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Management of proximal tibial stress fracture associated with advanced knee osteoarthritis:A systematic review

Chinese Journal of Traumatology 2024年第3期27卷 147-152页

作者： Mukesh kumar Saini Mahendra Singh Devendra Singh Prem Manohar Seervi Pera Jayavardhan Reddy Neelam Ramana Reddy Department of Orthopaedics Dr SN Medical CollegeJodhpur342011India Department of Orthopaedics Star HospitalsB Block Banjara HillsHyderabad500034India

Purpose:Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical *** is no clear existing treatment guideline for this uncommon clinical *** aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress ***:The study was performed using the databases of PubMed and *** index for non-randomized studies score was used to evaluate the included studies’*** concluded data included the treatment approach,reported outcome measure,and time to fracture *** literature search was started in December 2021 and accomplished in January 2022.A narrative description of the different methods and comparison of their results were ***:Out of total assessed 69 studies,9 studies were included in our *** commonest treatment approach used was total knee arthroplasty by long tibial stem *** mean preoperative knee society score and knee functional score were 30.62 and 23.17,*** mean postoperative knee society knee score was 86.87,while the functional score was *** average reported time to achieve fracture union was 4 months(a range of 2.07-5.50 months).Conclusion:The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee ***,due to heterogeneity of data,comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.

关键词： Tibial stress fracture Knee osteoarthritis Total knee arthroplasty

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Homotopy Perturbation Method for Time-Fractional Shock Wave Equation

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Advances in Applied Mathematics and Mechanics 2011年第6期3卷 774-783页

作者： Mithilesh Singh praveen kumar Gupta Department of Mathematics Dehradun Institute of TechnologyDehradunIndia Department of Applied Mathematics Institute of TechnologyBanaras Hindu UniversityVaranasiIndia

A scheme is developed to study numerical solution of the time-fractional shock wave equation and wave equation under initial conditions by the homotopy perturbation method(HPM).The fractional derivatives are taken in the Caputo *** solutions are given in the form of series with easily computable *** results are illustrated through the graph.

关键词： Partial differential equation fractional derivative shock wave equation homotopy perturbation method

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Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.kumar Sadaf K.baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-badi Abou-Samra Rakesh kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might be Due to the Inhibition of Carbonic Anhydrase Enzyme:An in vivo and in silico Investigation

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 62-68页

作者： Shikha Sharma Gaurav kumar Nitin kumar Neeraj K.Sethiya Dheeraj bisht Department of Pharmaceutical Sciences Lords UniversityAlwarRajasthan 301028India Navsahyadri Institute of Pharmacy NasrapurPuneMaharashtra 412213India Faculty of Pharmacy DIT UniversityMussoorie Diversion RoadDehradunUttarakhand 248009India Devsthali Vidyapeeth College of Pharmacy(Veer Madho Singh bhandari Uttarakhand Technical University Dehradun)LalpurRudrapurUttarakhand 263148India

background:Ayurvedic system of medicine is well established for prevention and treatment of renal *** are vast number of medicinal plants mentioned in Ayurvedic system of medicine,including Piper attenuatum buch.-*** Miq.,which has been known to exhibit diuretic ***:To investigate possible mechanism and diuretic activity of ethanol extract of *** ***:Present study reports an in vivo diuretic activity of ethanol extracts of *** ***-four Sprague-Dawley male rats were deprived from food and water for 20 h,followed by being divided into four groups to receive normal saline,Furosemide,and two doses of the ethanol extract,***,the ethanol extract were subjected for prelimnary phytochemical screening test,and analytical investigation was performed via high-performance thin-layer chromatography(HPTLC),followed by effectiveness exploration of putative bioactive compounds from *** against human carbonic anhydrase(hCA)enzyme using molecular docking ***:During phytochemicals screening,several groups of compounds such as amides,terpenoids,proteins,flavonoids,and glycosides have been ***,HPTLC reveals presence of carbohydrates,proteins,amino acids,steroids,alkaloids,flavonoids,tannins,glycosides,and *** diuretic action was revealed for both 200 mg/kg bw and 400 mg/kg bw of ethanol extract of *** ***,molecular docking analysis demonstrated greater binding affinity of compounds such as Cepharadione A,Nor-cepharadione b,Galbelgin,Crotepoxide,and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms(a key biomarker for diuretic)and score is comparable with standard drug ***:It was concluded from the present studies that ethanol extract of *** leaves exhibits signifi-cant diuretic *** activity may be correlated due to the presence of Cepharadione A,Norcepharadion

关键词： Piper attenuatum Diuretic activity Phytochemicals In silico and molecular docking

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Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman Tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

bACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease *** regenerative medicine,current treatments have *** regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism *** To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee *** The study included 50 patients with Kellgren-Lawrence grades II and III *** were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group b)*** were followed up at 1,3,6,12,and 24 *** analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all *** safety of SVF in terms of adverse and severe adverse events was *** analysis was performed with SPSS Version 26.0,IbM Corp,Chicago,IL,United *** both groups had similar demographics and baseline clinical ***-up showed minor patient loss,resulting in 23 and 24 in groups A and b *** A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group *** difference in pain reduction in group A was statistically significant from the third month ***,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group b saw a modest increase from 36.7 to *** improvement in Group A was statistically significant from 6 months and maintained through 24 *** Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in pa

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

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Isospin dependent properties of the isotopic chains of Scandium and Titanium nuclei within the relativistic mean-field formalism

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Chinese Physics C 2022年第8期46卷 155-169页

作者： praveen K.Yadav Raj kumar M.bhuyan School of Physics and Materials Science Thapar Institute of Engineering and TechnologyPatiala-147004PunjabIndia Center for Theoretical and Computational Physics Department of PhysicsFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Institute of Research and Development Duy Tan UniversityDa Nang 550000Vietnam

Density-dependent nuclear symmetry energy is directly related to iso spin asymmetry for finite and infinite nuclear *** is critical to determine the coefficients of symmetry energy and their related observables because they hold great importance in different areas of nuclear physics,such as the analysis of the structure of ground state exotic nuclei and neutron star *** ground state bulk properties of Scandium(Z=21) and Titanium(Z=22) nuclei are calculated,such as their nuclear binding energy(b.E.),quadrupole deformation(β_2),two-neutron separation energy(S_(2 n)),differential variation in the two-neutron separation energy(dS_(2 n)),and root-mean-square charge radius(r_(ch)).The iso spin properties,namely the coefficient of nuclear symmetry energy and its components,such as the surface and volume symmetry energy of a finite isotopic chain,from the corresponding quantities of infinite nuclear matter,are also ***,we correlate the neutron-skin thickness with the coefficient of symmetry energy and the related observables corresponding to the isotopic chains of these *** coherent density fluctuation model(CDFM) is used to estimate the iso spin-dependent properties of finite nuclei,such as symmetry energy,surface symmetry energy,and volume symmetry energy,from their corresponding component in infinite nuclear *** relativistic mean-field(RMF) formalism with non-linear NL3 and relativistic-Hartree-bogoliubov theory with density-dependent DD-ME2 interaction parameters are employed in the *** weight function |F(x)|^(2) is estimated using the total density of each nucleus,which in turn is used with the nuclear matter quantities to obtain the effective symmetry energy and its components in finite *** calculate the ground state bulk properties,such as nuclear binding energy,quadrupole deformation,two-neutron separation energy,differential variation in the two-neutron separation energy,and root-mean-square charge radius,fo

关键词： relativistic energy density functional symmetry energy weight function isospin asymmetry

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Identification of miR414 and Expression Analysis of Conserved miRNAs from Stevia rebaudiana

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Genomics, Proteomics & bioinformatics 2011年第6期9卷 211-217页

作者： praveen Guleria Sudesh kumar Yadav Plant Metabolic Engineering Laboratory Biotechnology Division CSIR-Institute of Himalayan Bioresource Technology Council of Scientific and Industrial ResearchPalampur 17606 India

MicroRNAs （miRNAs） usually contain 19-24 nucleotides and have been identified as important eukaryotic gene regulators. Applications of various computational approaches have simplified the task by predicting miRNAs from available sequence data sources. In this study, we identified a conserved miR414 from a computational analysis of EST sequence data available from Stevia rebaudiana. In addition, we also identified six conserved miRNAs namely miR169, miR319, miR414, miR164, miR167 and miR398 using stem-loop RT-PCR analysis. Hence, miR414 was commonly identified using both methods. The expression analysis of these miRNAs documented their roles in growth and development of Stevia. Furthermore, the detected miRNAs were found to target genes involved in plant growth, development, metabolism and signal transducfion. This is the first study reporting these conserved miRNAs and their expression in Stevia.

关键词： Stevia miRNA computational prediction expression analysis target prediction stem-loop reverse transcription

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Image based leaf segmentation and counting in rosette plants

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Information Processing in Agriculture 2019年第2期6卷 233-246页

作者： J.praveen kumar S.Domnic National Institute of Technology TiruchirappalliIndia

This paper proposes an efficient method to extract the leaf region and count the number of leaves in digital plant *** plant image analysis plays a significant role in viable and productive *** is used to record the plant growth,plant yield,chlorophyll fluorescence,plant width and tallness,leaf area,*** and *** growth is a major character to be analyzed among these plant characters and it directly depends on the number of leaves in the *** this paper,a new method is presented for leaf region extraction from plant images and counting the number of *** proposed method has three *** first step involves a new statistical based technique for image *** second step involves in the extraction of leaf region in plant image using a graph based *** third step involves in counting the number of leaves in the plant image by applying Circular Hough Transform(CHT).The proposed work has been experimented on benchmark datasets of Leaf Segmentation Challenge(LSC).The proposed method achieves the segmentation accuracy of 95.4%and it also achieves the counting accuracy of0.7(DiC)and 2.3(|DiC|)for datasets(A1,A2 and A3),which are better than the state-of-the-art methods.

关键词： Plant image analysis Plant phenotyping Leaf region extraction Leaf count

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R21 vaccine:A ray of hope for malaria elimination

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 243-244页

作者： Nitika Nitika Shrikant Nema praveen kumar bharti ICMR-National Institute of Malaria Research Sector 8DwarkaNew DelhiIndia

The steady decline in malaria cases and deaths in recent years is a step ahead toward elimination;however,an increasing number of reports of antimalarial and insecticide resistance highlight the importance of having newer approaches to achieve the goal in the stipulated time ***,having an effective and durable malaria vaccine is extremely crucial,which can complement the tools currently in *** the malaria vaccine development efforts initiated in the 1910’s with the first attempts to develop a malaria vaccine involved inoculating humans with live,attenuated strains of the malaria parasite but the efforts have been intensified over the previous decade,resulting in several significant developments.

关键词： malaria vaccine elimination

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Interleaved high-gain boost converter powered by solar energy using hybrid-based MPP tracking technique

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Clean Energy 2022年第3期6卷 460-475页

作者： S.Nagaraja Rao Suresh kumar Anisetty b.M.Manjunatha b.M.Kiran kumar V.praveen kumar S.Pranupa MS Ramaiah University of Applied Sciences Department of Electrical EngineeringBangaloreIndia RGM College of Engineering and Technology(Autonomous) NandyalIndia

This paper presents a solar-powered interleaved high-gain boost converter(IHGbC)that increases voltage gain with fewer ripples in the output voltage in comparison to existing DC-DC *** goal of this research is to develop a hybrid-based maximum power point tracking(MPPT)approach with the combination of a flower pollination(FP)algorithm assisted with a perturb&observe(P&O)MPPT approach for solar photovoltaic(SPV)systems integrated with *** ensure effective usage of both FP and P&O algorithms,this study incorporates and validates the hybrid-based MPPT *** proposed solar-powered IHGbC with a hybrid-based MPPT algorithm has been computationally modelled and simulated using MATLAb®and Simulink®for both uniform and non-uniform irradiation and analysed for voltage gain,ripples in the output waveforms and convergence *** proposed hybrid-based MPPT is based on a number of flowers that forecast the initial global peak,assisted by P&O in the last stage for faster convergence to attain the maximum power point(MPP).As a result,the hybrid-based MPPT approach alleviates the computational issues encountered in P&O and FP-based MPP *** proposed hybrid MPPT is compared with conventional MPPT for SPV and the results show that the solar-powered IHGbC using a hybrid-based MPPT technique has negligible oscillations of 0.14%with a high-voltage gain of 7.992 and a fast convergence rate of 0.05 seconds compared to individual P&O-based MPPT and FP-based MPPT *** simulation results of the proposed MPPT with IHGbC outperform the conventional MPPT with high-gain converters.

关键词： flower pollination interleaved high-gain boost converter maximum power point tracking technique perturb&observe solar photovoltaic

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