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Inflammatory bowel disease:Therapeutic limitations and prospective of the stem cell therapy

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World Journal of Stem Cells 2020年第10期12卷 1050-1066页

作者： Rangnath Mishra Punita Dhawan Anand S srivastava Amar b Singh Institute of Stem Cell Therapy and Research San DiegoCA 92122United States Department of biochemistry and Molecular biology University of Nebraska Medical CenterOmahaNE 68118United States Fred and Pamela buffett Cancer Center OmahaNE 68118United States VA Nebraska-Western Iowa Health Care System OmahaNE 68118United States

Inflammatory bowel disease(IbD),consisting primarily of ulcerative colitis and Crohn’s disease,is a group of debilitating auto-immune disorders,which also increases the risk of colitis-associated ***,due to the chronic nature of the disease and inconsistent treatment outcomes of current anti-IbD drugs(e.g.,approximately 30%non-responders to anti-TNFαagents),and related serious side effects,about half of all IbD patients(in millions)turn to alternative treatment *** this regard,mucosal healing is gaining acceptance as a measure of disease activity in IbD patients as recent studies have correlated the success of mucosal healing with improved ***,despite the increasing clinical realization of the significance of the concept of mucosal healing,its regulation and means of therapeutic targeting remain largely ***,stemcell therapy,which uses hematopoietic stem cells or mesenchymal stem cells,remains a promising *** cells are the pluripotent cells with ability to differentiate into the epithelial and/or immune-modulatory *** overreaching concept is that the stem cells can migrate to the damaged areas of the intestine to provide curative help in the mucosal healing ***,by differentiating into the mature intestinal epithelial cells,the stem cells also help in restoring the barrier integrity of the intestinal lining and hence prevent the immunomodulatory induction,the root cause of the *** this article,we elaborate upon the current status of the clinical management of IbD and potential role of the stem cell therapy in improving IbD therapy and patient’s quality of life.

关键词： Crohn′s disease Ulcerative colitis Mesenchymal stem cells Hematopoietic stem cells Mucosal healing

Free radical scavenging property and antiproliferative activity of Rhodiola imbricata Edgew extracts in HT-29 human colon cancer cells

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Asian Pacific Journal of Tropical Medicine 2013年第1期6卷 11-19页

作者： Ravichandran Senthilkumar Thangaraj Parimelazhagan Om Prakash Chaurasia R.b.srivastava bioprospecting Laboratory Department of BotanySchool of Life SciencesBharaihiar University.Coimbatore-641046Tamil NaduIndia DIHAR Defence Research Development OrganizationLeh-LadakhJammu and KashmirIndia Directorate of Life Sciences.DRDO Head Quarters New Delhi-110011India

Objective:To investigate the in vitro antioxidant and antiproliferative activity of rhizome extracts of Rhodiola imbricata(***) in HT-29 human colon cancer cell ***:The successively extracted rhizome of *** using various solvents was analyzed for their total phenolics,tannins and flavonoid *** vitro antioxidant activity was evaluated by employing different assays,including DPPH,AbTS radical scavenging assays,FRAP, phosphomolybdenum reduction assay,superoxide anion,hydroxyl radical scavenging activities and metal chelating ***:Acetone and methanol extracts recorded higher phenolic content and showed comparable antioxidant activity with standard ***,they also inhibited the proliferation of HT-29 cells upon treatment at higher concentration(200μg/mL) (acetone and methanol,84%and 84%.respectively).On examination acetone extract exhibited antiproliferative activity in a concentration dependent manner whereas,methanol extract showed both dose dependent and lime dependent inhibitory ***:The results obtained justify the traditional usage of *** from their promising antioxidant activity.

关键词： Rhodiola imbricata Antioxidant activity Phenolics Flavonoids Adenocarcinoma cell lines

Pediatric interfacility transport effects on mortality and length of stay

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World Journal of Pediatrics 2021年第4期17卷 400-408页

作者： Rod M.Shinozaki Andreas Schwingshackl Neeraj srivastava Tristan Grogan Robert b.Kelly David Geffen School of Medicine at UCLA Los AngelesCAUSA University of California IrvineIrvineCAUSA Children’s Hospital of Orange County 1201 West La Veta AvenueOrangeCA92868USA

background We aimed to evaluate the effects of interfacility pediatric critical care transport response time,physician presence during transport,and mode of transport on mortality and length of stay(LOS)among pediatric *** hypothesized that a shorter response time and helicopter transports,but not physician presence,are associated with lower mortality and a shorter *** Retrospective,single-center,cohort study of 841 patients(between 2014 and 2018 utilizing patient charts and transport *** linear and logistic regression analyses adjusted for age,diagnosis,mode of transport,response time,stabilization time,return duration,mortality risk(pediatric index of mortality-2 and pediatric risk of mortality-3),and inotrope,vasopressor,or mechanical ventilation presence on *** Four hundred and twenty-eight(50.9%)patients were transported by helicopter,and 413(49.1%)were transported by *** accompanied 239(28.4%)*** median response time was 2.0(interquartile range 1.4–2.9)*** physician presence increased the median response time by 0.26 hours(P=0.020),neither physician presence nor response time significantly affected mortality,ICU length of stay(ILOS)or hospital length of stay(HLOS).Helicopter transports were not significantly associated with mortality or ILOS,but were associated with a longer HLOS(3.24 days,95%confidence interval 0.59–5.90)than ambulance transports(P=0.017).Conclusions These results suggest response time and physician presence do not significantly affect mortality or *** may reflect the quality of pre-transport care and medical control *** transports were only associated with a longer *** analysis provides a framework for examining transport workforce needs and associated costs.

关键词： Helicopter Hospital length of stay Pediatric critical care Pediatric intensive care unit Transport medicine

Ce-Co-doped biFeO_3 multiferroic for optoelectronic and photovoltaic applications

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Chinese Physics b 2017年第11期26卷 383-388页

作者： Jyoti Sharma Deepak basandrai A K srivastava Department of Physics Lovely Professional University

The Ce-Co-doped biFeO3 multiferroic, bi（1-x）Ce）xFe（1-x）CoxO3（x = 0.00, 0.01, 0.03, and 0.05）, has been prepared by a sol-gel auto-combustion method and analyzed through Raman spectroscopy, photoluminescence, and UV-visible spectroscopy. We have observed an anomalous intensity of the second-order Raman mode at - 1260 cm^-1 in pure bFO and suppressed intensity in doped samples, which indicates the presence of spin two-phonon coupling in these *** photoluminescence spectra show reduction in the intensity of emission with the increasing dopant concentration, which indicates the high charge separation efficiency. A sharp absorption with three charge transfer（C-T） and two d-d transitions are shown by UV-visible spectra in the visible region. The band gap of biFeO3（bFO） is decreasing with increasing dopant concentrations and the materials are suitable for photovoltaic applications.

关键词： Raman and UV-visible spectroscopy photoluminescence and photo-voltaic applications

Numerical Algorithm based on Quintic Nonpolynomial Spline for Solving Third-Order boundary Value Problems Associated with Draining and Coating Flows

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Chinese Annals of Mathematics,Series b 2012年第6期33卷 831-840页

作者： Pankaj Kumar srivastava Manoj KUMAR Department of Mathematics Jaypee Institute of Information Technology Department of Mathematics Motilal Nehru National Institute of Technology

A numerical algorithm is developed for the approximation of the solution to certain boundary value problems involving the third-order ordinary differential equation associated with draining and coating flows. The authors show that the approximate so- lutions obtained by the numerical algorithm developed by using uonpolynomial quintic spline functions ave better than those produced by other spline and domain decomposition methods. The algorithm is tested on two problems associated with draining and coating flows to demonstrate the practical usefulness of the approach.

关键词： Third-order boundary value problem Spline functions Nonpolynomial quartic spline Nonpolynomial quintic spline Draining and coating flows

Tunneling properties of electromagnetic wave in slab su-perconducting material

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Optoelectronics Letters 2011年第4期7卷 277-281页

作者： Khem b.Thapa Sanjay srivastava Alka Vishwakarma S.P.Ojha Department of Physics Institute of Engineering & TechnologyChhatrapati Shahu ji Maharaj University Material Sciences & Metallurgy Engineering Maulana Azad National Institute of Technology Department of Applied Physics Institute of TechnologyBanaras Hindu University

When the electromagnetic wave propagates through a slab superconducting material in microwave ranges,tunneling properties of the electromagnetic wave at critical temperature are investigated *** transmittance and the reflectance of the slab superconducting material vary with the thickness of material as well as the refractive index of *** high transmittance is found for thin superconductor at low wavelength ***,optical properties are strongly dependent upon temperature and incidence *** electromagnetic wave is totally transmitted without loss for incidence wavelength(l = 5000 nm) due to the zero refractive index and infinite penetration depth of the superconductor at the critical temperature.

关键词：超导材料电磁波板坯属性隧道临界温度光学特性穿透深度

Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford b.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.balewski D.R.beavis N.K.behera R.bellwied M.J.betancourt R.R.betts A.bhasin A.K.bhat H.bichsel J.bieleik J.bielcikova b.biritz L.C.bland W.borowski J.bouchet E.braidot A.V.brandin A.bridgeman S.G.brovko E.bruna S.bueltmann I.bunzarov T.P.burton X.Z.Cai H.Caines M.Calderon de la barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.J.M.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn b.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman b.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.C.Lamont J.M.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight M.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis C.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski b.Mohanty M.M.Mondal b.Morozov D.A.Morozov M.G.Munhoz M Argonne National Laboratory Argonnellinois 60439USA brookhaven National Laboratory UptonNew York 11973USA University of Califomia BerkeleyCaliformnia 94720USA University of California DavisCalifornia 95616USA University of Califormnia Los AngelesCalifomia 90095USA Universidade Estadual de Campinas Sao PauloBrazil University of Illinois at Chicago ChicagoIlinois 60607USA Creighton University OmahaNebraska 68178USA Czech Technical University in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of Modern Physics LanzhouChina Lawrence berkeley National Laboratory BerkeleyCalifornia 94720USA Massachusetts Institute of Technology CambridgeMA 02139-4307USA Mx-Planck-Institut fir Physik MunichGermany Michigan State University East LansingMichigan 48824USA Moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of China Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

Effect of Dermal Exposure to Paraphenylenediamine and Linear Alkylbenzene Sulphonate in Guinea Pigs

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biomedical and Environmental Sciences 2005年第4期18卷 238-240页

作者： A. K. MATHUR R. b. RAIZADA M. K. srivastava A. SINGH Industrial Toxicology Research Centre P. B. No. 80 Mahatma Gandhi Marg Lucknow-226001 (U. P.) IndiaIndustrial Toxicology Research Centre P. B. No. 80 Mahatma Gandhi Marg Lucknow-226001 (U. P.) IndiaIndustrial Toxicology Research Centre P. B. No. 80 Mahatma Gandhi Marg Lucknow-226001 (U. P.) IndiaIndustrial Toxicology Research Centre P. B. No. 80 Mahatma Gandhi Marg Lucknow-226001 (U. P.) India

To study the effects of paraphenylenediamine （PPD） and linear alkylbenzene sulphonate （LAS） alone and in combination on the skin. Methods Forty-eight guinea pigs were divided equally into 4 groups and exposed to PPD （4 mg/kg）, LAS （12 mg/kg） and PPD （4 mg/kg） plus LAS （12 mg/kg） for 30 days. The biochemical parameters such as acid phosphatase, gtutathione-s-transferase, glutathione peroxidase, glutathione, lipid peroxidafion and histamine contents in exposed skin were estimated. The histopathological examination of the exposed skin was also carried out. Results The skin enzymes, lipid peroxidation, and histamine increased while glutathione decreased in skin. The simultaneously exposed group showed additive toxic effects. The histopathological examination showed severe hyperkeratosis, thickening of collagen fibres and vacuolisation of epidermal cells in PPD plus LAS exposed skin. Conclusion The findings of the present study suggest that simultaneous exposure to PPD and LAS has additive toxic effects.

关键词： Dermal Paraphenylenediamine Linear alkylbenzene sulphonate Enzymes Histopathology

STEP-based Feature Recognition System for b-spline Surface Features

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International Journal of Automation and computing 2018年第4期15卷 500-512页

作者： bitla Venu Venkateswara Rao Komma Deepanshu srivastava Department of Mechanical Engineering Motilal Nehru National Institute of Technology

The geometrical and topological information of 3D computer aided design （CAD） models should be represented as a neut- ral format file to exchange the data between different CAD systems. Exchange of 3D CAD model data implies that the companies must exchange complete information about their products, all the way from design, manufacturing to inspection and shipping. This informa- tion should be available to each relevant partner over the entire life cycle of the product. This led to the development of an international standard organization （ISO） neutral format file named as standard for the exchange of product model data （STEP）. It has been ob- served from the literature, the feature recognition systems developed were identified as planar, cylindrical, conical and to some extent spherical and toroidal surfaces. The advanced surface features such as b-spline and its subtypes are not identified. Therefore, in this work, a STEP-based feature recognition system is developed to recognize t--spline surface features and its sub-types from the 3D CAD model represented in AP203 neutral file format. The developed feature recognition system is implemented in Java programming language and the product model data represented in STEP AP203 format is interpreted through Java standard data access interface （JSDAI）. The developed system could recognize b-spline surface features such as b-Spline surface with knots, quasi uniform surface, uniform surface, rational surface and bezier surface. The application of extracted b-spline surface features information is discussed with reference to the toolpath generation for STEP-NC （STEP AP238）.

关键词： Feature recognition 3D computer aided design(CAD)model geometrical information standard for the exchange ofproduct model data(STEP)AP203 Java standard data access interface(JSDAI).