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Anti-programmed death 1 antibody in the treatment of coexistent Mycobacterium fortuitum and lung cancer: A case report

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World journal of Clinical Cases 2022年第12期10卷 3801-3807页

作者： cui-cui Zhang Peng Chen Department of Thoracic Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China

bACKGROUND Nontuberculous mycobacterium(NTM) refers to all mycobacteria except Mycobacterium tuberculosis and Mycobacterium leprae, also known as environmental Mycobacterium. The patients with lung cancer and NTM are somewhat special;the two diseases are inevitably influenced by each other. It brings difficulties and challenges to the choice of treatment. Recently, cancer immunotherapy has been considered one of the pillars for the treatment of lung cancer. However, the clinical experience in the application of immune checkpoint inhibitors is scarce for lung cancer patients with pulmonary tuberculosis, and lung cancer with NTM is even more rare. Although it ameliorates lung cancer, immunotherapy with immune checkpoint inhibitors presents complications of infectious diseases, including tuberculosis and *** SUMMARY A 61-year-old male patient visited a doctor in May 2019. His admitting diagnoses were:(1) Cancer of the left lung with a pathological diagnosis of poorly differentiated non-small cell carcinoma, likely poorly differentiated adenocarcinoma, clinical stage Ⅲb(T3N3M0);and(2) Mycobacterium fortuitum(M. fortuitum) infection. We chose to proceed with pembrolizumab treatment. After two treatment cycles, a chest computed tomography scan showed a new irregular subpleural mass in the anterior segment of the left upper lobe of the lung, a reduction in the mediastinal enlarged lymph node, and no other obvious changes. Next, an ultrasound-guided biopsy of the new tumor was performed. Pathological examination showed that a large number of carbon particles were deposited in the alveolar tissue with histiocyte reaction and multinucleated giant cell formation. The tuberculosis(Tb) specialist suggested that anti-Tb therapy be combined with continued antitumor treatment. The patient continued to be treated with pembrolizumab. After 14 cycles, the lesion shrunk by 79%, there was no recurrence of M. fortuitum infection, and there were no intolerable adverse ***

关键词： Mycobacterium fortuitum Nontuberculous mycobacterium Non-small cell lung cancer Immune checkpoint inhibitors Case report

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Polydopamine wrapped polyaniline nanosheets:Synthesis and anticorrosion application for waterborne epoxy coatings

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journal of Materials Science & Technology 2024年第9期176卷 155-166页

作者： X.P.Hu Y.H.Zhang C.b.Liu H.Z.cui School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

Two-dimensional materials have been proved to be effective in improving the performance of anticorrosive ***,most of the reported two-dimensional materials only have the ability to passively block corrosive media and cannot effectively inhibit localized corrosion reactions at the metal/coating ***,we first synthesized a novel polyaniline(PANI)nanosheet with both barrier and passivation functions for *** addition,polydopamine(PDA)wrapped PANI nanosheets(PANI@PDA)were obtained by in situ self-polymerization reaction of dopamine on the PANI surface,which enhance its interfacial interaction with polymeric *** chemical structure,morphology and corrosion inhibition properties of the nanosheets were systematically *** incorporated PANI@PDA nanosheets in composite coating provide a longer penetration path for corrosive ***,the uniformly dispersed two-dimensional nanosheets induce the formation of passivation film on the metal *** protective effect of PANI@PDA nanosheets on coatings was verified by electrochemical impedance spectroscopy(EIS).Results indicated that the prepared composite coating exhibited excellent corrosion resistance throughout the test *** simple and effective modification strategy based on conductive polymers provides a new insight into the development of environmentally adaptive composite coatings with active and passive protection.

关键词： Corrosion prevention Polyaniline Polydopamine Nanosheet Active protection

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NONLINEAR FREE SURFACE ACTION WITH AN ARRAY OF VERTICAL CYLINDERS

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Acta Mechanica Sinica 2004年第3期20卷 247-262页

作者： HUANG j.b. Department of Engineering Science University of OxfordUK

Nonlinear diffraction of regular waves by an array of bottom-seated circular cylindersis investigated in frequency domain,based on a Stokes expansion approach.A complete semi-analyticalsolution is developed which allows an efficient evaluation of the second-order potentials in the entirefluid domain,and the wave forces on the *** are derived for the second-orderpotential in the vicinity of individual *** expressions have a simple form,thus providingan effective means for investigating the wave enhancement due to nonlinear interactions with *** on the present method,the wave run-up and free-surface elevations around an arrayof two,three and four cylinders are investigated numerically.

关键词： nonlinear wave diffraction water waves frequency analysis semi-analytical method

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Interdecadal change of the linkage between the North Atlantic Oscillation and the tropical cyclone frequency over the western North Pacific

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Science China Earth Sciences 2014年第5期57卷 2148-2155页

作者： ZHOU boTao cui Xuan National Climate Center China Meteorological Administration Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology Nansen-Zhu International Research Center Institute of Atmospheric Physics Chinese Academy of Sciences

The relationship between the North Atlantic Oscillation(NAO) and the tropical cyclone frequency over the western North Pacific(WNPTCF) in summer is investigated by use of observation data. It is found that their linkage appears to have an interdecadal change from weak connection to strong connection. During the period of 1948–1977, the NAO was insignificantly correlated to the WNPTCF. However, during the period of 1980–2009, they were significantly correlated with stronger(weaker) NAO corresponding to more(fewer) tropical cyclones in the western North Pacific. The possible reason for such a different relationship between the NAO and the WNPTCF during the former and latter periods is further analyzed from the perspective of large-scale atmospheric circulations. When the NAO was stronger than normal in the latter period, an anomalous cyclonic circulation prevailed in the lower troposphere of the western North Pacific and the monsoon trough was intensified, concurrent with the eastward-shifting western Pacific subtropical high as well as anomalous low-level convergence and high-level divergence over the western North Pacific. These conditions favor the genesis and development of tropical cyclones, and thus more tropical cyclones appeared over the western North Pacific. In contrast, in the former period, the impact of the NAO on the aforementioned atmospheric circulations became insignificant, thereby weakening its linkage to the WNPTCF. Further study shows that the change of the wave activity flux associated with the NAO during the former and latter periods may account for such an interdecadal shift of the NAO–WNPTCF relationship.

关键词： tropical cyclone frequency North Atlantic Oscillation interdecadal change wave activity flux atmospheric circulation

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Nonlinear Preserver Problems on b（H）

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Acta Mathematica Sinica,English Series 2011年第1期27卷 193-202页

作者： jian Lian cui Department of Mathematical Science University of Tsinghua Beijing 100084 P. R. China

Let H be a complex Hilbert space of dimension greater than 2, and b（H） denote the banach algebra of all bounded linear operators on H. For A, b C b（H）, define the binary relation A ≤ b by A＊A = A＊b and AA＊ = Ab＊. Then （b（H）, ＂〈.＂） is a partially ordered set and the relation ＂≤＂ is called the star order on b（H）. Denote by bs（H） the set of all self-adjoint operators in b（H）. In this paper, we first characterize nonlinear continuous bijective maps on bs（H） which preserve the star order in both directions. We characterize also additive maps （or linear maps） on b（H）（or nest algebras） which are multiplicative at some invertible operator.

关键词： Star order fundamental operator algebras nest algebras preserver problems

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尾部风险、生产网络与行业增加值波动

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云南财经大学学报 2025年第1期41卷 19-36页

作者：任俊帆崔严心许祥云南开大学经济学院天津300071 安徽财经大学国际经贸学院安徽蚌埠233030

建立包含行业尾部风险的多行业生产网络一般均衡模型,从中分解出行业尾部风险扩散导致增加值波动的技术扭曲网络效应和配置扭曲网络效应,然后采用ICIO数据库1998—2020年中国的投入产出数据,实证检验两种扭曲网络效应对行业增加值波动... 详细信息

建立包含行业尾部风险的多行业生产网络一般均衡模型,从中分解出行业尾部风险扩散导致增加值波动的技术扭曲网络效应和配置扭曲网络效应,然后采用ICIO数据库1998—2020年中国的投入产出数据,实证检验两种扭曲网络效应对行业增加值波动的影响。研究表明:生产网络会放大并传导行业尾部风险,形成技术扭曲网络效应、配置扭曲网络效应,其中配置扭曲网络效应对行业增加值波动的负面影响更强烈;下游行业的需求侧冲击会通过生产网络向上游传导,使技术扭曲网络效应对上游行业的冲击更强;高技术水平的工业、均衡的生产网络结构以及高中间品替代弹性行业更容易抵御风险冲击;在极端事件冲击时期,两种扭曲网络效应的负面冲击更显著。建议政府正视生产网络对风险的传导作用,做好风险防范与对冲,以实现经济平稳运转。

关键词：尾部风险生产网络部门扭曲网络效应增加值波动

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Insight into element segregation mechanisms during creep in γ'-strengthened Co-based superalloy by elastoplastic phase-field simulation

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Progress in Natural Science:Materials International 2024年第5期34卷 873-879页

作者： jia Chen Min Guo Min Yang Tingting cui borong cui jun Zhang State Key Laboratory of Solidification Processing Northwestern Polytechnical University

The element segregation accompanying the creep process has been shown to significantly affect the deformation resistance of the superalloys. However, the processing and mechanism of element segregation are still *** paper investigated the concentration evolution of a model Co–9Al–9W(at. %) alloy during 900°C/275 MPa using developed ternary elastoplastic phase-field model coupled with CALPHAD method and crystal plasticity model. The results of simulation show that co-depletion of Al and W element occurs in γ' precipitate and in γ side at γ/γ' interface, and this depletion is gradually increasing with the accumulation of plastic strain. From the perspective of changes of driving force of element diffusion, it is found that these segregation phenomena are attributed to the high elastic potential caused by the large local plastic strain. In addition, the effects of these segregations on creep property are also predicted. The current research provides a new method for exploring the mechanism of element diffusion.

关键词： Co-based superalloys Creep Element segregation Phase-field simulation

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Efficient acetylene/carbon dioxide separation with excellent dynamic capacity and low regeneration energy by anion-pillared hybrid materials

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Frontiers of Chemical Science and Engineering 2022年第11期16卷 1616-1622页

作者： Yijian Li jianbo Hu jiyu cui Qingju Wang Huabin Xing Xili cui Zhejiang Key Laboratory of Smart biomaterials Key Laboratory of Biomass Chemical Engineering of Ministry of EducationCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China ZjU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China

Adsorptive separation of acetylene/carbon dioxide mixtures by porous materials is an important and challenging task due to their similar sizes and physical ***,remarkable acetylene/carbon dioxide separation featuring a high dynamic breakthrough capacity for acetylene(4.3 mmol·g^(–1))as well as an ultralow acetylene regeneration energy(29.5 kj·mol^(–1))was achieved with the novel TiF_(6)^(2–)-pillared material ZU-100(TIFSIX-bpy-Ni).Construction of a pore structure with abundant TiF_(6)^(2–)anion sites and pores with appropriate sizes enabled formation of acetylene clusters through hydrogen bonds and intermolecular interactions,which afforded a high acetylene capacity(8.3 mmol·g^(–1))and high acetylene/carbon dioxide uptake ratio(1.9)at 298 K and 1 ***,the NbO_(5)^(2–)anion-pillared material ZU-61 investigated for separation of acetylene/carbon *** addition,breakthrough experiments were also conducted to further confirm the excellent dynamic acetylene/carbon dioxide separation performance of ZU-100.

关键词： acetylene carbon dioxide separation dynamic capacity anion-pillared hybrid material

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On the hydro-mechanical behaviour of MX80 bentonite-based materials

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journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 183-192页

作者： Yu-jun cui Ecole des Ponts ParisTech Laboratoire Navier/CERMES 6e8 av. Blaise Pascal Cité Descartes Champs e sur e Marne 77455 Marne-la=Valléecedex 2France

bentonite-based materials have been considered in many countries as engineered barrier/backfilling materials in deep geological disposal of high-level radioactive *** the long period of waste storage,these materials will play an essential role in ensuring the integrity of the storage system that consists of the waste canisters,the engineered barrier/backfill,the retaining structures as well as the geological ***,it is essential to well understand the hydro-mechanical behaviours of these bentonite-based *** review paper presents the recent advances of knowledge on MX80 bentonite-based materials,in terms of water retention properties,hydraulic behaviour and mechanical *** is put on the effect of technological voids and the role of the dry density of *** swelling anisotropy is also discussed based on the results from swelling tests with measurements of both axial and radial swelling pressures on a sand-bentonite mixture compacted at different *** observation was used to help the interpretation of macroscopic hydromechanical ***,the evolution of soil microstructure thus the soil density over time is discussed based on the results from mock-up *** evolution is essential for understanding the longterm hydro-mechanical behaviour of the engineered barrier/backfill.

关键词： bentonite-based materials Water retention Hydraulic conductivity Mechanical behaviour Microstructure Dry density evolution

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Electrochemical synthesis,structure characterization and magnetic properties of Tb_(x)Fe_(7)Co_(3)(x=0,0.6,0.8) nanowires

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journal of Rare Earths 2021年第5期39卷 565-571页

作者： Licong Kang Chunxiang cui Yuanyuan Zhang Wei Yang Qiong Li Sen cui Key Lab.for New Type of Functional Material in Hebei Province School of Materials Science and EngineeringHebei University of TechnologyTianjin 300130China Department of Macromolecular Science and Engineering Case Western Reserve UniversityClevelandOH44106United States

Highly ordered Tb_(x)Fe_(7)Co_(3)(x=0,0.6,0.8)nanowires were synthesized in alumina templates by electrochemical deposition ***,the effects of Tb content and annealing treatment on the phase composition,morphology,crystalline structure and magnetic properties were *** asdeposited Tb_0 Fe_(7)Co_(3)nanowires comprise Fe_(7)Co_(3)*** after adding Tb,the diffraction peaks slightly shift left,indicating the infiltration of Tb atoms into Fe_(7)Co_(3)*** annealing,Tb_0 Fe_(7)Co_(3)nanowires still consist of Fe_(7)Co_(3)phase with a slight enhancement on *** the annealed nanowires with Tb doped present a complex phase composition containing Fe3 Tb,Fe_(2)Tb,Co_(3)Tb,Co_(17)Tb_(2),TbFeO_(3)and Fe_(2)O_(3)phases distribute in the central portion,and Co_(0.72)Fe_(0.28)at the nanowire outer *** annealed Tb_(x)Fe_(7)Co_(3)(x=0.6,0.8)nanowires show higher magnetic performance owing to the formation of hard magnetic phases,the interfacial elastic coupling between hard and soft phases and the coherent Fe3 Tb/Co_(3)Tb interface which restrain the domain wall *** be specific,the coercivity and remanence ratio of TbxFe_(7)Co_(3)(x=0.6,0.8)nanowires significantly enhance with increasing Tb content.

关键词： Tb-Fe-Co nanowires Electrodeposition Crystal structure Magnetic properties Coercivity mechanism Rare earths

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