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Frontiers of Medicine 2007年第1期1卷 79-86页

作者： LI Yanhua bi Zhigang Department of Dermatology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The aim of this research was to explore the effects and signaling pathway of ultraviolet-b(UVb)irradiation on the expression of hypoxia-inducible factor 1a(HIF-1α)and transferrin receptor(TfR).HIF-1α protein was measured by Western blot *** of epidermal growth factor receptor(EGFR),phosphor-EGF-R and TfR after UVb irradiation were determined with flow *** UVb irradiation,mRNA levels of HIF-1α and TfR were detected by real *** showed that compared with control groups,UVb was able to induce HIF1α and TfR protein expression in a dose-and time-dependent manner in HaCat cells(Pby UVb treatment(P>0.05).The EGFR/PI3K/AKT signaling pathway was required for the induction of HIF-1α and TfR expression induced by *** induced activation of EGFR in HaCat cells and EGFR regulated expression of TfR and HIF-1α.EGFR(−/−)MEF did not increase the HIF1 expression following UVb irradiation(P>0.05).In contrast,EGFR(+/+)MEF strongly enhanced HIF1a expression after UVb irradiation(Pbitor of EGFR tyrosine kinase,inhibited the TfR protein expression in UVb-treated cells in a dose-dependent manner(Pbitors,LY294002 and wortmannin,inhibited HIF-1a and TfR expressions induced by UVb(Pb irradiation(P>0.05).In contrast,DEC1(+/+)HaCat cells strongly enhanced TfR and HIF-1α protein expression after UVb irradiation(Pb induces TfR and HIF-1α expressions via EGFR/PI3K/AKT/DEC1 signaling pathway.

关键词： ultraviolet-b hypoxia-inducible factor 1α receptors,transferrin receptors,epidermal growth factor phosphatidylinositol-3-kinase DEC1

In-plane micro-sized energy storage devices:From device fabrication to integration and intelligent designs

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Journal of Energy Chemistry 2021年第12期30卷 25-39,I0002页

作者： Songshan bi Hongmei Cao Rui Wang Fang Wan Zhiqiang Niu Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

The rapid development of micro-electronics raises the demand of their power sources to be simplified,miniaturized and highly integratable with other electronics on a ***-plane Micro-sized energy storage devices(MESDs),which are composed of interdigitated electrodes on a single chip,have aroused particular attentions since they could be easily integrated with other miniaturized electronics,reducing the complexity of overall chip design via removing complex interconnections with bulky power *** review highlights the achievements in the device fabrication of in-plane MESDs,as well as their integration and intelligent *** also discussed the current challenges and future perspectives for the development of in-plane MESDs.

关键词： Micro-sized energy storage devices Micro-batteries Micro-supercapacitors Integration Intelligent designs

Competitive Analysis of Different Wireless Technologies

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China Communications 2007年第2期4卷 58-63页

作者： Xi Jiarong Shu Huaying bi Chunli beijing Univ Posts & Telecommun Beijing Peoples R China

This paper takes a closer look at different wireless technologies:WiFi,WiMAX,E3G and b3G,and compares their market potentials,potential applications and areas of competitive threat,co-existence,and potential convergence in future wireless communication markets, so as to provide some available information for the industry in ***,some characteristics of future mobile service are also ***,some valuable analysis and suggestions are also proposed for Chinese choice and development of different wireless technologies.

关键词： WiFi WiMAX E3G b3G service

Interaction between Janus Green b and bovine serum albumin:Electrochemistry and spectroscopy studies

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Chinese Chemical Letters 2011年第6期22卷 717-720页

作者： Neslihan zdemir Serkan zdemir Ender bier Ondokuz Mayrs University Faculty of Arts and Sciences Department of Chemistry

In this study,voltammetric and spectroscopic investigation of the interaction between Janus Green b（JGb） and bovine serum albumin（bSA） was *** interaction was observed at britton-Robinson buffer（pH 7.0）.When JGb was added to solution containing bSA,the peak currents of bSA decrease with the increasing of JGb concentrations which is due to the interaction of JGb and *** binding constant of JGb with bSA was obtained by voltammetric ***,this interaction was supported by means of UV-vis spectroscopic *** UV-vis absorption spectra of JGb in the presence of bSA decrease with the increasing of bSA concentrations.

关键词： Voltammetry bovine serum albumin Janus Green b Interaction

Why mosaic? Gene expression profiling of African cassava mosaic virus-infected cassava reveals the effect of chlorophyll degradation on symptom development

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Journal of Integrative Plant biology 2014年第2期56卷 122-132页

作者： Jiao Liu Jun Yang Huiping bi Peng Zhang Shanghai Chenshan Plant Science Research Center the Chinese Academy of Sciences Chenshan Botanical Garden National Key Laboratory of Plant Molecular Genetics and National Center for Plant Gene Research (Shanghai) Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences the Chinese Academy of Science Key Laboratory of Systems Microbial biotechnology Tianjin Institute of Industrial Biotechnology the Chinese Academy of Sciences Tianjin Airport Economic Park

Cassava mosaic disease, caused by cassava bego- moviruses, is the most serious disease for cassava in Africa. However, the pathogenesis of this disease is poorly under- stood. We employed high throughput digital gene expression profiling based on the Illumina Solexa sequencing technology to investigate the global transcriptional response of cassava to African cassava mosaic virus infection. We found that 3,21o genes were differentially expressed in virus-infected cassava leaves. Gene ontology term and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that genes implicated in photosynthesis were most affected, consistent with the chlorotic symptoms observed in infected leaves. The upregu- lation of chlorophyll degradation genes, including the genes encoding chlorophyUase, pheophytinase, and pheophorbide a oxygenase, and downregulation of genes encoding the major apoproteins in light-harvesting complex II were confirmed by qRT-PCR. These findings, together with the reduction of chlorophyll b content and fewer grana stacks in the infected leaf cells, reveal that the degradation of chlorophyll plays an important role in A^rican cassava mosaic virus symptom development. This study will provide a road map for future investigations into viral pathogenesis.

关键词： Afriican cassava mosaic virus cassava chlorophylldegradation digital gene expression mosaic symptom

Synthesis and Crystal Structure of a Dinuclear Cu(Ⅱ) Complex [Cu(C_(13)H_9N_2O)Cl]_2·(CH_3CN)_2 with Ligand 2-benzimidazol

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Chinese Journal of Structural Chemistry 2007年第2期26卷 149-152页

作者： LI Qing-Xiang YANG Xiang-Liang XU Hui-bi Hubei Key Laboratory of Novel Chemical Reactor andGreen Chemical Technology Wuhan Institute of Technology Wuhan 430073 China College of Life Science Huazhong University of Science and Technology Wuhan 430074 China

A new dinuclear copper complex, [Cu（C13HgN2O）Cl]2.（CH3CN）2 （C30H24C12Cu2N6O2）, has been synthesized and characterized by X-ray structure determination. It crystallizes in the triclirile system, space group P1, with a = 7.6677（14）, b = 9.2375（17）, c = 11.227（2） ]A, α = 81.338（3）,β = 88.173（4）, γ = 66.199（3）°, V = 718.9（2） ]A^3, Z = 1, Mr = 698.53, F（000） = 354, Dc = 1.613 g/cm^3, μ（MoKa） = 1.705 mm^-1, the final R = 0.0645 and wR = 0.1364 for 2474 unique reflections with 1809 observed ones （I 〉 20（I））. In the title complex, each copper（H） atom is located at the center of a distorted tetrahedron consisting of four coordinate atoms （one nitrogen atom, two oxygen anions, and one chlorine atom）. Two copper（Ⅱ） atoms are bridged by two oxygen anions （O（1） and O（la）） of two phenolates to form a Cu（Ⅱ）-Cu（Ⅱ） binuclear entity, and the distance between two copper（Ⅱ） atoms is 3.0144（15） A.

关键词： 2-benzimidazol phenolate Cu(Ⅱ) complex crystal structure

Enhanced conductivity and stability of Co_(0.98)Cu_(x)Mn_(2.02−x)O_(4)ceramics with dual phases and twin structures

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Journal of Advanced Ceramics 2023年第9期12卷 1742-1757页

作者： Chengjian Ma Longhua He Lei bi Hong Gao Jianxiang Ding Analytical and Testing Center Yancheng Institute of TechnologyYancheng 224051China School of Materials Science and Engineering Yancheng Institute of TechnologyYancheng 224051China School of Resource Environment and Safety Engineering University of South ChinaHengyang 421001China School of Mathematics and Physics Yancheng Institute of TechnologyYancheng 224051China School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243002China

Semiconductor materials with heterogeneous interfaces and twin structures generally demonstrate a higher concentration of carriers and better electrical stability.A variety of Cu-doped Co_(0.98)Cu_(x)Mn_(2.02−x)O_(4)(0≤x≤0.5)negative temperature coefficient(NTC)ceramics with dual phases and twin structures were successfully prepared in this *** refinement indicates that the content of a cubic spinel phase increases with increasing Cu *** addition of Cu can promote grain growth and ***-level structural characterization reveals the evolution of twin morphology from large lamellae with internal fine lamellae(LIT lamellae)to large lamellae without internal fine lamellae(L lamellae)and the distribution of twin boundary ***-principles calculations reveal that the dual phases and twin structures have lower oxygen-vacancy formation energy than those in the case of the pure tetragonal and cubic spinel,thereby enhancing the transmission of ***,the three-dimensional charge-density difference shows that metal ions at the interface lose electrons and dwell in high valence states,thereby enhancing electrical stability of the NTC ***,the additional Cu ions engage in electron-exchange interactions with Mn and Co ions,thereby reducing *** comparison to previous Cu-containing systems,the Co_(0.98)Cu_(x)Mn_(2.02−x)O_(4)series exhibit superior stability(aging value≤2.84%),tunable room-temperature resistivity(ρ),and material constant(b)value(17.5Ω·cm≤ρ≤7325Ω·cm,2836 K≤b≤4315 K).These discoveries lay a foundation for designing and developing new NTC ceramics with ultra-high performance.

关键词： negative temperature coefficient(NTC)ceramics Cu-containing spinel high electrical stability twin structure first-principles calculation electron-exchange interaction

Influence of physiological and environmental factors on the diurnal variation in emissions of biogenic volatile compounds from Pinus tabuliformis

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Journal of Environmental Sciences 2019年第7期31卷 102-118页

作者： Jungang Chen Huaxing bi Xinxiao Yu Yanlin Fu Wenchao Liao College of Soil and Water Conservation Beijing Forestry University Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of the Ministry of Education Peking University Ji County Station Chinese National Ecosystem Research Network (CNERN) Key Laboratory of State Forestry Administration on Soil and Water Conservation Beijing Forestry University beijing Engineering Research Center of Soil and Water Conservation Beijing Forestry University Engineering Research Center of Forestry Ecological Engineering Ministry of Education Beijing Forestry University beijing Collaborative Innovation Center for Eco-Environmental Improvement With Forestry and Fruit Trees beijing Water Consulting Co. LTD

biological volatile organic compounds(bVOCs) have a large influence on atmospheric environmental quality, climate change and the carbon cycle. This study assesses the composition and diurnal variation in emission rates of bVOCs from Pinus tabuliformis, using an enclosure technique. Environmental parameters(temperature and light intensity) and physiological parameters(net photosynthetic rate, P_n; stomatal conductance, g_s; intercellular CO_2 concentration, C_i; and transpiration rate, T_r) that may affect emission behavior were continuously monitored. The 10 most abundant compound groups emitted by P. tabuliformis were classified by gas chromatography–mass spectrometry. The dominant monoterpenoid compounds emitted were α-pinene, β-myrcene, α-farnesene and limonene. The diurnal emission rate of bVOCs changed with temperature and light intensity, with dynamic analysis of bVOCs emissions revealing that their emission rates were more affected by temperature than light. The variation in monoterpene emission rates was consistent with estimates of P_n, g_s and T_r. basal emission rates(at 30 °C,) of the main bVOCs ranged from 0.006 to 0.273 μg^(-1)/(hr g),while the basal ER standardization coefficients ranged from 0.049 to 0.144 °C^(-1). Overall, these results provide a detailed reference for the effective selection and configuration of tree species to effectively prevent and control atmospheric pollution.

关键词： biogenic volatile organic compounds Pinus tabuliformis Emission rate Monoterpenes

Analysis of Thermoelastohydrodynamic Performance of Journal Misaligned Engine Main bearings

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Chinese Journal of Mechanical Engineering 2015年第3期28卷 511-520页

作者： bi Fengrong SHAO Kang LIU Changwen WANG Xia ZHANG Jian State Key Laboratory of Engines Tianjin University

To understand the engine main bearings＇ working condition is important in order to improve the performance of engine. However, thermal effects and thermal effect deformations of engine main bearings are rarely considered simultaneously in most studies. A typical finite element model is selected and the effect of thermoelastohydrodynamic（TEHD） reaction on engine main bearings is investigated. The calculated method of main bearing＇s thermal hydrodynamic reaction and journal misalignment effect is finite difference method, and its deformation reaction is calculated by using finite element method. The oil film pressure is solved numerically with Reynolds boundary conditions when various bearing characteristics are calculated. The whole model considers a temperature-pressure-viscosity relationship for the lubricant, surface roughness effect, and also an angular misalignment between the journal and the bearing. Numerical simulations of operation of a typical I6 diesel engine main bearing is conducted and importance of several contributing factors in mixed lubrication is discussed. The performance characteristics of journal misaligned main bearings under elastohydrodynamic（EHD） and TEHD loads of an I6 diesel engine are received, and then the journal center orbit movement, minimum oil film thickness and maximum oil film pressure of main bearings are estimated over a wide range of engine operation. The model is verified through the comparison with other present models. The TEHD performance of engine main bearings with various effects under the influences of journal misalignment is revealed, this is helpful to understand EHD and TEHD effect of misaligned engine main bearings.

关键词： main bearings journal misaligned oil film pressure Reynolds equation finite difference methods thermoelastohydrodynamic(TEHD)

A novel domain decomposition-based model for efficient dynamic predictions of large composite machine tools

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Science China(Technological Sciences) 2024年第6期67卷 1765-1782页

作者： YU Yangbo JI Yu Lei CHEN YanRen XU Kun bi QingZhen State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China

We propose a large combined moving component composed of carbon fiber reinforced polymer(CFRP)laminates for making lightweight machine tools with high dynamic *** accurate dynamic prediction of composite machine tools is essential for the new generation machine *** paper aims to address two challenges in numerical dynamic modeling and the design of composite machine tools to enhance development efficiency.(1)Anisotropic composite laminates,which form the composite machine tool,exhibit coupling in various *** propose the generalized continuity condition of the boundary to tackle this dynamic modeling challenge.(2)Composite machine tools feature numerous composite-metal coupled *** mechanical model correction of isotropic metals is performed to address their *** take the example of a five-axis gantry machine tool with composite moving parts,establish a dynamic model for efficient prediction,and verify it through simulation and *** proposed method yields remarkable results,with an average relative error of only 3.85%in modal frequency prediction and a staggering 99.7%reduction in solution time compared to finite element *** further discuss the dynamic performance of the machine tool under varied stacking angles and layer numbers of the composite machine *** propose general design criteria for composite machine tools to consider the modal frequency and manufacturing cost of machine tools.

关键词： machine tool dynamics carbon fiber reinforced polymer composite laminates