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MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 79-93页

作者： Changqiang xie Yan Wang zhenzhen Cai Jianghai Du zhengyu Chen Junjie Wang Xingzhou Peng State Key Laboratory of Digital Medical Engineering School of biomedical Engineering Hainan University Haikou 570228P.R.China Key Laboratory of biomedical Engineering of Hainan Province One Health Institute Hainan University Haikou 570228P.R.China Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou 571199P.R.China Engineering Research Center for Hainan bio.Smart Materials and bio-Medical Devices Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and Trauma Hainan Medical UniversityHaikou 571199P.R.China

Monomethyl auristatin E(MMAE)is a derivative of the marine peptide Dolastatin 10,which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical *** antibody drug conjugate(ADC)of MMAE is currently used in clinical ***,the safety issues of MMAE-based ADC,such as high drug toxicity and poor bioavailability,still exist when using it for anticancer therapy.A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer ***,PLGA-b-PEG 2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective *** sustained release effect and the immunogenic cell death(ICD)effect of PLGA-MMAE nanoparticles were assessed by in vitro *** PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention(EPR)effect,inducing cell apoptosis and causing a certain degree of immune *** sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ***,this study provides a safe and effective chemotherapeutic approach,as well as a simple and effective synthetic process for MMAE-based nanoparticles,improving their therapeutic efficacy and safety.

关键词： Monomethyl auristatin E poly(lactic-co-glycolic acid)nanoparticles sustained release chemotherapy immunogenic cell death

Synergistic Ru/RuO_(2) heterojunctions stabilized by carbon coating as efficient and stable bifunctional electrocatalysts for acidic overall water splitting

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Nano Research 2024年第8期17卷 6931-6939页

作者： Man Wu Yuying Fan Yang Huang Dongxu Wang Ying xie Aiping Wu Chungui Tian Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

The development of highly active and stable acidic water oxidation electrocatalysts is of great significant for promoting the industrial application of proton exchange membrane ***-based catalysts have broad application prospects in acidic water oxidation,but their limitations in stability and activity hinder their further ***,a nitrogen-doped carbon(NC)coated porous Ru/RuO_(2) heterojunctional hollow sphere(Ru/RuO_(2)/NC)is designed as high-active and stable bifunctional electrocatalyst for acidic oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).In synthesis,the key is to use mesoporous polydopamine spheres as a template for forming hollow spheres,a source of NC coating and a reducing agent for forming Ru/RuO_(2) *** Ru/RuO_(2) heterojunction adjusts the electronic structure of Ru active sites,optimizing the adsorption of intermediate ***,the NC coating and the interaction between NC and Ru/RuO_(2) effectively prevent Ru from over-oxidation and *** porous hollow structure provides more exposed active sites and promotes mass ***,Ru/RuO_(2)/NC exhibits outstanding OER and HER performance with low overpotentials of 211 and 32 mV at 10 mA·cm^(−2),respectively,and shows excellent *** acid water splitting electrolyzer,based on the bifunctional Ru/RuO_(2)/NC,requires low cell voltages of 1.46 and 1.76 V at 10 and 100 mA·cm^(−2),respectively,with good stability for over 100 h operation,surpassing Pt/C||RuO_(2) and most of the reported catalysts.

关键词： hollow heterojunction bifunctional electrocatalysts oxygen evolution hydrogen evolution acidic water splitting

PKHD1L1 blocks the malignant behavior of lung adenocarcinoma cells and restricts tumor growth by regulating CbX7

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bIOCELL 2024年第8期48卷 1209-1221页

作者： KEWEI CHENG LEI SHI CAIWEN SHI SHUANSHUAN xie CHANGHUI WANG Department of Pulmonary and Critical Care Medicine The Affiliated Changzhou Second People’s Hospital of Nanjing Medical UniversityChangzhou213004China Department of Pulmonary and Critical Care Medicine Shanghai Tenth Clinical Medical College of Nanjing Medical UniversityShanghai200072China

Objective:To explore the role of polycystic kidney and hepatic disease 1-like 1(PKHD1L1)in lung adenocarcinoma(LUAD).Methods:bioinformatics tools were utilized to examine the clinical profile of PKHD1L1 and chromobox protein homolog 7(CbX7)in *** Cell Counting Kit-8,colony formation,terminal deoxynucleotidyl transferase dUTP nick end labeling,Transwell,and wound-healing assays were carried out to assess the proliferative,apoptotic,invasive,and migrative capacities of the ***,the interrelation between PKHD1L1 and CbX7 was validated using a co-immunoprecipitation assay.A LUAD mice model was constructed by subcutaneous injection of A549 ***,immunohistochemical staining was performed to evaluate CbX7 and Ki67 ***:PKHD1L1 was downregulated in LUAD and predicted dismal outcomes in patients with ***1L1 upregulation repressed the proliferative,invasive,and migrative capabilities of A549 cells and exacerbated the apoptotic ***,PKHD1L1 may bind to CbX7 and positively modulate CbX7 ***7 deletion partly abrogated the effects of PKHD1L1 upregulation on the cellular biological activities in A549 ***,the PKHD1L1/CbX7 axis regulates the Hippo signaling pathway in A549 ***1L1 restricted tumor growth in LUAD xenograft mice;this was partly abolished by CbX7 ***:PKHD1L1 can hinder LUAD progression by regulating CbX7-mediated Hippo signaling.

关键词： Lung adenocarcinoma Polycystic kidney and hepatic disease 1-like 1 CbX7 Hippo signaling

Regularly Tuning Quantum Interference in Single-Molecule Junctions through Systematic Substitution of Side Groups with Varied Electron Effects

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Chinese Journal of Chemistry 2024年第11期42卷 1217-1222页

作者： Xianjing xie Yirong zhang Junrui zhang Xingyuan Cui Wei Liu Xunshan Liu Key Laboratory of Surface&Interface Science of Polymer Materials of zhejiang Province School of Chemistry and Chemical EngineeringZhejiang Sci-Tech University928 Second StreetHangzhouZhejiang310018 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin130022 China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjingJiangsu210094 China

Investigating the quantum interference effect in single molecules is essential to comprehensively understand the underlying mechanism of single-molecule charge *** this study,we employed the mother molecule m-OPE and introduced a series of side groups with various electronic effects at the 2-position of the central phenyl ring,creating four daughter m-OPE *** single molecular conductivities of these molecule wires were measured using the scanning tunneling microscope breaking junction *** findings demonstrate that the substitutions regularly modulate the destructive quantum interference occurring within the m-OPE *** combining optical and electrochemical investigations,along with density functional theory computations,we discover that the conductivity of the molecules corresponds to the electron-donating/withdrawing ability of the ***,by adjusting the electron structures of the molecular backbone,we can systematically tailor the destructive quantum interference in the m-OPE molecules.

关键词： Quantum interference Single-molecule junctions Electron effect substituents Charge transport Molecular devices

A guidance strategy for rendezvous and docking to the space station in the Earth-Moon NRHO orbit

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中国空间科学技术（中英文） 2024年第4期44卷 29-39页

作者： xie Yongchun CHEN Changqing LI Xiangyu LI zhenyu beijing Institute of Control Engineering Beijing 100094China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

With the development of space technology,it is possible to build a space station in Earth-Moon space as a transit for Earth-Moon round-trip and entering in the deep *** and docking is one of the key technologies for building an Earth-Moon space station.A guidance strategy for rendezvous and docking from the Earth orbit to the space station in the Earth-Moon NRHO orbit is proposed in this paper,which is suitable for engineering ***,the rendezvous and docking process is divided into three sections,i.e.,the large-range orbit transfer section,far-range guidance section,and close-range approaching *** suitable terminal of large-range orbit transfer is selected according to the eigenvalue of NRHO orbit state transition *** two-impulse guidance method based on the relative motion equation in the three-body problem is adopted for the far-range guidance *** impulse time and amplitude are solved with the optimization *** linear constant three-body relative motion equation is proposed for the close-range approaching section,and the rendezvous and docking is completed by a two-stage linear ***,a simulation analysis is carried out,and the simulation results show that the adopted dynamics equations and the designed guidance law are effective,and the three flight phases are naturally connected to accomplish the rendezvous and docking mission from the Earth orbit to the space station on the Earth-Moon NRHO.

关键词： Earth-Moon space station rendezvous and docking NRHO orbit relative motion guidance strategy

Incorporation sodium ions into monodisperse lead-free double perovskite Cs_(2)AgbiCl_(6) nanocrystals to improve optical properties

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Chinese Chemical Letters 2024年第3期35卷 549-553页

作者： Song Wang Ying xie Wenchao Jiang binghang Liu Keying Shi Kai Pan Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationHeilongjiang UniversityHarbin 150080China School of Materials Science and Engineering Jiangsu Engineering Laboratory of Light-Electricity-Heat Energy-Converting Materials and ApplicationsChangzhou UniversityChangzhou 213164China State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Lead-free double perovskite nanocrystals(NCs)have emerged as a promising candidate in the optical field,owing to their non-toxic,good moist heat and chemical ***,their poor optical properties limited their *** improve the optical properties of lead-free double perovskite NCs,metal ion doping or alloying had been suggested as a promising ***,we prepared monodisperse,uniformly sized,cubic morphology of Cs_(2)AgbiCl_(6)NCs with different Na^(+)incorporation amounts via a simple hot-injection *** Na^(+)incorporation broke the parity-forbidden transition by reducing the inversion symmetry of the electron wave function at the Ag site,which changed the parity of the self-trapped exciton wave function and thus allowed radiative *** a result,the photoluminescence quantum yield(PLQY)of Na^(+)-alloyed Cs_(2)AgbiCl_(6)NCs(12.1%)was higher than that of Cs_(2)AgbiCl_(6)NCs(2.4%),and the exciton lifetime of Na^(+)-alloyed Cs_(2)AgbiCl_(6)NCs increased to 36.98 ns from 17.58 ns for Cs_(2)AgbiCl_(6)*** adjusting the amount of Na^(+)incorporation,the band gap of Cs_(2)AgbiCl_(6)NCs can be significantly tuned from~2.90 eV to~3.50 ***,the temperature-dependent photoluminescence spectra indicated that the Na^(+)-alloyed Cs_(2)AgbiCl_(6)NCs possessed higher longitudinal optical phonon energy and exciton binding energy compared to Cs_(2)AgbiCl_(6)*** suggested that there were strong exciton-phonon interactions during exciton recombination,a reduced probability of non-radiative processes,and excellent thermal *** offers a promising strategy for improving the optical properties of lead-free double perovskite NCs,and have the potential to replace traditional lead halide perovskite NCs in future optoelectronic applications.

关键词： Nanocrystals Alloy Double perovskites Optical properties Exciton binding energy

Probabilistic back-analysis of rainfall-induced landslides for slope reliability prediction with multi-source information

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JOURNAL OF ROCK MECHANICS AND GEOTECHNICAL ENGINEERING 2024年第9期16卷 3575-3594页

作者： Jiang, Shui-Hua Jie, Hong-Hu xie, Jiawei Huang, Jinsong zhou, Chuang-bing Nanchang Univ Sch Infrastruct Engn Xuefu Rd 999 Nanchang 330031 Peoples R China Univ Newcastle Fac Engn & Built Environm Discipline Civil Surveying & Environm Engn Callaghan NSW 2308 Australia

Probabilistic back-analysis is an important means to infer the statistics of uncertain soil parameters, making the slope reliability assessment closer to the engineering reality. However, multi-source information (including test data, monitored data, field observation and slope survival records) is rarely used in current probabilistic back-analysis. Conducting the probabilistic back-analysis of spatially varying soil parameters and slope reliability prediction under rainfalls by integrating multi-source information is a challenging task since thousands of random variables and high-dimensional likelihood function are usually involved. In this paper, a framework by integrating a modified bayesian Updating with Subset simulation (mbUS) method with adaptive Conditional Sampling (aCS) algorithm is established for the probabilistic back-analysis of spatially varying soil parameters and slope reliability prediction. Within this framework, the high-dimensional probabilistic back-analysis problem can be easily tackled, and the multi-source information (e.g. monitored pressure heads and slope survival records) can be fully used in the back-analysis. A real Taoyuan landslide case in Taiwan, China is investigated to illustrate the effectiveness and performance of the established framework. The findings show that the posterior knowledge of soil parameters obtained from the established framework is in good agreement with the field observations. Furthermore, the updated knowledge of soil parameters can be utilized to reliably predict the occurrence probability of a landslide caused by the heavy rainfall event on September 12, 2004 or forecast the potential landslides under future rainfalls in the Fuhsing District of Taoyuan City, Taiwan, China. (c) 2024 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting by Elsevier b.V. This is an open access article under the CC bY-NC-ND license (http://***/ licenses/by-nc-nd/4.0/).

关键词： Rainfall-induced landslide Spatial variability Probabilistic back-analysis Slope reliability analysis bayesian updating SHEAR-STRENGTH SOIL SLOPE SPATIAL VARIAbILITY bAYESIAN FRAMEWORK MODEL FIELD PERMEAbILITY PARAMETERS CALIbRATION KNOWLEDGE

biomimetic porous silicon oxycarbide ceramics with improved specific strength and efficient thermal insulation

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Journal of Materials Science & Technology 2024年第1期168卷 185-193页

作者： zhuoqing zhang Jinghan Li Lei Cao Yu Shi Huajie Yang Rui Yang Fan xie Xing zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Shenyang Aircraft Design and Research Institute Shenyang 110035China

Considering the challenge of aerodynamic heating,the development of high-performance insulating ce-ramic materials with lightweight and low thermal conductivity is crucially important for aerospace vehi-cles to achieve flight at high speed for a long *** this work,macro-porous silicon oxycarbide(SiOC)ceramics with directional pores(DP-SiOC)(mean pore size of 88.1μm)were prepared using polysiloxane precursors via freeze casting and photocrosslinking,followed by *** DP-SiOC samples were lightweight(density∼0.135 g cm^(-3))with a porosity of 90.4%,which showed good shapability through the molding of polysiloxane *** DP-SiOC samples also exhibited an ultra-low thermal con-ductivity of 0.048 W(m K)^(-1)at room temperature,which can also withstand heat treatment at 1200°C for 1 *** addition,scaffolds with triply periodic minimal surfaces(TPMS)were fabricated using digital light processing(DLP)printing,which was further filled with polysiloxane precursors for increasing the strength of *** TPMS scaffolds filled with macro-porous SiOC ceramics(TPMS-DP-SiOC)showed good integration between TPMS and macro-pore structures,which had a porosity∼75%and high specific strength of 9.73×10^(3)N m kg^(-1).The thermal conductivity of TPMS-DP-SiOC samples was 0.255 W(m K)^(-1)at room *** biomimetic TPMS-DP-SiOC ceramics developed in this study are likely used for thermal protection systems.

关键词： Thermal insulation Light weight Macro-porous ceramics SiOC

bipolar membrane electrodialysis integrated with in-situ CO_(2)absorption for simulated seawater concentrate utilization,carbon storage and production of sodium carbonate

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Journal of Environmental Sciences 2024年第8期142卷 21-32页

作者： Jingtao bi Tianyi Chen Yue xie Ruochen Shen bin Li Mengmeng Sun Xiaofu Guo Yingying zhao School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300401China Engineering Research Center of Seawater Utilization Technology of Ministry of Education School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300401China Hebei Collaborative Innovation Center of Modern Marine Chemical Technology Tianjin 300401China Tianjin Key Laboratory of Chemical Process Safety Tianjin 300130China Shandong Technology Innovation Center of Seawater and brine Efficient Utilization Weifang 262737China

In the context of carbon capture,utilization,and storage,the high-value utilization of carbon storage presents a significant *** address this challenge,this study employed the bipolar membrane electrodialysis integrated with carbon utilization technology to prepare Na_(2)CO_(3)products using simulated seawater concentrate,achieving simultaneous saline wastewater utilization,carbon storage and high-value production of Na_(2)CO_(3).The effects of various factors,including concentration of simulated seawater concentrate,current density,CO_(2)aeration rate,and circulating flow rate of alkali chamber,on the quality of Na_(2)CO_(3)product,carbon sequestration rate,and energy consumption were *** the optimal condition,the CO_(3)^(2-)concentration in the alkaline chamber reached a maximum of 0.817 mol/L with 98 mol%*** resulting carbon fixation rate was 70.50%,with energy consumption for carbon sequestration and product production of 5.7 k Whr/m^(3)CO_(2)and1237.8 k Whr/ton Na_(2)CO_(3),*** coupling design provides a triple-win outcome promoting waste reduction and efficient utilization of resources.

关键词： bipolar membrane electrodialysis(bMED) Carbon capture Utilization and storage(CCUS) Seawater concentrate Sodium carbonate