检索结果-南通市图书馆

Helmholtz decomposition with a scalar Poisson equation in elastic anisotropic media

Petroleum Science 2024年第3期21卷 1597-1610页

作者： xin-Yu Fang Gang Yao Qing-Qing Zheng Ping-Min Zhang Di Wu feng-Lin Niu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Unconventional Petroleum Research Institute China University of Petroleum(Beijing)Beijing102249China Department of Mathematics College of ScienceChina University of Petroleum(Beijing)Beijing102249China College of Geophysics China University of Petroleum(Beijing)Beijing102249China Department of Earth Environmental and Planetary SciencesRice UniversityHoustonTX77005UA

P-and S-wave separation plays an important role in elastic reverse-time *** can reduce the artifacts caused by crosstalk between different modes and improve image *** addition,P-and Swave separation can also be used to better understand and distinguish wave types in complex *** present,the methods for separating wave modes in anisotropic media mainly include spatial nonstationary filtering,low-rank approximation,and vector Poisson *** of these methods require multiple Fourier transforms or the calculation of large matrices,which require high computational costs for problems with large *** this paper,an efficient method is proposed to separate the wave mode for anisotropic media by using a scalar anisotropic Poisson operator in the spatial *** 2D problems,the computational complexity required by this method is 1/2 of the methods based on solving a vector Poisson ***,compared with existing methods based on pseudoHelmholtz decomposition operators,this method can significantly reduce the computational *** examples also show that the P and S waves decomposed by this method not only have the correct amplitude and phase relative to the input wavefield but also can reduce the computational complexity significantly.

关键词： Anisotropic media Scalar anisotropic Poisson equation Improved elastic wavefield decomposition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng Ma Jin-xin Fu feng Duan Mao-Qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical School Beijing 100853China

bACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April *** survival(OS)and progression-free survival(PFS)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in Solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median OS was 26.43 months(95%CI:17.00-35.87),and the median PFS was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with barcelona Clinic Liver Cancer Classification(bCLC)b stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior OS and PFS than their *** This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with bCLC b-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of ball Milling Time on Microstructure and Hydrogen Storage Properties of Nd_(5)Mg_(41)Ni Alloy

引用

Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1201-1214页

作者： Zeming Yuan Chenxu Liu xiaoming Li Yongqi Sui Zhonggang Han Tingting Zhai Dianchen feng Yanghuan Zhang Instrumental Analysis Center Inner Mongolia University of Science and TechnologyBaotou014010China Department of Functional Material Research Central Iron and Steel Research InstituteBeijing100081China

Mg-based alloys must be dehydrogenated at high pressure and temperatures, limiting their practical application. In this paper, Nd_(5)Mg_(41)Ni alloy was prepared by vacuum melting, and the as-cast alloy was ball milled for 5 h, 10 h, 15 h, and 20 h. The effect of ball milling time on the microstructure and hydrogen storage properties of the alloy was systematically studied. The alloy comprises Nd_(5)Mg_(41), NdMg_(12), NdMg_(3), and Mg_(2)Ni phases. The Nd_(5)Mg_(41)Ni alloy milling for 10 h can reach 95% of the saturated hydrogen absorption at 553 K by 40 s, and the alloy can desorb hydrogen only by 20 min. The dehydrogenation activation energy is only 99.9 kJ/mol H_(2). ball milling makes the alloy produce many nanocrystalline and amorphous structures. The nano-grain boundary provides a channel for the diffusion of hydrogen atoms, and the high energy at the grain boundary provides energy for the phase deformation nucleus. ball milling leads to the refinement of alloy particles and shortens the diffusion distance of hydrogen atoms to the interior of alloy particles. Defects such as twins and dislocations generated by milling provide energy for the phase deformation nucleus during the hydrogen absorption and desorption.

关键词： Hydrogen storage materials Magnesium-base alloy ball milling Nanocrystal Kinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance Li-ion battery

引用

Rare Metals 2024年第7期43卷 2994-3006页

作者： Ying Li Yi-Han Zhao Lu-Lu Zhao Peng-Fei Wang Ying xie Ting-feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries(LIbs)due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of Li~+limits its practical *** this work,C-Sb composite was constructed as anode material of LIbs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2(the mass ratio of polyacrylonitrile to Sb source is 1:2)electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g^(-1)at 0.1,0.2,0.3,0.5,1 and 2 A·g^(-1),*** when the current density returned to 0.1 A·g^(-1),the charge capacity was 939.3 mAh·g^(-1),revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ xRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory(DFT)calculations revealed the gradual enhancement of the interface interaction between Sb_(x)Li_(y) and amorphous carbon(AMC)with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sb_(x)Li_(y) to *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： Li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

引用

Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： Yujing Huang xiaohan Guo Yi Wu xingyu Chen Lixiang feng Na xie Guobo Shen Department of biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging *** rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory *** recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated *** types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and *** can also directly combat pathogens and *** addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory *** review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory *** also discusses the challenges associated with clinical translation in this field and explores the latest developments and *** conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

引用

biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han Lin xUE Yan feng CUI bao Qiu LIU Hong SHEN xin xin Shandong Provincial Research Center for bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113,154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the Drugbank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLC6A4,GRIN2A,GRIN2C,SCN10A,and IL1b expression are associated with an increased risk of *** contrast,ADRb1,CHRNA3,HTR3A,GSTP1,and GAbRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The determination of sedimentary environment and associated energy in deep-buried marine carbonates:insights from natural gamma ray spectrometry log

引用

Frontiers of Earth Science 2024年第1期18卷 204-218页

作者： Jingyan LIU Qian CHANG Junlong ZHANG Hui CHAI feng HE Yizan YANG Shiqiang xIA School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Exploration and Development Research Institute Daqing Oilfield CompanyPetroChinaDaqing 163712China China National Oil and Gas Exploration and Development Co. Ltd(CNODC)Beijing 100032China beijing Research Institute of Uranium Geology Beijing 100029China College of Mining Engineering North China University of Science and TechnologyTangshan 063210China

It has always been challenging to determine the ancient sedimentary environment and associated energy in deep-buried marine *** energy represents the hydrodynamic conditions that existed when the carbonates were *** energy includes light and chemical energies in compounds and kinetic energy in currents and mass ***-buried marine carbonates deposited during the Ordovician depositional period in the eastern Tarim basin result from a complex interplay of tectonics,sedimentation,and *** a result,determining the ancient sedimentary environment and associated energy is *** natural gamma-ray spectrometry(GRS)log(from 12 wells)is used in this paper to conduct studies on the sedimentary environment and associated energy in deep-buried marine *** findings show that the values of thorium(Th),uranium(U),potassium(K),and gamma-ray without uranium(KTh)in a natural GRS log can reveal lithological associations,mineral composition,diagenetic environment,stratigraphic water activity,and ancient climatic *** the Ordovician,quantitative analysis and determination of sedimentary environment energy are carried out using a comprehensive calculation of natural GRS log parameters in typical wells(penetrating through the Ordovician with cores and thin sections)of well GC4,well GC6,well GC7,and well *** results show that GRS log can determine different lithology associations in typical wells than a sieve residue ***,cores and thin sections can be used to validate the determination of lithology *** on the determination of lithology associations,the lithology associations that reflect the sedimentary environment and associated energy can be analyzed in a new ***,the sedimentary environment energy curve derived from a natural GRS log can reveal hydrodynamic fluctuations during depositional periods,which will aid in the discovery of carbonate reservoirs,establishing sequence stratigra

关键词： ancient sedimentary environment energy of sedimentary environment marine deep-buried carbonates natural GRS the Ordovician eastern Tarim basin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway

引用

Current Medical Science 2024年第1期44卷 93-101页

作者： Li-wei ZHANG Hong-qi feng Song-bo FU Dian-jun SUN Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityNHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University)Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceHarbin 150086China

Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein *** induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the *** study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial *** A low Se and low protein animal model was *** hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).ELISA was used to detect serum creatine kinase Mb(CK-Mb),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-GOT)***-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1b light chain 3b(MAP1LC3b).Results The MMP was significantly decreased and the activity of CK-Mb,cTnI,and M-GOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(Pxpression levels of PINK1,Parkin and MAP1LC3b were profoundly increased,and those of P62 markedly decreased in the experimental groups compared with the control group(Pxacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.

关键词： Keshan disease low selenium and low protein myocardial mitochondrial injury PTEN induced putative kinase 1(PINK1)/Parkin mitochondrial autophagy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation on photonic crystal nanobeam cavity based on mixed diamond–circular holes

引用

Nanotechnology and Precision Engineering 2024年第1期7卷 63-70页

作者： Jingtong bin Kerui feng Shang Ma Ke Liu Yong Cheng Jing Chen Qifa Liu College of Telecommunication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210003China State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China

A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is *** performance of the cavity is simulated and studied *** theﬁnite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance *** modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding *** optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength *** can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole ***,the energy can be conﬁned within a small mode volume to achieve an ultra-high Q/Vm ratio.

关键词： Photonic crystal nanobeam cavity Mixed diamond–circular holes Slots and anti-slots FDTD simulation Quality factor Mode volume

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization,expression dynamics,and potential function of OPA1 for regulation of mitochondrial morphology during spermiogenesis in Phascolosoma esculenta

引用

Journal of Oceanology and Limnology 2024年第1期42卷 187-200页

作者： xinming GAO binbin feng Chen DU Congcong HOU Shan JIN Daojun TANG Junquan ZHU Key Laboratory of Applied Marine biotechnology by the Ministry of Education and Key Laboratory of Marine biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China College of Ecology Lishui UniversityLishui 323000China

Mitochondria undergo morphological changes during spermatogenesis in some *** mechanism and role of mitochondrial morphology regulation,however,remain somewhat *** this study,we analyzed the molecular characteristics,expression dynamics and subcellular localization of optic atrophy protein 1(OPA1),a mitochondrial fusion and cristae maintenance-related protein,to reveal the possible regulatory mechanisms underlying mitochondrial morphology in Phascolosoma esculenta *** full-length cDNA of the *** opa1 gene(Pe-opa1)is 3743 bp in length and encodes 975 amino *** Pe-OPA1 protein is highly conservative and includes a transmembrane domain,a GTPase domain,two helical bundle domains,and a lipid-interacting *** and protein expression was higher in the coelomic fluid(a site of spermatid development)of male *** and increased first and then decreased from March to ***,their expression during the breeding stage was significantly higher than during the non-breeding stage,suggesting that Pe-OPA1 is involved in *** *** Pe-OPA1 protein was more abundant in components consisting of many spermatids than in components without,indicating that Pe-OPA1 mainly plays a role in the spermatid in coelomic ***,Pe-OPA1 was mainly detected in the spermatid *** experiments showed that the Pe-OPA1 are constitutively expressed and co-localized with mitochondria during spermiogenesis,suggesting its involvement in *** *** results provide evidence for Pe-OPA1's involvement in the regulation of mitochondrial morphology during spermiogenesis.

关键词： optic atrophy protein 1(OPA1) spermiogenesis Phascolosoma esculenta mitochondrial dynamics spermatid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：