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国际医学放射学杂志 2014年第5期 501-501页

作者： D.Rai b.Wisniowski b.bradshaw R.Velu P.Tosenovsky F.Quigley 陈国中 Queensland Research Centre for Peripheral Vascular Disease School of Medicine and DentistryJames Cook University

摘要目的主动脉钙化及血栓被认为是恶化腹主动脉瘤腔内修补术(EVAR)疗效的因素。本研究旨在利用一个可重复的、定量的CT评估方法评价腹主动脉钙化及血栓体积

关键词：腹主动脉瘤修补术 EVAR 血栓疗效

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Exogenous and endogenous determinants of spatial aggregation patterns in tibetan Plateau meadow vegetation

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Journal of Plant Ecology 2013年第4期6卷 277-285页

作者： Jiajia Liu Deyan Wu Xiaoyu Peng Shurong Zhou Corey J.A.bradshaw Ministry of Education Key Laboratory for biodiversity Science and Ecological Engineering School of life SciencesFudan UniversityShanghai 200433China State Key Laboratory of Grassland Agro-ecosystems School of Life SciencesLanzhou UniversityLanzhou 730000China The Environment Institute and School of Earth and Environmental Sciences The University of AdelaideSouth Australia 5005Australia South Australian Research and Development Institute PO Box 120Henley BeachSouth Australia 5022Australia

Aims We aim to quantify the relative importance of various endogenous and exogenous processes influencing the spatial distribution of the individuals of plant species at different temporal and spatial scales in a species-rich and high-cover meadow in the eastern tibetan *** We calculated green’s index of dispersion to infer the spatial dis-tribution patterns of 73 herbaceous species at two scales(0.25 and 1.0 m2).We constructed a series of generalized linear models to test the hypotheses that different species traits such as mean plant stem density,per capita dry biomass,maximum plant height and mean seed mass contribute to their spatial *** used the first principal component of soil C,N and P to explain abundance vari-ation across quadrats and *** Findingsthe individuals of the species studied were highly spatially *** both spatial scales,biomass and stem density explained the most variation in aggregation,but there was no evidence for an effect of mean seed mass on aggregation *** effects of soil carbon,nitrogen and phosphorus at different depths affected plant abundance mostly at the broader spatial *** results demonstrate that self-thinning and habitat heterogeneity all contribute to determine the spatial aggregation patterns of plant individuals in alpine meadow vegetation in the eastern tibetan Plateau.

关键词： alpine meadow community dispersal limitation habitat heterogeneity self-thinning

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World regional geography : the new global order / Michael bradshaw. 2nd ed.

World regional geography : the new global order / Michael Br...

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2000年

作者： Michael bradshaw.

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CONTEMPORARY WORLD REGIONAL GEOGRAPHY : 2nd ed.

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2007年

作者： MICHAEL bradshaw ... [ET AL.].

Accompanied by 2 CD-ROMs entitled: Interactive world issues: of place and planet.

ISBN: (纸本)0072826835

Accompanied by 2 CD-ROMs entitled: Interactive world issues: of place and planet.

关键词： Geography

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Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts

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bioactive Materials 2024年第1期31卷 463-474页

作者： Charles M.Kerr Sophia E.Silver Yi Sun Choi Martha E.Floy Amy D.bradshaw Seung-Woo Cho Sean P.Palecek Ying Mei Molecular Cell biology and Pathobiology Medical University of South CarolinaCharlestonSCUSA bioengineering Department Clemson UniversityClemsonSCUSA Department of biotechnology Yonsei UniversitySeoulSouth Korea Department of Chemical and biological Engineering University of Wisconsin-MadisonMadisonWIUSA Department of Regenerative Medicine and Cell biology Medical University of South CarolinaCharlestonSCUSA Department of Medicine Division of CardiologyMedical University of South CarolinaCharlestonSCUSA Ralph H.Johnson Veterans Affairs Medical Center SCUSA

Human induced pluripotent stem cell derived cardiac fibroblasts(hiPSC-CFs)play a critical role in modeling human cardiovascular diseases in ***,current culture substrates used for hiPSC-CF differentiation and expansion,such as Matrigel and tissue culture plastic(TCPs),are tissue mismatched and may provide pathogenic ***,we report that hiPSC-CFs differentiated on Matrigel and expanded on tissue culture plastic(M-TCP-iCFs)exhibit transcriptomic hallmarks of activated fibroblasts limiting their translational *** alleviate pathogenic activation of hiPSC-CFs,we utilized decellularized extracellular matrix derived from porcine heart extracellular matrix(HEM)to provide a biomimetic substrate for improving hiPSC-CF *** show that hiPSC-CFs differentiated and expanded on HEM(HEM-iCFs)exhibited reduced expression of hallmark activated fibroblast markers versus M-TCP-iCFs while retaining their cardiac fibroblast ***-iCFs also maintained a reduction in expression of hallmark genes associated with pathogenic fibroblasts when seeded onto ***,HEM-iCFs more homogenously integrated into an hiPSC-derived cardiac organoid model,resulting in improved cardiomyocyte sarcomere *** conclusion,HEM provides an improved substrate for the differentiation and propagation of hiPSC-CFs for disease modeling.

关键词： Activated fibroblast biomimetic substrate Extracellular matrix hiPSC-derived cardiac fibroblasts RNA sequencing

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钼的地表递减和淋滤

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地质与勘探 1972年第4期 62-66页

作者：梁园 J.J.barakso b.A.bradshaw

在不列颠哥伦比亚西部和中部三个较大的钼矿山(爱丽斯湾、恩达可和貝尔格)进行了岩石地球化学研究。目的是观察不同气候条件下钼的表生氧化和递减的程度。爱丽斯湾钼矿位于温哥华西北490英里,爱丽斯海湾以南约6英里处,海拔2000英尺,年... 详细信息

在不列颠哥伦比亚西部和中部三个较大的钼矿山(爱丽斯湾、恩达可和貝尔格)进行了岩石地球化学研究。目的是观察不同气候条件下钼的表生氧化和递减的程度。爱丽斯湾钼矿位于温哥华西北490英里,爱丽斯海湾以南约6英里处,海拔2000英尺,年沉积量超过100英寸。矿床产于一个直径约0.5英里的花岗岩类杂岩岩株中。该岩株由石英二长斑岩中心带组成,逐渐过渡到石英闪长岩边缘带。岩株的周围可能是侏罗系杂砂岩和泥质板岩。近岩株的杂砂岩和泥质板岩变质为黑云母角页岩。矿体分布在岩株的周围或靠近黑云

关键词：淋滤作用针铁矿黄钾铁矾铁矿物钾矿物氢氧化铁氢氧化物地表

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In search of effective therapies to overcome resistance to Temozolomide in brain tumours

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Cancer Drug Resistance 2019年第4期2卷 1018-1031页

作者： Kaouthar bouzinab Helen Summers Jihong Zhang Malcolm F.G.Stevens Christopher J.Moody Lyudmila Turyanska Neil R.Thomas Pavel Gershkovich Marianne b.Ashford Emily Vitterso Lisa C.D.Storer Richard Grundy Tracey D.bradshaw School of Pharmacy University of NottinghamNottingham NG72RDUK School of Chemistry University of NottinghamNottingham NG72RDUK School of Physics and Astronomy University of NottinghamNottingham NG72RDUK Advanced Drug Delivery Pharmaceutical SciencesR&DAstraZenecaMacclesfield SK104TFUK School of Medicine Queen’s Medical CentreUniversity of NottinghamNottingham NG72UHUK.

Glioblastoma multiforme is the most common and lethal brain *** current standard of care includes Temozolomide(TMZ)***,inherent and acquired resistance to TMZ thwart successful *** direct repair protein methylguanine DNA methyltransferase(MGMT)removes the cytotoxic O6-methylguanine(O6-MeG)lesion delivered by TMZ and so its expression by tumours confers *** mismatch repair(MMR)is essential to process O6-MeG adducts and MMR-deficiency leads to tolerance of lesions,resistance to TMZ and further DNA *** this article,two strategies to overcome TMZ resistance are discussed:(1)synthesis of imidazotetrazine analogues-designed to retain activity in the presence of MGMT or loss of MMR;(2)preparation of imidazotetrazine-nanoparticles to deliver TMZ preferably to the brain and tumour *** promising results encourage belief in a future where better prognoses exist for patients diagnosed with this devastating disease.

关键词： brain cancer temozolomide-resistance analogues drug delivery apoferritin

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