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SPINOPHILIN: A multiplayer tumor suppressor

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Genes & Diseases 2023年第1期10卷 187-198页

作者： eva m.Verdugo-Sivianes Amancio Carnero Instituto de biomedicina de Sevilla IBISHospital Universitario Virgen del RocioConsejo Superior de Investigaciones CientificasUniversidad de SevillaSeville 41013Spain CIbERONC Instituto de Salud Carlos IlMadrid 28029Spain

SPINOPHILIN(SPN,PPP1R9b or NEURAbIN-2)is a multifunctional protein that regulates protein-protein interactions in different cell signaling *** is also one of the regulatory subunits of protein phosphatase 1(PP1),implicated in the dephosphorylation of retinoblastoma protein(pRb)during cell *** SPN gene has been described as a tumor suppressor in different human tumor contexts,in which low levels of SPN are correlated with a higher grade and worse *** addition,mutations of the SPN protein have been reported in human ***,an oncogenic mutation of sPN,A566V,was described,which affects both the SPN-PP1 interaction and the phosphatase activity of the holoenzyme,and promotes p53-dependent tumorigenesis by increasing the cancer stem cell(CsC)pool in breast ***,the loss or mutation of SPN could be late events that promotes tumor progression by increasing the CSC pool and,eventually,the malignant behavior of the tumor.

关键词： Cancer therapy Phosphatase PP1 SPINOPHILIN Tumor suppressor Tumorigenesis

Distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naphthofurans in source rock extracts from Niger Delta basin,Nigeria

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Acta Geochimica 2020年第6期39卷 973-987页

作者： Abiodun b.Ogbesejana Oluwasesan m.bello Department of Applied Chemistry Federal University Dutsin-MaP.M.B.5001Dutsin-MaKatsina StateNigeria

The distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naptho-furans in source rocks from Niger Delta basin,Nigeria,were investigated by Rock-eval pyrolysis and gas chro-matography--mass spectrometry(GC--mS).The data obtained from the source rocks evaluation showed that the rock samples contained type 1/III kerogen capable of generating oil and gas and were within immature to early mature *** relative abundance of the Cor,C1-and C2-dibenzofurans range from 1.75%to 29.82%,27.60%to 40.52%and 29.66%to 6889%,*** diben-zofurans were dominated by *** the C1-dibenzofurans,2-+3-methyldibenzofuran was the most abundant in the rock samples while 1-methy ldibenzofuran appeared to be the *** relative abundance of benzo[b]naphtho[1,2-d]furan(1,2]bNF),benzo[b]naph-tha[2,1-d]furan(2.1]bNF)and benzo[b]naphtha[2,3-d]fu-ran([2.3]bNF)in the rock extracts range from 12.01%to 52.58%,32.61%to 75.219%and 10.27%to 52.43%.The wide range of values recorded for the three isomers of benzo[b lnapthofurans in the samples suggest source rocks formed from mixed organic *** the pheny ldibenzofuran isomers,4-pheny ldibenzofuran was the most abundant while 1-phenyldibenzofuran was the *** ratio-1(PhFR-1)and pheny ldibenzofuran ratio-2(PhFR-2)values range from 0.13 to 1.20 and 0.11 to 2.11,*** resuls showed that the relative abundance of PhFR-1 and PhFR-2 increase gradually with increasing burial depth and maturity(VRo≤0.77%,mPI-1≤*** s 443℃),and have a good correlations with calculated vitrinite ***-I and maximum Temperature(Tmax)-This range of values suggested immature to early mature source *** source rocks were found to have shale and coul lithologics and deposited in a lacustrine/fuvial deltaic settings within immature to early mature stages based on the distribution of dibenzofurans,pheny ldiben-zofurans and benzo[b]naphthofurans in the source rock

关键词： Dibenzofurans benzo[b]napthofurans Source rocks Niger delta Gas chromatography-mass spectrometry

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de biología molecular Severo Ochoa(Cbm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Synthesis, spectroscopic characterization, and thermal decomposition kinetics of some lanthanide(III) nitrate complexes of 2-(N-o-hydroxyacetophenone) amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene

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Journal of Rare Earths 2008年第4期26卷 463-468页

作者： K. mohanan m. Thankamony b. Sindhu Kumari Department of Chemistry University of Kerala Kariavattom Campus Trivandrum-695 581. Kerala India

Complexes of La（Ⅲ）, Ce（Ⅲ）, Pr（Ⅲ）, Nd（Ⅲ）, Sm（Ⅲ）, Eu（Ⅲ）, Gd（Ⅲ）, Dy（Ⅲ）, Yb（Ⅲ）, and Lu0ID with 2-（N-o- hydroxyacetophenone）amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene （HAAT） formed by the condensation of o-hydroxyacetophenone and 2-amino-3-carboxyethyl-4,5,6,7-tetrahydrobenzo[b]thiophene were synthesized and characterized on the basis of elemental analyses, molar conductance measurements, magnetic susceptibility data, UV-Visible, IR, and NmR spectral studies. The spectral data revealed that the ligand acted as a neutral tridentate coordinating to the metal ion through ONO donor sequence. A coordination number nine was proposed for the complexes. Thermal decomposition studies of the ligand and lanthanum（Ⅲ） complex were carried out and kinetic parameters were calculated using Coats-Redfem equation. The decomposition reactions followed random nucleation mechanism with one nucleus on each particle.

关键词： lanthanides o-hydroxyacetophenone molar conductance magnetic susceptibility thermal study rare earths

TmPRSS2,a novel host-directed drug target against SARS-CoV-2

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2665-2667页

作者： Christian Keller eva böttcher-Friebertshäuser michael Lohoff Institute of Virology Philipps University MarburgMarburgGermany Institute of medical microbiology and Hygiene Philipps University MarburgMarburgGermany

In a recent study in Nature,1 Shapira et *** that the peptidomimetic compound N-0385 inhibited SARS-CoV-2 infection in vitro in remarkably low concentrations by blocking the host cell protease TmPRSS2,which mediates proteolytic cleavage of the SARS-CoV-2 major surface glycoprotein spike(S).Accordingly,N-0385 protected experimentally infected mice from severe SARS-CoV-2 pathology.

关键词： directed protected cleavage

P-T path of metamorphism and U-Pb monazite and zircon age of the Kitoy terrane: Implication for Neoarchean collision in SW Siberian Craton

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Geoscience Frontiers 2020年第6期11卷 1915-1934页

作者： Vasiliy P.Sukhorukov Valentina b.Savel’eva Yingde Jiang Zhiyong Li V.S.Sobolev Institute of Geology and mineralogy Sb RAS 3 Koptyuga Av.Novosibirsk630090Russia Novosibirsk State University 2 Pirogova St.Novosibirsk630090Russia Institute of the Earth Crust Sb RAS 128 Lermontova St.Irkutsk664033Russia State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

The first data on P-T metamorphic conditions coupled with U-Pb monazite and zircon age obtained for the Neoarchean Kitoy granulite-gneiss terrane(SW Siberian Craton).Alumina gneisses of the Kitoy terrane indicate two-staged metamorphic *** first stage of regional metamorphism(m1)occurred at high-amphibolite facies conditions at T=780-800℃ and P=8-9 *** second stage(m2)belongs to mT-HT/LP type of metamorphism with the wide temperature interval 600-750℃ and pressure 2-4 *** age peaks were established on the basis of U-Pb monazite and zircon dating in garnet-anthophyllite *** of them correspond to the Neoarchean age:the age of m1 falls into the interval of ca.2489-2496 ma,the age of m2-ca.2446-2456 *** high-temperature metamorphism of the Kitoy block and nearly coeval granitoid magmatism can be an evidence for the Neoarchean collision in SW Siberian craton.

关键词： Siberian craton Neoarchean Kitoy terrane metamorphism P-T path

Estimation of radiative capture^(13)b(n,γ0+1)^(14)b reaction rate in the modified potential cluster model

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Chinese Physics C 2023年第10期47卷 130-142页

作者： A.S.Tkachenko N.A.burkova b.m.Yeleusheva S.b.Dubovichenko Fesenkov Astrophysical Institute 050020AlmatyKazakhstan al-Farabi Kazakh National University 050040AlmatyKazakhstan

We discuss current attempts to employ the modified potential cluster model to describe the available experimental data on the^(13)b(n,γ0+1)^(14)b total *** estimated results of the m1 and E1 transitions from the n^(13)b scattering states to the ground and first excited states of^(14)b are *** 1st resonance at Ex=1.275 meV(1+)is revealed in both the cross-section and reaction *** the variation in the asymptotic constant,a thermal cross-section interval of 5.1-8.9 mb is *** on the theoretical total cross-sections at energies of 0.01 eV to 5 meV,we calculate the reaction rate in the temperature range of 0.01 to *** ignition T9 values of the^(13)b(n,γ0+1)^(14)b reaction depending on a neutron number density n_(n)of~10^(22)cm^(−3)are *** radiative neutron capture reaction rates on the boron^(10-13)b and carbon^(12-14)Сisotopes are compared.

关键词： radiative neutron capture ^(14)b nucleus total cross-sections reaction rate potential cluster model r-process

Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 74-90页

作者： Ayşe N Erbakan müzeyyen Arslan bahadır FatoşN Kaya büşra Güleç miraçVural Keskinler Ümmügülsüm AktemurÇelik Özge Faydalıel banu mesçi Aytekin Oğuz Department of Internal medicine Prof Dr Suleyman Yalcin City HospitalIstanbul Medeniyet UniversityIstanbul 34722Türkiye Department of Family medicine Istanbul Medeniyet UniversityIstanbul 34722Türkiye

bACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2Dm)is a major public health problem and a significant risk factor for the progression of diabetic *** To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2Dm with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic *** This prospective observational study investigated glycemic control in patients with poorly controlled T2Dm over 12 *** were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as *** analysis focused on the success rates of good glycemic control and the associated factors within each *** The study showed significant improvements in HbA1c levels in all *** most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,*** one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and *** In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored ***

关键词： Type 2 diabetes mellitus Glycated hemoglobin Glycemic control Patient-centered care Diabetes management glycemic background

The use of botulinum toxin A in chemical component separation: a review of techniques and outcomes

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Plastic and Aesthetic Research 2020年第4期7卷 1-9页

作者： Sharbel A.Elhage eva b.Deerenberg Jenny m.Shao Vedra A.Augenstein b.Todd Heniford Department of Gastrointestinal and minimally Invasive Surgery Carolinas Medical CenterCharlotteNC 28204USA

Fascial closure is crucial for abdominal wall reconstruction (AWR) but can be especially difficult in patients with massive ventral hernias or loss domain. Recently, botulinum toxin A (bTA) has been increasingly utilized as an adjunct in AWR to aid in fascial closure. This review aims to evaluate the current literature on the use of bTA in AWR to assess current treatment regimens, side effects, outcomes and complications. A literature search was performed, yielding 10 studies that met the inclusion criteria. There was a significant amount of heterogeneity in treatment regimens, with studies differing in bTA injection timing, dosage, concentration, and location. The majority of studies showed that injection of bTA preoperatively was able to augment abdominal wall musculature, with many showing a decrease in mean transverse defect size and high rates of successful fascial closure. No major complications were reported from bTA administration, with only mild side effects reported by some studies. The most common side effects include a weak cough or sneeze, bloating, and back pain, which generally all resolved prior to surgery. While bTA appears to be a promising adjunct for AWR, further investigation is needed to determine optimal patient selection and treatment regimens.

关键词： Hernia abdominal wall reconstruction botulinum toxin botox chemical component separation