vivo measurements of sickle cell disorder sufferers with aim of monitoring the polymerization of sickled red blood ***,hyperspectral imaging for measuring oxygen saturation is *** accuracy of such measurements is affected by the non-linear relationship between scattering and absorption and it is demonstrated that polarization techniques can be used to make the relationship more linear,thus improving ***,the use of smart CMOS optical sensors for laser Doppler blood flowmetry is described.A 32×32 pixel imaging array with on-chip processing is described and the potential for full field laser Doppler blood flow imaging is demonstrated through measurement on blood flow of tissue before and after occlusion.

关键词： capillaroscopy laser Doppler hyperspectral

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未来阻燃剂的设计(英文)

中国材料进展 2013年第3期32卷 129-136,171页

作者： Alexander b.morgan 代顿大学研究所俄亥俄州代顿45460

阻燃剂已经存在数千年了,但最近200年才发展出一些新化学结构的阻燃剂。目前使用的阻燃剂主要包括7种类型,它们是卤素基、磷基、膨胀体系、矿物填料、氮基、无机物基、高分子纳米复合体系等。现在,阻燃剂的使用仅仅专注于提供消防,也没... 详细信息

阻燃剂已经存在数千年了,但最近200年才发展出一些新化学结构的阻燃剂。目前使用的阻燃剂主要包括7种类型,它们是卤素基、磷基、膨胀体系、矿物填料、氮基、无机物基、高分子纳米复合体系等。现在,阻燃剂的使用仅仅专注于提供消防,也没有考虑如何延长它们的使用寿命,没有考虑如何处理阻燃剂使用结束后的后处理问题。随着将来对环境保护新要求的提升,以及新型起火原因的出现,现有的几类阻燃剂显然是不够的,必须努力开发新型阻燃剂,例如硅基阻燃剂、过度金属催化作用阻燃剂等。讨论了未来阻燃剂的设计必须考虑的环境保护和新的起火原因等问题,以及与未来新型阻燃剂有关的潜在化学问题。最后提出了在新型阻燃剂研究过程中,减少环境污染、保持防火安全的原则。

关键词：阻燃剂阻燃设计汽车塑料复合材料环境保护

Process development for green part printing using binder jetting additive manufacturing

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Frontiers of Mechanical Engineering 2018年第4期13卷 504-512页

作者： Hadi MIYANAJI morgan ORTH Junaid Muhammad AKbAR Li YANG Department of Industrial Engineering University of Louisville Louisville KY 40292 USA Department of Mechanical Engineering University of LouisvilleLouisville KY 40292 USA

Originally developed decades ago, the binder jetting additive manufacturing （b J-AM） process possesses various advantages compared to other additive manufacturing （AM） technologies such as broad material compat- ibility and technological expandability. However, the adoption of b J-AM has been limited by the lack of knowledge with the fundamental understanding of the process principles and characteristics, as well as the relatively few systematic design guideline that are available. In this work, the process design considerations for b J-AM in green part fabrication were discussed in detail in order to provide a comprehensive perspective of the design for additive manufacturing for the process. Various process factors, including binder saturation, in- process drying, powder spreading, powder feedstock characteristics, binder characteristics and post-process curing, could significantly affect the printing quality of the green parts such as geometrical accuracy and part integrity. For powder feedstock with low flowability, even though process parameters could be optimized to partially offset the printing feasibility issue, the qualities of the green parts will be intrinsically limited due to the existence of large internal voids that are inaccessible to the binder. In addition, during the process development, the balanced combination between the saturation level and in-process drying is of critical importance in the quality control of the green parts.

关键词： binder jetting additive manufacturing green part process optimization process development

Cold adaptation does not alter ATP homeostasis during cold exposure in Drosophila melanogaster

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Integrative Zoology 2018年第4期13卷 471-481页

作者： Caroline M.WILLIAMS James R.ROCCA Arthur S.EDISON David b.ALLISON Theodore J.morgan Daniel A.HAHN Department of Integrative biology University of CaliforniaBerkeleyCaliforniaUSA Departments of Entomology and Nematology University of FloridaGainesvilleFloridaUSA biochemistry University of FloridaGainesvilleFloridaUSA Advanced Magnetic Resonance Imaging and Spectroscopy Facility McKnight Brain InstituteUniversity of FloridaGainesvilleFloridaUSA Departments of Genetics and biochemistry Complex Carbohydrate Research CenterUniversity of GeorgiaAthensGeorgiaUSA Department of Epidemiology and biostatistics School of Public HealthIndiana University BloomingtonBloomingtonIndianaUSA Division of biology Kansas State UniversityManhattanKansasUSA

In insects and other ectotherms,cold temperatures cause a coma resulting from loss of neuromuscular function,during which ionic and metabolic homeostasis are progressively *** adaptation improves homeostasis during cold exposure,but the ultimate targets of selection are still an open *** acclimation and adaptation remodels mitochondrial metabolism in insects,suggesting that aerobic energy production during cold exposure could be a target of ***,we test the hypothesis that cold adaptation improves the ability to maintain rates of aerobic energy production during cold exposure by using^(31)P NMR on live *** lines of Drosophila melanogaster artificially selected for fast and slow recovery from a cold coma,we show that cold exposure does not lower ATP levels and that cold adaptation does not alter aerobic ATP production during cold ***-hardy and cold-susceptible lines both experienced a brief transition to anaerobic metabolism during cooling,but this was rapidly reversed during cold exposure,suggesting that oxidative phosphorylation was sufficient to meet energy demands below the critical thermal minimum,even in cold-susceptible *** thus reject the hypothesis that performance under mild low temperatures is set by aerobic ATP supply limitations in ***,excluding oxygen and capacity limitation as a weak link in energy *** work suggests that the modulations to mitochondrial metabolism resulting from cold acclimation or adaptation may arise from selection on a biosynthetic product(s)of those pathways rather than selection on ATP supply during cold exposure.

关键词： chill coma energetics insect oxygen limitation thermal tolerance

Triassic to Cenozoic multi-stage intra-plate deformation focused near the bogd Fault system,Gobi Altai,Mongolia

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Geoscience Frontiers 2015年第5期6卷 723-740页

作者： Douwe J.J.van Hinsbergen Dickson Cunningham Gijsbert b.Straathof morgan Ganerod bart W.H.Hendriks Arjan H.Dijkstra Department of Earth Sciences Utrecht University Department of Environmental Earth Science.Eastern Connecticut State University SGS Horizon b.V. Stationsplein 6.2270 JB VoorburgThe Netherlands Geological Survey of Norway.Center of Geodynamics Statoil ASA.Rotvoll Norway School of Geography.Earth and Environmental Sciences.Plymouth University

The Gobi Altai region of southern Mongolia has been in the Eurasian plate interior since the midMesozoic,yet has experienced episodic phases of deformation since that *** this paper,we document field evidence to characterize and date the intra-plate tectonic history of the Gobi Altai region from the Triassic to the *** this end,we provide detailed mapping of the structure and stratigraphy of the eastern flanks of *** bogd that contains the widest variety of rock-time units in the *** carry out geochronological analysis of basaltic lavas and basement granite in the *** demonstrate that a crystalline basement with a 502 ± 8 Ma granitoid（U/Pb） underwent two phases of basin formation in the *** we date with new40Ar/39Ar lava ages of 218.5 ± 1.5,123.2 ± 0.7 and 124.8 ± 1.2 Ma,*** phases are linked to deposition of fluvio-lacustrine sediments and trap-like basaltic volcanics,with cumulative thicknesses of 1000-1500 *** basins were likely north-facing half-grabens that developed underN-S extension,but were subsequently overthrusted by Paleozoic and older crystalline basement during a less well constrained,but likely mid-Cretaceous phase of N-S shortening and basin *** results are consistent with recent seismic imaging of rift basins100 km to the NE of the study area where a similar history was *** multiple phases of intra-plate deformation appear to have parallel structural trends,most likely due to reactivated Paleozoic basement structures created during the original terrane amalgamation of the Central Asian Orogenic belt continental *** strong basement heterogeneity may predispose it to reactivation,and make it sensitive to changes in the overall stress field of the Eurasian plate driven by forces at its margins and *** study of Mongolia’s multi-stage tectonic history may thus provide a key proxy for the long-term dynamics of the Eurasian *** addition,the repeated reactivation

关键词： Ar/Ar geochronology Intra-plate deformation U/Pb geochronology Compression Extension

Model of hybrid interfacial domain wall in ferromagnetic/antiferromagnetic bilayers

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Chinese Physics b 2015年第4期24卷 436-440页

作者：章文翟亚鹿牧游彪翟宏如 Caroline G morgan Department of Physics Southeast University National Laboratory of Solid Microstructure Nanjing University Physics Department Wayne State University

A general model of a hybrid inteffacial domain wall （HIDW） in ferromagnetic/antiferromagnetic exchange biased bilayers is proposed, where an inteffacial domain wall is allowed to extend into either the ferromagnetic or antiferromagnetic layer or across both. The proposition is based on our theoretical investigation on thickness and field dependences of ferromagnetic domain wall （FMDW） and antiferromagnetic domain wall （AFDW）, respectively. Good match of the simulation to the hysteresis loops of a series of NiFe/FeMn exchange-biased bilayers confirms the existence of the HIDW, where the AFDW part is found to preferentially occupy the entire antiferromagnetic layer while the FMDW shrinks with the increased magnetic field as expected. The observed asymmetry between the ascending and descending branches of the hysteresis loop is explained naturally as a consequence of different partition ratios between AFDW and FMDW.

关键词： exchange bias interfacial domain wall ferromagnetic/antiferromagnetic bilayer