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Analysis of TRPA1 antagonist,A-967079,in plasma using high-performance liquid chromatography tandem mass-spectrometry

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Journal of Pharmaceutical Analysis 2020年第2期10卷 157-163页

作者： Obed A.Gyamfi Nesta bortey-Sam Abigail b.Donkor Carl W.White brian A.Logue Department of Chemistry and biochemistry South Dakota State UniversityBox 2202BrookingsSD57007USA Pediatrics-Pulmonary Medicine University of Colorado-DenverDenverCO80045USA

The noxious effects from exposure to toxic inhalation hazards(TIHs,such as isocyanates,chlorine,etc.)are known to be triggered by the activation of transient receptor potential ankyrin 1(TRPA1)ion *** of TRPA1 have shown near complete attenuation of the noxious effects from TIH *** of the TRPA1 antagonists,(1E,3E)-1-(4-fluorophenyl)-2-methyl-1-pentene-3-one oxime(A-967079),has shown impressive efficacy,high selectivity,high potency,and oral *** a vali-dated method to quantify A-967079 in biological matrices is vital for the further development of A-967079 as a therapeutic agent,no method for its analysis from any matrix is currently ***,a rapid and simple HPLC-MS/MS method was developed and validated to quantify A-967079 in rabbit *** method presented here features an excellent LOD of 25 nM and a wide linear range(0.05-200μM),with good accuracy and precision(100±10.5%andbility of A-967079 in plasma was excellent for most of the storage conditions *** method was successfully applied to determine A-967079 from treated animals and it may facilitate the development of this TRPA1 antagonist as a therapeutic agent against the noxious effects of TIH exposure.

关键词： Transient receptor potential(TRP)ion channel HPLC-MS/MS Toxic inhalation hazard(TIH) Method development Pharmacokinetics

Empirical pairing gaps and neutron-proton correlations

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Chinese Physics C 2019年第1期43卷 109-121页

作者： b.S.Ishkhanov S.V.Sidorov T.Yu.Tretyakova E.V.Vladimirova Faculty of Physics Lomonosov Moscow State University Skobeltzyn Institute of Nuclear Physics Lomonosov Moscow State University

Analysis of various mass formulas related to neutron-proton correlations in atomic nuclei is carried *** the example of the N =Z chain it is shown that for self-adjoint nuclei various formulas proposed in literature for estimating the np pairing energy lead to similar results. Significant differences between the calculation methods arise when nuclei with N = Z are considered, which allows to reveal the complexity of neutron-proton correlations in different types of atomic nuclei and to make assumptions on the correspondence of the mass relation to the real effect of np pairing. The Shell Model parametrization of the binding energy makes it possible to draw additional conclusions on the structure of mass formulas and their relationship.

关键词： nucleon interaction models of atomic nuclei nucleon pairing in atomic nuclei

Nonlinear vibration of an elastically restrained tapered beam

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Science China(Physics,Mechanics & Astronomy) 2012年第10期55卷 1925-1930页

作者： KARIMPOUR S. GANJI S.S. bARARI A. IbSEN L.b. DOMAIRRY G. Department of Civil and Mechanical Engineering Babol University of TechnologyP.O.Box 484BabolIran Young Researchers Club Science and Research BranchIslamic Azad UniversityTehranIran Department of Civil Engineering Aalborg UniversitySohng rdsholmsvej 57DK-9000 AalborgAalborgDenmark

This paper presents the analytical simulation of an elastically restrained tapered cantilever beam using the energy balance method(EbM) and the iteration perturbation method(IPM).To assess the accuracy of solutions,we compare the results with the harmonic balance method(HbM).The obtained results from EbM and IPM are in excellent agreement with HbM *** results show that both methods can be easily extended to other nonlinear oscillations and it can be predicted that both methods can be found widely applicable in engineering and physics.

关键词： energy balance method (EbM) iteration perturbation method (IPM) nonlinear oscillation

INFLUENCES OF CASTING SPEED AND SEN DEPTH ON FLUID FLOW IN THE FUNNEL TYPE MOLD OF A THIN SLAb CASTER

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Acta Metallurgica Sinica(English Letters) 2007年第1期20卷 15-26页

作者： b.W. Li X.Y. Tian E.G. Wang J.C. He Key Laboratory of National Education Ministry for Electromagnetic Processing of Materials Northeastern University Shenyang 110004 China

In recent years, thin slab continuous casting technology has been widely used to improve the quality of the product and to reduce the cost. One of the challenges faced by this technology is to design reasonable flow patterns, which strongly affect the surface and inner properties of the final slab in the mold. With the fixed scales and complex geometrical structures of nozzle and funnel type mold, a series of numerical simulations are made to analyze the flow patterns in melt steel using finite volume method based on structured body fitted coordinate grids. The CFD （computational fluid dynamics） package is validated first using one typical case described in previously published studies, and then it is developed to study the effect of operational parameters on fluid flow in thin slab caster. Two operational parameters, casting speed and SEN （submerged entry nozzle） depth, are mainly considered for numerical analysis. On the basis of present simulations, the reasonable SEN submergence depths corresponding to different casting speeds are suggested according to fluid flow characteristics like, flow jet impingement on the narrow side of the mold, flow speed of the melt steel beneath the meniscus and the recirculation region. This is the first stage of study on the numerical analysis of the whole thin slab casting process with electromagnetic brake.

关键词： continuous casting thin slab submerged entry nozzle (SEN) numerical analysis funnel type mold standard k-ε model RNG (renormalization group) k-ε model

脑卒中简明ICF核心要素信和效度检验的Rasch模型分析

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中华物理医学与康复杂志 2011年第4期33卷 260-264页

作者：卫小梅胡昔权窦祖林郭铁成喻勇中山大学附属第三医院康复医学科广州510630 华中科技大学同济医学院附属同济医院康复医学科

目的运用多层面Rasch模型检验中国版脑卒中国际功能、残疾与健康分类（ICF）核心要素的信度和效度.方法由2名评定员对38例脑卒中患者采用中国版简明ICF核心要素的＂身体功能＂成分包含的20个类目分别进行评分,运用FACETS统计软件计算... 详细信息

目的运用多层面Rasch模型检验中国版脑卒中国际功能、残疾与健康分类（ICF）核心要素的信度和效度.方法由2名评定员对38例脑卒中患者采用中国版简明ICF核心要素的＂身体功能＂成分包含的20个类目分别进行评分,运用FACETS统计软件计算个人分离指数和信度、拟合分析等检验ICF核心要素的信度和效度.结果中国版简明ICF核心要素量表中＂身体功能＂成分类目内部一致性信度好（个人分离指数为6.02,分离信度为0.94,χ2=2158.3,P＜0.01）,评定者内信度好（未加权的均方拟合统计量为0.92～1.12）,但2位评定员评分时的严格程度有显著差异（χ2=1042.5,P=0.01）.该部分量表的结构效度较好（分离指数为1050,分离信度为0.80,χ2=467.3,P=0.01）.但是拟合分析表明,b117智力功能处于非拟合状态,而b152情感功能和b755不随意运动反应功能处于过度拟合状态.结论中国版脑卒中简明ICF核心要素的身体功能成分具有良好的信度和结构效度.多层面 Rasch模型对于检验简明ICF核心要素的信度和效度能够提供更全面的信息,具有良好应用前景.

关键词：多层面Rasch模型脑卒中简明ICF核心要素信度效度

Visualizing light-induced dynamic structural transformations of Au clusters-based photocatalyst via in situ TEM

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Nano Research 2021年第8期14卷 2805-2809页

作者： bo Weng Youhong Jiang Hong-Gang Liao Maarten b.J.Roeffaers Feili Lai Haowei Huang Zichao Tang State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China cMACS Department of Microbial and Molecular SystemsKU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium Department of Chemistry KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium

Ultrasmall gold(Au)clusters have been regarded as one of the prototypes materials for solar energy conversion due to their unique strong molecular-like light absorption ***,the light-induced aggregation of Au clusters into nanoparticles is one of the most important factors that restricts its application in *** Au clusters aggregation has been widely demonstrated,the underlying mechanism for cluster fusion is still unclear due to the lack of experimental ***,we report the direct observation of Au clusters on TiO_(2) nanosheets aggregating when used as visible light photocatalysts for the reduction of *** in situ high-resolution transmission electron microscopy(TEM),the coexistence of two fusion mechanisms of Au clusters on TiO_(2) under ultraviolet-visible(UV-Vis)light irradiation in air is identified,i.e.,the migration and coalescence(MC)and Ostwald ripening(OR).Additionally,the correlation between the photostability of Au clusters and reaction atmospheres has been investigated,among which Au clusters have higher stability in an inert N_(2) atmosphere or vacuum than the oxidizing atmospheres(i.e.,air and O_(2)).These results indicate the inherent stability of Au cluster during photocatalysis,and instability comes from the consuming of ligand *** work not only discloses the underlying mechanism of Au cluster sintering but also provides guidelines for enhancing metal clusters-based photocatalysts stability.

关键词： photocatalysis dynamic structural transformation Au clusters in situ TEM

FEM SIMULATION FOR LASER FORMING PROCESSING

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Acta Metallurgica Sinica(English Letters) 2004年第3期17卷 317-322页

作者： L.Q.Li Y.b.Chen X.Y Wang S.Y Lin State Key Laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China Harbin Research Institute of Welding Harbin 150001 ChinaState Key Laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China Harbin Research Institute of Welding Harbin 150001 ChinaHarbin Research Institute of Welding Harbin 150001 ChinaHarbin Research Institute of Welding Harbin 150001 China

Laser forming involves heating sheet metal workpiece along a certain path with adefocused laser beam directed irradiate to the surface. During laser forming, a tran-sient temperature fields is caused by the irradiation and travelling of a laser beam.Consequently, thermal expansion and contraction take place, and allows the thermal-mechanical forming of complex shapes. This is a new manufacturing technique thatforming metal sheet only by thermal stress. Therefore, the analysis of temperaturefields and stress fields are very useful for studying the forming mechanism and con-trolling the accuracy of laser forming. The non--liner finite element solver, MARC, isemployed to solve the thermal--mechanical analysis. Using this model, the stress andstrain distribution of pure aluminum plate with different thickness are analyzed. Theinfluence of scanning speed on temperature fields and plastic strain of metal sheet un-der the condition of constant line energy are also presented. Numerical results agreewell with the experimental results.

关键词： laser forming FEM simulation temperature fields stress distributton

Lanthanide-doped nanoscintillators

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Light(Science & Applications) 2022年第10期11卷 2264-2266页

作者： Jean-Claude Georges bünzli institute of Chemical Sciences and Engineering Swiss Federal Institute of TechnologyLausanne(EPFL)LausanneSwitzerland Department of biomedical Engineering Southern University of Science and Technology(SUSTech)ShenzhenChina

Lanthanide-doped nanoscintillators are taking the lead in several important fields including radiation detection,biomedicine,both at the level of diagnosis and therapy,and information encoding.

关键词： diagnosis Lanthanide ill

Distinct physiological mechanisms underpin growth and rehydration of Hymenaea courbaril and Hymenaea stigonocarpa upon short-term exposure to drought stress

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Journal of Forestry Research 2023年第1期34卷 113-123页

作者： Luana M.Luz Ediane C.Alves Nariane Q.Vilhena Tamires b.Oliveira Zara G.b.Silva Joze M.N.Freitas Candido F.O.Neto Roberto C.L.Costa Lucas C.Costa Universidade Federal Rural da AmazOia CapanemaPA 68700-665Brazil Universidade Federal Rural da AmazEia BelémPA 66077-830Brazil

Plants hold biochemical and physiological mechanisms to withstand drought ***,depending on water deficit interval,plant rehydration relies on how it can retain growth or a positive water balance—or rarely *** this study,two species of Hymenaea,one from the Amazon and the other from the brazilian Cerrado,were investigated for their physiological mechanism associated with growth rehydration upon short-term exposure to drought *** findings demonstrate that Hymenaea courbaril tends to invest in nitrogen to the detriment of carbon compounds,-as it is limited by lower net photosynthesis-and adjust root growth to attenuate drought stress *** contrast,Hymenaea stigonocarpa takes advantage of higher water potential and a basal rate of lower net photosynthesis to support aboveground growth under such ***,it is postulated that there are distinct ways of controlling water status and growth between *** and ***,which are determined either by the ability of the species to keep net photosynthesis at low levels of water content or by favoring the accumulation of nitrogen *** mechanisms were effective with regards to water use efficiency and thus it is reasonable to suggest that strategies are not exclusive and may work under adverse conditions,as observed in Amazon and brazilian Cerrado ***.

关键词： Hymenaea courbaril Hymenaea stigonocarpa Growth Photosynthesis Water deficit