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Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin bao yongjia Song Minghui Hang Hao Xu Qiang Li Pengyu wang Tao Chen Mengxiong Xia Qi Shi yongjun wang Xiaoyun wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China Key Laboratory of Theory and Therapy of Muscles and bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse ***: DbA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 ***: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor *** decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-Κb and ***: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating bCL2–bECN1 interaction

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Acta Pharmaceutica Sinica b 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen Ningning Li Shan Sun Nana wang yang Chen Chunsheng Dong Kin yip Tam Jochen H.M.Prehn Hongfeng wang Zheng ying Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China Dept.of Physiology&Medical Physics and FUTURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Sciences University of MacaoTaipaMacao 999078China Insititutes of biology and Medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FTD,whether these DPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing DPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between bCL2 and bECN1/beclin 1 by inhibiting bCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between bECN1 and bCL2,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy bCL2 bECN1/beclin 1 Dipeptide repeat Neurodegeneration

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丹酚酸b-葛根素联用对氧糖剥夺/复氧损伤的SH-Sy5y神经细胞焦亡的影响

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中国实验方剂学杂志 2024年第3期30卷 54-63页

作者：涂舒欣王艳贺晓丽中国医学科学院北京协和医学院药用植物研究所北京100193

目的:基于细胞焦亡探讨丹酚酸b和葛根素合用对氧糖剥夺/复氧(oxygen-glucose deprivation/reoxygenation,OGD/R)损伤的SH-Sy5y神经细胞的保护作用及机制。方法:利用SH-Sy5y细胞构建OGD/R损伤模型,设立正常对照组(control)、模型组(OGD/R)、10μmol·L^(-1)丹酚酸b组(salvianolic acid b,Sal b)、100μmol·L^(-1)葛根素组(puerarin,Pue)、10μmol·L^(-1)丹酚酸b和100μmol·L^(-1)葛根素合用组(SP)及10μmol·L^(-1)NOD样受体蛋白3(NLRP3)炎症小体抑制剂MCC950组。除正常组外,其余各组细胞在氧糖剥夺6 h后迅速复糖复氧12 h进行OGD/R造模。采噻唑蓝(MTT)法检测细胞存活率,光学显微镜下观测细胞形态,分光光度计法检测培养上清中乳酸脱氢酶(LDH)释放率,Hoechst/PI染色检测细胞膜损伤情况,实时荧光定量聚合酶链式反应(RT-qPCR)检测NLRP3、半胱氨酸蛋白酶1(caspase-1)、消皮素D(GSDMD)、凋亡斑点样蛋白(ASC)和白细胞介素-1β(IL-1β)的mRNA表达水平,免疫荧光检测NLRP3和caspase-1蛋白表达的变化,蛋白免疫印迹法(Western blot)检测IL-1β、ASC、NLRP3、caspase-1和活化半胱氨酸蛋白酶1(cleaved caspase-1)蛋白表达的变化。结果:与正常组比较,模型组SHSy5y细胞存活率显著降低(P3、caspase-1、GSDMD、ASC和IL-1β的mRNA表达水平显著提高(P3、caspase-1和cleaved caspase-1蛋白的表达水平显著提高(Pb、葛根素与丹酚酸b和葛根素合用均能显著提高OGD/R损伤后SH-Sy5y细胞的存活率(Pb和葛根素合用及MCC950均能改善细胞形态,降低细胞上清液LDH的渗漏(Py5y细胞NLRP3、caspase-1、GSDMD、ASC和IL-1β的mRNA表达水平(P3、caspase-1和cleaved caspase-1蛋白的表达水平(Pb和葛根素合用能减轻OGD/R对SH-Sy5y细胞造成的损伤,这可能与其能够抑制细胞焦亡相关。

关键词：缺血性脑卒中氧糖剥夺/复氧模型丹酚酸b 葛根素细胞焦亡

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Enhancing Strength-Ductility Synergy of CoCrNi-based Medium-Entropy Alloy Through Coherent L1_(2)Nanoprecipitates and Grain boundary Precipitates

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 78-88页

作者： Leilei Li Kaikai Song Qingwei Gao Changshan Zhou Xiaoming Liu yaocen wang Xiaojun bai Chongde Cao School of Physical Science and Technology Northwestern Polytechnical UniversityXi’an710016China Weihai Research Institute of Industrial Technology Shandong UniversityWeihai264209China Research and Development Institute of Northwestern Polytechnical University in ShenzhenShenzhen518057China

The L1_(2)-strengthened Co_(34)Cr_(32)Ni_(27)Al_(4)Ti_(3)medium-entropy alloy(MEA)with precipitations of grain boundaries has been developed through selective laser melting(SLM)followed by cold rolling and annealing,exhibiting excellent strength-ductility *** as-printed alloy exhibits low yield strength(yS)of~384 MPa,ultimate tensile strength(UTS)of~453 MPa,and uniform elongation(UE)of 1.5%due to the existence of the SLM-induced *** cold rolling and annealing,the yS,UTS,and UE are significantly increased to~739 MPa,~1230 MPa,and~47%,*** enhancement primarily originates from the refined grain structure induced by cold rolling and *** presence of coherent sphericalγ'precipitates(L1_(2)phases)and Al/Ti-rich precipitates at the grain boundaries,coupled with increased lattice defects such as dislocations,stacking faults,and ultrafine deformation twins,further contribute to the property’s *** study highlights the potential of SLM in producing high-strength and ductile MEA with coherent L1_(2)nanoprecipitates,which can be further optimized through subsequent rolling and annealing *** findings offer valuable insights for the development of high-performance alloys for future engineering applications.

关键词： Medium-entropy alloy Selective laser melting Precipitation Strength Ductility

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A First-principles Study on the Adhesion Strength,Interfacial Stability,and Electronic Properties of Mg/Mg_(2)y Interface

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 537-550页

作者： yunxuan Zhou Wenjun Tian Quan Dong Hailian wang Jun Tan Xianhua Chen Kaihong Zheng Fusheng Pan College of Materials Science and Engineering National Engineering Research Center for Magnesium AlloysChongqing UniversityChongqing 400044China State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400044China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

The interfacial microstructures and configurations directly affect the comprehensive properties of the composites,but their interfacial adhesion mechanism is complicated to expound by experimental *** this work,based on the stacking sequence of the Mg/Mg_(2)y interface models,nine different Mg/Mg_(2)y interface configurations with top site,bridge site,and hollow site(HCP)under Mg1,Mg_(2),and y terminations were successfully constructed and systematically explored by first-principles *** results showed that the Mg_(2)y(0001)surface with y termination is the most stable when the yttrium chemical potential()is less than-1.09 eV;otherwise,Mg_(2)y(0001)surface with Mg1 termination is the most *** seven-layer Mg(0001)and eleven-layer Mg_(2)y(0001)slabs are employed to reflect the bulk-like interior ***,the Mg(0001)/Mg_(2)y(0001)with the y-HCP stacking has the largest interface thermodynamic stability with the value of 2.383 J/m^(2) in all interface configurations owing to its largest work of *** addition,the interfacial energy of y-HCP stacking is significantly smaller than those of Mg1-HCP when is approximately less than-0.55 eV,showing that it is more *** thermodynamic stability of Mg/Mg_(2)y with y-HCP is due to Mg-y chemical bonds formed between Mg and y ***,the Mg/Mg_(2)y interfaces are strong interfaces based on the Griffith fracture theory.

关键词： Mg/Mg_(2)y interface Interface stability Work of adhesion Electronic structure First-principles calculations

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Physics-informed deep learning for fringe pattern analysis

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Opto-Electronic Advances 2024年第1期7卷 4-15页

作者： Wei yin yuxuan Che Xinsheng Li Mingyu Li yan Hu Shijie Feng Edmund y.Lam Qian Chen Chao Zuo Smart Computational Imaging Laboratory(SCILab) School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China Smart Computational Imaging Research Institute(SCIRI)of Nanjing University of Science and Technology Nanjing 210019China Jiangsu Key Laboratory of Spectral Imaging&Intelligent Sense Nanjing 210094China Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong Kong SAR 999077China

Recently,deep learning has yielded transformative success across optics and photonics,especially in optical *** neural networks (DNNs) with a fully convolutional architecture (e.g.,U-Net and its derivatives) have been widely implemented in an end-to-end manner to accomplish various optical metrology tasks,such as fringe denoising,phase unwrapping,and fringe ***,the task of training a DNN to accurately identify an image-to-image transform from massive input and output data pairs seems at best naive,as the physical laws governing the image formation or other domain expertise pertaining to the measurement have not yet been fully exploited in current deep learning *** this end,we introduce a physics-informed deep learning method for fringe pattern analysis (PI-FPA) to overcome this limit by integrating a lightweight DNN with a learning-enhanced Fourier transform profilometry (Le FTP) *** parameterizing conventional phase retrieval methods,the Le FTP module embeds the prior knowledge in the network structure and the loss function to directly provide reliable phase results for new types of samples,while circumventing the requirement of collecting a large amount of high-quality data in supervised learning *** by the initial phase from Le FTP,the phase recovery ability of the lightweight DNN is enhanced to further improve the phase accuracy at a low computational cost compared with existing end-to-end *** results demonstrate that PI-FPA enables more accurate and computationally efficient single-shot phase retrieval,exhibiting its excellent generalization to various unseen objects during *** proposed PI-FPA presents that challenging issues in optical metrology can be potentially overcome through the synergy of physics-priors-based traditional tools and data-driven learning approaches,opening new avenues to achieve fast and accurate single-shot 3D imaging.

关键词： optical metrology deep learning physics-informed neural networks fringe analysis phase retrieval

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Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance Li-ion battery

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Rare Metals 2024年第7期43卷 2994-3006页

作者： ying Li yi-Han Zhao Lu-Lu Zhao Peng-Fei wang ying Xie Ting-Feng yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries(LIbs)due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of Li~+limits its practical *** this work,C-Sb composite was constructed as anode material of LIbs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2(the mass ratio of polyacrylonitrile to Sb source is 1:2)electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g^(-1)at 0.1,0.2,0.3,0.5,1 and 2 A·g^(-1),*** when the current density returned to 0.1 A·g^(-1),the charge capacity was 939.3 mAh·g^(-1),revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory(DFT)calculations revealed the gradual enhancement of the interface interaction between Sb_(x)Li_(y) and amorphous carbon(AMC)with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sb_(x)Li_(y) to *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： Li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

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Sigmatropic rearrangements of b(MIDA)-propargylic alcohols towards the diverse synthesis of α-functionalized organoborons

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Science China Chemistry 2024年第2期67卷 568-575页

作者： Jiasheng Qian Li-Cai Liu Zhi-Hao Chen yuan Liu yin Li Qingjiang Li Honggen wang Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China

α-Functionalized organoborons are useful building blocks and key structural elements in functional *** previous synthesis relied on the famous Matteson reaction or the late-stage borylative modification of alkynes or ***,the synthetic transformation of borylated building blocks offers another useful strategy and is currently actively *** report herein that b(MIDA)-propargylic alcohols(bPAs) are a useful type of borylated building *** two complementary functional group handles(alkyne and hydroxyl) in close proximity,the redox-neutral [3,3] and [2,3] sigmatropic rearrangements of bPAs allow the efficient synthesis of several types of α-functionalized boronates,including α,β-unsaturated acylborons,α-S/P-substituted allenylborons,boryl-substituted thiazoles and a borylated α,β-unsaturated hydrazine,some of which are otherwise challenging targets using other synthetic methods.

关键词： organoboron diverse synthesis sigmatropic rearrangement heteroarene amide

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人类排放情景的设计与全球变暖预估

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气候变化研究进展 2024年第2期20卷 261-264页

作者：赵宗慈罗勇黄建斌清华大学地球系统科学系北京100084 中国气象局国家气候中心北京100081 中国科学院大学资源环境学院北京100049

1气候变化的原因全球气候变化除地球系统内部变率外,自然强迫和人为强迫是重要的外部驱动力。其中自然强迫包括太阳活动和火山活动。人为强迫即人类活动,包括大量化石燃料燃烧排放温室气体、土地利用,以及气溶胶与污染排放等,其强度取... 详细信息

1气候变化的原因全球气候变化除地球系统内部变率外,自然强迫和人为强迫是重要的外部驱动力。其中自然强迫包括太阳活动和火山活动。人为强迫即人类活动,包括大量化石燃料燃烧排放温室气体、土地利用,以及气溶胶与污染排放等,其强度取决于人口发展与变化、社会经济发展、技术变化及其内部的协调性等。本文重点给出人类强迫的影响。IPCC第六次评估报告明确表明,近百年特别是近几十年来观测到的全球变暖归因为人类活动的影响。

关键词：太阳活动火山活动排放情景全球变暖社会经济发展全球气候变化人类强迫变率

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Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.Sagisaka K.Ogura T.Zh.Esirkepov b.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz S.A.Pikuz W.yan T.M.Jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Velyhan T.Hayakawa y.Fukuda J.K.Koga M.Ishino K.Kondo y.Miyasaka A.Kon M.Nishikino y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriyama y.Kato G.Korn K.Kondo S.V.bulanov T.Kawachi A.S.Pirozhkov ELI beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan Hb11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics ASCR PragueCzech Republic FZU-Institute of Physics ASCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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