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Nucleolin Mediates LPS-induced Expression of Inflammatory Mediators and Activation of Signaling Pathways

Current Medical Science 2020年第4期40卷 646-653页

作者： Li FANG Kang-kai WANG Qing HUANG feng CHENG Fang HUANG Wei-wei LIU Department of Cardiology the First Hospital of ChangshaChangsha 410008China Department of Pathophysiology Xiangya School of MedicineCentral South UniversityChangsha 410008China

Summary:In this study,we investigated the effects of nucleolin on lipopolysaccharide(LPS)-induced activation of MAPK and NF-Kappab(NF-kb)signaling pathways and secretion of TNF-a,IL-1βand HMGb1 in THP-1 *** assay and Western blotting were used to identify the nucleolin expression in cell membrane,cytoplasm and nucleus of THP-1 *** of nucleolin was induced by neutralizing antibody against ***-1 monocytes were pretreated with anti-nucleolin antibody for 1 h prior to LPS *** irrelevant IgG group was used as *** of inflammatory mediators(TNF-a,IL-1β and HMGb1)and activation of MAPK and NF-kb/I-kb signaling pathways were examined to assess the effects of nucleolin on LPS-mediated inflammatory *** existed in cell membrane,cytoplasm and nucleus of THP-1 *** of anti-nucleolin antibody significantly inhibited the LPS-induced secretion of TNF-a,IL-1β and HMGb1.P38,JNK,ERK and NF-κb subunit p65 inhibitors could significantly inhibit the secretion of IL-1β,TNF-a and HMGb1 induced by ***,the phosphorylation of p38,JNK,ERK and p65(or nuclear translocation of p65)was significantly increased after LPS *** contrast,pretreatment of anti-nucleolin antibody could significantly inhibit the LPS-induced phosphorylation of p38,JNK,ERK and p65(or nuclear translocation of p65).However,the irrelevant IgG,as a negative control,had no effect on LPS-induced secretion of TNF-a and IL-Iβ and phosphorylation of p38,JNK,ERK and p65(or nuclear translocation of p65).We demonstrated that nucleolin mediated the LPS-induced activation of MAPK and NF-κb signaling pathways,and regulated the secretion of inflammatory mediators(TNF-a,IL-1β and HMGb1).

关键词： nucleolin THP-1 monocytes lipopolysaccharide MAPK NF-κb signaling pathway inflammatory mediators

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Angiogenesis,Kaposi’s Sarcoma and Kaposi’s Sarcoma-associated Herpesvirus

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Virologica Sinica 2008年第6期23卷 449-458页

作者： Tao KANG feng-chun Ye Shou-jiang gao Lin-ding WAN Tumor Virology Group State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China Tumor Virology Program Greehey Children＇s Cancer Research Institute and Department of Pediatrics The University of Texas Health Science Center at San Antonio San Antonio Texas USA

Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors,serving to supply nutrients and oxygen,and remove metabolic wastes. Kaposi’s sarcoma (KS),a multifocal angioproliferative disorder characterized by spindle cell proliferation,neo-angiogenesis,inflammation,and edema,is associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV). Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines. Many of these cytokines are also expressed in KS lesions,implicating a direct role of KSHV in the pathogenesis of this malignancy. Several KSHV genes are involved in KSHV-induced angiogenesis. These studies have provided insights into the pathogenesis of KS,and identified potential therapeutic targets for this malignancy.

关键词： Angiogenesis Kaposi's sarcoma (KS) Kaposi's sarcoma-associated herpesvirus (KSHV)

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Influence of Chain Architectures on Crystallization behaviors of PLLA block in PEG/PLLA block Copolymers

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Chinese Journal of Polymer Science 2019年第3期37卷 258-267页

作者： Sheng xiang Dong-Dong Zhou Li-Dong feng xin-Chao bian Gao Li xue-Si Chen Tian-Chang Wang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Jilin biomedical Polymers Engineering Laboratory University of Chinese Academy of Sciences South China Advanced Institute for Soft Matter Science and Technology South China University of Technology

The effect of the architecture of poly(ethylene glycol)/poly(L-lactide)(PEG/PLLA) block copolymers on the non-isothermal crystallization behaviors of PLLA blocks was investigated by differential scanning calorimetry(DSC) and wide angle x-ray diffraction(WAxD). 1-Arm MPEG-b-PLLA and 4-arm PEG-b-PLLA(4PEG-b-PLLA) were synthesized by the ring-opening polymerization of Llactide in the presence of poly(ethylene glycol) methyl ether(MPEG) and 4-arm poly(ethylene glycol)(4PEG). 4-Arm PLLA-b-MPEG(4PLLA-b-PEG) was synthesized by coupling 4-arm PLLA and MPEG. The WAxD results indicated that the crystalline structure of PLLA blocks did not alter due to the different chain architectures. The average values of Avrami index(ˉn) were all above 4, which indicated that the nucleation mechanism of PLLA blocks was heterogeneous nucleation, regardless of the architectures. The overall crystallization rates were decreased markedly as following: MPEG-b-PLLA > 4PEG-b-PLLA > 4PLLA-b-PEG, ascribed to the different confinement by PEG blocks and to the steric hindrance of chain architectures. Therefore, the crystallization of PLLA blocks became more difficult and the crystallization activation energy of the PLLA blocks increased due to the confinement of chain architectures.

关键词： Poly(L-lactide) Poly(ethylene glycol)/poly(L-lactide)block copolymer Non-isothermal crystallization Chain architecture

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Role of black Carbon-Induced Changes in Snow Albedo in Predictions of Temperature and Precipitation during a Snowstorm

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Atmospheric and Oceanic Science Letters 2009年第4期2卷 230-236页

作者： ZHANG Ying LIAO Hong ZHU Ke-feng and YIN Yan Key Laboratory for Atmospheric Physics and Environment （LAPE） Nanjing University of Information Science and Technology Nanjing 210044 China State Key Laboratory of Atmospheric boundary Layer Physics andAtmospheric Chemistry （LAPC） Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Laboratory of Cloud-Precipitation Physics and Severe Storms （LACS） Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

In this study the authors apply the chemistry version of the Weather Research and Forecasting model （WRF-Chem） to examine the impacts of black carbon （bC）-induced changes in snow albedo on simulated temperature and precipitation during the severe snowstorm that occurred in southern China during 0800 26 January to 0800 29 January 2008 （Note that all times are local time except when otherwise stated）. black carbon aerosol was simulated online within the WRF-Chem. The model resuits showed that surface-albedo, averaged over 27-28 January, can be reduced by up to 10% by the deposition of bC. As a result, relative to a simulation that does not consider deposition of bC on snow/ice, the authors predicted surface air temperatures during 27-28 January can differ by -1.95 to 2.70 K, and the authors predicted accumulated precipitation over 27-28 January can differ by -2.91 to 3.10 mm over Areas A and b with large bC deposition. Different signs of changes are determined by the feedback of clouds and by the availability of water vapor in the atmosphere.

关键词： black carbon snow albedo weather

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基于能量检测的自适应通信频谱感知算法

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通信技术 2024年第4期57卷 375-378页

作者：石伟宏唐韬赵润晖文红冯学炜电子科技大学航空航天学院四川成都611731 电子科技大学飞行器集群智能感知与协同控制四川省重点实验室四川成都611731 电子科技大学四川省智慧物联通信技术工程研究中心四川成都611731

在传统的能量检测算法的基础上,对于无法准确测量噪声功率的信号,提出了一种基于能量检测的自适应通信频谱感知算法。该算法考虑了在噪声功率估计值不准确时利用噪声功率计算能量检测判决门限的问题,能够对先验信息较少和噪声功率无法... 详细信息

在传统的能量检测算法的基础上,对于无法准确测量噪声功率的信号,提出了一种基于能量检测的自适应通信频谱感知算法。该算法考虑了在噪声功率估计值不准确时利用噪声功率计算能量检测判决门限的问题,能够对先验信息较少和噪声功率无法准确估计的信号进行自适应通信频谱感知。仿真结果表明,基于能量检测的自适应通信频谱感知算法可以有效提高对于信号的频谱感知性能,在合理设置判决系数的条件下,算法可以对信号进行有效检测和感知。

关键词：认知无线电频谱感知能量检测自适应

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Effect of 1,8-Diiodooctane Content on the Performance of P_(3)HT:PC_(61)bM bulk Heterojunction Photodetectors

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Chinese Journal of Polymer Science 2021年第7期39卷 831-837页

作者： xin Wang Shi-Jia Gao Jin-feng Han Yu-Lin Zhang Sai Zhang Wen-Qiang Qiao Zhi-Yuan Wang StateKey Laboratory of Fine Chemicals Department of Polymer Science&MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Department of Materials Science and Engineering and Department of Chemistry Johns Hopkins UniversityBaltimoreMD 21218USA Department of Chemistry Carleton UniversityOntario K1S 5B6Canada

A series of polymer photodetectors with device configuration of ITO/PEDOT:PSS/P_(3)HT:PC_(61)bM/C_(60)/AI were prepared by using P3HT as the donor material and PC61bM as the acceptor *** regulating the content of 1,8-diiodooctane(DIO)(V/V:1%,3%,5%)as a processing additive,the morphology of the active layer can be greatly improved With Ceo as the hole blocking layer,the dark current density of the device can be reduced by about an order of *** employing 3%DIO(V/V)in the active layer processing,the photodetetcors present the best performance,and the detectivity of the device is 1.52×10^(12)Jones at 540 nm under a bias of-0.1 ***,it also has a wider linear dynamic range of 60 db as well as faster response speed(T1/T2=0.53/0.71μs)than those of devices with other content of DIO additives.

关键词： Polymer photodeteaor Configuration 1,8-Diiodooctane Morphology

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Surfactant-enhanced electrochemical detection of bisphenol A based on Au on ZnO/reduced graphene oxide sensor

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Rare Metals 2023年第4期42卷 1274-1282页

作者： Ai-Yun Zha Qing-bing Zha Zhi Li Hong-Min Zhang xue-feng Ma Wen xie Ming-Shan Zhu Department of Nephrology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Department of Clinical Laboratory The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital)Heyuan517000China Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou511443China

bisphenol A(bPA),one of the most commonly used plastic organic monomers,is widely used in manufacturing food packaging and ***,the gradual emissions of bPA from manufacturing plastic products bring great potential in human health threats,which urgently need to develop a simple and rapid method for detecting *** bromide(CTAb),a typical surfactant,is used to enhance the electrochemical detection of trace endocrine disruptors due to the fact that it can effectively enrich and absorb hydrophobic phenolic compounds through the hydrophobicity of its long-chain *** on these,the present study reports a ternary composite of Au on zinc oxide/reduced graphene oxide nanosheets(Au/ZnO/rGO)as electrochemical sensor for detecting bP *** the addition of CTAb,the analytic performances toward bP A detection are significantly improved 3.8 times compared with those without *** pH,accumulation potential and time are ***,the electrochemical activity of CTAb/Au/ZnO/rGO sensor is also evaluated by cyclic voltammetry(CV),electrochemical impedance spectroscopy(EIS),differential pulse voltammetry(DPV)and scan *** sensor displays two linear range from 10to 1340 nmol·L^(-1)and 1340 to 10,000 nmol·L^(-1),and a low detection limit of 4.95 nmol·L^(-1).Lastly,the sensor also exhibits good reproducibility,selectivity and potential practical application for bPA detection in real samples.

关键词： bisphenol A(bPA) Cetyltrimethylammonium bromide(TAb) Electrochemical detection(ED) Electron transmission

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Solidification microstructures of Al-Zn-Mg-Cu alloys prepared by spraydeposition and conventional casting methods

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Rare Metals 2008年第2期27卷 210-215页

作者： HE xiaoqing xIONG baiqing SUN Zeming ZHANG Yongan WANG feng ZHU baohong State Key Lab for Fabrication ＆ Processing of Nonferrous Metals/National Analysis and Testing Center for Nonferrous Metals ＆ Electronic Materials General Research Institute for Nonferrous Metals Beijing 100088 China

High strength Al-Zn-Mg-Cu alloys were prepared by spray deposition and casting techniques. The microstructures of the Al-Zn-Mg-Cu alloys were studied using scanning electron microscopy, transmission electron microscopy, and x-ray diffraction. Secondary phases in the microstructures of the alloys prepared by spray deposition and conventional cast were examined. The results indicate that under the conventional casting condition, the microstructure of the alloy revealed the presence of coarse Al/Mg（ZnCu）2 eutectic phases, and the spray deposited process causes an obvious modification in size, morphology, and distribution of secondary phases in the microstructure as well as reduction of segregation. The superior microstructure of the spray-deposited Al-Zn-Mg-Cu alloy was attributed to the high cooling rate, and associated with the rapid solidification process.

关键词： aluminium alloys spray deposition conventional casting microstructure

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CD19^(+)CD27^(+)IgD^(+)b细胞与甲状腺相关性眼病患者疾病活动度相关性研究

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包头医学院学报 2024年第4期40卷 33-37页

作者：冯月兰刘志英王媛媛张伟包头医学院第一附属医院内蒙古包头014010

目的:探讨甲状腺相关性眼病(thyroid-associated ophthalmopathy,TAO)患者外周血CD19^(+)CD27^(+)IgD^(+)b细胞比例变化与病情活动度的关系。方法:采用流式细胞术检测TAO患者和健康对照组CD19^(+)CD27^(+)IgD^(+)b细胞比例,分析TAO患者CD19^(+)CD27^(+)IgD^(+)b细胞比例与健康对照组的差异,并分析CD19^(+)CD27^(+)IgD^(+)b细胞比例与TAO疾病活动度之间的相关性。结果:TAO患者CD19^(+)CD27^(+)IgD^(+)b细胞比例明显低于健康对照(Pb细胞比例细胞显著低于非活动性TAO患者;CD19^(+)CD27^(+)IgD^(+)b细胞比例与TAO患者CAS评分呈显著负相关(r=-0.7128,Pb细胞比例降低,与疾病活动度呈负相关。

关键词：甲状腺相关性眼病疾病活动度 CD19^(+)CD27^(+)IgD^(+)b细胞流式细胞术

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猪毛菜总生物碱提取工艺优化研究

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山东化工 2024年第17期53卷 59-63页

作者：冯煜博冀子婵闫鹏赵聪憬陈叶洛阳师范学院食品与药品学院河南洛阳471934

以猪毛菜总生物碱提取率为指标,通过单因素试验和响应面试验优化猪毛菜总生物碱提取工艺。以DPPH和羟基自由基清除率确认猪毛菜总生物碱抗氧化能力。结果表明,猪毛菜总生物碱最优提取工艺为液料比36∶1(mL∶g)、超声提取时间60 min、复... 详细信息

以猪毛菜总生物碱提取率为指标,通过单因素试验和响应面试验优化猪毛菜总生物碱提取工艺。以DPPH和羟基自由基清除率确认猪毛菜总生物碱抗氧化能力。结果表明,猪毛菜总生物碱最优提取工艺为液料比36∶1(mL∶g)、超声提取时间60 min、复合酶含量2%、酶解时间1.4 h、乙醇体积分数57%,在最优条件下,猪毛菜总生物碱提取率可达0.6982%。抗氧化活性实验表明,随着猪毛菜生物碱浓度增加,抗氧活性随之增加,当猪毛菜生物碱质量浓度为0.5 mg/mL时,DPPH自由基和羟基自由基清除率分别达到84.34%和75.69%。本研究优化了猪毛菜总生物碱的提取工艺,初步分析猪毛菜生物碱抗氧化活性,为猪毛菜有效药用成分的分析研究和功能性食品的开发提供科学依据。

关键词：猪毛菜总生物碱提取工艺响应面法抗氧化活性

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