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The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long jiajia Liu Yu Wang Haidong Guo Guohong cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κb-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

基于多尺度融合金字塔焦点网络的接触网零部件检测

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工程科学学报 2025年第2期47卷 315-327页

作者：朱新宇崔浩锐宋洋中国民用航空飞行学院航空电子电气学院西南交通大学利兹学院

作为高铁牵引供电系统的重要组成部分，接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明，受弓网交互产生的持续冲击以及外部环境的影响，接触网支撑部件可能会出现“松、脱、断、裂”等缺陷，导致接触网结构可靠性下降... 详细信息

作为高铁牵引供电系统的重要组成部分，接触网系统承担着向动车组传输电能的重要功能.实际工程运营表明，受弓网交互产生的持续冲击以及外部环境的影响，接触网支撑部件可能会出现“松、脱、断、裂”等缺陷，导致接触网结构可靠性下降，严重影响接触网系统稳定运行.因此，及时精确定位接触网支撑部件（CSCs），对保障高铁安全运行和完善接触网检修维护策略具有重大意义.然而，CSCs的检测通常面临着零部件种类多、尺度差异大、部分零部件微小的问题.针对以上问题，本文提出一种基于多尺度融合金字塔焦点网络的接触网零部件检测算法，将平衡模块和特征金字塔模块相结合，提高对小目标的检测性能.首先，设计了可分离残差金字塔聚合模块（SRPAM），用于优化模型多尺度特征提取能力、扩大感受野，缓解CSCs检测的多尺度问题；其次，设计了一种基于平衡特征金字塔的路径聚合网络（PA-bFPN）,用于提升跨层特征融合效率和小目标检测性能.最后，通过对比试验、可视化实验和消融实验证明了所提方法的有效性和优越性.其中，所提的MFPFCOS在CSCs数据集上的检测精度（mAP）能够在达到48.6%的同时，实现30的FLOPs (Floating point operations per second)，表明所提方法能够在检测精度和检测速度之间保持良好的平衡.

关键词：深度学习目标检测接触网支撑组件(CSCs) 路径聚合特征金字塔(PA-FPN) 空洞空间卷积池化金字塔(ASPP)

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MODELING AND EXPERIMENTAL RESEARCH OF FOUR-STRAND LOW-FREQUENCY ELECTROMAGNETIC CASTING ALUMINUM ALLOY

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Acta Metallurgica Sinica(English Letters) 2007年第3期20卷 157-166页

作者： j.C. Li b.F. Wang j.Z. cui School of Materials ＆ Metallurgy Inner Mongolia University of Science and Technology Baotou 014010 China The Key Laboratory of Electromagnetic Processing of Materials Ministry of Education Northeastern University Shenyang 110004 China

With the aid of ANSYS software, the effect of different mould external part materials on magnetic flux density in the aluminum melt and magnetic field interaction of four coils applied with same currents were investigated. Calculating results showed that magnetic flux density in the aluminum melt was greatly improved and the magnetic field interaction among different coils was decreased when external part of mould is made of soft magnetic material. based on the finding, a four-strand low-frequency electromagnetic casting 6063 aluminum alloy experiment was carried out in the laboratory . The experiment showed that the surface of the billet was smooth and had no exudations and cold shuts, the as-cast microstructures were fine, uniform, equiaxed, net-globular or globular under low-frequency electromagnetic field. The microstructure becomes finer with increased current value.

关键词： low-frequency electromagnetic casting finite element method aluminum alloy mould

Energy-aware deployment of dense heterogeneous cellular networks with QoS constraints

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Science China(Information Sciences) 2017年第4期60卷 148-165页

作者： Qimei cui Zhiyan cui Wei ZHENG Riku jNTTI Weiliang XIE National Engineering Laboratory for Mobile Network Security Beijing University of Posts and Telecommunications Department of Communications and Networking Aalto University China Telecom Corporation Limited

The base station(bS) configuration is a key factor to improve energy efficiency(EE). In this paper,we focus on designing the network deployment parameters(i.e., bS densities) for biased K-tier heterogeneous cellular network(HCN) with quality of service(Qo S) provisioning. Using appropriate approximations, we derive the closed-form expressions of optimal bS density across all tiers to minimize the area power consumption(APC) by applying the stochastic geometry theory, while satisfying the users’ Qo S requirements. These results are used to obtain some new insights into the EE performance of biased HCN deployment. With the aid of this approach, the best type of bSs to be deployed or switched off for energy saving purposes can be identified from the perspectives of bS transmission power. More precisely, if the bS transmission power ratio between an arbitrary pair of tiers of K-tier HCN, e.g., the small cell bS and macro bS tiers, is higher than a threshold which is a function of path loss exponent, bias factor and power consumption, the small cell bSs are *** opposite situation takes place otherwise. Furthermore, it is also shown that, compared to the unbiased HCN scenario, significant energy savings are possible by appropriately biasing the HCN and optimizing the bS density, subject to the Qo S constraints among all tiers.

关键词： heterogeneous cellular networks stochastic geometry energy efficiency bS density energy saving

Recycling of automotive aluminum

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Transactions of Nonferrous Metals Society of China 2010年第11期20卷 2057-2063页

作者： jirang cui Hans j.ROVEN Department of Materials Science and Engineering Norwegian University of Science and Technology(NTNU)

With the global warming of concern,the secondary aluminum stream is becoming an even more important component of aluminum production and is attractive because of its economic and environmental *** this work,recycling of automotive aluminum is reviewed to highlight environmental benefits of aluminum recycling,use of aluminum alloys in automotive applications,automotive recycling process,and new technologies in aluminum scrap *** survey shows that newly developed techniques such as laser induced breakdown spectroscopy(LIbS) and solid state recycling provide promising alternatives in aluminum scrap *** with conventional remelting and subsequent refinement,solid state recycling utilizing compression and extrusion at room or moderate temperature can result in significant energy savings and higher metal yield.

关键词： recycling automotive aluminum sorting mechanical separation solid state recycling

Refolding of reduced/denatured bovine pancreatic insulin with ion-exchange chromatography coupled with MALDI-TOF MS

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Chinese Chemical Letters 2009年第12期20卷 1487-1490页

作者： cui E. Lin Quan b ai Institute of Modern Separation Science Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education Northwest University Xi'an 710069 China

The refolding of the reduced/denatured insulin from bovine pancreas as the model protein was investigated with weak anion exchange chromatography （WAX） coupled with MALDI-TOF MS. The results indicated that the disulfide bonds almost cannot be formed correctly with the common mobile phase by WAX. However, with the urea gradient elution and in the presence of GSSG/ Cyst as the ratio 1：6 in the mobile phase employed, the disulfide exchange of reduced/denatured insulin can be accelerated resulting in forming the correct three disulfide bonds. The protein refolding efficiency of reduced/denatured insulin can be increased from 3 % to 34%. The effects of urea gradient and the oxidant and reductant groups, such as GSSG/GSH, Cyst, and GSSG/Cyst, on the forming the disulfide bonds of reduced/denatured insulin were investigated in detail. The results were further tested by the separation of the WAX fraction of reduced/denatured insulin with RPLC and MALDI-TOF MS.

关键词： Protein refolding Liquid chromatography Reduced/denaturation Insulin MALDI-TOF MS

The role of crystallinity on differential attachment/ proliferation of osteoblasts and fibroblasts on poly （caprolactone-co-glycolide） polymeric surfaces

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Frontiers of Materials Science 2012年第1期6卷 47-59页

作者： Helen cui Patrick j.SINKO Advanced Technology and Regenerative Medicine(ATRM) LLCSomervilleNJ 08876USA Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNJ 08854USA

The objective of the present study is to systematically evaluate the role of polymer crystallinity on fibroblast and osteoblast adhesion and proliferation using a series of poly（caprolactone-co-glycolide）（PCL/PGA） polymers. PCL/PGA polymers were selected since they reflect both highly crystalline and amorphous materials. PCL/PGA polymeric materials were fabricated by compression molding into thin films. Five compositions, from PCL or PGA to intermediate copolymeric compositions of PCL/PGA in ratios of 25：75, 35：65 and 45：55, were studied. Pure PCL and PGA represented the crystalline materials while the copolymers were amorphous. The polymers/copolymers were characterized using DSC to assess crystallinity, contact angle measurement for hydrophobicity, and AFM for nanotopography. The PCL/PGA films demonstrated similar hydrophobicity and nanotopography whereas they differed significantly in crystallinity. Cell adhesion to and proliferation on PCL/PGA films and proliferation studies were performed using osteoblasts and NIH-3T3 fibroblasts. It was observed that highly crystalline and rigid PCL and PGA surfaces were significantly more efficient in supporting fibroblast growth, whereas amorphous/flexible PCL/PGA 35：65 was significantly more efficient in supporting growth of osteoblasts. This study demonstrated that while chemical composition, hydrophobicity and surface roughness of PCL/PGA polymers were held constant, crystallinity and rigidity of PCL/PGA played major roles in determining cell responses.

关键词： crystallinity attachment proliferation osteoblast fibroblast PCL-PGA

A two-scale method for identifying mechanical parameters of composite materials with periodic configuration

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Acta Mechanica Sinica 2006年第6期22卷 581-594页

作者： j.Z. cui X.G. Yu Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 10080 China

In this paper, a two-scale method （TSM） is presented for identifying the mechanics parameters such as stiffness and strength of composite materials with small periodic configuration. Firstly, a formulation is briefly given for two-scale analysis （TSA） of the composite materials. And then a two-scale computation formulation of strains and stresses is developed by displacement solution with orthotropic material coefficients for three kinds of such composites structures, i.e., the tension column with a square cross section, the bending cantilever with a rectangular cross section and the torsion column with a circle cross section. The strength formulas for the three kinds of structures are derived and the TSM procedure is discussed. Finally the numerical results of stiffness and strength are presented and compared with experimental data. It shows that the TSM method in this paper is feasible and valid for predicting both the stiffness and the strength of the composite materials with periodic configuration.

关键词： Two-scale method Stiffness Strength Composite materials Small periodic configuration

Structural and optical properties of periodically ordered ZnO nanowires

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Science China(Technological Sciences) 2009年第2期52卷 313-317页

作者： j.b.cui Department of Physics and Astronomy, University of Arkansas at Little Rock, Little Rock, AR 72204, USA 1. Department of Physics and Astronomy University of Arkansas at Little Rock Little Rock AR 72204 USA

Periodically ordered ZnO nanowire arrays were fabricated by a combination of soft templates created by electron beam lithography and an electrochemical process. Individual ZnO nanowires were precisely placed in desired locations to form two-dimensional periodic structures with specific patterns. Scanning electron microscopy and light diffraction measurements confirmed the long-range ordered structures in the nanowire arrays. Variable temperature photoluminescence revealed both band edge and defect emissions. The obtained photonic structures may have potential applications in optical and optoelectronic devices.

关键词： Zinc oxide nanowires ordered structure optical property