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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes Marina c.Waiteman Liliam b.Priore Neal R.glaviano David M.bazett-Jones Ronaldo V.briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,cINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%cI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%cI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%cI:-0.82 to-0.14),concentric(SMD=-1.07,95%cI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%cI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%cI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

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blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés berardo cristian R.bacaglio bárbara b.báez Rubén Sambuelli Kazim A.Sheikh Pablo H.H.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química biológica-centro de Investigaciones en Química biológica de córdoba(cIQUIbIc)-consejo Nacional de Investigaciones cientificas y Técnicas(cONIcET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in guillain-barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small gTPase Rho A/ROcK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROcK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides gD1a and gT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-gD1a/gT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-gD1a/gT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROcK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-gD1a/gT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside guillain-barrésyndrome nerve repair ROcK Y-27632

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First-principles calculation on the electronic structures, phonon dynamics, and electrical conductivities of Pb_(10)(PO_(4))_(6O) and Pb_(9)cu(PO_(4))_(6O) compounds

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Journal of Materials Science & Technology 2024年第6期173卷 218-224页

作者： L.Y.Hao E.g.Fu State Key Laboratory of Nuclear Physics and Technology Department of Technical PhysicsSchool of PhysicsPeking UniversityBeijing 100871China

Superconducting materials with high critical temperature have the potential to revolutionize many fields,including military,electronic communications,and power ***,scientists around the world have been tirelessly working with the ultimate goal of achieving high-temperature *** 2023,a preprint by Lee et *** South Korea claimed the discovery of ultra-high-temperature superconductivity with a critical temperature of up to 423 K in cu-doped lead-apatite(LK-99)(arXiv:2307.12008,arXiv:2307.12037),which caused a worldwide sensation and ***,the electronic structures,phonon dynamics,and electrical conductivities of LK-99 and its parent compound lead-apatite have been calculated using first-principles *** results show that the lead-apatite compound and the LK-99 compound are insulator and half-metal *** flat band characteristic is consistent with previous *** electrical conductivity of the LK-99 compound shows two extreme points,and the electrical conductivity along the c-axis increases significantly after 400 *** phonon dispersion spectra of the compounds were investigated,demonstrating their dynamic instability.

关键词： Superconductivity LK-99 Lead-apatite First-principles calculation

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Academic productivity correlates with industry earnings in foot and ankle fellowship programs in the United States:A retrospective analysis

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World Journal of Orthopedics 2024年第2期15卷 129-138页

作者： Albert T Anastasio Anthony N baumann Kempland c Walley Kyle J Hitchman conor O’Neill Jonathan Kaplan Samuel b Adams Department of Orthopedic Surgery Duke University HospitalDurhamNC 27710United States college of Medicine Northeast Ohio Medical UniversityRootstownOH 44272United States Department of Orthopedic Surgery University of MichiganAnn ArborMI 48109United States School of Osteopathic Medicine Campbell UniversityLillingtonNC 27546United States

bAcKgROUND The study investigates the connection between academic productivity and industry earnings in foot and ankle orthopedic surgery *** metrics like the H-index and Open Payments Database(OPD)data,it addresses a gap in understanding the relationship between scholarly achievements and financial outcomes,providing a basis for further exploration in this specialized medical *** To elucidate the trends between academic productivity and industry earnings across foot and ankle orthopedic surgery fellowship programs in the United *** This study is a retrospective analysis of the relationship between academic productivity and industry earnings of foot and ankle orthopedic surgery fellowships at an individual faculty and fellowship *** productivity was defined via H-index and recorded from the Scopus *** earnings were recorded from the *** Forty-eight foot and ankle orthopedic surgery fellowships(100%of fellowships)in the United States with a combined total of 165 physicians(95.9%of physicians)were *** individual physician(n=165)total life-time earnings reported on the OPD website was United States Dollar(USD)451430.30±1851084.89(range:USD 25.16-21269249.85;median:USD 27839.80).Mean physician(n=165)H-index as reported on Scopus is 14.24±12.39(range:0-63;median:11).There was a significant but weak correlation between individual physician H-index and individual physician total life-time earnings(Pgnificant and moderate positive correlation between combined fellowship H-index and total life-time earnings per fellowship(P=0.004,Spearman’s rho=0.409).cONcLUSION There is a significant and positive correlation between academic productivity and industry earnings at foot and ankle orthopedic surgery fellowships in the United *** observation is true on an individual physician level as well as on a fellowship level.

关键词： Sunshine act Foot and ankle Orthopedic surgery Orthopedic fellowship Industry earnings

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Advancements in prokaryotic systematics and the role of bergey's International Society for Microbial Systematics in addressing challenges in the meta-data era

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National Science Review 2024年第7期11卷 292-304页

作者： Jian-Yu Jiao Rashidin Abdugheni Dao-Feng Zhang Iftikhar Ahmed Mukhtiar Ali Maria chuvochina Svetlana N.Dedysh Xiuzhu Dong Markus g?ker brian P.Hedlund Philip Hugenholtz Kamlesh Jangid Shuang-Jiang Liu Edward R.b.Moore Manik Prabhu Narsing Rao Aharon Oren Ramon Rossello-Mora bhagwan Narayan Rekadwad Nimaichand Salam Wensheng Shu Iain c.Sutcliffe Wee Fei Aaron Teo Martha E.Trujillo Stephanus N.Venter William b.Whitman guoping Zhao Wen-Jun Li State Key Laboratory of biocontrol Guangdong Provincial Key Laboratory of Plant Resources and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) School of Life Sciences Sun Yat-Sen University State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and Geography Chinese Academy of Sciences Jiangsu Province Engineering Research center for Marine bio-resources Sustainable Utilization&college of Oceanography Hohai University National culture collection of Pakistan(NccP) Land Resources Research Institute(LRRI) National Agricultural Research Centre(NARC) The University of Queensland School of Chemistry and Molecular Biosciences Australian Centre for Ecogenomics Winogradsky Institute of Microbiology Research Center of BiotechnologyRussian Academy of Sciences State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Leibniz Institute DSMZ–german collection of Microorganisms and cell cultures School of Life Sciences University of Nevada Nevada Institute of Personalized Medicine University of Nevada bioenergy group MACS Collection of Microorganisms Agharkar Research Institute State Key Laboratory of Microbial Technology Shandong University Department of Infectious Disease Institute for Biomedicine and Culture Collection University of Gothenburg(CCUG) Institute for BiomedicineSahlgrenska AcademyUniversity of Gothenburg Instituto de ciencias Aplicadas Facultad de Ingeniería Universidad Autónoma de Chile The Alexander Silberman Institute of Life Sciences The Edmond J.Safra Campus The Hebrew University of Jerusalem Marine Microbiology group Department of Animal and Microbial Biodiversity Mediterranean Institute for Advanced Studies(IMEDEA CSIC-UIB) MicrobeAI Lab Division of Microbiology and Biotechnology Yenepoya Research Centre Yenepoya(Deemed to be University) National Agri-Food biotechnology Institute Institute of Ecological Science Sch

Prokaryotes are ubiquitous in the biosphere, important for human health and drive diverse biological and environmental processes. Systematics of prokaryotes, whose origins can be traced to the discovery of microorganisms in the 17th century, has transitioned from a phenotype-based classification to a more comprehensive polyphasic taxonomy and eventually to the current genome-based taxonomic *** transition aligns with a foundational shift from studies focused on phenotypic traits that have limited comparative value to those using genome sequences. In this context, bergey's Manual of Systematics of Archaea and bacteria(bMSAb) and bergey's International Society for Microbial Systematics(bISMiS) play a pivotal role in guiding prokaryotic systematics. This review focuses on the historical development of prokaryotic systematics with a focus on the roles of bMSAb and bISMiS. We also explore significant contributions and achievements by microbiologists, highlight the latest progress in the field and anticipate challenges and opportunities within prokaryotic systematics. Additionally, we outline five focal points of bISMiS that are aimed at addressing these challenges. In conclusion, our collaborative effort seeks to enhance ongoing advancements in prokaryotic systematics, ensuring its continued relevance and innovative characters in the contemporary landscape of genomics and bioinformatics.

关键词： prokaryotic systematics bergey's Manual of Systematics of Archaea and bacteria (bMSAb) bergey's International Society for Microbial Systematics (bISMiS) meta-data era

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carbon Monoxide as c1 building block in Fine chemical Synthesis

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chinese Journal of chemistry 2024年第2期42卷 199-221页

作者： Rui M.b.carrilho Mario J.F.calvete gabor Mikle Laszlo Kollar Mariette M.Pereira University of coimbra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Department of general and Inorganic chemistry and ELKH-PTE Research groupfor Selective chemical Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

carbon monoxide(cO)has become one of the most relevant and versatile renewable c1 building blocks for chemical synthesis,especially in the fine chemicals industry,due to the development of efficient and selective catalysts for its *** this review,we present a comprehensive critical analysis of the last 10 years literature on the use of cO as a renewable feedstock for fine chemicals *** review is organized by type of catalytic reaction,namely alkene and alkyne carbonylation,hydroformylation,carbonylation of aryl halides,carbonylative cross-coupling and c-H *** examples of the synthesis of relevant building blocks and/or known pharmaceuticals are *** is placed on examples of utilizing cO as the c1 building block in one or more catalytic *** catalyst used and the reaction conditions are consistently presented throughout all of the examples.

关键词： carbon monoxide Fine chemicals carbonylation Hydroformylation c-H functionalization

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Astrophysical S-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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chinese Physics c 2024年第4期48卷 130-145页

作者： S.b.Dubovichenko A.S.Tkachenko R.Ya.Kezerashvili N.A.burkova b.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York city college of Technology City University of New YorkBrooklyn11201 New YorkUSA graduate School and University center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPcM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)S_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy S-factor,and the extrapolated S(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(Ac)for the ^(15)N(p,γ0)16O process with interfering ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances is elucidated.A comparison of our calculation for the S-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of Ac but shows a strong impact of the interference of ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances in reference to the cNO gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.c.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPcM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model cNO-cycle

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cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage

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Stroke & Vascular Neurology 2024年第4期9卷 446-456,I0147页

作者： Yunke Li Sung-Min cho Radhika Avadhani Hassan Ali Yi Hao Santosh b Murthy Joshua N goldstein Fan Xia Xin Hu Natalie L Ullman Issam Awad Daniel Hanley Wendy c Ziai The george Institute for global Health BeijingChina Department of Neurology Division of Neurocritical CareJohns Hopkins Medical InstitutionsBaltimoreMarylandUSA Department of Neurology Division of Brain Injury OutcomesJohns Hopkins Medical Institutions CampusBaltimoreMarylandUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNew YorkUSA Department of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Department of Neurosurgery West China Hospital of MedicineChengduSichuanChina Department of Neurosurgery University of Chicago Pritzker School of MedicineChicagoIllinoisUSA

background Minimally invasive surgery(MIS)for spontaneous supratentorial intracerebral haemorrhage(IcH)is controversial but may be beneficial if end-of-treatment(EOT)haematoma volume is reduced to≤15 *** explored whether MRI findings of cerebral small vessel disease(cSVD)modify the effect of MIS on long-term *** Prespecified blinded subgroup analysis of 288 subjects with qualified imaging sequences from the phase 3 Minimally Invasive Surgery Plus Alteplase for Intracerebral Haemorrhage Evacuation(MISTIE)*** tested for heterogeneity in the effects of MIS and MIS+EOT volume≤15 mL on the trial’s primary outcome of good versus poor function at 1 year by the presence of single cSVD features and cSVD scores using multivariable *** Of 499 patients enrolled in MISTIE III,288 patients had MRI,149(51.7%)randomised to MIS and 139(48.3%)to standard medical care(SMc).Median(IQR)IcH volume was 42(30–53)*** the full MRI cohort,there was no statistically significant heterogeneity in the effects of MIS versus SMc on 1-year outcomes by any specific cSVD feature or by cSVD scores(all P_(interaction)>0.05).In 94 MIS patients with EOT IcH volume≤15 mL,significant reduction in odds of poor outcome was found with cerebral amyloid angiopathy scorection)=0.006),absence of lacunes(OR,0.37(0.18–0.80);P_(interaction)=0.02)and absence of severe white matter hyperintensities(WMHs)(OR,0.22(0.08–0.58);P_(interaction)=0.03).conclusions Following successful haematoma reduction by MIS,we found significantly lower odds of poor functional outcome with lower total burden of cSVD in addition to absence of lacunes and severe *** features may have utility for prognostication and patient selection in clinical trials of MIS.

关键词： Surgery surgery absence

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Study of ZnO nanoparticle-supported clay minerals for electrochemical sensors,photocatalysis,and antioxidant applications

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chemPhysMater 2024年第1期3卷 83-93页

作者： Mylarappa M N.Raghavendra N.R.bhumika c.H.chaithra b.N.Nagalaxmi K.N.Shravana Kumara Department of chemistry Sri Jagadguru Renukacharya College of ScienceArts&CommerceBengaluru 560009India Department of chemistry East West Institute of TechnologyBengaluru 560091India Department of chemistry Maharani Lakshmi Ammanni College for WomenBengaluru 560012India

In view of the current study’s demonstration of the synthesis of clay-doped ZnO composites,we present a low-cost method for producing clay-metal oxide(clay/ZnO).Utilizing the solution combustion technique,a composite of clay/ZnO was produced utilizing citric acid as both a fuel and a complexing *** hexagonal unit cell structure of the created clay/ZnO may be seen using XRD *** ZnO-infused clay was visible in FE-SEM micrographs as homogenous,sphere-shaped *** possible involvement of clay/ZnO photocatalytic activity in the UV-induced photodegradation of malachite green dye was *** 90%degradation rate shows the composite’s outstanding photocatalytic degradation *** resulting substance was electrochemically analyzed using a constructed electrode in 0.1 M KOH *** increased its sensor capabilities,which now include chemical and biomolecule sensors,and it excelled in cyclic voltammetry-based redox potential *** efficiently evaluate chemically synthesized NPs for electrochemical,sensing,and photocatalytic applications,this study intends to create a solution combustion procedure for the synthesis of clay/ZnO nanocomposite using urea as fuel.

关键词： clay clay/ZnO Photocatalytic Electrochemical sensors

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STcF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.c.Ai L.P.An R.Aliberti Q.An X.Z.bai Y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov D.bodrov A.bogomyagkov A.bondar I.boyko Z.H.bu F.M.cai H.cai J.J.cao Q.H.cao X.cao Z.cao Q.chang K.T.chao D.Y.chen H.chen H.X.chen J.F.chen K.chen L.L.chen P.chen S.L.chen S.M.chen S.chen S.P.chen W.chen X.chen X.F.chen X.R.chen Y.chen Y.Q.chen H.Y.cheng J.cheng S.cheng T.g.cheng J.P.Dai L.Y.Dai X.c.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.g.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang g.Fedotovich c.Q.Feng X.Feng Y.T.Feng J.L.Fu J.gao Y.N.gao P.S.ge c.Q.geng L.S.geng A.gilman L.gong T.gong b.gou W.gradl J.L.gu A.guevara L.c.gui A.Q.guo F.K.guo J.c.guo J.guo Y.P.guo Z.H.guo A.guskov K.L.Han L.Han M.Han X.Q.Hao J.b.He S.Q.He X.g.He Y.L.He Z.b.He Z.X.Heng b.L.Hou T.J.Hou Y.R.Hou c.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.c.Hu J.Hua g.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.b.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.b.Jiang J.Jiang S.Z.Jiang J.b.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang b.c.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev c.H.Li c.Li D.Y.Li F.Li g.Li g.Li H.b.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang g.R.Liao L.Z.Liao Y.Liao c.X.Lin D.X.Lin X.S.Lin b.J.Liu c.W.Liu D.Liu F.Liu g.M.Liu H.b.Liu J.Liu J.J.Liu J.b.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.b.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long c.g.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov g.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata b.b.Qi Y.Q.Qi W.b.Qian Y.Qian c.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker c.F.Redmer H.Y.Sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Physics Novosibirsk 630090Russia cAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom central china Normal University Wuhan 430079China central South University Changsha 410083China china University of geosciences Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China goethe University Frankfurt D-60325 Frankfurt am MainGermany guangxi Normal University Guilin 541004China guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STcF)is an electron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 geV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STcF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEPcII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STcF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STcF,describes conceptual designs of the STcF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STcF detector conceptual design

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