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急性冠状动脉综合征患者经皮冠状动脉介入术后出血情况分析

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中国医药 2017年第6期12卷 801-805页

作者：严研王晓范婧尧聂绍平宋现涛 Sergio Raposeiras-Roubin Emad Abu-Assi Jose Paulo Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose Ramon Gonza1ez-Juanatey Stephen b. wilton Ivan Nufiez-Gil Albert Ariza-Sole Dimitrios Alexopoulos [ Christoph Liebetrau Testuma Kawaji Zenon Huczek Toshiharu Fujii Luis Claudio Correia Masa-aki Kawashiri Sasko Kedev 首都医科大学附属北京安贞医院急诊危重症中心 100029 首都医科大学附属北京安贞医院心内科 100029 西班牙比戈市阿尔瓦罗康克雷诺医院心内科 36312 荷兰阿姆斯特丹大学学术医学中心心内科 1105 意大利都灵市圣乔瓦尼巴蒂斯塔医院心内科 10126 美国芝加哥市北岸大学医院心内科 60201 西班牙圣地亚哥·德·孔波斯特拉大学临床医院心内科 15706 加拿大卡尔加里市阿尔伯塔省利宾心血管研究所心脏科学医学科 T2N4N1 西班牙马德里市圣卡洛斯医院心内科 28040 西班牙巴塞罗纳市贝尔维尔医院心内科 08907 希腊雅典市佩特雷大学医院心内科 26504 德国法兰克福市基尔霍夫胸腔心脏中心心内科 61231 日本京都大学医学研究生院心内科 606-8507 日本东京市东海大学医学院心内科 259-1193 巴西萨尔瓦多市圣拉斐尔医院心内科 41253-190 日本金泽大学医学研究生院心内科 920-0942 马其顿斯科普里市临床心脏病诊所心内科 1000

目的分析急性冠状动脉综合征（ACS）经皮冠状动脉介入（PCI）术后出血情况。方法回顾性分析2003年1月至2014年12月来自11个国家16个临床中心的18077例行PCI的ACS患者的临床资料。根据是否出现出血事件，将患者分为出血组（558例）和非... 详细信息

目的分析急性冠状动脉综合征（ACS）经皮冠状动脉介入（PCI）术后出血情况。方法回顾性分析2003年1月至2014年12月来自11个国家16个临床中心的18077例行PCI的ACS患者的临床资料。根据是否出现出血事件，将患者分为出血组（558例）和非出血组（17519例），比较2组患者的基本临床特征、手术情况及生化指标。分析ACS患者PCI术后出血相关情况。结果马其顿中心数据因关键变量缺失过多而被排除患者2676例，故最终纳入10个国家15个中心15401例ACS患者。排除缺失数据，本研究共有12910例患者收集到出血部位的数据，409例患者存在出血事件。胃肠道是最常见出血部位，占48．7％（199／409），颅内出血占7．6％（31／409）。Logistic逐步回归方法多因素分析显示，既往出血病史、高血压病史是术后1年内消化道出血的危险因素。排除马其顿中心数据（2676例）与Cox回归模型和倾向性评分调整再排除5972例，剩余9429例作分层分析。根据是否联用质子泵抑制剂（PPI），将出院应用氯吡格雷生存患者8942例分为氯吡格雷联合应用PPI组（4814例）和氯吡格雷未联合应用PPI组（4126例）；将出院应用替格瑞洛生存患者489例分为替格瑞洛联合应用PPI组（351例）和替格瑞洛未联合应用PPI组（138例）。Kaplan-Meier法分析显示氯吡格雷联合应用PPI组1年出血事件发生率明显高于氯吡格雷未联合应用PPI组，差异有统计学意义（P=0．004）；替格瑞洛联合应用PPI组1年出血事件发生率与替格瑞洛未联合应用PPI组比较，差异无统计学意义（P=0．573）。结论ACS患者PCI术后最常见的出血部位为消化道，PPI与替格瑞洛联合应用在胃肠道出血风险较高患者中适用。

关键词：急性冠状动脉综合征出血质子泵抑制剂氯吡格雷替格瑞洛

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi bansal Razaz Waheeb Attar Mosiur Rahman brij b.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

Machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： badi Rawashdeh Haneen Al-abdallat Emre Arpali beje Thomas Ty b Dunn Matthew Cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

bACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United States emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence Solid organ transplantation bibliometric analysis

Compact embedding in besov spaces and b-separable elleptic operators

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Science China Mathematics 2010年第4期53卷 1067-1084页

作者： SHAKHMUROV Veli b. Department of Electronics Engineering and Communication Okan University

Necessary and sufficient conditions for compactness of sets in banach space valued besov class bp,q s(Ω;E) is *** embedding theorems in besov-Lions type spaces b l,s p,q(Ω;E0,E) are studied,where E0,E are two banach spaces and E 0  *** most regular class of interpolation space E α,between E 0 and E are found such that the mixed differential operator D α is bounded and compact from b p,q l,s (Ω;E 0,E) to b p,q s (Ω;E α) and Ehrling-Nirenberg-Gagliardo type sharp estimates *** using these results the separability of differential operators with variable coefficients and the maximal b-regularity of parabolic Cauchy problem are *** applications,the infinite systems of the elliptic partial differential equations and parabolic Cauchy problems are studied.

关键词： embedding theorems banach-valued function spaces differential-operator equations maximal b-regularity operator-valued Fourier multipliers interpolation of banach spaces abstract parabolic Cauchy problem

Estimation of radiative capture^(13)b(n,γ0+1)^(14)b reaction rate in the modified potential cluster model

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Chinese Physics C 2023年第10期47卷 130-142页

作者： A.S.Tkachenko N.A.burkova b.M.Yeleusheva S.b.Dubovichenko Fesenkov Astrophysical Institute 050020AlmatyKazakhstan al-Farabi Kazakh National University 050040AlmatyKazakhstan

We discuss current attempts to employ the modified potential cluster model to describe the available experimental data on the^(13)b(n,γ0+1)^(14)b total *** estimated results of the M1 and E1 transitions from the n^(13)b scattering states to the ground and first excited states of^(14)b are *** 1st resonance at Ex=1.275 MeV(1+)is revealed in both the cross-section and reaction *** the variation in the asymptotic constant,a thermal cross-section interval of 5.1-8.9 mb is *** on the theoretical total cross-sections at energies of 0.01 eV to 5 MeV,we calculate the reaction rate in the temperature range of 0.01 to *** ignition T9 values of the^(13)b(n,γ0+1)^(14)b reaction depending on a neutron number density n_(n)of~10^(22)cm^(−3)are *** radiative neutron capture reaction rates on the boron^(10-13)b and carbon^(12-14)Сisotopes are compared.

关键词： radiative neutron capture ^(14)b nucleus total cross-sections reaction rate potential cluster model r-process

Microstructural characteristics of Nd_2Fe_(14)b/α-Fe nanocomposite ribbons bearing Nb element

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Rare Metals 2008年第3期27卷 299-302页

作者： WANG Zhanyong LIU Wenqing ZHOU bangxin NI Jiansen XU Hui LI Qiang Department of Materials Engineering Shanghai Institute of Technology Shanghai 200235 China Institute of Materials Shanghai University Shanghai 200072 China

The effects of Nb on the microstructure and magnetic properties of （Nd0.9Dy0.1）9.5Fe79_xCo5Nbxb6.5 （x = 0, 1） nanocomposite magnets were investigated. A fine and uniform microstructure was achieved for the ribbons annealed at 710℃ for 4 min, enhancing the interaction coupling between grains and improving the magnetic properties. The results of three-dimensional atom probe （3DAP） indicated that Fe-Nb-b inter- granular phase existed at the grain boundaries, suppressing the grain growth during the crystallization process. The coercivity was improved from 224 to 643 kA/m for the modification of the microstructure.

关键词： Nd2Fe14b/α-Fe nanocomposite magnet 3DAP magnetic properties

The fat and the furious:fatty acids fuel hyperproliferative germinal center b cells

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Cellular & Molecular Immunology 2020年第8期17卷 794-796页

作者： Rens Peeters Annemiek b.van Spriel Department of Tumor Immunology Radboud Institute for Molecular Life SciencesRadboudumcNijmegenThe Netherlands

The germinal center(GC)reaction is considered the cornerstone of our humoral immune *** in specialized follicles inside secondary lymphoid organs,germinal center b cells(GCbCs)execute a pivotal *** an infection,the number of GCbCs is rapidly expanded,and subsequently GCbCs differentiate into specialized antibody-secreting *** intricate process is driven by the positive selection of GCbCs via the b-cell receptor with the highest affinity for the respective *** this period of extensive proliferation,GCbCs are among the fastest dividing cells in our *** has been established that cell proliferation requires tremendous amounts of energy and building ***,there remains a paucity of evidence to explain how proliferating GCbCs meet these metabolic *** their latest publication in Nature Immunology,Weisel et *** new insights that may have a far-reaching impact on the evolution of the immunometabolism field.

关键词： metabolism organs specialized

Distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naphthofurans in source rock extracts from Niger Delta basin,Nigeria

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Acta Geochimica 2020年第6期39卷 973-987页

作者： Abiodun b.Ogbesejana Oluwasesan M.bello Department of Applied Chemistry Federal University Dutsin-MaP.M.B.5001Dutsin-MaKatsina StateNigeria

The distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naptho-furans in source rocks from Niger Delta basin,Nigeria,were investigated by Rock-Eval pyrolysis and gas chro-matography--mass spectrometry(GC--MS).The data obtained from the source rocks evaluation showed that the rock samples contained type 1/III kerogen capable of generating oil and gas and were within immature to early mature *** relative abundance of the Cor,C1-and C2-dibenzofurans range from 1.75%to 29.82%,27.60%to 40.52%and 29.66%to 6889%,*** diben-zofurans were dominated by *** the C1-dibenzofurans,2-+3-methyldibenzofuran was the most abundant in the rock samples while 1-methy ldibenzofuran appeared to be the *** relative abundance of benzo[b]naphtho[1,2-d]furan(1,2]bNF),benzo[b]naph-tha[2,1-d]furan(2.1]bNF)and benzo[b]naphtha[2,3-d]fu-ran([2.3]bNF)in the rock extracts range from 12.01%to 52.58%,32.61%to 75.219%and 10.27%to 52.43%.The wide range of values recorded for the three isomers of benzo[b lnapthofurans in the samples suggest source rocks formed from mixed organic *** the pheny ldibenzofuran isomers,4-pheny ldibenzofuran was the most abundant while 1-phenyldibenzofuran was the *** ratio-1(PhFR-1)and pheny ldibenzofuran ratio-2(PhFR-2)values range from 0.13 to 1.20 and 0.11 to 2.11,*** resuls showed that the relative abundance of PhFR-1 and PhFR-2 increase gradually with increasing burial depth and maturity(VRo≤0.77%,MPI-1≤*** s 443℃),and have a good correlations with calculated vitrinite ***-I and maximum Temperature(Tmax)-This range of values suggested immature to early mature source *** source rocks were found to have shale and coul lithologics and deposited in a lacustrine/fuvial deltaic settings within immature to early mature stages based on the distribution of dibenzofurans,pheny ldiben-zofurans and benzo[b]naphthofurans in the source rock

关键词： Dibenzofurans benzo[b]napthofurans Source rocks Niger delta Gas chromatography-mass spectrometry