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Effects of water extracts of Davallia formosana on ovariectomized mice

Chinese Herbal Medicines 2018年第1期10卷 66-72页

作者： chia-feng wu cheng-yu chen ming-chang wu jen-shinn lin department of food science national pingtung university of science and technologypingtung 91201china department of medicinal plant development yupintang traditional chinese medicine foundationkaohsiung 000800china

Objective： The Taiwan Residents native fern, Davallia formosana, is used to treat bone diseases in traditional Chinese medicine, but, very few animal tests to verify. To study how this fern and its active components alter bone metabolism. Methods： The effects of low and high doses of D. formosana water extracts （DFW, 50 and 200 mg/（kg·d）） and （-）-epicatechin-3-O-D-allopyranoside isolates of DFW （ECAP, 0.06 and 2.5 mg/（kg·d）） on protein lev- els of important indicators of osteoclast and osteoblast activities were examined. Ovariectomized mice were used as a model of osteoporosis. bone morphogenetic protein 2 （bMP-2）, collagen 1 （COL-1）, alka- line phosphatase （ALP）, runt-related transcription factor 2 （RUNX2）, osteocalcin （OCN）, and osteopontin （OPN） were analyzed using western blotting of femur tissue. interleukin （iL）-1β and tumor necrosis fac- tor （TNF）-a were measured in the serum, and hematoxylin and eosin staining were used to assess bone morphology. Results： Treatment with DFW or ECAP significantly induced bMP-2, COL-l, ALP, RUNX2, OCN, and OPN protein expression, indicating stimulation of osteogenesis. The treatments also reduced iL-1β and TNF- expression, indicating inhibition of osteoclastogenesis. in histological examinations, mice treated with DFW or ECAP had more bone trabeculae. The results demonstrate that DFW and ECAP inhibit osteo- clast differentiation and promote osteoblast differentiation, and effectively ameliorate ovariectomy （OVX）- induced osteoporosis. Conclusion： ECAP is a major component of DFW, which may have therapeutic potential for the treatment of diseases associated with excessive osteoclastic and insufficient osteogenic activity. ECAP may not be the specific active molecule because it is unstable in the stomach. However, the major active molecule needs to be confirmed using a relevant pharmacological model.

关键词： Davallia formosana Hayata osteoporosis osteogenesis osteoclastogenesis

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抗癫癎药物应用指南Ⅱ:新型抗癫癎药物的药力和耐受性:难治性癫癎的治疗美国神经病学学会治疗学和技术评定分委会和质量标准分委会及美国癫癎协会报告

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神经病学与神经康复学杂志 2008年第4期5卷 265-277页

作者：陆钦池冯智英李颖季伟华 J.A.French A.M.Kanner J.bautista b.Abou-Khalil T.browne C.L.Harden W.H.Theodore C.bazil J.Stern S.C.Schachter D.bergen D.Hirtz G.D.Montouris M.Nespeca b.Gidal W.J.Marks Jr. W.R.Turk J.H.Fischer b.bourgeois A.Wilner R.E.Faught Jr. R.C.Sachdeo A.beydoun T.A.Glauser 上海交通大学医学院附属仁济医院神经内科上海200127

目的对有关7种用以治疗儿童和成人部分性和全面性难治性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin, GbP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGb)、奥卡西平(oxcarbazepine,OXC)、左乙拉西坦(levetiracetam,lev)和唑尼沙胺(zonisamide,ZNS)的药力(efficacy)、耐受性和安全性进行评估。方法由23位成人神经病学家、小儿神经病学家、癫癎病学家和药理学家组成的专家组,依据从1987年到2002年9月Medline,Current Contents和Cochrane上发表的相关文献和2003年以前的指南提供的证据进行循证医学评估。结果所有新型抗癫癎药物都适用于成人难治性部分性癫癎的添加治疗,加巴喷丁对混合性癎性发作有效,加巴喷丁、拉莫三嗪、托吡酯和奥卡西平对儿童难治性部分性癫癎有效。有限的证据还表明,拉莫三嗪和托吡酯对成人和儿童特发性全面性发作和Lennox-Gastaut综合征的添加治疗也有效。结论抗癫癎药物的选择要考虑癫癎发作和/或癫癎综合征的类型、患者的年龄、合用的药物、药物的耐受性、安全性和药力等因素。循证医学评估结果提供了难治性癫癎患者的抗癫癎药物应用指南,但尚需更为有力的证据用以鉴定其在癫癎型或综合征中疗效。

关键词：药物应用指南耐受性难治性癫治疗学美国神经病学技术评定质量标准分 antiepileptic drugs new society american quality technology refractory epilepsy 拉莫三嗪加巴喷丁托吡酯

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抗病毒治疗适应证变化对提高慢性乙型肝炎治疗率的影响

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临床肝胆病杂志 2022年第6期38卷 1269-1274页

作者：王皓单姗尤红徐小元魏来侯金林庄辉孔媛媛贾继东中国消除乙肝临床研究平台(CR-Hepb)研究组首都医科大学附属北京友谊医院临床流行病学与循证医学研究室北京100050 首都医科大学附属北京友谊医院肝病中心北京100050 北京大学第一医院感染疾病科北京100034 北京清华长庚医院肝胆胰内科北京100044 南方医科大学南方医院感染内科广州510515 北京大学医学部病原生物学系北京100191 不详

目的探讨抗HbV治疗适应证变化对治疗率和需要治疗人群特征的影响。方法研究对象来自于中国消除乙肝临床研究平台(CR-Hepb)数据库中未经治慢性乙型肝炎患者,收集其人口学、病毒学、血液学及血生化信息。不符合正态分布的定量资料在两组... 详细信息

目的探讨抗HbV治疗适应证变化对治疗率和需要治疗人群特征的影响。方法研究对象来自于中国消除乙肝临床研究平台(CR-Hepb)数据库中未经治慢性乙型肝炎患者,收集其人口学、病毒学、血液学及血生化信息。不符合正态分布的定量资料在两组间比较采用Mann-Whitney U检验,多组间比较采用Kruskal-Wallis H检验,定性资料组间比较采用χ^(2)检验或Fisher确切概率检验。结果本研究共纳入3640例未经治慢性乙型肝炎患者,64.4%为男性,68.7%年龄为30~59岁,46.8%临床分期不确定。根据2015年版、2019年版慢性乙型肝炎防治指南和2022年版专家共识,分别有625例(17.2%)、1333例(36.6%)、和2890例(79.4%)符合抗病毒治疗适应证。2022年版共识新增需治疗患者1557例,其中1424例(91.5%)符合男性ALT>30 U/L、女性ALT>19 U/L的治疗阈值。2022年版专家共识新增需治疗患者的ALT、HbV DNA水平、APRi和Fib-4评分显著低于2019年版指南新增需治疗患者(P值均<0.05)。结论随着慢性乙型肝炎抗病毒治疗的适应证扩展,将显著提高患者的治疗比例,有利于更多有疾病进展风险的轻症患者得到及时治疗并改善长期预后。

关键词：乙型肝炎,慢性抗病毒药适应证

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iL-6而非松弛素,可预测对宫颈功能不全妇女行补救性环扎术的效果

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 12-12页

作者： Lee K.-Y. Kim H.-b. 程广艳 Dept.of Obstetrics and Gynecolog y Hallym UniversitySeoulSouth Korea Dr.

Objective We investigated the poten tial roles of relaxin and subclinical intra -amniotic inflam mation by quantitating amniotic fluid relaxin and interleu kin -6concentrations for the prediction of outcome of rescue c erclage in women with cervical *** desig n Cervical incompe-tence was diagnosed when cervical di latation exceeded 2cm with intact but bulging membranes an d no detectable uter-ine *** woman underwent a mniocentesis to fa-cilitate the performance of a rescue cerclage between 15and 27weeks of gestation(n =40women).Forty -five additional women who underwent amni ocentesis for chro-mosomal testing between 16and 27weeks of gestation served as a control *** contro l patients were de-livered of chromosomally normal inf ants at>37weeks of *** cases and control patients were singleton *** -6and rela xin were determined in all amniotic fluid samples by enzyme -linked im-munosorbent *** Amnioti c fluid interleukin -6levels were significantly higher in women with cervical incompetence than in control patien ts(control patients,50.4pg /mLrange,19.4-97.4pg /mLvs cervical incompetence patients,5459.1pg /m Lrange,1131.4-14425.7pg /mL;P in contrast to inter-leukin -6,relaxin levels did not dif fer between the 2groups(control patients,67.5pg /mLrange,35.1-153.5pg /mLvs cervical incompetence patients,45.6pg /mLrange,30.1-75.5pg /mL;P =.061).There was a significant difference i n interleukin -6lev-els in women with shorter latencies(Pintervals that were examined:delivery within 24hours,3days,7days,before 33and 37completed weeks of gestation).Linear regression analysis with th e use of the latency interval from cerclage to delivery as the depen-dent and with interleukin -6as the in dependent variable revealed a significant inverse rela tionship(r =-0.62;Pion of int erleukin -6).There was no relationship on regression analysis between relaxin and the

关键词：宫颈功能不全环扎术补救性松弛素羊膜腔穿刺术子宫活动度染色体检测单胎妊娠宫颈扩张周因

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bETAXOLOL DiSTRibUTES TO THE HU-MAN RETiNA AND OPTiC NERVE HEAD AT PHARMACOLOGiCALLY ACTiVE lev-ELS AFTER CHRONiC TOPiCAL OCULAR ADMiNiSTRATiON OF bETOPiC

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国际眼科杂志 2003年第1期3卷 83-83页

作者： G.Hollo J.T.Whitson R.Faulkner M.Curtis H.Wieland L.De Santis b.McCue J.T.Przydryga D.C.Dahlin Semmelweis University Medical School HungaryUniversity of Texas Southwestern Medical Center TXAlcon Research Ltd TX USA Alcon Research Ltd GermanyAlcon Research Ltd TX USA Alcon Research Ltd GermanyAlcon Research Ltd TX USA Alcon Research Ltd GermanyAlcon Research Ltd TX USA Alcon Research Ltd GermanyAlcon Research Ltd TX USA Alcon Research Ltd GermanyAlcon Research Ltd TX USA Alcon Research Ltd GermanyAlcon Research Ltd TX USA Alcon Research Ltd Germany

Objective: To measure steady-state concentrations of betax-olol (bTX) in ocular tissues from patients requiring enucleation for glaucoma-related ocular pain and blindness. bTX has potential for enhancement of retinal ... 详细信息

关键词：倍他米松慢性眼内局部用药视网膜视神经乳头倍他洛尔分布药理活性水平

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Fungal diversity notes 491–602: taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2017年第2期83卷 1-261页

作者： Saowaluck Tibpromma Kevin D.Hyde Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Jian-Kui Liu D.Jayarama bhat E.b.Gareth Jones Eric H.C.McKenzie Erio Camporesi Timur S.bulgakov Mingkwan Doilom AndreLuiz Cabral Monteiro de Azevedo Santiago Kanad Das Patinjareveettil Manimohan Tatiana b.Gibertoni Young Woon Lim Anusha Hasini Ekanayaka benjarong Thongbai Hyang burm Lee Jun-bo Yang Paul M.Kirk Phongeun Sysouphanthong Sanjay K.Singh Saranyaphat boonmee Wei Dong K.N.Anil Raj K.P.Deepna Latha Rungtiwa Phookamsak Chayanard Phukhamsakda Sirinapa Konta Subashini C.Jayasiri Chada Norphanphoun Danushka S.Tennakoon Junfu Li Monika C.Dayarathne Rekhani H.Perera Yuanpin Xiao Dhanushka N.Wanasinghe indunil C.Senanayake ishani D.Goonasekara N.ide Silva Ausana Mapook Ruvishika S.Jayawardena Asha J.Dissanayake ishara S.Manawasinghe K.W.Thilini Chethana Zong-Long Luo Kalani Kanchana Hapuarachchi Abhishek baghela Adriene Mayra Soares Alfredo Vizzini Angelina Meiras-Ottoni Armin Mesic Arun Kumar Dutta Carlos Alberto Fragoso de Souza Christian Richter Chuan-Gen Lin Debasis Chakrabarty Dinushani A.Daranagama Diogo Xavier Lima Dyutiparna Chakraborty Enrico Ercole Fang Wu Giampaolo Simonini Gianrico Vasquez Gladstone Alves da Silva Helio Longoni Plautz Jr Hiran A.Ariyawansa Hyun Lee ivana Kusan Jie Song Jingzu Sun Joydeep Karmakar Kaifeng Hu Kamal C.Semwal Kasun M.Thambugala Kerstin Voigt Krishnendu Acharya Kunhiraman C.Rajeshkumar Leif Ryvarden Margita Jadan Mdiqbal Hosen Michal Miksık Milan C.Samarakoon Nalin N.Wijayawardene Nam Kyu Kim Neven Matocec Paras Nath Singh Qing Tian R.P.bhatt Rafael JoseVilela de Oliveira Rodham E.Tulloss S.Aamir Saithong Kaewchai Sayali D.Marathe Sehroon Khan Sinang Hongsanan Sinchan Adhikari Tahir Mehmood Tapas Kumar bandyopadhyay Tatyana YuSvetasheva Thi Thuong Thuong Nguyen Vladimır Antonın Wen-Jing Li Yong Wang Yuvraj indoliya Zdenko Tkalcec Abdallah M.Elgorban Ali H.bahkali Alvin M.C.Tang Hong-Yan Su Huang Zhang itthayakorn Promputtha Jennifer Luangsa-ard Jianchu Xu Jiye Yan Kang Ji-Chuan Marc Stadler Pete Key Laboratory for Plant Diversity and biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.b.Gruppo Micologico Forlivese“Antonio Cicognani” Via Roma 18Forlı`Italy A.M.b.Circolo Micologico“Giovanni Carini” C.P.314BresciaItaly Societa`per gli Studi Naturalistici della Romagna C.P.144BagnacavalloRAItaly Formerly Department of botany Goa UniversityTaleigaoGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa VelhaIndia 33 b St.Edwards Road Southsea Hants Hampshire PO53DHUK Landcare Research Manaaki Whenua Private Bag 92170AucklandNew Zealand Department of biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Division of Applied Science College of International EducationThe Hong Kong Baptist UniversityHong Kong SARChina PostGraduate Program in biology of Fungi Department of MycologyFederal University of PernambucoAv.Nelson Chavess/nRecifePE 50670-420Brazil institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Environmental Microbiology Lab Division of Food TechnologyBiotechnology&AgrochemistryCollege of Agriculture and Life SciencesChonnam National UniversityYongbong-Dong 300Buk-GuGwangju 61186Korea Guizhou Key Laboratory of Agricultural biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China College of Agriculture and biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China Yunnan institute of Food Safety Kunming University of Science&TechnologyKunming 650500YunnanPeople’s Republic

This is a continuity of a series of taxonomic and phylogenetic papers on the fungi where materials were collected from many countries,examined and *** addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets to infer phylogenetic relationships and substantiate systematic positions of taxa within appropriate ***ever new species or combinations are proposed,we apply an integrative approach using morphological and molecular data as well as ecological features wherever *** on 112 fungal taxa are compiled in this paper including biatriosporaceae and Roussoellaceae,Didysimulans ***.,81 new species,18 new host records and new country records,five reference specimens,two new combinations,and three sexual and asexual morph *** new species are Amanita cornelii,***,Angustimassarina alni,***,***,***,***,Ascochyta italica,***,Austroboletus appendiculatus,barriopsis thailandica,berkleasmium ariense,Calophoma petasitis,Camarosporium laburnicola,***,***,***,***,Colletotrichum sambucicola,Coprinopsis cerkezii,Cytospora gelida,Dacrymyces chiangraiensis,Didysimulans italica,***,Entodesmium italica,Entoloma magnum,Evlachovaea indica,Exophiala italica,Favolus gracilisporus,Femsjonia monospora,Fomitopsis flabellata,***,Gongronella brasiliensis,Helvella crispoides,Hermatomyces chiangmaiensis,***nae,Hysterium centramurum,inflatispora caryotae,inocybe brunneosquamulosa,***,***,Keissleriella cirsii,Lepiota cylindrocystidia,***,***,Lophiotrema guttulata,Marasmius luculentus,Morenoina calamicola,Moelleriella thanathonensis,Mucor stercorarius,Myrmecridium fluviae,Myrothecium septentrionale,Neosetophoma garethjonesii,Nigrograna cangshanensis,Nodulosphaeria guttulatum,***tata,***,Panus subf

关键词： Agaricomycetes Ascomycota basidiomycota Dacrymycetes Dothideomycetes Eurotiomycetes New combination Mucoromycotina New genus New records New species Pezizomycetes Phylogeny Sordariomycetes Taxonomy

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抗癫癎药物应用指南Ⅰ:新型抗癫癎药物的药力和安全性:新发癫癎的治疗美国神经病学学会治疗学和技术评定分委会和质量标准分委会及美国癫癎协会报告

引用

神经病学与神经康复学杂志 2008年第3期5卷 190-197页

作者：高枚春陆钦池 J.A.French A.M.Kanner J.bautista b.Abou-Khalil T.browne C.L.Harden W.H.Theodore C.bazil J.Stern S.C.Schachter D.bergen D.Hirtz G.D.Montouris M.Nespeca b.Gidal W.J.Marks W.R.Turk J.H.Fischer b.bourgeois A.Wilner R.E.Faught R.C.Sachdeo A.beydoun T.A.Glauser 上海交通大学医学院附属仁济医院神经内科上海200127

目的对有关7种用以治疗儿童和成人新诊断部分性和全身性癫癎的新型抗癫癎药物(AEDs):加巴喷丁(gabapentin,GbP)、拉莫三嗪(lamotrigine,LTG)、托吡酯(topiramate,TPM)、噻加宾(tiagabine,TGb)、奥卡西平(oxcarbazepine,OXC)、左乙拉西坦(levetiracetam,lev)和唑尼沙胺(zonisamide,ZNS)的药力(efficacy)、耐受性和安全性按序进行评估(这些药物已受到美国食品与药品管理局FDA的批准)。方法由23位成人神经病学家、儿科神经病学家、癫癎病学家及药理学家组成的,依据从1987年到2002年9月Medline,Current Contents和Cochrane上发表的相关文献和2003年以前的指南提供的证据进行专家组循证医学评估。结果有证据通过对照试验或剂量控制试验显示:加巴喷丁、拉莫三嗪、托吡酯和奥卡西平单药治疗对新诊断的青少年和成人部分性或混合性癫癎是有效的。亦有证据显示,拉莫三嗪对于新诊断的儿童失神发作有效。但尚缺乏证据证明新型抗癫癎药物对新诊断的其他类型的全身性癫癎综合征是否有效。结论循证医学评估结果提供了新诊断癫癎患者的抗癫癎药物应用指南,但尚需更多的证据用以鉴定其在癫癎的类型或综合征中的疗效。

关键词：抗癫药物新诊断噻加宾加巴喷丁癫癎卡马西平托吡酯妥泰拉莫三嗪利必通抗癫癎药物丙戊酸盐苯妥英钠抗心律失常药奥卡西平部分性应用指南技术评定治疗学临床医学质量

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