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Novel functional association of rat testicular membrane-associated cytosolic glutathione S transferases and cyclooxygenase in vitro

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Asian Journal of Andrology 2005年第2期7卷 171-178,页

作者： S.Neeraja b.ramakrishna A.S.Sreenath G.V.Reddy P.R.K.Reddy P.Reddanna Department of Animal Sciences School of Life SciencesUniversity of HyderabadHyderabad 500046India

Aim:To analyze the role of cytosolic glutathione S-transferases (cGSTs) and membrane-associated cytosolic GSTs (macGSTs) in prostaglandin biosynthesis and to evaluate the possible interaction between glutathione S-transferases (GSTs) and cyclooxygenase (COX) in ***:SDS-PAGE analysis was undertaken for characterization of GSTs,thin layer chromatography (TLC) to monitor the effect of GSTs on prostaglandin biosynthesis from arachi- donic acid (AA) and spectrophotometric assays were done for measuring activity levels of COX and ***: SDS-PAGE analysis indicates that macGSTs have molecular weights in the range of 25-28 *** a coupled assay involving GSTs,arachidonic acid and cyclooxygenase-1,rat testicular macGSTs produced prostaglandin E2 and F2~, while the cGSTs caused the generation of prostaglandin D2,E2 and F_(2α).In vitro interaction studies on GSTs and COX at the protein level have shown dose-dependent inhibition of COX activity by macGSTs and vice *** effect, however,is not seen with *** inhibitory effect of COX on macGST activity was relieved with increasing concentrations of reduced glutathione (GSH) but not with 1-chloro 2,4-dinitrobenzene (CDNb).The inhibition of COX by macGSTs,on the other hand,was potentiated by ***:We isolated and purified macGSTs and cGSTs from rat testis and analyzed their involvement in prostaglandin *** studies reveal a revers- ible functional interaction between macGSTs and COX in vitro,with possible interactions between them at the GSH binding site of macGSTs.

关键词： glutathione S-transferase cyclooxygenase arachidonic acid glutathione prostaglandins

Ion source perturbation and control in intense laser plasma interaction

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Matter and Radiation at Extremes 2020年第4期5卷 47-52页

作者： b.ramakrishna S.Krishnamurthy M.Tayyab S.bagchi K.Makur Raoul Trines Robbie Scott Alex Robinson J.A.Chakera Department of Physics Indian Institute of Technology HyderabadKandiSangareddy 502285India Laser Plasma Division Raja Ramanna Centre for Advanced TechnologyIndore 452013India Homi bhabha National Institute Training School ComplexAnushakti NagarMumbai 400094India Central Laser Facility STFC Rutherford-Appleton LaboratoryDidcot OX110QXUnited Kingdom

We present here experimental results on the optimization of the mega-electronvolt ion source from the target front surface by using relativistic(10^(18)W/cm^(2))interactions with ultra-short laser pulses(50 fs).The source perturbation in the accelerated proton/ion beam was primarily controlled by the addition of a pre-pulse to main pulse contrast *** 2D particle-in-cell simulations agreed well with the observed experimental results for the ion source perturbation and *** work provides insights into ion source perturbations(temporal and spatial)and the need to control them in intense laser–plasma *** results may assist in the efficient guiding of proton/ion beams to the core of fusion fuel or of ions in cancer therapy.

关键词： intense source primarily

Facile one-step hydrothermal route to MSe/Mo_(3)Se_(4)(M:Zn,Mn,and Ni)-based electrode materials for ultralong-life hybrid supercapacitors

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Journal of Materials Science & Technology 2023年第25期156卷 230-240页

作者： b.N.Vamsi Krishna Obula Reddy Ankinapalli Ayyaluri ramakrishna Reddy Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

Transition metal selenides have attracted great interest in electrochemical energy storage applications because of their good electrochemical activity and conductivity ***,we reported the metal molybdenum selenide(M Se/Mo_(3)Se_(4)(M:Zn,Mn,and Ni))electrode materials on their morphological and electrochemical properties by varying the metal ions via a facile hydrothermal *** effects of the structural,morphological,and surface area properties of the prepared powder materials on their electrochemical performance were *** to the hierarchical porous and unique interconnected structure,the nickel molybdenum selenide nanosheet spheres(NMS NSSs)-based electrode material delivered an excellent specific capacity value of 252 mAh g^(-1) at a current density of 1 Ag^(-1).Moreover,the optimized NMS NSSs electrode exhibited outstanding cycling stability with a capacity retention of 80%and a corresponding coulombic efficiency of 99%after 80,000 ***,a pouch-type hybrid supercapacitor(HSC)device was assembled using NMS NSSs material as a positive electrode and activated carbon as a negative electrode in 1 M aqueous KOH ***,the assembled HSC device exhibited superior energy and power density values as well as magnificent cycling *** real-time practical applications,light-emitting diodes and a digital display were powered using two series-connected HSC ***,the obtained tremendous results strongly suggest that the NiSe/Mo_(3)Se_(4) NSSs-based materials could be a promising electrode for ultralong-life energy storage applications.

关键词： Nickel selenides Molybdenum selenides Nanosheet spheres Ultralong-life cycling stability

G-protein coupled receptors and synaptic plasticity in sleep deprivation

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World Journal of Psychiatry 2021年第11期11卷 954-980页

作者： Shweta Parmar ramakrishna Tadavarty bhagavatula R Sastry Department of Anesthesiology Pharmacology and TherapeuticsThe University of British ColumbiaVancouver V6T 1Z3British ColumbiaCanada

Insufficient sleep has been correlated to many physiological and psychoneurological *** the years,our understanding of the state of sleep has transcended from an inactive period of rest to a more active state involving important cellular and molecular *** addition,during sleep,electrophysiological changes also occur in pathways in specific regions of the mammalian central nervous system(CNS).Activity mediated synaptic plasticity in the CNS can lead to long-term and sometimes permanent strengthening and/or weakening synaptic strength affecting neuronal network *** consolidation and learning that take place during sleep cycles,can be affected by changes in synaptic plasticity during sleep disturbances.G-protein coupled receptors(GPCRs),with their versatile structural and functional attributes,can regulate synaptic plasticity in CNS and hence,may be potentially affected in sleep deprived *** this review,we aim to discuss important functional changes that can take place in the CNS during sleep and sleep deprivation and how changes in GPCRs can lead to potential problems with therapeutics with pharmacological interventions.

关键词： G-protein coupled receptors Metabotropic glutamate receptors Gammaamino butyric acid-b receptor Synaptic plasticity Sleep deprivation Memory consolidation

Metal Organic Framework Derived Zirconia-Carbon Nanoporous Mat for Integrated Strain Sensor Powered by Solid‑State Supercapacitor

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Advanced Fiber Materials 2023年第4期5卷 1404-1416页

作者： brindha Ramasubramanian Vundrala Sumedha Reddy Ye Zhen Seeram ramakrishna Vijila Chellappan Department of Mechanical Engineering Center for Nanofibers and NanotechnologyNational University of SingaporeSingapore 117574Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)#08‑032 Fusionopolis WayInnovisSingapore 138634Singapore

Flexible electronics are essential for the rapid development of human-machine interface technology,encompassing sensors and energy storage ***-state supercapacitors with 1D nanofiber electrodes are critical for enhancing ion *** this study,a flexible supercapacitor integrated with a strain sensor was designed using a polyvinyl alcohol/polymethyl methacrylate(PVA/PMMA)-based electrolyte and a metal-organic framework(MOF)-derived Zr-nanoporous carbon mat(Zr-NPC).The sensor showed remarkable sensitivity over a broad strain range,enabling reliable and precise detection of mechanical *** supercapacitor with Zr-NPC@PVDF electrode also demonstrated a specific capacitance of 286 mF cm^(-2) at 0.5 mA cm^(-2),maintaining high flexibility and mechanical *** fabricated supercapacitor maintained around 81%charge retention after 10,000 ***,the self-powered integrated model was directly connected to the human body to detect physical motion,accentuating its potential for widespread applications in wearable technology.

关键词： Supercapacitor Piezoresistive sensor Porosity Nanocarbon

A facile and convenient synthesis of novel imidazo[1,2-b] isoxazoles and their Mannich bases as potential biodynamic agents

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Chinese Chemical Letters 2015年第12期26卷 1511-1513页

作者： E.Rajanarendar K.Thirupathaiah S.ramakrishna D.Nagaraju Department of Chemistry Kakatiya University

A series of novel imidazo[1,2-b]isoxazoles 3 and their Mannich bases 4–6 were synthesized via convenient reactions. The reaction of 3-aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6-methyl-3-aryl imidazo[1,2-b]isoxazoles 3 in good *** 3 on treatment with 37% formaline and secondary amines furnished the corresponding novel Mannich bases viz., 6-methyl-3-aryl-2-（morpholine/pyrrolidin-1-yl/piperidin-1-yl）-methyl-imidazo[1,2-b]isoxazoles 4–6.

关键词： convenient facile bases substituted amines antibacterial acetic chloroform ethanol pyrrolidine

Efficacy of low dose peginterferon alpha-2b with ribavirin on chronic hepatitis C

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World Journal of Gastroenterology 2006年第34期12卷 5554-5556页

作者： Rajesh Gupta CH ramakrishna Sandeep Lakhtakia Manu Tandan Rupa banerjee D Nageshwar Reddy Department of Medical Gastroenterology and Hepatology Asian Institute of Gas-troenterology Somajiguda 63661 Hyderabad India

AIM: To assess the effi cacy of peginterferon alpha 2b at doses of 50 μg weekly and 80 μg weekly (based on body weight) plus ribavirin in HCV genotype 2 and genotype 3 chronic hepatitis C patients. METHODS: During the study period of Jan 2002 to Dec 2003, all patients diagnosed as chronic hepatitis C or HCV related compensated cirrhosis were treated with peginterferon alpha 2b 50 μg S/C weekly (body weight body weight > 60 kg) plus ribavirin 800 mg/d for 24 wk. RESULTS: Overall 28 patients, 14 patients in each group (based on body weight) were treated during the period. Out of 28 patients, 75% were genotype 3, 18% were genotype 2 and 7% were genotype 1. The mean dose of peginterferon alpha 2b was 0.91 μg/kg in group 1 and 1.23 μg/kg in group 2 respectively. The end of treatment and sustained virologic response rates were 82% and 78% respectively. Serious adverse effects were seen in 3.5% patients. CONCLUSION: Low dose peginterferon alpha 2b in combination with ribavirin for 24 wk is effective in HCV genotype 2 and 3 chronic hepatitis C patients.

关键词： Chronic hepatitis C Peginterferon alpha 2b Ribavirin

Spectral change and far-red emission of Mn^(2+)ions co-doped NaSrb_(5)O_(9):Dy^(3+)luminescence material for plant growth LEDs

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Journal of Rare Earths 2022年第2期40卷 218-225,I0002页

作者： K.Munirathnam Koduru Mallikarjuna R.Vijaya P.C.Nagajyothi K.ramakrishna Reddy M.Srinivas Department of Physics School of Applied SciencesREVA UniversityBengaluru560064India Department for Management of Science and Technology Development Ton Due Thang UniversityHo Chi Minh CityVietnam Faculty of Applied Sciences Ton Due Thang UniversityHo Chi Minh CityVietnam Department of Physics Visvodaya Government Degree CollegeVenkatagiri524132India School of Mechanical Engineering Yeungnam UniversityGyeongsan33541South Korea Department of Chemistry School of Applied SciencesREVA UniversityBengaluru560064India

Due to the characteristic emission of phosphors,phosphor-converted LEDs have been employed to provide the requisite light sources for indoor plant growth in the optical agricultural ***,we prepared a series of Mn^(2+)co-doped NaSrb5 O9:Dy^(3+)phosphors via a solid-state reaction *** phosphors have significant three-band emissions at 467 nm(blue region),606 nm(orange region),and765 nm(far-red region),ascribed to the^(4)F_(9/2)-^(6)H_(15/2)and 4 F9/2-6 H13/2 transitions of the Dy^(3+)ions and the^(4)T_(1g)(G)-^(6)A_(1g)(S)spin-forbidden transition of the Mn^(2+)ions,respectively,when excited by light of 376 nm(near-UV region).The co-dopant in the host material facilitates tunable photoluminescence(PL)due to energy transfer from the Dy^(3+)ions to the Mn^(2+)*** three emission peaks from the prepared phosphors well match with the absorption spectra of the photosynthesis pigments of plants,chlorophyll and phytochrome,which can absorb blue(400-500 nm),orange-red(550-700 nm),and infrared(IR)radiation,indicating that these phosphors have potential applications in the fabrication of plant-growth *** to the PL studies,the structure of the phosphors was determined by X-ray diffraction,refined by Rietveld method and chemically quantified by X-ray photoelectron spectroscopy.

关键词： Phosphors Refinement X-ray photoelectron spectroscopy Energy transfer Plant growth LEDs Rare earths

Mineralized Composite Nanofibrous Mats for bone Tissue Engineering

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Journal of Donghua University(English Edition) 2013年第5期30卷 359-361页

作者：刘威詹建朝吴桐苏艳莫秀梅廖素三 ramakrishna Seeram State Key Laboratory for Modifications of Chemical Fiber and Polymer Materials College of Material Science and EngineeringDonghua University biomaterials and Tissue Engineering Laboratory College of ChemistryChemical Engineering and BiotechnologyDonghua University College of Materials and Textile Engineering Jiaxing University School of Materials Science and Engineering Nanyang Technological University Department of Mechanical Engineering National University of Singapore

Composite nanofibrous mats consisting of poly( L-lactideco-ε-caprolactone)( PLCL) and collagen type I( COL) were fabricated by electrospinning,and ten times simulated body fluid(10SbF) were employed to mineralize nanofibrous mats. ballshaped hydroxyapatite( HA) was deposited on the surface of nanofibrous mats in 1. 5 h at room temperature. Human fetal osteoblasts( hFob) were seeded to investigate their proliferation and differentiation on mineralized composite nanofibrous mats. The results showed that hFob grew well on mineralized composite nanofibrous mats and alkaline phosphatase( ALP) activity of hFob on mineralized composite nanofibrous mats at 14 d was much higher than that on untreated nanofibrous mats. Moreover,the expression of osteocalcin of cells on mineralized composite nanofibrous mats was also much higher than those on untreated nanofibrous mats at 7 d and 14 d. This mineralized composite nanofibrous mats may have a great potential for bone tissue engineering.

关键词： electrospnning nanofibrous mat mineralization bone tissue engineering