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Applied Mathematics and Mechanics(English Edition) 2023年第4期44卷 653-668页

作者： b.J.GIREESHA M.l.KEERTHI Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India

A moving trapezoidal profiled convective-radiative porous longitudinal fin wetted in a single-phase fluid is considered in the current *** periodic variation in the fin base temperature is taken into account along with the temperature sensitive thermal conductivity and convective heat transfer *** modeled problem,which is resolved into a non-linear partial differential equation(PDE),is made dimensionless and solved by employing the finite difference method(FDM).The results are displayed through graphs and *** effects of amplitude,frequency of oscillation,wet nature,Peclet number,and other relevant quantities on the distribution of temperature through the fin length and with the dimensionless time are *** is deciphered that the periodic heat transfer gives rise to the wavy nature of the fin thermal profile against *** analysis is beneficial in the design of fin structures for applications like solar collectors,space/airborne applications,and refrigeration industries.

关键词： convection fully wet porous fin trapezoidal profile moving fin unsteady periodic thermal condition

Creep mechanism of as-cast Mg-6Al-6Nd alloy

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Rare Metals 2010年第5期29卷 538-541页

作者： WU Yufeng du Wenbo ZHANG Yinan WANG Zhaohui Institute of Recycling Economy Beijing University of Technology Beijing 100124 China College of Materials Science and Engineering Bei.l'ing University of Technology Beijing 100124 China

The creep mechanism of as-cast Mg-6A1-6Nd alloy was studied. The stress exponent for creep is 5.8 under the applied stresses of 50-70 MPa at 175℃. The activation energy for creep is 189 ***^-1 under the applied stress of 70 MPa in the range of 150-200℃. The true stress exponent and threshold stress for creep are calculated as 4.96 and 10.2 MPa, respectively. The true stress exponent indicates that its creep mechanism b.l.ngs to the dislocation climb-controlled creep, which is in agreement with the microstructure changes before and after creep. The high value for stress exponent is attributed to the interaction of Al11Nd3 phase with dislocations. The activation energy is more than the self-diffusion activation energy of Mg, which is attributed to the load transfer taking place from the matrix to Al11Nd3 phase during creep.

关键词： magnesium alloys creep creep resistance neodymium

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一生的头三年

black hole shadows in Einstein-b.l.Robinson gravity

作者： b.l.·怀特(b.l. White)

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Chinese Physics C 2024年第5期48卷 272-283页

作者： b.Hamil b.C.lütfüoğlu laboratoire de Physique Mathématique et Subatomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physics University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given by higher-order scalar curvature corrections are b.l.eved to bear important consequences. Einstein-b.l.Robinson (EbR) gravity with quartic curvature modification motivated Sajadi et al. to explore static spherically symmetric black hole solutions using perturbative methods. In this study, inspired by their work, we investigate AdS black hole shadows in EbR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presence of plasma, because the black holes are thought to be surrounded by a medium that changes the geodesic of photons.

关键词： black hole shadows Einstein-b.l.Robinson gravity plasma

Combined Effects of Different Overload Ratios and Nitriding Process on Fatigue Crack Growth of AISI 4140 Steel

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Journal of Iron and Steel Research International 2014年第8期21卷 797-803页

作者： A.b.Sengül A.elik Department of Mechanical Engineering anakkale Onsekiz Mart University Department of Mechanical Engineering Ataturk University

The combined effects of different overload ratios（OlRs）and nitriding process on fatigue crack growth（FCG）were *** compact tension specimens made of AISI 4140 steel were subjected to the plasma nitrification process using agas mixture of 50% N2 and 50% H2 at 500℃for *** properties of the samples were studied by scanning electron microscopy,optical microscopy,microhardness testing and digital *** nitriding slowed down FCG,but the crack growth retardation caused by the overload was reduced when the OlR was 2.0and *** did not take effect when the OlR was 1.5and 3.0.

关键词： fatigue crack growth plasma nitriding overload ratio retardation digital image correlation

Treatment of inflammatory bowel disease:A review of medical therapy

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World Journal of Gastroenterology 2008年第3期14卷 354-377页

作者： Patricia l Kozuch Stephen b Hanauer Division of Gastroenterology and Hepatology Department of Medicine Thomas Jefferson University Hospital Philadelphia PA United States University of Chicago Hospitals Department of Medicine Section of Gastroenterology and Nutrition Chicago IL 60637 United States

Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract. While a cure remains elusive, both can be treated with medications that induce and maintain remission. With the recent advent of therapies that inhibit tumor necrosis factor (TNF) alpha the overlap in medical therapies for UC and CD has become greater. Although 5-ASA agents have been a mainstay in the treatment of both CD and UC, the data for their efficacy in patients with CD, particularly as maintenance therapy, are equivocal. Antibiotics may have a limited role in the treatment of colonic CD. Steroids continue to be the first choice to treat active disease not responsive to other more conservative therapy; non- systemic steroids such as oral and rectal budesonide for ileal and right-sided CD and distal UC respectively are also effective in mild-moderate disease. 6-mercaptopurine (6-MP) and its prodrug azathioprine are steroid-sparing immunomodulators effective in the maintenance of remission of both CD and UC, while methotrexate may be used in both induction and maintenance of CD. Infliximab and adalimumab are anti-TNF agents approved in the US and Europe for the treatment of Crohn's disease, and infliximab is also approved for the treatment of UC.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Medical therapy

Immunotherapy and therapeutic vaccines in prostate cancer： an update on current strategies and clinical implications

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Asian Journal of Andrology 2014年第3期16卷 364-371页

作者： b Harpreet Singh James l Gulley Medical Oncology branch Center for Cancer Research National Cancer Institute National Institutes of Health 10 Center Drive Bethesda Maryland USA

In recent years, immunotherapy has emerged as a viable and attractive strategy for the treatment of prostate cancer. While there are multiple ways to target the immune system, therapeutic cancer vaccines and immune checkpoint inhibitors have been most successful in late-stage clinical trials. The landmark Food and Drug Administration approval of sipuleuceI-T for asymptomatic or minimally symptomatic metastatic prostate cancer set the stage for ongoing phase III trials with the cancer vaccine PSA-TRICOM and the immune checkpoint inhibitor ipilimumab. A common feature of these immune-based therapies is the appearance of improved overall survival without short-term changes in disease progression. This class effect appears to be due to modulation of tumor growth rate kinetics, in which the activated immune system exerts constant immunologic pressure that slows net tumor growth. Emerging data suggest that the ideal population for clinical trials of cancer vaccines is patients with lower tumor volume and less aggressive disease. Combination strategies that combine immunotherapy with standard therapies have been shown to augment both immune response and clinical benefit.

关键词： androgen deprivation immunotherapy prostate cancer therapeutic cancer vaccines

全球环境变化中的土地使用与地面覆盖:供研讨的几点思考

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国际社会科学杂志（中文版） 1992年第4期9卷 81-91页

作者： b.l.特纳第二威廉·b·迈耶高銛乔治·珀金斯·马什研究所

自然与社会的关系对于全球环境变化研究的重要性,已经日益得到承认,人们对这个变化中的"人的因素",大书特书。社会科学的一些部分,有着研究社会与自然环境相互作用的长期传统,而"全球环境变化中的人的因素"的明显意义有希望促使这些部... 详细信息

自然与社会的关系对于全球环境变化研究的重要性,已经日益得到承认,人们对这个变化中的"人的因素",大书特书。社会科学的一些部分,有着研究社会与自然环境相互作用的长期传统,而"全球环境变化中的人的因素"的明显意义有希望促使这些部分分工合作,共同进行探讨。

关键词：土地使用环境变化地面覆盖社会与自然土地状况全球变化工业用地人口增长人的因素机会成本

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia Nürnberger barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig b.l.zmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availab.l.ty of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tub.l.r nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tub.l.r walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tub.l.r walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Strengthening synergistic effects between hard carbon and soft carbon enabled by connecting precursors at molecular level towards high-performance potassium ion batteries

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Nano Research 2023年第8期16卷 10985-10991页

作者： Hongqiang Xu boshi Cheng Quan du Yuting Zhang Haojie duan Ishioma l.Egun bo Yin Haiyong He Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 101400China

Synergistic effects between hard carbons and soft carbons are proven to be helpful for improving the electrochemical performance of carbonaceous anode for potassium-ion batteries(PIbs).However,the phase separation of precursors limits the synergistic effects and improvement of electrochemical ***,inspired by the esterification reaction,the precursors of two sorts of carbon are connected at the molecular level,which boosts the synergistic effects in hybrid carbon,resulting in excellent electrochemical kinetics and low charge/discharge ***,the hybrid carbon anode exhibited a high specific capacity of 121 mAh·g^(−1)at 3.2 A·g^(−1),a high-rate capab.l.ty,and stable cycling *** 500 cycles at 1 A·g^(−1),the average capacity fading is only 0.078%per cycle.

关键词： potassium ion batteries anode carbon chemical bond