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International journal of Digital Earth 2014年第8期7卷 650-670页

作者： giles M.Foody School of Geography University of NottinghamNottinghamUK

Crowdsourcing has become a popular means to acquire data about the Earth and its environment inexpensively,but the data-sets obtained are typically imperfect and of unknown *** common imperfections with crowdsourced data are the contributions from cheats or spammers and missing *** effect of the latter two imperfections on a method to evaluate the accuracy of crowdsourced data via a latent class model was *** simulated and real data-sets,it was shown that the method is able to derive useful information on the accuracy of crowdsourced data even when the degree of imperfection was very *** practical potential of this ability to obtain accuracy information within the geospatial sciences and the realm of Digital Earth applications was indicated with reference to an evaluation of building damage maps produced by multiple bodies after the 2010 earthquake in ***,the method allowed data-sets to be ranked in approximately the correct order of accuracy and this could help ensure that the most appropriate data-sets are used.

关键词： volunteered geographic information accuracy error

Association between fundamental motor skills and physical activity in the early years:A systematic review and meta-analysis

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journal of Sport and Health Science 2020年第6期9卷 542-552页

作者： Dan jones Alison Innerd Emma L.giles Liane b.Azevedo School of Health and Life Sciences Teesside UniversityMiddlesbrough TS13BXUK

background:Physical activity(PA)in the early years is associated with a range of positive health *** motor skill(FMS)competence is associated with PA and is theorized to be driven by PA in the early years and vice versa in mid to late ***,to date,no studies have meta-analyzed the association between PA and FMS in the early ***:Six electronic databases were searched for articles published up to April ***-sectional and longitudinal studies were included if they targeted children(ages 3-6 year)as the population of the study and assessed the association between objectively measured PA and *** FMS,total physical activity(TPA),and moderate-to-vigorous physical activity(MVPA)data were meta-analyzed using a random effects ***:We identified 24,815 titles and *** total,19 studies met the inclusion criteria,including 14 cross-sectional and 4 longitudinal studies,as well as 1 study with cross-sectional and longitudinal *** was a significant but small positive association between FMS and MVPA(r=0.20,95%confidence interval(CI):0.13-0.26)and TPA(r=0.20,95%CI:0.12-0.28).Findings from longitudinal studies revealed that PA drives FMS in early *** was explored in 1 study,which found that perceived motor competence did not mediate the association between FMS and ***:Using a meta-analysis,this study is the first to show a positive association between FMS,MVPA,and TPA in the early years of childhood,suggesting that the association begins at an early *** evidence from longitudinal studies supports the theory that PA drives FMS in the early years of *** evidence is needed from large studies to track PA and FMS until mid to late childhood and to explore the mediators of this association.

关键词： Early years Fundamental motor skills Physical activity

Occupational hand injuries:a current review of the prevalence and proposed prevention strategies for physical therapists and similar healthcare professionals

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journal of Integrative Medicine 2018年第2期16卷 84-89页

作者： giles Gyer jimmy Michael james Inklebarger The London College of Osteopathic Medicine 8-10 Boston PlaceLondon NWI 6QHUnited Kingdom

Hand injury is the second most common work-related musculoskeletal injury among physical therapists （PTs） and other manual therapy professionals such as osteopaths, physiotherapists, chiropractors, acupuncturists and massage therapists. However, the nature and extent of this problem have not been fully explored yet. Therefore, the objective of this study was to review the existing literature published on the prevalence, risk factors, consequences, and prevention of hand injuries among PTs and similar healthcare professionals. The lifetime prevalence of hand injuries was about 15%-46%, and the annual prevalence was reported as 5%-30%. Thumb injuries were found to be the most prevalent of all injuries, accounting more than 50% of all hand-related problems. The most significant risk factors for job-related hand injuries were performing manual therapy techniques, repetitive workloads, treating many patients per day, continued work while injured or hurt, weakness of the thumb muscles, thumb hypermobility, and instability at the thumb joints. Frs reported modifying treatment technique, taking time off on sick leave, seeking intervention, shifting the specialty area, and decreasing patient contact hours as the major consequences of these injuries. The authors recommend that PTs should develop specific preventive strategies and put more emphasis on the use of aids and equipment to reduce the risk of an unnecessary injury.

关键词： Occupational injuries Public health Physical therapists Occupational therapists Complementary therapies

Effects of biomechanical parameters of spinal manipulation: A critical literature review

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journal of Integrative Medicine 2022年第1期20卷 4-12页

作者： giles Gyer jimmy Michael james Inklebarger Imtiaz Ibne Alam Department of Clinical Skills the London College of Osteopathic MedicineBoston PlaceLondon NW1United Kingdom Department of Pharmacy Stamford University BangladeshDhaka 1217Bangladesh

Spinal manipulation is a manual treatment technique that delivers a thrust,using specific biomechanical parameters to exert its therapeutic *** parameters have been shown to have a unique dose-response relationship with the physiological responses of the *** far,however,there has not been a unified approach to standardize these biomechanical *** fact,it is still undetermined how they affect the observed clinical outcomes of spinal *** study,therefore,reviewed the current body of literature to explore these dosage parameters and evaluate their significance,with respect to physiological and clinical *** the experimental studies reviewed herein,it is evident that the modulation of manipulation’s biomechanical parameters elicits transient physiological responses,including changes in neuronal activity,electromyographic responses,spinal stiffness,muscle spindle responses,paraspinal muscle activity,vertebral displacement,and segmental and intersegmental acceleration ***,to date,there have been few clinical trials that tested the therapeutic relevance of these *** addition,there were some inherent limitations in both human and animal models due to the use of mechanical devices to apply the *** studies evaluating the effects of varying biomechanical parameters of spinal manipulation should include clinicians to deliver the therapy in order to explore the true clinical significance of the dose-response relationship.

关键词： Spinal manipulation biomechanical characteristics biomechanical parameters Dosage Force-time profile

Plasma-polymerized pericyte patches improve healing of murine wounds through increased angiogenesis and reduced inflammation

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Regenerative biomaterials 2021年第4期8卷 21-32页

作者： Hannah M.Thomas Parinaz Ahangar Robert Fitridge giles T.S.Kirby Stuart j.Mills Allison j.Cowin Future Industries Institute University of South AustraliaMawson Lakes SA 5095Australia Cell Therapy Manufacturing Cooperative Research Centre Adelaide SA 5000Australia Faculty of Health and Medical Sciences University of AdelaideAdelaide SA 5005Australia

Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning ***,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte *** polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)*** pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization *** AA surface provided the superior transfer of the cells to de-epidermized *** murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the *** delivery also enhanced angiogenesis through a mechanism independent of VEGF ***,when delivered to wounds,improved healing responses by dampening inflammation and promoting *** of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into ***-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.

关键词： pericytes cell therapy wound healing plasma polymerization advanced surfaces

Spinal manipulation therapy: Is it all about the brain? A current review of the neurophysiological effects of manipulation

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journal of Integrative Medicine 2019年第5期17卷 328-337页

作者： giles Gyer jimmy Michael james Inklebarger jaya Shanker Tedla The London College o f Osteopathic Medicine London NW1 6QHUnited Kingdom Department of Medical Rehabilitation Sciences College of Applied Medical SciencesKing Khalid University3665 GuraigerAbhaSaudi Arabia

Spinal manipulation has been an effective intervention for the management of various musculoskeletal disorders. However,the mechanisms underlying the pain modulatory effects of spinal manipulation remain elusive. Although both biomechanical and neurophysiological phenomena have been thought to play a role in the observed clinical effects of spinal manipulation, a growing number of recent studies have indicated peripheral, spinal and supraspinal mechanisms of manipulation and suggested that the improved clinical outcomes are largely of neurophysiological origin. In this article, we reviewed the relevance of various neurophysiological theories with respect to the findings of mechanistic studies that demonstrated neural responses following spinal manipulation. This article also discussed whether these neural responses are associated with the possible neurophysiological mechanisms of spinal manipulation. The body of literature reviewed herein suggested some clear neurophysiological changes following spinal manipulation, which include neural plastic changes, alteration in motor neuron excitability,increase in cortical drive and many more. However, the clinical relevance of these changes in relation to the mechanisms that underlie the effectiveness of spinal manipulation is still unclear. In addition,there were some major methodological flaws in many of the reviewed studies. Future mechanistic studies should have an appropriate study design and methodology and should plan for a long-term follow-up in order to determine the clinical significance of the neural responses evoked following spinal manipulation.

关键词： Occupational injuries Public health Physical therapists Occupational therapists Complementary therapies

NONLINEAR FREE SURFACE ACTION WITH AN ARRAY OF VERTICAL CYLINDERS

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Acta Mechanica Sinica 2004年第3期20卷 247-262页

作者： HUANG j.b. Department of Engineering Science University of OxfordUK

Nonlinear diffraction of regular waves by an array of bottom-seated circular cylindersis investigated in frequency domain,based on a Stokes expansion approach.A complete semi-analyticalsolution is developed which allows an efficient evaluation of the second-order potentials in the entirefluid domain,and the wave forces on the *** are derived for the second-orderpotential in the vicinity of individual *** expressions have a simple form,thus providingan effective means for investigating the wave enhancement due to nonlinear interactions with *** on the present method,the wave run-up and free-surface elevations around an arrayof two,three and four cylinders are investigated numerically.

关键词： nonlinear wave diffraction water waves frequency analysis semi-analytical method

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy b, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： biorefinery Carbon mitigation Climate change Global warming Lignin utilization bioeconomy

Irreversibility investigation of Casson fluid flow in an inclined channel subject to a Darcy-Forchheimer porous medium:a numerical study

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Applied Mathematics and Mechanics(English Edition) 2021年第1期42卷 95-108页

作者： A.ROjA b.j.GIREESHA b.NAGARAjA Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghattaShimoga 577451KarnatakaIndia

The heat transfer and entropy generation characteristics of the magnetohydrodynamic Casson fluid flow through an inclined microchannel with convective boundary conditions are ***,the effects of the viscous forces,joule heating,heat source/sink,and radiation on the flow are taken into *** non-dimensional transformations are used to solve the governing ***,the reduced system is resolved by the fourth-fifth order Runge-Kutta-Fehlberg method along with the shooting *** effects of different physical parameters on the heat transfer and entropy generation are discussed in detail through *** the perspective of numerical results,it is recognized that the production of entropy can be improved with the joule heating,viscous dissipation,and convective heating *** is concluded that the production of entropy is the maximum with increases in the Casson parameter,the angle of inclination,and the Hartmann *** the Reynolds number and the radiation parameter cause the dual impact on entropy generation.

关键词： inclined channel Casson fluid magnetism radiation entropy generation bejan number