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中国神经科学学会第十二届全国学术会议

作者： Mengyao Huang Xiaoxiu tie Laijian Wang bin Jiang Guangdong Province Key Laboratory of brain Function and Disease Faculty of Forensic Medicine Zhongshan School of Medicine Sun Yat-sen University

Objective Some neurons in lateral hypothalamus release the peptides orexin A and b（also know as hypocretin 1 and 2）. As is evident from the pathological consequences of its absence in narcolepsy, orexin appears to be critical for the maintenance of wakefulness. Via diffuse projections through the brain, orexin-containing neurons in the hypothalamus may act on a number of wake-promoting systems. Indeed, the axons of these orexin-containing neurons project to the whole brain including visual cortex. It is reported that orexin can depolarize and excite some types of neurons, named as orexin-sensitive neuron in layer 6 b of visual cortex by the decrease of a potassium conductance. However, neurons in layer 6 b demonstrate the different cellular morphology and each neuron displays specific input and output connections as well as specialized local circuitry. Which cell types are sensitive to orexin and whether orexin mediates the synaptic transmission to these orexin-sensitive neurons in layer 6 b of visual cortex are unanswered. Methods Photomicrograph of biocytin-loaded cells from visual cortical slices was used for the cellular morphology of orexin-sensitive neurons. Wholecell EPSCs were recorded in orexin-sensitive neurons in layer 6 b evoked from layer 5 and orexin b was bath application to cortical slices. Results（1）: About 52% of pyramidal neuron and 45% of multipolar spiny neuron, but not other types of neurons in layer 6 b are sensitive to orexin b.（2） Orexin b induced an LTP-like enhancement of EPSCs recorded in these orexin-sensitive neurons in layer 6 b evoked from layer 5. This effect was blocked by orexin b receptor antagonist, by a phospholipase C inhibitor, and by Ca 2+ chelator, respectively. Conclusion In layer 6 b of mouse visual cortex, pyramidal neuron and multipolar spiny neuron are orexin-sensitive neurons and orexin b potentiates the excitatory synaptic transmission to these orexin-sensitive neurons.

关键词： Visual cortex Layer 6b Orexin b Orexin-sensitive neurons Excitatory synaptic transmission

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Simulating hydrological responses to climate change using dynamic and statistical downscaling methods: a case study in the Kaidu River basin, Xinjiang, China

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Journal of Arid Land 2018年第6期10卷 905-920页

作者： bA Wulong DU Pengfei LIU tie bAO Anming LUO Min Mujtaba HASSAN QIN Chengxin State Key Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua University Beijing 100084China State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Department of Space Sciences Institute of Space TechnologyIslamabad 44000Pakistan

Climate change may affect water resources by altering various processes in natural ecosystems. Dynamic and statistical downscaling methods are commonly used to assess the impacts of climate change on water resources. Objectively, both methods have their own advantages and disadvantages. In the present study, we assessed the impacts of climate change on water resources during the future periods (2020–2029 and 2040–2049) in the upper reaches of the Kaidu River basin, Xinjiang, China, and discussed the uncertainties in the research processes by integrating dynamic and statistical downscaling methods (regional climate models (RCMs) and general circulation modes (GCMs)) and utilizing these outputs. The reference period for this study is 1990–1999. The climate change trend is represented by three bias-corrected RCMs (i.e., Hadley Centre Global Environmental Model version 3 regional climate model (HadGEM3-RA), Regional Climate Model version 4 (RegCM4), and Seoul National University Meso-scale Model version 5 (SUN-MM5)) and an ensemble of GCMs on the basis of delta change method under two future scenarios (RCP4.5 and RCP8.5). We applied the hydrological SWAT (Soil and Water Assessment Tool) model which uses the RCMs/GCMs outputs as input to analyze the impacts of climate change on the stream flow and peak flow of the upper reaches of the Kaidu River basin. The simulation of climate factors under future scenarios indicates that both temperature and precipitation in the study area will increase in the future compared with the reference period, with the largest increase of annual mean temperature and largest percentage increase of mean annual precipitation being of 2.4°C and 38.4%, respectively. based on the results from bias correction of climate model outputs, we conclude that the accuracy of RCM (regional climate model) simulation is much better for temperature than for precipitation. The percentage increase in precipitation simulated by the three RCMs is generally higher t

关键词： RCM GCM climate change downscaling bias correction SWAT Tianshan Mountains

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Rapid and controllable in-situ self-assembly of main-group metal nanofilms for highly efficient CO_(2)electroreduction to liquid fuel in flow cells

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Nano Research 2024年第6期17卷 5718-5725页

作者： Miao Wang Huaizhu Wang Yaoda Wang Junchuan Liang Mengfei Zhu Jiarui Li Zuoxiu tie Zhong Jin State Key Laboratory of Coordination Chemistry MOE Key Laboratory of Mesoscopic ChemistryMOE Key Laboratory of High Performance Polymer Materials and TechnologyJiangsu Key Laboratory of Advanced Organic MaterialsTianchang New Materials and Energy Technology Researc

The electrocatalytic reduction of CO_(2)is a promising pathway to generate renewable fuels and ***,its advancement is impeded by the absence of electrocatalysts with both high selectivity and ***,we present a scalable in-situ thermal evaporation technique for synthesizing series of bi,In,and Sn nanofilms on carbon felt(CF)substrates with a high-aspect-ratio *** resulting main-group metal nanofilms exhibit a homogeneously distributed and highly exposed catalyst surface with ample active sites,thereby promoting mass transport and ad-/desorption of reaction *** from the unique fractal morphology,the bi nanofilms deposited on CF exhibit optimal catalytic activities for CO_(2)electroreduction among the designed metal nanofilms electrodes,with the highest Faradaic efficiency of 96.9%for formate production at−1.3 V *** hydrogen electrode(RHE)in *** an industrially relevant current density of 221.4 mA·cm−2 in flow cells,the bi nanofilms retain a high Faradaic efficiency of 81.7%at−1.1 V(***)and a good long-term stability for formate ***,a techno-economic analysis(TEA)model shows the potential commercial viability of electrocatalytic CO_(2)conversion into formate using the bi nanofilms *** results offer a green and convenient approach for in-situ fabrication of stable and inexpensive thin-film catalysts with a fractal structure applicable to various industrial settings.

关键词： CO_(2)electroreduction non-noble metal nanofilms flow cells efficiency and selectivity techno-economic analysis

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Correlation of microRNAs responding to high dose γ-irradiation with predicted target mRNAs in HeLa cells using microarray analyses

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Chinese Science bulletin 2013年第36期58卷 4622-4629页

作者： HU Zheng tie Yi Lü GuiXiang FU HanJiang XING RuiYun ZHU Jie SUN ZhiXian ZHENG XiaoFei beijing Institute of Radiation Medicine Department of biochemistry and Molecular biology Harbin Medical University

An increasing data indicates that altered microRNAs(miRNAs)participate in the radiation-induced DNA damage ***,a correlation of mRNA and miRNA profiles across the entire genome and in response to irradiation has not been thoroughly *** analyzed miRNA microarray data collected from HeLa cells after ionizing radiation(IR),quantified the expression profiles of mRNAs and performed comparative analysis of the data sets using target prediction algorithms,Gene Ontology(GO)analysis,pathway analysis,and gene network *** results showed that the altered miRNAs were involved in regulation of various cellular ***-gene network analyses revealed that miR-186,miR-106b,miR-15a/b,CCND1and CDK6 played vital role in the cellular radiation *** qRT-PCR,we confirmed that twenty-two miRNAs showed differential expression in HeLa cells treated with IR and some of these miRNAs affected cell cycle *** study demonstrated that miRNAs influence gene expression in the entire genome during the cellular radiation response and suggested vital pathways for further research.

关键词： HeLa细胞目标基因 microRNA 预测算法微阵列分析照射高剂量 miRNA

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The Ecological Effects of Young Elm Trees belt-Pumpkin Strip Intercropping System at the Agro-Pastoral Ecotone in Northern China

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Agricultural Sciences in China 2010年第8期9卷 1183-1193页

作者： DU Xiong DOU tie-ling FENG Li-xiao ZHANG Wei-hong ZHANG Li-feng College of Agronomy Agricultural University ofHebei Baoding 071001 P.R.China Zhangbei Agricultural Resource and Ecological Environment Key Field Research Station Ministry of Agriculture Zhangjiakou 076450 P. R. China College of Plant Protection Agricultural University of Hebei Baoding 071001 P.R. China

Young elm trees belt-pumpkin strip intercropping was studied to solve the actual problem of resource losses in the large barren area resulted from reconverting cultivated land into forest in the agro-pastoral ecotone in northern China. The final objective was to realize effective utilization of the barren land with both ecological improvement and economic development. Field experiments were conducted together with laboratory analysis. The results indicated that the soil moisture level was remarkably increased in young elm trees belt-pumpkin strip intereropping because the pumpkin vines covered the gap between pumpkin planting-furrow and elm trees belt. The water use efficiency of the intercropping system was increased by 23.7-163.3% as compared with the single cropping. Elm trees belt-pumpkin strip intercropping changed the sequential succession trend of the grasses growing in the gap of the pumpkin planting-furrow. The annual grasses become the dominant vegetation. The nutritive value as fodder and yield of the annual grasses were also increased remarkably. The biomass of pumpkin, elm trees and grasses under intercropping increased by 24.4, 28.4 and 144.4%, respectively, as compared with those under single cropping. The land use efficiency was increased by 132%. It was also indicated that the soil erosion from the intercropping land was not increased due to pumpkin plantation. The differences in the soil erosion among intercropped area, elm trees belt and pumpkin strip with single cropping were not remarkable. Therefore, it was concluded that young elm trees belt-pumpkin strip intercropping is an effective way to utilize the barren land between the young elm trees belt and realize synergistic enhancement of ecological benefit and economic profit.

关键词： ecotone young elm trees belt-pumpkin strip intercropping water use efficiency land use efficiency ecological benefit economic profit

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Terahertz metadevices for silicon plasmonics

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Chip 2022年第4期1卷 37-65页

作者： Yuan Liang Hao Yu Hong Wang Hao Chi Zhang tie Jun Cui Southern University of Science and Technology(SUSTech) and the Engineer-ing Research Center of Integrated Circuits for Next-Generation Communica-tionsMinistry of EducationSouthern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering&Shenzhen Engineering Research Center for Novel Electronic Information Ma-terials and Devices Southern University of Science and TechnologyShenzhenChina State Key Laboratory of Millimeter Waves and Institute of Electromag-netic Space Southeast UniversityNanjing 210096China

Metamaterial devices(metadevices)have been developed in progress aiming to generate extraordinary performance over traditional de-vices in the(sub-)terahertz(THz)domain,and their planar integra-tion with complementary-metal-oxide-semiconductor(CMOS)cir-cuits pave a new way to build miniature silicon plasmonics that over-comes existing challenges in chip-to-chip *** an effort towards low-power,crosstalk-tolerance,and high-speed data link for future exascale data centers,this article reviews the recent progress on two metamaterials,namely,the spoof surface plasmon polaritons(SPPs),and the split-ring resonator(SRR),as well as their imple-mentations in silicon,focusing primarily on their fundamental the-ories,design methods,and implementations for future THz *** to their respective dispersion characteristic at THz,these two metadevices are highly expected to play an important role in miniature integrated circuits and systems toward compact size,dense integration,and outstanding performance.A design example of a fully integrated sub-THz CMOS silicon plasmonic system integrating these two metadevices is provided to demonstrate a dual-channel crosstalk-tolerance and energy-efficient on-off keying(OOK)communication *** directions and potential applications for THz metade-vices are discussed.

关键词： CMOS I/O transceiver Channel crosstalk Metamaterial Metawaveguide Spoof surface plasmon polaritons Split-ring resonator Terahertz Transmission line Interconnect

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X-site doping in AbX_(3) triggers phase transition and higher T_(c) of the dielectric switch in perovskite

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Chinese Chemical Letters 2021年第11期32卷 3558-3561页

作者： Youya Yu Peizhi Huang Yuzhen Wang Zhixu Zhang tie Zhang Yi Zhang Dawei Fu Ordered Matter Science Research Centerjiangsu Key Laboratory for Science andApplications of Molecular Ferroelectrics Southeast UniversityNanjing 211189China Institute for Science and Applications of Molecular Ferroelectrics Key Laboratory of the Ministry of Education for Advanced Catalysis MaterialsZhejiang Normal UniversityJinhua 321004China

Material stability is always the key factor for applied materials especially the working environment that requires higher temperature sensitivity or temperature fluctuation *** which,the stimulus-response perovskite materials are just sensitive to stability to ensure the accuracy and stability of the signals,in the applied devices of batteries and memory storage devices and so ***,it is still a tremendous challenge to improve the stability of perovskite materials,and maintain reliability in the ***,a novel AbX_(2)X'_(1)(X-site doping in an AbX_(3))compound[CEMP]-[Cdbr_(2)(SCN)](1,CEMP=1-(2-chloro-ethyl)-1-methyl-piperidine)with remarkable high-temperature reversible dielectric switching behavior was *** strategy of[SCN]^(−)doping in perovskite for improving the stability was successfully ***,the steric hindrance is increased while the energy barrier is also increased by replacing hydrogen with flexible groups,which leads to a high-temperature reversible phase *** new finding provides a new direction to enrich new applications and design ideas of perovskite *** the X-site strategy of doping or substitution in the AbX_(3),it will promote ingenious and perfect experimental results in material synthesis and performance improvement by chemistry disciplines.

关键词： Dielectric switch X-site doping High-temperature Phase transition Molecule design

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Magnolol attenuates sepsis-induced gastrointestinal dysmotility in rats by modulating inflammatory mediators

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World Journal of Gastroenterology 2008年第48期14卷 7353-7360页

作者： tie-Cheng Yang Shu-Wen Zhang Li-Na Sun Hong Wang Ai-Min Ren Intensive Care Unit and Medical Department of Infection Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Pharmacology School of Chemical Biology and Pharmaceutical Sciences Capital Medical University Beijing 100069 China

AIM： To investigate the protective effects of magnolol on sepsis-induced inflammation and intestinal dysmotility. METHODS： Sepsis was induced by a single intraperitoneal injection of lipopolysaccharide （LPS）. Male Wistar rats were randomly assigned to one of three treatment groups： magnolol prior to LPS injection （LPS/Mag group）; vehicle prior to LPS injection （LPS/Veh group）; vehicle prior to injection of saline （Control/Veh）. Intestinal transit and circular muscle mechanical activity were assessed 12 h after LPS injection. Tumor necrosis factor-α （TNF-α）, interleukin-10 （IL-10）, monocyte chemoattractant protein-1 （MCP-1） and inducible nitric oxide synthase （iNOS） mRNA in rat ileum were studied by RT-PCR 2 h after LPS injection. Nuclear factor-κb （NF-κb） activity in the intestine was also investigated at this time using electrophoretic mobility shift assay. In addition, antioxidant activity was determined by measuring malondialdehyde （MDA） concentration and superoxide dismutase （SOD） activity in the intestine 2 h after LPS ***： Magnolol significantly increased intestinal transit and circular muscle mechanical activity in LPS- treated animals. TNF-α, MCP-1 and iNOS mRNA expression in the small intestine were significantly reduced after magnolol treatment in LPS-induced septic animals, compared with untreated septic animals. Additionally,magnolol significantly increased IL-10 mRNA expression in septic rat ileum. Magnolol also significantly suppressed NF-κb activity in septic rat intestine. In addition, magnolol significantly decreased MDA concentration and increased SOD activity in rat ileum. CONCLUSION： Magnolol prevents sepsis-induced suppression of intestinal motility in rats. The potential mechanism of this benefit of magnolol appears to be modulation of self-amplified inflammatory events and block of oxidative stress in the intestine.

关键词： Sepsis Motility Cytokines Magnolol Lipopolysaccharide

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Hepatitis b Immunoprophylactic Failure and Characteristics of the Hepatitis b Virus Gene in Mother-Infant Pairs in Parts of China

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biomedical and Environmental Sciences 2016年第11期29卷 790-801页

作者： YIN Wen Jiao SHEN Li Ping WANG Fu Zhen ZHANG Guo Min ZHENG Hui WANG Feng LIU tie Zhu MENG Qing Ling YI Yao CUI Fu Qiang bI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Immunization Planning Program Chinese Center for Disease Controland PreventionBeijing 102206China

Objective To determine the hepatitis b immunoprophylactic failure rate in infants born to hepatitis b virus （HbV） infected mothers and to characterize HbV genes. Methods HbV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HbV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis b vaccination program was 5.76% （32/556）. High sequence homology （99.8%-100%） was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype b2 strains, and 2 subgenotype Cl strains. Three serotypes were detected： adr （19/30）, adw （9/30）, and ayw （2/30）. The frequency of amino acid mutation of the ＇a＇ determinant region was 16.67% （5/30）, including that of Q129H, F134Y,S136Y, and G145E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HbV-infected mothers is low in the regions of China examined during this study. Moreover, HbV mutation in the ＇a＇ determinant region could not account for immunoprophylactic failure for all infants.

关键词： Mother-to-infant transmission Scheduled vaccination Gene characteristics 'a' determinantmutation Immune escape

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Cascade Enzymatic Hydrolysis Coupling with Ultrafine Grinding Pretreatment for Sugarcane bagasse Saccharification

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Chinese Journal of Chemical Physics 2015年第3期28卷 355-360,I0002页

作者： Zheng-qiu Yuan Jin-xing Long tie-jun Wang Yu-qin Li Qi Zhang Long-long Ma Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Science Guangzhou 510640 China University of Chinese Academy of Science Beijing 100049 China School of Chemical EngineerinE Xiangtan University Xiangtan 411105 China

The biorefinery process for sugarcane bagasse saccharification generally requires signifcant accessibility of cellulose. We reported a novel method of cascade cellulase enzymatic hydrol- ysis coupling with ultrafine grinding pretreatment for sugarcane bagasse saccharification. Three enzymatic hydrolysis modes including single cellulase enzymatic hydrolysis, mixed cellulase enzymatic hydrolysis, and cascade cellulase enzymatic hydrolysis were compared. The changes on the functional group and surface morphology of bagasse during cascade cellulase enzymatic hydrolysis were also examined by FT-IR and SEM respectively. The results showed that cascade enzymatic hydrolysis was the most efficient way to enhance the sugarcane bagasse saccharification. More than 65% of reducing sugar yield with 90.1% of glucose selectivity was achieved at 50 ℃, pH=4.8 for 72 h （1200 r/min） with cellulase I of 7.5 FPU/g substrate and cellulase II of 5 FPU/g substrate.

关键词： Sugarcane bagasse Ultrafine grinding pretreatment Cascade enzymatic hydrolysis Reducing sugars Glucose

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