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Reduction effect of final-pass heavy reduction rolling on the texture development,tensile property and stretch formability of ZWK100 alloy plates

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Journal of Materials Science & Technology 2022年第16期111卷 211-223页

作者： b.Q.Shi L.Y.Zhao X.L.Shang b.h.nie D.C.Chen C.Q.Li Y.Q.Cheng School of Materials Science and hydrogen Energy Foshan UniversityFoshan 528000China School of Materials and Energy Guangdong University of TechnologyGuangzhouGuangdong 510006China GD Midea Air-Conditioning Equipment Co. Ltd.Foshan 528311China Guangdong Key Laboratory of hydrogen Energy Technology Foshan 528000China YunFu(Foshan)R&D Center of hydrogen Energy Standardization Yunfu 527326China

Obviously planar anisotropy due to‘TD split’orthotropic texture(TD indicates Transverse direction)always exist in the Rare-earth(RE)or Ca containing Mg alloy sheets,which is likely caused by the lowreduction rolling(and annealing)as revealed in our previous research.In this work,the as-cast billets of a ZWK100 alloy were subjected to final-pass heavy reduction rolling(FhRR)at 500°C with different reductions(30%-70%)after rough rolling,aiming to investigate the reduction effect on the microstructure and texture formation.The results show that FhRR with higher reductions above 50%is in favor of shear banding formation but has little effect on the as-deformed texture components,and the excellent formability with single-pass reduction up to 70%is mainly ascribed to the activation of prismatic slip.FhRR with reduction above 50%and annealing can generate uniform grain structures of~10μm and symmetrical‘oblique-line split’texture in(0001)pole figures,with basal poles tilting by about 50°from ND(Normal direction)towards some oblique-line of TD and RD(Rolling direction)as well as uniform distribution of counter lines as an annular shape,resulting in excellent elongation to failure of~50%and ultra-low planar anisotropyΔr_of~0.1 and high stretch formability(Erichsen value:8.1).The formation‘oblique-line split’texture in(0001)pole figures is mainly correlated with the preferred growth tendency of grains with■//RD,which was suggested to relate to the high mobility of some special boundaries such as 40°-45°■.The influences of starting textures on the mechanical properties,planar anisotropy and related deformation modes,as well as their correlations with the stretch formability were comparatively investigated with the‘TD split’orthotropic texture as a counterpoint.

关键词： Magnesium alloys Texture Plane anisotropy Stretch formability Rolled sheets

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Construct a 3D microsphere of hMX/b/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： Jian Wang Jie Chen Yaofeng Mao Yongjun Deng Wei Cao Fude nie Jun Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy density.Unfortunately,the low combustion efficiency and reactivity of metal fuels,especially boron(b),severely limit their practical applications.herein,multi-component 3D microspheres of hMX/b/Al/PTFE(hbA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion reactivity.The reactivity and energy output of hbA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb calorimetry.Due to the increased interfacial contact and reaction area,hbA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(hbA-P).Meanwhile,hbA also shows enhanced energy output and reactivity than 3D microspheres of hMX/b/PTFE(hb)resulting from the high reactivity of Al.The reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of hbA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and b_(2)O_(3))and the initiation effect of Al to b.This work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： hMX/b/Al/PTFE 3D microspheres Surface etching Reaction mechanism

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Recent advances in small-scale hydrogel-based robots for adaptive biomedical applications

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Nano Research 2024年第2期17卷 649-662页

作者： Mingzhe nie Qilong Zhao Xuemin Du Institute of biomedical&health Engineering Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of Sciences(CAS)Shenzhen 518055China

Small-scale robots,ranging in size from micrometers to centimeters,have gained significant attention in the biomedical field.however,conventional small-scale robots made of rigid materials encounter challenges in adapting themselves to the soft tissues and complicated environments of human body.Compared to the rigid counterpart,small-scale hydrogel-based robots hold great promises due to their tissue-like low modulus,outstanding biocompatibility and accessible stimuli-responsive capabilities.These attributes offer small-scale hydrogel-based robots with multimodal locomotion and reinforced functions,further enhancing the adaptability in manipulation and tasks execution for various biomedical applications.In this review,we present recent advances in small-scale hydrogel-based robots.We first summarize the design principles of small-scale hydrogel-based robots including materials,fabrication techniques and manipulation strategies,then highlighting their upgraded functions and adaptive biomedical applications.Finally,we discuss existing challenges and future perspectives for small-scale hydrogel-based robots.

关键词： small-scale robot hydrogel locomotion multi-function adaptability

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Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

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Research 2024年第1期2023卷 139-147页

作者： Xi Luan Xiaoxuan Zhang Min nie Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of PharmacyClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Traditional Chinese medicine,such as Tripterygium wilfordii and Paeonia lactiflora,has potential values in treating systemic sclerosis(SSc)and other autoimmune diseases,while their toxic side effect elimination and precise tropical drug delivery are still challenges.here,we present multiple traditional Chinese medicine integrated photoresponsive black phosphorus(bP)microneedles(MNs)with the desired features for the SSc treatment.by employing a template-assisted layer-by-layer curing method,such MNs with triptolide(TP)/paeoniflorin(Pae)needle tips and bP-hydrogel needle bottoms could be well generated.The combined administration of TP and Pae can not only provide anti-inflammatory,detoxification,and immunomodulatory effects to treat skin lesions in the early stage of SSc but also remarkably reduce the toxicity of single drug delivery.besides,the additive bPs possess good biocompatibility and near-infrared(NIR)responsiveness,imparting the MN photothermal-controlled drug release capability.based on these features,we have demonstrated that the traditional Chinese medicine integrated responsive MNs could effectively improve skin fibrosis and telangiectasia,reduce collagen deposition,and reduce epidermal thickness in the SSc mouse models.These results indicated that the proposed Chinese medicine integrated responsive MNs had enormous potential in clinical therapy of SSc and other diseases.

关键词： needle precise template

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A reduced-order model for fast predicting ionized flows of hypersonic vehicles along flight trajectory

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Chinese Journal of Aeronautics 2024年第1期37卷 89-105页

作者： Jingchao ZhANG Chunsheng nie Jinsheng CAI Shucheng PAN School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Space Physics Laboratory China Academy of Launch Vehicle TechnologyBeijing 100076China Institute of Extreme Mechanics Northwestern Polytechnical UniversityXi’an 710072China

An improved Reduced-Order Model(ROM)is proposed based on a flow-solution preprocessing operation and a fast sampling strategy to efficiently and accurately predict ionized hypersonic flows.This ROM is generated in low-dimensional space by performing the Proper Orthogonal Decomposition(POD)on snapshots and is coupled with the Radial basis Function(RbF)to achieve fast prediction speed.however,due to the disparate scales in the ionized flow field,the conventional ROM usually generates spurious negative errors.here,this issue is addressed by performing flow-solution preprocessing in logarithmic space to improve the conventional ROM.Then,extra orthogonal polynomials are introduced in the RbF interpolation to achieve additional improvement of the prediction accuracy.In addition,to construct high-efficiency snapshots,a trajectory-constrained adaptive sampling strategy based on convex hull optimization is developed.To evaluate the performance of the proposed fast prediction method,two hypersonic vehicles with classic configurations,i.e.a wave-rider and a reentry capsule,are used to validate the proposed method.both two cases show that the proposed fast prediction method has high accuracy near the vehicle surface and the free-stream region where the flow field is smooth.Compared with the conventional ROM prediction,the prediction results are significantly improved by the proposed method around the discontinuities,e.***.the shock wave and the ionized layer.As a result,the proposed fast prediction method reduces the error of the conventional ROM by at least 45%,with a speedup of approximately 2.0×105compared to the Computational Fluid Dynamic(CFD)simulations.These test cases demonstrate that the method developed here is efficient and accurate for predicting ionized hypersonic flows.

关键词： Reduced-order model Radial basis function Constrained sampling Transfer function Fast flow prediction Ionized hypersonic flows

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Fault diagnosis of hVAC system with imbalanced data using multi-scale convolution composite neural network

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building Simulation 2024年第3期17卷 371-386页

作者： Rouhui Wu Yizhu Ren Mengying Tan Lei nie School of Mechanical Engineering Hubei University of TechnologyWuhan430068China Industrial Research Institute of Xiangyang hubei University of Technology Xiangyang441100China

Accurate fault diagnosis of heating,ventilation,and air conditioning(hVAC)systems is of significant importance for maintaining normal operation,reducing energy consumption,and minimizing maintenance costs.however,in practical applications,it is challenging to obtain sufficient fault data for hVAC systems,leading to imbalanced data,where the number of fault samples is much smaller than that of normal samples.Moreover,most existing hVAC system fault diagnosis methods heavily rely on balanced training sets to achieve high fault diagnosis accuracy.Therefore,to address this issue,a composite neural network fault diagnosis model is proposed,which combines SMOTETomek,multi-scale one-dimensional convolutional neural networks(M1DCNN),and support vector machine(SVM).This method first utilizes SMOTETomek to augment the minority class samples in the imbalanced dataset,achieving a balanced number of faulty and normal data.Then,it employs the M1DCNN model to extract feature information from the augmented dataset.Finally,it replaces the original Softmax classifier with an SVM classifier for classification,thus enhancing the fault diagnosis accuracy.Using the SMOTETomek-M1DCNN-SVM method,we conducted fault diagnosis validation on both the AShRAE RP-1043 dataset and experimental dataset with an imbalance ratio of 1:10.The results demonstrate the superiority of this approach,providing a novel and promising solution for intelligent building management,with accuracy and F1 scores of 98.45%and 100%for the RP-1043 dataset and experimental dataset,respectively.

关键词： fault diagnosis chiller imbalanced data SMOTETomek multi-scale neural networks

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Ameliorating the Strength-Modulus Synergy in GNPs Reinforced Mg-Zn-Zr Composites via Multidirectional Forging and hot Extrusion Deformation

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 425-437页

作者： Yuhao Chen Kaibo nie Kunkun Deng Zhilong Liu Quanxin Shi College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China State Key Laboratory of Compressor Technology(Compressor Technology Laboratory of Anhui Province) Hefei 230031China Instrumental Analysis Center Taiyuan University of TechnologyTaiyuan 030024China

The integration of lightweight and high-modulus magnesium-based materials is becoming increasingly valued as structural materials due to the complexity and intelligence of industrial products like automobiles and electronics.In this study,the graphene nanoplatelets(GNPs)/Mg-Zn-Zr composites with 0.5 wt%GNPs were successfully prepared by the combination of multidirectional forging(MDF)and hot extrusion(Ex).The newly-developed composites after multi-step deformation possessed excellent strength and modulus,with a tensile strength exceeding 375 MPa and an elastic modulus reaching 54 GPa.The results revealed that the stripping and thinning of GNPs bands parallel to the extrusion direction occurred after MDF+Ex,which promoted the dynamic recrystallization and the formation of numerous fine grains.The significant improvement in comprehensive mechanical performances of the composites could be primarily ascribed to the refinement of grain size caused by the optimized distribution of GNPs,and efficient load transfer facilitated by the tight interface.

关键词： Magnesium matrix composites Graphene nanoplatelets(GNPs) Multi-step deformation Microstructure Strength-modulus

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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Charles h.Nelson Udai b.Pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding protein.As the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent protein.Although many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its discovery.In this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder itself.Additionally,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of study.This review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease SMN complex

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Singlet oxygen-dominated peroxymonosulfate activation by layered crednerite for organic pollutants degradation in high salinity wastewater

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Journal of Environmental Sciences 2024年第1期135卷 86-96页

作者： Chengji Sui Zixuan nie huan Liu Grzegorz boczkaj Weizhen Liu Lingshuai Kong Jinhua Zhan Key Laboratory for Colloid&Interface Chemistry of Education Ministry Department of ChemistryShandong UniversityJinan 250100China School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and RecyclingSouth China University of TechnologyGuangzhou 510006China Gdansk University of Technology Faculty of Civil and Environmental EngineeringDepartment of Sanitary EngineeringG.Narutowicza St.11/1280-233 GdanskPoland EkoTech Center Gdansk University of TechnologyG.Narutowicza St.11/1280-233 GdanskPoland

Advanced oxidation processes have been widely studied for organic pollutants treatment in water,but the degradation performance of radical-dominated pathway was severely inhibited by the side reactions between the anions and radicals,especially in high salinity conditions.here,a singlet oxygen(^(1)O_(2))-dominated non-radical process was developed for organic pollutants degradation in high salinity wastewater,with layered crednerite(CuMnO_(2))as catalysts and peroxymonosulfate(PMS)as oxidant.based on the experiments and density functional theory calculations,^(1)O_(2)was the dominating reactive species and the constructed Cu-O-Mn with electron-deficient Mn captured electron from PMS promoting the generation of^(1)O_(2).The rapid degradation of bisphenol A(bPA)was achieved by CuMnO_(2)/PMS system,which was 5-fold and 21-fold higher than that in Mn_(2)O_(3)/PMS system and Cu_(2)O/PMS system.The CuMnO_(2)/PMS system shown prominent bPA removal performance under high salinity conditions,prominent PMS utilization efficiency,outstanding total organic carbon removal rate,wide range of applicable ph and good stability.This work unveiled that the^(1)O_(2)-dominated non-radical process of CuMnO_(2)/PMS system overcame the inhibitory effect of anions in high salinity conditions,which provided a promising technique to remove organic pollutants from high saline wastewater.

关键词： Singlet oxygen Non-radical process high salinity Mixed metal oxides Wastewater treatment

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blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés berardo Cristian R.bacaglio bárbara b.báez Rubén Sambuelli Kazim A.Sheikh Pablo h.h.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química biológica-Centro de Investigaciones en Química biológica de Córdoba(CIQUIbIC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-barrèsyndrome,mostly related to halted axon regeneration.Cross-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon regeneration.These effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so far.The aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated fibers.Our results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of Y-27632.Treatment with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous sensitivity.In contrast,the same dose showed toxic effects on the regeneration of myelinated fibers.Interestingly,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only Y-27632.Overall,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal antibody.Our findings open the possibility of therapeutic pharmacological intervention targeting Rho A/Rock pathway in immune neuropathies associated wi

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-barrésyndrome nerve repair ROCK Y-27632

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