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Neuroinflammation revisited through the microglial lens

中国科学院地质与地球物理研究所2003学术年会

作者： b.kamenov P.Monchev Department of Geology and Geography Sofia University St.Kliment Ohridski15 Tzar Osvoboditel Bd.1000 SofiaBalgaria

Fifteen new K-Ar ages in the range of 79-31 Ma are partially confirmed by three Ar/Ar plateaus and isochron data of 64.9±0.4, 55.5±0.1 and 52.8±0.6 *** geochronological data reveal a much more detailed picture of the subduction imprint in the Hurd *** cutting relationships,the dyke emplacement history is divided into four *** Late Cretaceous-Paleocene dykes in the range of 80-60 Ma are related to the main magmatism in Livingston Island and most likely reflect the final stages of subduction of the proto-Pacific oceanic *** Early Eocene dykes(56-52 Ma) fill the gap in volcanic activity 70-50 Ma *** are the only magmatic event manifested at this time in the *** 45-42 Ma dykes may be related to the intrusion of the barnard Point *** samples of Oligocene age appear to represent the last igneous activities on the Hurd Peninsula prior to the opening of the bransfield Strait.

关键词： 40Ar/39Ar dating Dykes Livingston Island Antarctica

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第01期 314-316页

作者： Miguel A.Liuzzi-Vaamonde Jackson b.Lancaster Samantha A.Mason Yuanning Feng Department of Chemistry and biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi bansal Razaz Waheeb Attar Mosiur Rahman brij b.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

Nano-Enhanced Dairy Scum biodiesel blends:Unleashing the Power of Aluminium Oxide for Sustainable and Efficient Engine Performance

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Journal of Thermal Science 2025年第1期 283-302页

作者： Veeranna MODI Prasad b.RAMPURE Sunil Kumar SHETTY Madeva NAGARAL Channa Keshava NAIK N Johar MGM Muhammad Irsyad AbDULLAH Abdullah I.AL-MANSOUR Shamshad ALAM KLE College of Engineering and Technology ChikodiVisvesvaraya Technological University Nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research and Design Centre HAL Department of Mechanical Engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil Engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in b20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(Random Forest（RF）and Catboost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced brake Specific Fuel Consumption（bSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl Ester biodiesel 20%+Neat Diesel 80%（in volume）,DSMEb20),57.14% less CO,40.8% less hydrocarbon,and increased NOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** b20NP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced brake Thermal Efficiency（bTE） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSME b20 and other DSME b20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（bTE,bSFC）,and emissions（CO,CO2,NOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for bTE and bSFC shows that Catboost-based bTE models perform superior to RF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

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Compact embedding in besov spaces and b-separable elleptic operators

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Science China Mathematics 2010年第4期53卷 1067-1084页

作者： SHAKHMUROV Veli b. Department of Electronics Engineering and Communication Okan University

Necessary and sufficient conditions for compactness of sets in banach space valued besov class bp,q s(Ω;E) is *** embedding theorems in besov-Lions type spaces b l,s p,q(Ω;E0,E) are studied,where E0,E are two banach spaces and E 0  *** most regular class of interpolation space E α,between E 0 and E are found such that the mixed differential operator D α is bounded and compact from b p,q l,s (Ω;E 0,E) to b p,q s (Ω;E α) and Ehrling-Nirenberg-Gagliardo type sharp estimates *** using these results the separability of differential operators with variable coefficients and the maximal b-regularity of parabolic Cauchy problem are *** applications,the infinite systems of the elliptic partial differential equations and parabolic Cauchy problems are studied.

关键词： embedding theorems banach-valued function spaces differential-operator equations maximal b-regularity operator-valued Fourier multipliers interpolation of banach spaces abstract parabolic Cauchy problem

Estimation of radiative capture^(13)b(n,γ0+1)^(14)b reaction rate in the modified potential cluster model

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Chinese Physics C 2023年第10期47卷 130-142页

作者： A.S.Tkachenko N.A.burkova b.M.Yeleusheva S.b.Dubovichenko Fesenkov Astrophysical Institute 050020AlmatyKazakhstan al-Farabi Kazakh National University 050040AlmatyKazakhstan

We discuss current attempts to employ the modified potential cluster model to describe the available experimental data on the^(13)b(n,γ0+1)^(14)b total *** estimated results of the M1 and E1 transitions from the n^(13)b scattering states to the ground and first excited states of^(14)b are *** 1st resonance at Ex=1.275 MeV(1+)is revealed in both the cross-section and reaction *** the variation in the asymptotic constant,a thermal cross-section interval of 5.1-8.9 mb is *** on the theoretical total cross-sections at energies of 0.01 eV to 5 MeV,we calculate the reaction rate in the temperature range of 0.01 to *** ignition T9 values of the^(13)b(n,γ0+1)^(14)b reaction depending on a neutron number density n_(n)of~10^(22)cm^(−3)are *** radiative neutron capture reaction rates on the boron^(10-13)b and carbon^(12-14)Сisotopes are compared.

关键词： radiative neutron capture ^(14)b nucleus total cross-sections reaction rate potential cluster model r-process

Microstructural characteristics of Nd_2Fe_(14)b/α-Fe nanocomposite ribbons bearing Nb element

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Rare Metals 2008年第3期27卷 299-302页

作者： WANG Zhanyong LIU Wenqing ZHOU bangxin NI Jiansen XU Hui LI Qiang Department of Materials Engineering Shanghai Institute of Technology Shanghai 200235 China Institute of Materials Shanghai University Shanghai 200072 China

The effects of Nb on the microstructure and magnetic properties of （Nd0.9Dy0.1）9.5Fe79_xCo5Nbxb6.5 （x = 0, 1） nanocomposite magnets were investigated. A fine and uniform microstructure was achieved for the ribbons annealed at 710℃ for 4 min, enhancing the interaction coupling between grains and improving the magnetic properties. The results of three-dimensional atom probe （3DAP） indicated that Fe-Nb-b inter- granular phase existed at the grain boundaries, suppressing the grain growth during the crystallization process. The coercivity was improved from 224 to 643 kA/m for the modification of the microstructure.

关键词： Nd2Fe14b/α-Fe nanocomposite magnet 3DAP magnetic properties

The fat and the furious:fatty acids fuel hyperproliferative germinal center b cells

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Cellular & Molecular Immunology 2020年第8期17卷 794-796页

作者： Rens Peeters Annemiek b.van Spriel Department of Tumor Immunology Radboud Institute for Molecular Life SciencesRadboudumcNijmegenThe Netherlands

The germinal center(GC)reaction is considered the cornerstone of our humoral immune *** in specialized follicles inside secondary lymphoid organs,germinal center b cells(GCbCs)execute a pivotal *** an infection,the number of GCbCs is rapidly expanded,and subsequently GCbCs differentiate into specialized antibody-secreting *** intricate process is driven by the positive selection of GCbCs via the b-cell receptor with the highest affinity for the respective *** this period of extensive proliferation,GCbCs are among the fastest dividing cells in our *** has been established that cell proliferation requires tremendous amounts of energy and building ***,there remains a paucity of evidence to explain how proliferating GCbCs meet these metabolic *** their latest publication in Nature Immunology,Weisel et *** new insights that may have a far-reaching impact on the evolution of the immunometabolism field.

关键词： metabolism organs specialized