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初次全膝置换术使用抗生素骨水泥对关节感染微生物类型和耐药性的影响

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临床骨科杂志 2014年第1期17卷 45-45页

作者： hansen E N Adeli b Kenyon R 胡孔足

在欧洲，初次全膝置换术普遍采用初次全膝、全髋置换术，分析术后微生物含抗生素骨水泥；在北美，FDA仅批准感染类型、细菌耐药性。发现使用含抗在感染性全膝翻修术使用含抗生素骨水生素骨水泥对微生物感染类型、细菌耐泥。

关键词：初次全膝置换术抗生素骨水泥细菌耐药性生物类型关节感染感染类型全髋置换术微生物

Soluble membrane attack complex in ascites in patients with liver cirrhosis without infections

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World Journal of Hepatology 2010年第6期2卷 221-225页

作者： Mette bjerre Peter Holland-Fischer Henning Grφnbk Jan Frystyk Troels K hansen Hendrik Vilstrup Allan Flyvbjerg The Medical Research Laboratories Clinical Institute and Department of Endocrinology and Internal Medicine Aarhus University Hospital Department of Medicine V (Hepatology and Gastroentology) Aarhus University Hospital

AIM: To study complement activation in 46 patients with alcoholic cirrhosis and ascites but no spontaneous bacterial peritonitis (SbP) and 10 healthy controls. METHODS: Complement activation was determined by the measurement of soluble membrane attack complex (sMAC) concentrations in ascites and plasma. In patients, metabolic liver function was determined by the galactose elimination capacity and the clinical status assessed by the Model of End-Stage Liver Disease and Child-Pugh scores. RESULTS: Ascites sMAC levels were markedly higherthan in the corresponding plasma sample (median (range): 596 (170 - 1519) vs 160 (77 - 848) μg/L; P between ascites sMAC and leukocyte count. No relationship between ascites sMAC and blood C-reactive protein, albumin or neutrophile count was found. Plasma sMAC concentrations were slightly higher in patients than in controls [130 μg/L (70 - 204); P = 0.04]. Neither sMAC in ascites nor plasma was related to mortality. CONCLUSION: The increased sMAC concentration in ascites and plasma indicate an activation of the complement system in cirrhosis even in the absence of SbP. This was particularly evident in the peritoneal fluid and most marked in patients with preserved liver status. The high ascites sMAC levels may reflect transudation of membrane attack complexes from the liver. Whether this complement activation has any clinical implications remains to be clarified.

关键词： Ascites Cirrhosis Complement sC5b-9 Soluble membrane attack complex

科罗拉多州东部平原限水灌溉对玉米生理、生长及水分利用效率的影响

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科罗拉多州东部平原限水灌溉对玉米生理、生长及水分利用效率的影...

PLANAREED Al PROCESSES FOR SUb-HALF MICRON VLSI INTERCONNECT TECHNOLOGY

全国农业水土工程第六届学术研讨会

作者：胡笑涛康绍忠 Neil hansen Allan A.Andales 西北农林科技大学旱区农业水土工程教育部重点实验室中国农业大学农业水问题研究中心科罗拉多州立大学土壤与作物科学系

大田试验在科罗拉多州立大学农业研究发展教育中心试验站开展,灌溉处理包括充分灌溉、旱地不灌溉、2个水平的限水灌溉4种处理,4个重复。结果表明:限水灌溉玉米苗期及拔节期不灌溉的限水处理,能够控制长势,降低植株高度和叶面积指数,进... 详细信息

大田试验在科罗拉多州立大学农业研究发展教育中心试验站开展,灌溉处理包括充分灌溉、旱地不灌溉、2个水平的限水灌溉4种处理,4个重复。结果表明:限水灌溉玉米苗期及拔节期不灌溉的限水处理,能够控制长势,降低植株高度和叶面积指数,进入抽穗期以后复水,光合作用增强,出现一定补偿效应,玉米籽粒水分利用效率明显提高,同时提高了谷草比,说明生长后期复水,有利于光合产物向经济产量转化。因此在美国中部大平原区采取玉米生育前期（抽穗之前）不灌溉,之后复水,可以在产量降低不多的条件下,实现大幅度节约用水,提高水分利用效率的目的。

关键词：玉米限水灌溉水分利用效率

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PLANAREED Al PROCESSES FOR SUB-HALF MICRON VLSI INTERCONNECT...

1995 4th International Conference on Solid-State and Integrated Circuit Technology

作者： b.Zhao C.H.Ting L.Ta P.K.Vasudev M.A.biberger V.Hoffman SEMATECH 2706 Montopolis Drive Austin TX 78741 USA SEMATECH 2706 Montopolis Drive Austin TX 78741 USA SEMATECH 2706 Montopolis Drive Austin TX 78741 USA SEMATECH 2706 Montopolis Drive Austin TX 78741 USA Varian Associates 611 Hansen Way Palo Alto CA 94303 USA Varian Associates 611 Hansen Way Palo Alto CA 94303 USA

＜正＞ Planarized Al processes have been investigated by electrical measurement and scanning electron microscopy to study their feasibility in building multi-level interconnect structures for VLSI circuits of sub micron geometry. A variety of test structures have been used to characterize these planarized Al processes. It has been demonstrated that 0.35μm via holes with nearly vertical side-wall can be filled without using collimated Al deposition. Contact resistance of about 0.3Ωand specific contact resistivity of approximately 6×10-10 Ω-cm2 were obtained for 0.5μm vias. Under optimized condition, very high yield was obtained for both 0.35μm and 0.5μm via hole fill.

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来源： cnki会议评论

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新型有序介孔材料在药物传递系统中的应用

材料导报 2010年第19期24卷 71-74页

作者：钟国英王秀芳林汉森广东药学院药科学院广州510006

根据近10年来有序介孔材料用于药物传递系统的研究报道,综述了几种新型介孔材料的合成方法,讨论分析了药物传递系统中孔径、孔道长度、形貌和功能基团修饰等影响因素,着重阐述和评价了影响有序介孔材料结构特征的合成工艺条件,以及这些... 详细信息

根据近10年来有序介孔材料用于药物传递系统的研究报道,综述了几种新型介孔材料的合成方法,讨论分析了药物传递系统中孔径、孔道长度、形貌和功能基团修饰等影响因素,着重阐述和评价了影响有序介孔材料结构特征的合成工艺条件,以及这些有序介孔材料潜在的药学应用价值和急需解决的问题,旨在为新型有序介孔材料在药物传递系统中的应用提供参考。

关键词：有序介孔材料药物传输药物载体

Cr(VI)阳性患者的Cr(III)反应性与足部皮炎

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 47-47页

作者： hansen M.b. Menné T. Johansen J.D. 潘敏 National Allergy Research Centre Ledreborg Allé40DK-2820 Gentofte Denmark

Chromium allergy has become synonymous with Cr(VI) ***, real exposure to chromium from leather products may include both Cr(III) and Cr(VI). In this study,we investigate the reactivity to both Cr(VI) and Cr(III) in consecutive patients to analyse the relation between foot eczema/leather exposure and reactivity to Cr(III). From March 2002 to December 2004, 2211 consecutive patients with suspected allergic contact dermatitis were patch tested with 0.5%potassium dichromate (Cr(VI)) and 13%chromium trichloride(Cr(III)). A total of 71 (3.2%) patients had a positive reaction to Cr(VI), of which 31 also had a positive Cr(III) reaction. No Cr(VI) negative patients had a positive reaction to Cr(III). An increased risk of foot dermatitis was found in Cr(VI) positive patients with a concomitant positive or doubtful reaction to Cr(III) compared with Cr(VI) positive patients with no reactions to Cr(III). The increased risk was not due to a higher degree of sensitivity to Cr(VI). Leather was reported most frequently as the suspected cause of chromium dermatitis (54%).However, Cr(VI) allergics having foot eczema and positive or doubtful Cr(III) reactions often had positive reactions to other shoe allergens. Thus, Cr(III) allergy is part of a multiple shoe allergy pattern.

关键词：变态反应性接触性皮炎 Cr(Ⅲ) Cr(Ⅵ) 阳性患者足部湿疹三氯化铬阳性反应阴性患者过敏者斑贴试验

日粮中补充维生素E对猪肉α-生育酚浓度和脂质氧化影响的Meta分析

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饲料博览 2012年第3期22卷 50-50页

作者： Trefan L L bünger J bloom-hansen J A Rooke b Salmi C Larzul C Terlouw Doeschl-Wilson A 不详

通过Meta分析对日粮中添加维生素E对猪背最长肌α-生育酚的积累和脂质氧化的影响进行了研究。基于13个维生素E积累试验和10个脂质过氧化试验进行分析,经过一系列标准化程序后,发现日粮中补充维生素E和猪肉α-生育酚的积累之间呈现非线... 详细信息

通过Meta分析对日粮中添加维生素E对猪背最长肌α-生育酚的积累和脂质氧化的影响进行了研究。基于13个维生素E积累试验和10个脂质过氧化试验进行分析,经过一系列标准化程序后,发现日粮中补充维生素E和猪肉α-生育酚的积累之间呈现非线性关系,其最大值为3.4μg.g-1。猪肉脂质过氧化水平采用硫代巴比妥酸反应物质(TbARS)值进行衡量。对TbARS值进行分析表明,维生素E的剂量、肌肉的α-生育酚的浓度和补充时间对其有显著影响,并形成了脂质过氧化的两个预测模型。通过Meta分析对量化日粮维生素E对猪的影响证明,Meta分析是一种有价值的工具,有利于模型校正和增加派生模型的预测能力。

关键词：维生素E α-生育酚脂质过氧化猪肉品质 TbARS Meta分析

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HLA系统命名规则,2002

国外医学（输血及血液学分册） 2003年第3期26卷 194-209页

作者： S.G.E.Marsh E.D.Albert W.F.bodmer R.E.bontrop b.Dupont H.A.Erlich D.E.Geraghty J.A.hansen b.Mach W.R.Mayr P.Parham E.W.Petersdorf T.Sasazuki G.M.Th.Schreuder J.L.Strominger A.Svejgaard P.I.Terasaki 池永斌不详上海第二医科大学免疫学研究所200025

由于分子生物学技术的引入及世界范围内群体调查的扩大使原有的命名规则不适应HLA等位基因数目的增加,2002年6月命名委员会补充和修订了命名规则,由原来的5位增至8位,为便于从事免疫、遗传及有关临床医生了解新命名规则及HLA多态性现状... 详细信息

由于分子生物学技术的引入及世界范围内群体调查的扩大使原有的命名规则不适应HLA等位基因数目的增加,2002年6月命名委员会补充和修订了命名规则,由原来的5位增至8位,为便于从事免疫、遗传及有关临床医生了解新命名规则及HLA多态性现状,特刊此译文。

关键词： HLA系统命名规则 2002年 HLA等位基因数目 HLA多态性

S2A-5 Targeting PDE4 for Alzheimer’s Disease and Alcoholism:An implication in Alcohol-Related Dementia?

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神经药理学报 2018年第4期8卷 39-41页

作者： WANG Hao ZHANG Fang-fang FU Hua-rong ZHOU Yan-meng LIU Xin HOU Xue-qin HU Wei Rolf hansen XU Ying James O’Donnell 张汉霆 Institute of Pharmacology the First Medical University of ShandongTai’an271016China Departments of behavioral Medicine&Psychiatry Physiology&Pharmacologyand Neurosciencethe Rockefeller Neurosciences InstituteWest Virginia University Health Sciences CenterMorgantownWV 26506USA Department of Pharmaceutical Sciences School of Pharmacy&Pharmaceutical SciencesState University of New York at BuffaloBuffaloNY 14214USA

background:Phosphodiesterase 4(PDE4),one of the 11 PDE enzyme families that hydrolyze cyclic nucleotides,is critical for controlling intracellular cyclic AMP(cAMP)concentrations and plays an important role in regulating alcohol consumption and mediating memory in dementia such as Alzheimer’s disease(AD).Chronic alcohol consumption can cause alcohol-related dementia and 50%~75%of detoxified alcoholics have memory or cognition ***,the role of PDE4 and its mechanism remain to be characterized and ***:Using the water-maze,passive avoidance,or novel object recognition test,we examined the effects of rolipram,a prototypical PDE4 inhibitor,and roflumilast,a potent PDE4 inhibitor which has been approved for treatment of chronic obstructive pulmonary disease(COPD)in humans,on memory loss in APP/PS1 double transgenic mice,a widely used model for *** addition,we tested the effects of the PDE4 inhibitors,via ip,intra-gastric,or intrastriatum infusion,on ethanol intake and preference using the mouse two-bottle choice *** deficient in PDE4A,PDE4b,or PDE4D(4AKO,4bKO,and 4DKO,respectively)and their wild type(WT)controls were tested for ethanol consumption and memory;the latter was measured in the absence or presence of beta-amyloid peptide 1-42(Abeta42)infused into the dorsal ***:Similar to rolipram,roflumilast reversed memory deficits in APP/PS1 mice in all the memory tests and reduced ethanol intake and preference in C57bL/6 mice in two-bottle *** with the results in the memory tests,roflumilast reduced the loss of neurons and neurocyte apoptosis in AD mice,as shown using HE and Nissl *** also reversed the decreased ratio of bcl-2/bAX in the cerebral cortex and hippocampus of AD *** addition,roflumilast reversed the decreased levels of cAMP and expression of phosphorylated cAMP response element-binding protein(CREb)and brain derived neurotrophic factor(bDNF)in AD *** to the WT controls,4

关键词： Phosphodiesterase-4(PDE4) Alzheimer’s disease(AD) alcoholism cAMP signaling memory trangenic mice