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Enhanced population of excited single state strategy:Irradiation and ultrasound dual-response and host tumor-driven nanosensitizers construction in triple synergistic therapy

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Nano research 2024年第6期17卷 5501-5511页

作者： Yaning Li Mengyan Tian Tianyue Yang Jiayu Cao Hongli Chen Jun Guo pai Liu Yi Liu State Key Laboratory of Separation Membranes and Membrane Processes School of Materials Science and EngineeringTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membranes and Membrane Processes School of Life ScienceTiangong UniversityTianjin 300387China State Key Laboratory of Separation Membrane and Membrane Process&Tianjin Key Laboratory of Green Chemical Technology and Process Engineering School of ChemistryTiangong UniversityTianjin 300387China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China Cangzhou Institute of Tiangong University Cangzhou 061000China

Phototheranostics is an emerging field in synergistic antitumor therapy in which irradiation and sensitizers are combined to produce reactive oxygen species(rOS),bio-images,and high *** of these are arrived from the energy of sensitizers,which located in excited single state(S_(1)).Undeniably,the decentralization of the S_(1)population indirectly decreases the effect of each individual *** this study,a strategy was proposed for enhancing the S_(1)population,and a sensitizer with mitochondrial targeting property,1,4-indolyl iodinated pyrrolo[3,2-b]pyrrole derivative(2I-TPIS),was assembled into adenosine triphosphate(ATP)-responsive nanoparticles(DPA-2I NPs)to achieve dual responses to irradiation and ultrasonication(US)for application to photo-sonodynamic therapy(PSDT).Compared with monotherapies,2I-TPIS generated more rOS in PSDT,inducing mitochondrial autophagy and apoptosis,which in turn triggered immunogenic cell death(ICD).Subsequently,DPA-2I NPs were constructed and self-assembled with the chemotherapeutic agents DPA-Cd and 2I-TPIS to achieve a triple synergistic strategy involving chemotherapy(CT)and ***-2I NPs exhibited absolute sensitization,intra-tumoral overexpression of ATP,and ***,the biosafety and potent antitumor efficiency of the DPA-2I NP-based“PSDT+CT”therapy were revealed using a 4T1 tumor *** study results provide insights into the design of sensitizers possessing a sufficient S_(1)population and a highly efficient tumor ablation capacity derived from molecular structural modulation,further enabling triple synergistic antitumor therapies,and expanding the clinical application of sensitizers.

关键词： triphosphate(ATP)-activated nano-sensitizers photo-sonodynamic therapy aggregation-induced emission enhanced excited state population

Optimization of Machining Characteristics for Al/SiCp Composites using ANN/GA

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Journal of Materials Science & Technology 2002年第1期18卷 47-50页

作者： r.Karthikeyan b.C.pai 等 DepartmentofProductionEngineering AnnamalaiUniversityAnnamalainagar-608002India regionalresearchLaboratory ThiruvananthapuramIndia

The present work is focused on optimization of machining characteristics of AI/SiCp composites. The machining characteristics such as specific energy, tool wear and surface roughness were studied. The parameters such as volume fraction of SiC, cutting speed and feed rate were considered. Artificial neural networks (ANN) was used to train and simulate the experimental data. Genetic algorithms (GA) was interfaced with ANN to optimize the machining conditions for the desired machining characteristics. Validation of optimized results was also performed by confirmation experiments.

关键词： Al/SiCp composites Artificial neural networks Genetic algorithms

双钙钛矿氧化物A_(2)bOsO_(6)(A=Sr,Ca;b=Cr,Mo)磁光克尔效应的第一性原理研究

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人工晶体学报 2024年第2期53卷 267-275页

作者：刘派祖宁宁李瑞齐齐哈尔大学理学院齐齐哈尔161003

Sr_(2)CrOsO_(6)具有双钙钛矿氧化物中最高的磁转变温度(725 K)。使用体积更小的Ca离子取代Sr离子后得到了Ca_(2)CrOsO_(6),其磁转变温度同样高于室温。进一步使用d轨道更加离域化的Mo离子取代Cr离子,得到了Ca_(2)MoOsO_(6)。通过密度... 详细信息

Sr_(2)CrOsO_(6)具有双钙钛矿氧化物中最高的磁转变温度(725 K)。使用体积更小的Ca离子取代Sr离子后得到了Ca_(2)CrOsO_(6),其磁转变温度同样高于室温。进一步使用d轨道更加离域化的Mo离子取代Cr离子,得到了Ca_(2)MoOsO_(6)。通过密度泛函理论,系统地计算了双钙钛矿氧化物Sr_(2)CrOsO_(6)、Ca_(2)CrOsO_(6)和Ca_(2)MoOsO_(6)的电子结构和磁光克尔效应,电子结构表明,三种材料均为半导体。Sr_(2)CrOsO_(6)和Ca_(2)CrOsO_(6)的电子结构非常相似,Ca_(2)MoOsO_(6)的带隙极小,仅有0.10 eV。观察磁光克尔效应谱线,三种材料在红外到可见光谱的范围内均表现出显著的磁光克尔效应。Sr_(2)CrOsO_(6)、Ca_(2)CrOsO_(6)和Ca_(2)MoOsO_(6)的最大克尔旋角分别为1.18°、0.98°和0.65°。三种材料的最大克尔旋角均大于0.2°,是理想的磁光材料。计算结果表明化合物内同时包含3d(4d)和5d过渡金属离子有助于形成显著的磁光克尔效应。对光学电导率张量的分析表明,三种材料的磁光克尔谱线峰值源自带间跃迁,并且由光学电导率张量的非对角元虚部主导。

关键词：双钙钛矿氧化物磁光克尔效应带间跃迁第一性原理自旋轨道耦合

爱尔兰岛高比例新能源电力系统运行经验与启示

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电网技术 2024年第2期48卷 498-508页

作者：闫景皓黄越辉卢慧宋子源李湃可再生能源并网全国重点实验室(中国电力科学研究院有限公司) 北京市海淀区100192

随着全球能源转型步伐的加快,世界各国电力系统均大力发展以风电和光伏发电为主的新能源。爱尔兰岛电力系统为岛屿独立同步电网,具有新能源渗透率高、与外部电网交互功率小等特点。经过长期摸索与发展,爱尔兰岛高比例新能源电力系统运... 详细信息

随着全球能源转型步伐的加快,世界各国电力系统均大力发展以风电和光伏发电为主的新能源。爱尔兰岛电力系统为岛屿独立同步电网,具有新能源渗透率高、与外部电网交互功率小等特点。经过长期摸索与发展,爱尔兰岛高比例新能源电力系统运行水平处于世界前列,其先进经验对我国新型电力系统建设具有重要借鉴意义。介绍了爱尔兰岛电力工业的概况,分析了爱尔兰岛电力系统的运行情况,探究了爱尔兰岛电力公司为保证高比例新能源电力系统安全高效运行采取的措施,最后总结其对我国新型电力系统建设的经验与启示。

关键词：爱尔兰电力系统新能源 SNSP 运行经验

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Developments in Processing of Functionally Gradient Metals and Metal–Ceramic Composites:A review

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Acta Metallurgica Sinica(English Letters) 2014年第5期27卷 825-838页

作者： T.P.D.rajan b.C.pai Materials Science and Technology Division CSIR-National Institute for Interdisciplinary Science and TechnologyIndustrial Estate PO

Functionally gradient/graded materials （FGMs）, an emerging new class of materials, are the outcome of the recent innovative concepts in materials technology. FGMs are in their early stages of evolution and expected to have a strong impact on the design and development of new components and structures with better performance. FGMs exhibit gradual transitions in the microstructure and/or the composition in a specific direction, the presence of which leads to variation in the functional performance within a part. The presence of gradual transitions in material composition in FGMs can reduce or eliminate the deleterious stress concentrations and result in a wide gradation of physical and/or chemical properties within the material. Functionally graded metal-ceramic composites are also getting the attention of the researchers. Among the fabrication routes for FGMs such as chemical vapour deposition, physical vapour deposition, the sol-gel technique, plasma spraying, molten metal infiltration, self propagating high temperature synthesis, spray forming, centrifugal casting, etc., the ones based on solidification route are preferred for FGMs because of their economics and capability to make large size products. The present paper discusses and compares various solidification processing tech- niques available for the fabrication of functionally gradient metals and metal-ceramic composites and lists their properties and possible applications. The other processing methods are briefly described.

关键词： Functionally gradient materials Solidification Aluminium Centrifugal casting Infiltration

randomized, double-blind, comparative study of dexrabeprazole 10 mg versus rabeprazole 20 mg in the treatment of gastroesophageal reflux disease

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World Journal of Gastroenterology 2007年第30期13卷 4100-4102页

作者： Vikas pai Nitin pai pai Clinic Pune Abhinav Apts 778/B-1 Shivajinagar Pune 411005 India

AIM：TO compare the efficacy and safety of dexrabe-prazole 10 mg versus rabeprazole 20 mg in the treatment of gastroesophageal reflux disease （GErD）.METHODS： This was a randomized, double-blind clinical study. Fifty patients with GErD were randomly assigned to receive dexrabeprazole 10 mg or rabeprazole 20 mg once daily. Efficacy was assessed by evaluating improvement in visual analog scale （VAS） scores of heart-burn and regurgitation and safety was assessed by recording incidence of any adverse drug reactions. Laboratory investigations and upper gastro-intestinal endoscopy was conducted at baseline and after 28 d of therapy.rESULTS： A total of 50 patients （n = 25 in dexrabeprazole group and rabeprazole group each） completed the study. There were no significant differences in the baseline characteristics between the two groups. The VAS score （mean 4. SD） of heartburn and regurgitation in dexrabeprazole （64.8±5.1 and 64 ± 8.1, respectively） and rabeprazole （64.4 ± 8.7 and 57.6 ± 9.7, respectively） groups significantly reduced （P 〈 0.0001） to 30 ± 11.5, 24 ± 10 and 32 ± 9.5, 29.2±11.9, respectively on d 28. A significantly higher （P = 0.002） proportion of patients showed ≥ 50% improvement in regurgitation with dexrabeprazole 10 mg （96%） compared to rabeprazole 20 mg （60%）. Onset of symptom improvement was significantly earlier with dexrabeprazole than with rabeprazole （1.8 ± 0.8 d vs 2.6 ± 1.4 d; P 〈0.05）. The incidences of esophagitis in the dexrabeprazole group and rabeprazole group before therapy were 84% and 92%, respectively （P = 0.38）. The incidence of improvement/healing of esophagitis after therapy was more （P = 0,036） in the dexrabeprazole group （95.2%） compared to the rabeprazole group （65.2%）. No adverse drug reaction was seen in either group.CONCLUSION： In the treatment of GErD, efficacy of dexrabeprazole 10 mg is better than rabeprazole 20 mg, with regards to improvement/healing of endoscopic lesions and relief from symptoms of regurgitation.

关键词： Dexrabeprazole/r(+) rabeprazole Gastroesophageal reflux disease Efficacy Safety

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文化依恋概念辨析

心理科学 2024年第4期47卷 933-939页

作者：李雅宁杨伊生辛自强梁丽王湃内蒙古师范大学心理学院呼和浩特010022 包头师范学院教育科学学院包头014030 中国人民大学心理学系北京100872 西南石油大学心理发展与教育中心成都610500

文化依恋指个体与所属文化相互作用形成的特殊情感联结。对文化依恋的内涵及其邻近概念(一般依恋、文化认同、文化自信与文化适应)的辨析有助于确保文化依恋研究的独立地位和后续研究的开展。未来研究重点应包括开发文化依恋的本土化测... 详细信息

文化依恋指个体与所属文化相互作用形成的特殊情感联结。对文化依恋的内涵及其邻近概念(一般依恋、文化认同、文化自信与文化适应)的辨析有助于确保文化依恋研究的独立地位和后续研究的开展。未来研究重点应包括开发文化依恋的本土化测量工具、探究文化依恋的形成机制和拓展考察文化依恋的社会价值。

关键词：文化依恋一般依恋文化认同文化自信文化适应

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Z4变质岩潜山油藏裂缝特征及地震预测

新疆石油地质 2024年第5期45卷 516-521页

作者：丁圣刘金华尚娅敏彭湃傅劲翔中石化石油物探技术研究院有限公司南京211103 西南石油大学地球科学与技术学院成都610500 中国石油新疆油田分公司采油二厂新疆克拉玛依834008 中国石油川庆钻探工程有限公司地质勘探开发研究院成都610051

裂缝地震预测是裂缝型油藏评价的基础。变质岩潜山油藏具有裂缝类型多、不同部位裂缝发育程度差异大、裂缝非均质性强、预测难度大等特征,针对Z4变质岩潜山油藏开展裂缝特征及地震预测研究。Z4潜山油藏裂缝发育程度具有成层性,可分为4段... 详细信息

裂缝地震预测是裂缝型油藏评价的基础。变质岩潜山油藏具有裂缝类型多、不同部位裂缝发育程度差异大、裂缝非均质性强、预测难度大等特征,针对Z4变质岩潜山油藏开展裂缝特征及地震预测研究。Z4潜山油藏裂缝发育程度具有成层性,可分为4段:顶部风化-半充填裂缝段、上部网状裂缝发育段(发育程度高)、中部低角度裂缝发育段(发育程度中等)和下部高角度裂缝发育段(发育程度低)。提出了综合多尺度通用谱分解、倾角导向的本征值相干处理和迭代蚂蚁体分析的综合裂缝预测技术。将岩心上裂缝产状及发育程度与地震预测结果进行对比,结果显示吻合度较高,提出的多方法综合裂缝地震预测具有较高的准确性。

关键词：东营凹陷 Z4潜山油藏变质岩裂缝特征地震预测蚂蚁体

A MATHEMATICAL MODEL OF ENTErPrISE COMPETITIVE AbILITY AND PErFOrMANCE THrOUGH A PArTICULAr EMDEN-FOWLEr EQUATION

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Acta Mathematica Scientia 2011年第5期31卷 1749-1764页

作者： pai Jente Chang Yueloong Chiu Sumiao Department of Land Economics National Chengchi University Department of Phychology National Chengchi University Department of Mathematical Sciences National Chengchi University

In this paper we work with the ordinary diffential equation u′′ u3 = 0 and obtain some interesting phenomena concerning blow-up, blow-up rate, life-spann, zeros and critical points of solutions to this equation.

关键词： estimate life-span blow-up blow-up rate performance competitive ability