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Combined treatment of pancreatic cancer xenograft with 90Y-ItGA6b4-mediated radioimmunotherapy and PI3K/m tOR inhibitor

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World Journal of Gastroenterology 2017年第42期23卷 7551-7562页

作者： Winn Aung Atsushi b tsuji Hitomi sudo Aya sugyo Yoshinori Ukai Katsushi Kouda Yoshikazu Kurosawa takako Furukawa tsuneo saga tatsuya Higashi Department of Molecular Imaging and theranostics National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and Technology(QST-NIRS) Perseus Proteomics Inc. Innovation Center for Advanced Medicine Fujita Health University Department of Radiological and Medical Laboratory sciences Nagoya University Graduate School of Medicine Department of Diagnostic Radiology Kyoto University Hospital

AIM to investigate the therapeutic effect of combined integrin α6β4-targeted radioimmunotherapy(RIt) and PI3 K/m tOR inhibitor bEZ235 in a pancreatic cancer *** Phosphorylation of Akt, m tOR, the downstream effectors eukaryotic initiation factor 4 E binding protein 1(4 EbP1) and s6 ribosomal protein(s6) were evaluated in bx PC-3 human pancreatic cancer cells treated with Yttrium-^(90)(^(90) Y) labeled anti-integrin α6β4 antibody(ItGA6 b4) and bEZ235 by western blotting. the cytotoxic effect of bEZ235 was investigated using a colony formation assay. therapeutic efficacy enhancement by oral bEZ235 administration was assessed using mice bearing bx PC-3 xenograft tumors. tumor volume measurements and immunohistochemical analyses(cell proliferation marker Ki-67, DNA damage marker p-H2 AX and p-4 EbP1 staining) of tumors were performed for evaluation of combined treatment with ^(90) Y-ItGA6 b4 plus bEZ235, or each arm *** We found that phosphorylation of Akt(p-Akt), 4 EbP1(p-4 EbP1) and s6(p-s6) was inhibited by bEZ235. Colony formation in bx PC-3 cells was additively suppressed by the combination of ^(90) Y-ItGA6 b4 and bEZ235. Pretreatment with bEZ235 before ^(90) Y-ItGA6 b4 exposure resulted in significant reduction of cells plating efficiency(PE)(0.54 ± 0.11 vs 2.81 ± 0.14 with 185 k bq/m L ^(90) Y-ItGA6 b4 exposure, P s 1.88 ± 0.09 with 370 k bq/m L ^(90) Y-ItGA6 b4 exposure, P s per dish were plated. In vivo, the combined treatment with ^(90) Y-ItGA6 b4 plus bEZ235 enhanced the inhibition of tumor growth and statistically significant differences of relative tumor volume were observed for 27 d after the treatment start date when compared with the ^(90) Y-ItGA6 b4 single injection treatment(1.03 ± 0.38 vs 1.5 ± 0.15 at Day 27, P th the bEZ235 treatment alone(1.8 ± 0.7 vs 3.14 ± 1.19 at Day 41, P tumors from treatment groups showed reduction in volumes, dec

关键词： Radioimmunotherapy Pancreatic cancer Anti-integrin α6β4 antibody Yttrium-90 NVP-bEZ235

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系统设计和应用的可靠性工程

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1987年

作者：（加）b.s.迪隆周广涛译

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LMP Congestion Management Using Enhanced stF-LODF in Deregulated Power system

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Circuits and systems 2016年第9期7卷 2489-2498页

作者： K. b. Ravindra Kumar Dr. s. Chandra Mohan Meenakshi College of Engineering Chennai Tamil Nadu India College of Engineering Anna University Chennai Tamil Nadu India

Nowadays electricity market industry is become a major impact on power system for privatization and deregulation of power in global wise. As per the limitation of the transmission system, the complexity arises and the supply fact will be with demand at the time of balancing. the congestion of the power system is occurring based on the transmission limits of the power desire and amount for operating the system. In order to avoid transmission line congestion, enhanced stF-LODF method is proposed. It shows the regulated line transmission flow with generating units by implementing renewable energy resources (RER) based on enhanced stF-LODF in power systems. It avoids the congestion of transmission line frequently in the power system and manages price based on pricing and sensitivity approach, and also manages optimal location of congestion transmission and instability issues of voltage. the congestion management of Locational Marginal Pricing (LMP) is performed with minimum line loss, less cost, line flow, better sensitivity and better performances in optimal power flow and control flow. the efficiency of the proposed power system is analyzed and verified by the simulation results of tested IEEE 14 bus system.

关键词： LODF Factor sensitivity LMP Congestion Management Optimal Power Flow Renewable Resource

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stabilization of cubic ordering of zirconium dioxide nanoclusters on silicon with laser ablation

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Rare Metals 2007年第S1期26卷 10-13页

作者： KUZ'MENKO A P PEtERsON M b KUZ'MENKO N A ZAVODINsKY V G PUGACHEVsKY M A DObROMYsLOV M b Laboratory Quantum Electronic & Laser technology Pacific National University Institute for Materials science FEb RAs

Regimes of continuous and pulsed laser action on high-melting oxide compounds of ZrO2 were found with the aim of obtaining steady coatings on monocrystal silicon on laser ablation.X-ray phase analyses,scanning and atomic-force microscopy reveal that the coatings obtained are of nanocluster structure with the cubic *** this case the nanoclusters reach several hundreds of nanometers in *** assumption was made that on laser ablation of ZrO2 thermostabilization may take place where a minimum of the surface energy is attained just at cubic ordering.

关键词： laser ablation thermostabilization atomic-force microscopy nanocluster structure monocrystal silicon

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Response of testicular antioxidant enzymes to hexachlorocy clohexane is species specific

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Asian Journal of Andrology 2002年第3期4卷 191-194页

作者： Luna samanta G.b.N. Chainy biochemistry Unit & ICAbPs Department of Zoology Utkal University Bhubaneswar-751004 IndiaBiochemistry Unit & ICABPS Department of Zoology Utkal University Bhubaneswar-751004 India

Aim: to find out whether the response of testicular oxidative stress parameters to hexachlorocyclohexane (HCH) is species specific. Methods: In rats and mice (n=5 in each group), HCH was administered at a dose of 20 mg/kg/day intraperitoneally for 30 days in 0.1 ml of refined groundnut oil. the control groups received equal volume of the vehicle. Animals were sacrificed 24 hours after the last injection and various oxidative stress parameters were measured immediately. Results: the level of both endogenous as well as FesO_4 and ascorbic acid-stimulated lipid peroxidation was increased significantly in the HCH-treated rats, whereas the pattern was just the reverse in case of mice. Although the level of H_2O_2 content increased in response to HCH in both groups, a totally different trend was observed for the activity of the principal H_2O_2-metabolising enzyme, catalase. In case of rats, a significant decline in the activity of catalase was recorded in response to HCH whereas a sharp augmentation in the enzyme activity was noticed in mice. similarly, the decreased activity of superoxide dismutase observed in rats remained unaltered in mice. Conclusion: HCH induces oxidative stress in the testis of both rats and mice. However, the pattern of response of testicular oxidative stress parameters seems to be species specific.

关键词： hexachlorocyclohexane rat testes lipid peroxidation antioxidant defence

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Imperfection Insensitivity of Origami-Inspired tubular structures

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Acta Mechanica solida sinica 2023年第4期36卷 541-553页

作者： Qian Zhang Chongyao Wang Yan Li Ahmad b.H.Kueh Jianguo Cai Key Laboratory of C and PC structures of Ministry of Education National Prestress Engineering Research CenterSoutheast UniversityNanjing 210096China Department of Civil Engineering Faculty of EngineeringUniversiti Malaysia Sarawak94300 Kota SamarahanSarawakMalaysia

Axially loaded tubular structures are known to be highly sensitive to initial geometric imperfections,which can significantly reduce their design bearing *** address this issue,this study explores the potential of an origami-inspired design for tubular structures to achieve a lower sensitivity to *** study considers various designs,including diamond-shaped,pyramid-shaped,new Kresling,and pre-embedded rhombic origami tubes,and employs knockdown factors(KDFs)to illustrate the reduction of the design bearing capacity of these structures with initial geometric imperfections for safety *** element analysis shows that some of the origami tubes have superior design bearing capacity,mass efficiency,and KDFs when compared to standard circular *** the origami tubes considered,the rhombic tube demonstrates the best performance and is further studied through parametric analyses of geometric design,aspect ratio,and wall thickness to achieve additional performance ***,the superior performance of the rhombic tube is evaluated and verified for various loading scenarios,including eccentric compression and compression-torsion *** findings of this study provide a promising approach to designing and fabricating imperfection-insensitive tubes using advanced processing technologies such as additive *** work can potentially lead to the development of innovative tubular structures with enhanced safety and reliability in various engineering applications.

关键词： Imperfection insensitivity Origami tube buckling Parametric analysis Knockdown factor

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soft-Chemical synthesis of Vanadium Oxide Nanostructures Using 3,3’,3”-Nitrilotripropionic Acid(NtP)as a Carrier

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soft Nanoscience Letters 2011年第3期1卷 66-70页

作者： V.s.Reddy Channu Rudolf Holze b.Rambabu Institut für Chemie AG ElektrochemieTechnische Universitat ChemnitzChemnitzGermany solid state Ionics and surface sciences Lab Department of PhysicsSouthern University and A&M CollegeBaton RougeUSA

Vanadium oxide nanostructures were synthesized using NtP as a carrier through soft-chemical method. the influence of calcination temperature on the phase and morphology of obtained pristine product were characterized using X-ray diffraction (XRD), thermal gravimetric analysis (tGA) and scanning electron microscopy (sEM). Cyclic voltammogram studies were conducted to examine the electrochemical performance of cathodes made of vanadium oxide nanostructures. X-ray diffraction results show that, the particle size of the nanomaterials is increases with the increasing of calcination temperature.

关键词： Nanomaterials soft-Chemical Method Morphology Cyclic Voltammogram

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Development of 16-channels Compact EEG system Using Real-time High-speed Wireless transmission

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Engineering（科研） 2013年第5期5卷 93-97页

作者： b. R. Myung s. K. Yoo Correspondence author Department of medical Engineering College of Medicine Yonsei University Seoul Korea Graduate Programs of biomedical Engineering Yonsei University Seoul Korea

For the convenience of people with disability and for normal people, a demand for intelligent interfaces is ever increasing and therefore related studies are actively being conducted. Recently a study is being conducted to develop an interface through face expression, movement of the body and eye movements, and further more active attempts to use electrical signals(brainwave, electrocardiogram, electromyogram) measured from the human body is also actively being progressed. In addition, the development and the usage of mobile devices and smart devices are promoting these research activities even more. the brainwave is measured by electrical activities between nerve cells in the cerebral cortex using scalp electrodes. the brainwave is mainly used for diagnosis and treatment of diseases such as epilepsy, encephalitis, brain tumors and brain damage. As a result, the brainwave measurement methods and analytical methods were developed. Interface using the brainwave will not go through language or body behavior which is the result of the information processed by the brain but will pass directly to the system providing a brain-computer interface (bCI). this is possible because a variety of the brainwave appears depending on the human’s physical and mental state. Using the brainwave with the intelligent brain-computer interface or combining it with mobile devices and smart devices, regardless of space constraints, the brainwave measurement should be possible.[4,7] In this study, in order to measure the brainwave without spatial constraint, 16 channel compact brainwave measurements system using a high-speed wireless communications were designed. It was designed with a 16 channel to classify the various brainwave patterns that appear and for estimating the location of the nerve cells that triggered the brainwave. And in order to transmit the brainwave data within the channel without loss, a high-speed wireless communication must be possible that can enable a high-speed wireles

关键词： Electroencephalography High-speed Wireless transmission Real-time

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Analytical study of friction coefficients of pomegranate seed as essential parameters in design of post-harvest equipment

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Information Processing in Agriculture 2016年第3期3卷 133-145页

作者： s.M.shafaei A.Nourmohamadi-Moghadami s.Kamgar Department of biosystems Engineering College of AgricultureShiraz UniversityShiraz 71441-65186Iran

Friction coefficients(static friction coefficient(sFC)and dynamic friction coefficient(DFC))of pomegranate seed on different structural surfaces(glass,aluminum,plywood,galvanized steel and rubber)as affected by moisture content(4-21.9%(d.b.))and sliding velocity(1.4-16(cm/s))were *** of variance(ANOVA)was performed to determine the effect of main treatments and their interactions on sFC and *** of single or multiple effect of the main treatments with five levels was assessed using Duncan’s multiple range test(DMRt).to predict sFC and DFC,multiple linear regression(MLR)modeling technique was applied for each type of structural *** goodness of fit of each MLR model was evaluated using statistical parameters:coefficient of determination,root mean square error and mean relative deviation *** showed that the minimum and maximum sFC or DFC were in minimum and maximum moisture content on glass and rubber surface,*** table indicated the significant effect of main treatments and their interactions on sFC and DFC at significance level of 1%(Pto DMRt results,sFC linearly increased as moisture content increased and DFC increased also linearly as individual or simultaneous increment of moisture content and sliding velocity occurred,for all experimental *** to the obtained statistical parameters,both sFC and DFC were properly predicted by means of MLR modeling technique.

关键词： Duncan’s multiple range test Analysis of variance Multiple linear regression technique Moisture content sliding velocity

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Mechanical and degradation behaviour of biodegradable magnesium-zinc/hydroxyapatite composite with different powder mixing

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Journal of Magnesium and Alloys 2019年第4期7卷 566-576页

作者： siti Nur Hazwani Mohamad Rodzi Hussain Zuhailawati b.K.Dhindaw biomaterials Niche Area Group School of Materials and Mineral Resources EngineeringUniversiti Sains MalaysiaEngineering Campus14300 Nibong TebalPenangMalaysia school of Minerals Metallurgical and Materials EngineeringIndian Institute of Technology BhubaneswarBhubaneswar 751007India

Magnesium-based biomaterials have recently gained great attention as promising candidates for the new generation of biodegradable *** study investigated the mechanical performance and biodegradation behaviour of magnesium-zinc/hydroxyapatite(Mg-Zn/HA)composites fabricated by different powder mixing techniques.A single step mixing process involved mechanical alloying or mechanical milling techniques,while double step processing involved a combination of both mechanical alloying and mechanical *** mechanical properties of the composite were observed when the powders were prepared using single step processing via mechanical alloying ***,Mg-Zn/HA composite fabricated through single step processing via mechanical milling technique was found to have the most desirable low degradation rate coupled with highest *** composite achieved the lowest degradation rate of 0.039×10^−3 mm/year as measured by immersion test and 0.0230 mm/year as measured by electrochemical ***:P ratio of the composite also slightly more than enough to aid the initial bone mineralization,that is 1:1.76,as the required Ca:P ratio for initial bone mineralization is between 1:1 and 1:1.67.

关键词： Magnesium-based composite biodegradable implant Powder metallurgy Mechanical alloying Mechanical milling

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