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放射学实践 2001年第6期16卷 380-380页

作者： b.kreft D.Pauleit R.bachmann 关键华中科技大学同济医学院附属同济医院

目的：分析在有或无恶笥病史时，由MRI检出的小灶性肝脏病变（≤2cm)的发病率和重要性。方法：评价1994－1996年间所行的628例肝脏MRI检查，纳入研究的标准是检出的局灶性肝脏病变≤2cm，分析局灶性肝脏病变的发病率，大小，诊断标准和... 详细信息

目的：分析在有或无恶笥病史时，由MRI检出的小灶性肝脏病变（≤2cm)的发病率和重要性。方法：评价1994－1996年间所行的628例肝脏MRI检查，纳入研究的标准是检出的局灶性肝脏病变≤2cm，分析局灶性肝脏病变的发病率，大小，诊断标准和鉴别诊断，注意患者明确的恶性肿瘤病史。结果：628例患者中179例（28．5％）有≤2cm的局灶性肝脏病变（n=338)，58．9％的病灶通过进一步的超声，CT或MRI，或活检被分类，41．1％的病灶因未做进一步检查而不能分类。57．3％的病灶被证实为良性，而42．7％的病灶为恶性，所有出现肝脏小病灶的患者中，有恶性肿瘤病史的占76．7％，然而，这些患者中良性病灶占病例的50．6％。无明确恶性病史的患者中，75％的病灶为良性，25％为恶性，而且，出现恶性病变的11例中有10例肝癌发生于肝硬化患者。结论：即使有恶性肿瘤病史的病例，MRI检出的肝脏小病灶中约50％为良性。无肿瘤病史的病例，发生小恶性肝脏病变的可能性很低，即使无肝硬化，小肝癌仍可发生。

关键词：小灶性肝病变发病率 MRI 病灶恶性肿瘤病史诊断

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单侧痣样毛细血管扩张综合征

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 15-16页

作者： kreft b. Marsch W.C. Wohlrab J. 党倩丽 Dept. of Dermatology and Venereology Martin Luther Univ. Halle-WittenbergErnst-Kromayer-Strasse 5DE-06097 Halle/SaaleGermany Dr.

We report on a 29-year-old patient with a unilateral nevoid telangiectasia syndrome (UNTS). based on microcirculation examinations,both functional impairments at the blood vessel level (laser-Doppler flowmetry) and morphologically altered capillaries (capillary microscopy) could be observed. We could demonstrate that microcirculatory examinations are suitable to demonstrate pathophysiological defects at the vascular level,especially since subclinical functional defects can also be recorded. To our knowledge,no such observations have yet been published with regards to UNTS.

关键词：微循环检测临床功能病理生理学血管功能障碍多谱勒

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Comparative and population genomics of buckwheat species reveal key determinants of flavor and fertility

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Molecular Plant 2023年第9期16卷 1427-1444页

作者： Kaixuan Zhang Yuqi He Xiang Lu Yaliang Shi Hui Zhao Xiaobo Li Jinlong Li Yang Liu Yinan Ouyang Yu Tang Xue Ren Xuemei Zhang Weifei Yang Zhaoxia Sun Chunhua Zhang Muriel Quinet Zlata Luthar Mateja Germ Ivan kreft Dagmar Janovska Vladimir Meglic barbara Pipan Milen I.Georgiev bruno Studer Mark A.Chapman Meiliang Zhou Institute of Crop Sciences Chinese Academy of Agricultural SciencesNational Crop Genebank BuildingZhongguancun South Street No.12Haidian DistrictBeijing 100081China College of Agronomy Sichuan Agricultural UniversityChengdu 611130China Annoroad Gene Technology(beijing)Co. LtdBeijing 100176China College of Agriculture Institute of Agricultural BioengineeringShanxi Agricultural UniversityTaigu 030801ShanxiChina Shanxi Key Laboratory of Minor Crops Germplasm Innovation and Molecular breeding Shanxi Agricultural UniversityTaiyuan 030031ShanxiChina Tongliao Institute Agricultural and Animal Husbandry Sciences Tongliao 028015Inner MongoliaChina Groupe de Recherche en Physiologie Ve´ge´tale(GRPV) Earth and Life Institute-Agronomy(ELI-A)Universite´Catholique de LouvainCroix du Sud 4-5bo^ıte L7.07.13B-1348Louvain-la-NeuveBelgium biotechnical Faculty University of Ljubljana1000 LjubljanaSlovenia Nutrition Institute Trzaska 401000 LjubljanaSlovenia Gene bank Crop Research InstituteDrnovska´507Prague 6Czech Republic Agricultural Institute of Slovenia Hacquetova ulicaLjubljanaSlovenia Laboratory of Metabolomics Institute of MicrobiologyBulgarian Academy of SciencesPlovdivBulgaria Center of Plant Systems biology and biotechnology PlovdivBulgaria Molecular Plant breeding Institute of Agricultural SciencesETH ZurichUniversitaetstrasse 28092 ZurichSwitzerland biological Sciences University of SouthamptonLife Sciences Building 85Highfield CampusSouthampton SO171BJUK

Common buckwheat(Fagopyrum esculentum)is an ancient crop with a world-wide *** to its excellent nutritional quality and high economic and ecological value,common buckwheat is becoming increasingly important throughout the *** availability of a high-quality reference genome sequence and population genomic data will accelerate the breeding of common buckwheat,but the high heterozygosity due to the outcrossing nature has greatly hindered the genome *** we report the assembly of a chromosome-scale high-quality reference genome of *** ***,a homozygous self-pollinating variant of common *** genomics revealed that two cultivated buckwheat species,common buckwheat(***)and Tartary buckwheat(***),underwent metabolomic divergence and ecotype *** expansion of several gene families in common buckwheat,including FhFAR genes,is associated with its wider distribution than Tartary *** number variation of genes involved in the metabolism of flavonoids is associated with the difference of rutin content between common and Tartary ***,we present a comprehensive atlas of genomic variation based on whole-genome resequencing of 572 accessions of common *** and evolutionary genomics reveal genetic variation associated with environmental adaptability and floral development between Chinese and non-Chinese cultivated ***-wide association analyses of multi-year agronomic traits with the content of flavonoids revealed that Fh05G014970 is a potential major regulator of flowering period,a key agronomic trait controlling the yield of outcrossing crops,and that Fh06G015130 is a crucial gene underlying flavor-associated ***,we found that the gene translocation and sequence variation of FhS-ELF3 contribute to the homomorphic self-compatibility of common ***,our results elucidate the genetic basis of spe

关键词： buckwheat genomics natural variation adaptation flavonoids Fagopyrum

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