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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

The NMR core analyzing tomograph:a multi-functional tool for non-destructive testing of building materials

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Magnetic Resonance Letters 2023年第3期3卷 207-219,I0003页

作者： Sabine kruschwitz Sarah Munsch Melissa Telong Wolfram Schmidt Thilo bintz Matthias Fladt Ludwig Stelzner bundesanstalt für Materialforschung und-prüfung Unter den Eichen 87Berlin12205Germany Technische Universitat berlin Gustav-Meyer-Allee 25Berlin13355Germany

NMR is becoming increasingly popular for the investigation of building materials as it is a non-invasive technology that does not require any sample preparation nor causes damage to the *** on the specific application it can offer insights into properties like porosity and spatial saturation degree as well as pore *** it enables the determination of moisture transport properties and the(re-)distribution of internal moisture into different reservoirs or chemical phases upon damage and ***,as yet most investigations were carried out using devices originally either designed for geophysical applications or the analysis of rather homogeneous small scale(er describes the capabilities of an NMR tomograph,which has been specifically optimized for the investigation of larger,heterogeneous building material samples(diameters of up to 72 mm,length of up to 700 mm)with a high flexibility due to interchangeable coils allowing for a high SNR and short echo times(50-80 ms).

关键词： Natural stone Concrete Sensitivity Moisture transport Cement hydration Supplementary cementitious materials Frost and salt attack Fire spalling

Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第01期 314-316页

作者： Miguel A.Liuzzi-Vaamonde Jackson b.Lancaster Samantha A.Mason Yuanning Feng Department of Chemistry and biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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electronic,optical,and mechanical properties of bN,AlN,and InN with zinc-blende structure under pressure

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Chinese Physics b 2017年第8期26卷 320-327页

作者： A R Degheidy e b elkenany Department of Physics Faculty of ScienceMansoura UniversityP.O.Box 35516MansouraEgypt

In this work, the electronic, optical, and mechanical properties of bN, AlN, and InN under the action of pressure are calculated. For each of these compounds, the energy band structure, band gaps（e^L_g, e~Γ_g, e^X_g）, refractive index（n）,dielectric constants（ε_∞, ε_0）, elastic constants（C_11, C_12, C_44）, and relevant parameters such as bulk（b_u）, shear（S_h）, and Young＇s（Y_0） moduli are studied, and other important parameters such as bond-stretching（α）, bond-bending（β） force constant, internal-strain parameter（ζ）, effective charges（e~＊_T, Z~＊）, anisotropy factor（I_s）, Poisson＇s ratio（P_o）, Cauchy ratio（C_a）, the ductility index（μ_D）, and linear compressibility（C0_） are also calculated. The effects of pressure on all studied properties are investigated. Our results are in good agreement with the available experimental and theoretical data for bN,AlN, and InN.

关键词： electronic properties optical properties mechanical properties bN A1N InN

enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon byeon Department of Digital Anti-aging Healthcare(bK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

Why Matter Occupies so Large a Volume?

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Communications in Theoretical Physics 2013年第12期60卷 677-686页

作者： e.b.Manoukian Institute for Fundamental Study Naresuan University

The paper represents a rigorous treatment of the underlying quantum theory, not just in words but providing the underlying technical details, as to why matter occupies so large a volume and its intimate connection with the Pauli exclusion principle, as more and more matter is put together, as well as of the contraction or shrinkage of ＂bosonic matter＂, upon collapse, for which the Panli exclusion is abolished. From the derived explicit bounds of integrals of powers of the particle number densities, explicit bounds on probabilities of the occurrences of the events just described are extracted. These probabilities lead one to infer the change of the ＂size＂ or extension of such matter, upon expansion or contraction, respectively, as their content is increased.

关键词： expansion of matter and the Pauli exclusion principle contraction or shrinkage of "bosonic mat-ter" upon collapse

Synthesis of bicyclooctane Derivatives for Kinetic Resolution

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Chinese Chemical Letters 1997年第5期8卷 389-392页

作者： Deng, b Winterfeldt, e SHANXI UNIV DEPT CHEM TAIYUAN 030006 PEOPLES R CHINA UNIV HANNOVeR INST ORGAN CHEM D-30167 HANNOVER GERMANY

Synthesis of five 7-membered compounds containing silane, sulfur and phosphorus groups was achieved by using endo, endo-bicyclo[3.3.0]octanediol 2. These tricyclic molecules are considered as ideal substrates far kinetic resolution of the diol. A discussion of the spectral data about these compounds was given and four of them would be substrate molecules containing an sp(3) hybridized prochiral center and could be used for molecules for a kinetic resolution combining configurational diastereotopos-differentiating and diastereoisomer-differentiating reactions.

关键词： Cl Mel Synthesis of bicyclooctane Derivatives for Kinetic Resolution ppm

A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi bansal Razaz Waheeb Attar Mosiur Rahman brij b.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

NeCAb family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAb1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAb1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAb2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAb3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAb proteins exhibit distinct subcellular localizations: NeCAb1 is found in the nucleus and cytosol, NeCAb2 resides in endosomes and the plasma membrane, and NeCAb3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAb proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAb proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction