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对结核病治疗依从性不佳患者实行法律干预

国际结核病与肺部疾病杂志 2010年第4期5卷 152-156页

作者： E.N.Pritchett D.Schlossberg G.Lovett-Glenn J.beck b.dickman 高静韬何广学 Tuberculosis Control Program Philadelphia Department of Public Health Association of Public Health Laboratories

背景:美国公共卫生结核病控制规划费城部针对依从性不佳的结核病患者实施逐步严格、有序的法律干预措施进行管理,最终可能对患者采取监禁措施。目的:回顾法律干预措施的执行情况并评价这些措施对依从性不佳的结核病患者治疗管理的影响... 详细信息

背景:美国公共卫生结核病控制规划费城部针对依从性不佳的结核病患者实施逐步严格、有序的法律干预措施进行管理,最终可能对患者采取监禁措施。目的:回顾法律干预措施的执行情况并评价这些措施对依从性不佳的结核病患者治疗管理的影响。方法:回顾2001—2005年患者治疗记录,确定依从性不佳的患者并评价他们的治疗结果。结果:在这期间,我们对39例治疗依从性不佳的患者采取法律干预措施,其中1例死亡,9例丢失,29例患者在实施法律干预后依从性得以保证,最终治疗完成率达到76.3%。结论:我们采取的法律措施提高了治疗依从性不佳患者的治疗完成率。治疗完成率的提高降低了结核病的复发和传播风险,减少了耐药结核病的出现。

关键词：结核病依从性不佳法律限制

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SGT1 Is Induced by the Potato virus X TGbp3 and Enhances Virus Accumulation in Nicotiana benthamiana

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Molecular Plant 2012年第5期5卷 1151-1153页

作者： Chang-Ming Ye Vicky Kelly Mark Payton Martin b. dickman Jeanmarie Verchot Department of Entomology and Plant Pathology Oklahoma State UniversityStillwaterOK 74078USA Department of Statistics Oklahoma State University StillwaterOK 74078USA Institute for Plant Genomics and biotechnology Department of Plant Pathology and MicrobiologyTexas A&M UniversityCollege StationTX 77843USA

Dear Editor, Host chaperone proteinsarecritical factors in plant virus infec- tion. One ofthe most commonly identified host factors involved in plant virus infection is Hsp70, which functions in ATP hydroly- sis, protein folding, assembly of protein complexes, and translo- cation between cellular compartments. A comparative study of plant virus infection, including Potato virus X （PVX）, reported that Hsp70 is up-regulated by virus infection and possibly con- tributes to pathogenesis in both Arabidopsis and N. benthami- ana plants （Aparicio et al., 2005）. Cytosolic Hsp70 interacts with the tombusvirus and tymovirus replication complexes （Wang et al., 2009）, the potyvirus coat protein （Hafren et al., 2010）, and closteroviruses encode an HSP70 homolog that functions to enable virus intercellular transport （Agranovsky et al., 1998）.

关键词： LETTERS to the editor NICOTIANA benthamiana POTATO virus X

Effect of the transcutaneous electrical stimulation system on esophageal-acid exposure in patients non-responsive to once-daily proton-pump inhibitor:proof-of-concept study

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Gastroenterology Report 2021年第4期9卷 323-328,I0002页

作者： Ram dickman Sigal Levy Tsachi Tsadok Perets Maor Hazani-Pauker Doron boltin Hemda Schmilovitz-Weiss Issa Nidal Matan Siterman Dan Carter Ronnie Fass Rachel Gingold-belfer Department of Gastroenterology Rabin Medical CenterBeilinson CampusesPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Statistics Education Unit Academic College of Tel Aviv-YafoTel Aviv-YafoIsrael Department of Surgery b Rabin Medical CenterHasharon CampusPetah Tikva and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Division of Gastroenterology and Hepatology Chaim Sheba Medical CenterRamat Gan and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Division of Gastroenterology and Hepatology Metrohealth Medical CenterClevelandOHUSA

background:Gastroesophageal reflux disease(GERD)is a common ***,≤35%of GERD patients fail the standard dose of proton-pump-inhibitor(PPI)*** to the high prevalence and low satisfaction rate with treatment failure,there is an unmet need for new *** aim was to evaluate whether the use of the transcutaneous electrical stimulation system(TESS)can reduce esophageal-acid exposure in GERD patients unresponsive to standard-dose ***:We enrolled 10 patients suffering from heartburn and regurgitation with an abnormal esophageal-acid exposure(off PPIs)who failed standard-dose *** the placement of a wireless esophageal pH capsule,all patients were treated with *** primary end point was the reduction in the baseline(pretreatment)24-hour percent total time pHby 50%.Results:Seven GERD patients(five females and two males,aged 49.3610.1 years)completed the *** baseline,the mean percent total time pHbaseline,the mean DeMeester score was *** TESS,the mean DeMeester score dropped to 15.869.2,13.266.8,11.269.4,and 12.066.8 on Days 1,2,3,and 4,***:TESS is a safe and potentially effective modality in reducing esophageal-acid exposure in GERD patients unresponsive to standard-dose PPI.A larger and prospective controlled study is needed to verify these preliminary results.

关键词： gastroesophageal reflux disease transcutaneous electrical stimulation system proton-pump inhibitor

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将老年患者的药物不良反应降到最低

中国实用乡村医生杂志 2008年第10期15卷 37-39页

作者： Cung b.Pham Robert L.dickman 周泓旭 Tufts University Family Medicine Residency MaldenMassachusetts M.D. Tufts University School of Medicine BostonMassachusetts M.D 中国医科大学

老年患者承受着不可预见的药物副作用。失落、抑郁、精神错乱以及皮疹都会导致药物不良反应的发生。大约1／3使用5种以上药物的老年患者每年都会发生药物间的不良反应，这些患者中，约2／3需要医疗关注。而实际上，这些反应中，约95％... 详细信息

老年患者承受着不可预见的药物副作用。失落、抑郁、精神错乱以及皮疹都会导致药物不良反应的发生。大约1／3使用5种以上药物的老年患者每年都会发生药物间的不良反应，这些患者中，约2／3需要医疗关注。而实际上，这些反应中，约95％可以被预料到，28％可以被预防。

关键词：不良反应老年干预措施

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肺移植患者术后淋巴增生性疾病与胃肠道相关性:1例病例报道

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 18-19页

作者： Shitrit D. Shitrit A. b. -G. dickman R. M.R. Kramer. 张欣(译) 史敏(校) 不详 Pulmonary Institute Rabin Medical Center Beilinson Campus Petah Tikva 49100 Israel

PURPOSE: Lymphoproliferative disorder is a well-recognized complication of lung transplantation. Risk factors include Epstein-barr virus infection and immuno-suppression. The gastrointestinal manifestations of posttransplant lymphoproliferative disorder in lung transplant recipients have not been fully characterized. METHODS: Case presentation and 16 previously reported cases of posttransplant lymphoproliferative disorder with gastrointestinal involvement are reviewed. RESULTS: Patient ages ranged from 25 to 65 (median, 52) years. Median time fromlung transplantation to onset of posttransplant lymphoproliferative disorder was 36 (range, 1-109) months; 35 percent of cases (6/17) occurred within 18 months; Eighty-eight percent of patients (15/17) had positive Epstein-barr virus serology before transplantation. In five patients (29 percent), the posttransplant lymphoproliferative disorder also involved sites other than the gastrointestinal tract. The most common gastrointestinal site of posttransplant lymphoproliferative disorder was the colon, followed by the small intestine and stomach. Clinical features included abdominal pain, nausea, and bloody diarrhea. Diagnosis was based on typical pathologic changes on gastrointestinal tract biopsy obtained mainly by colonoscopy. Treatment included a reduction in the immunosuppressive regimen in 15 of 17 cases (88 percent) and surgical resection in 10 (59 percent). One patient was untreated. Seven of 16 patients (44 percent) responded to treatment and 9 patients died. Median time from onset of posttransplant lymphoproliferative disorder to death was 70 (range,10-85) days. CONCLUSIONS: Posttransplant lymphoproliferative disorder with gastrointestinal involvement is a unique entity that should be considered in all Epstein-barr-Virus-positive lung transplant recipients who present with abdominal symptoms. Although immunosuppressive modulation and resection can lead to remission, the risk of death is 50 percent.

关键词：移植后淋巴增生性疾病疾病患者病例报道胃肠道肺移植术后 Eb病毒感染血清学指标阳性淋巴增生性病变免疫抑制剂

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补充燕麦AVA和耐力训练对恢复期心梗大鼠的影响

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补充燕麦AVA和耐力训练对恢复期心梗大鼠的影响