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国际医学放射学杂志 2021年第2期44卷 245-245页

作者： C.L.Nordberg M.boesen G.L.Fournier H.bliddal P.hansen b.b.hansen 王凤丹

摘要目的研究腰椎间盘突出的生物力学变化。方法经1.5～3.0 T MR设备检查证实的椎间盘突出症病人,在0.25 T负重MR设备行以下体位的检查:(1)站立位,(2)腰椎相对过

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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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bone Research 2024年第1期12卷 180-198页

作者： Morten S.hansen Kaja Madsen Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEb) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin b(FLNb)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

Trajectory sampling and finite-size effects in first-principles stopping power calculations

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npj Computational Materials 2023年第1期9卷 238-246页

作者： Alina Kononov Thomas W.Hentschel Stephanie b.hansen Andrew D.baczewski Center for Computing Research Sandia National LaboratoriesAlbuquerqueNMUSA School of Applied&Engineering Physics Cornell UniversityIthacaNYUSA Pulsed Power Sciences Center Sandia National LaboratoriesAlbuquerqueNMUSA

Real-time time-dependent density functional theory(TDDFT)is presently the most accurate available method for computing electronic stopping powers from first ***,obtaining application-relevant results often involves either costly averages over multiple calculations or ad hoc selection of a representative ion *** consider a broadly applicable,quantitative metric for evaluating and optimizing trajectories in this *** methodology enables rigorous analysis of the failure modes of various common trajectory choices in crystalline *** randomly selecting trajectories is common practice in stopping power calculations in solids,we show that nearly 30%of random trajectories in an FCC aluminum crystal will not representatively sample the material over the time and length scales feasibly simulated with TDDFT,and unrepresentative choices incur errors of up to 60%.We also show that finite-size effects depend on ion trajectory via“ouroboros”effects beyond the prevailing plasmon-based interpretation,and we propose a cost-reducing scheme to obtain converged results even when expensive core-electron contributions preclude large *** work helps to mitigate poorly controlled approximations in first-principles stopping power calculations,allowing 1–2 order of magnitude cost reductions for obtaining representatively averaged and converged results.

关键词： size prevailing selecting

Nuclear physics program at MAX-lab

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Chinese Physics C 2009年第12期33卷 1159-1166页

作者： W.J. briscoe Jason brudvik K.G. Fissum K. hansen L. Isaksson M. Lundin b. Nilsson b. Schroder Center for Nuclear Studies The George Washington University Washington DC 20052 USA Department of Physics Lund University Lund SE-221 00 Sweden MAX-lab Lund SE-221 00 Sweden

The upgrade of the MAX-lab injector and the construction of MAX Ⅲ, provided the opportunity for upgrading the tagged-photon facility and thus lead to the possibility of more extensive program in nuclear physics research. This upgrade increased the injected electron energy to an eventual maximum of 250 MeV and allows for the extraction of electrons from the MAX Ⅰ ring operated in the stretcher mode. The first stretched beam was delivered in September 2005. The tagged-photon facility was commissioned in parallel with the commissioning of new experimental equipment. The PAC approved experimental program is current in progress, including measurements of pion photoproduction below the △（1232）. The efforts at the tagged photon-facility are pursued within an international collaboration with around fifty members.

关键词： photonuclear reactions pion production compton scattering

Mapping wetlands in Indonesia using Landsat and PALSAR data-sets and derived topographical indices

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Geo-Spatial Information Science 2014年第1期17卷 60-71页

作者： belinda A.MARGONO Jean-Robert b.bWANGOY Peter V.POTAPOV Matthew C.hansen Department of Geographical Sciences University of Maryland4321 Hartwick Bld.College ParkMD 20742USA GIS Center of Excellence South Dakota State University1021 Medary Ave.Wecota HallBrookingsSD 57007USA The Ministry of Forestry(MoF)of Indonesia Manggala Wanabhkati Bld.Jakarta 10270Indonesia

Wetlands play an important role in the provision of ecosystem services,ranging from the regulation of hydrological systems to carbon sequestration and biodiversity *** paper reports the mapping of Indonesia’s wetland cover as a single thematic class,including peatlands,freshwater wetlands,and ***-interpreted training data were used to identify wetland formations including areas of likely past wetland extent that have been converted to other land *** indices(Shuttle Radar Topography Mission-derived)and optical(Landsat)and radar(PALSAR)image inputs were used to build a bagged classification tree model based on training data in order to generate a national-scale map of wetland extent at a 60 m spatial *** resulting wetland map covers 21.0%(39.6 Mha)of Indonesia’s land,including 25.2% of Sumatra(11.9 Mha),22.9% of Kalimantan(12.2 Mha),and 28.9% of Papua(11.8 Mha).Results agree with existing image-interpreted products from Indonesia’s Ministries of Forestry and Agriculture and Wetlands International(89% overall agreement),and with the Ministry of Forestry forest inventory data for Sumatra and Kalimantan(91% overall agreement).An internally consistent algorithm-derived national wetland extent map can be used to quantify changing rates of land conversion inside and outside of ***,wetlands extent can be used to efficiently allocate field resources in national assessments of wetland sub-types such as peatlands,which are a current focus of policies aiming to reduce carbon emissions from land use change.

关键词： wetlands Indonesia remote sensing Landsat digital elevation model(DEM) PALSAR Shuttle Radar Topography Mission(SRTM)

Reversible solid-oxide cells for clean and sustainable energy

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Clean Energy 2019年第3期3卷 175-201页

作者： M.b.Mogensen M.Chen H.L.Frandsen C.Graves J.b.hansen K.V.hansen A.Hauch T.Jacobsen S.H.Jensen T.L.Skafte X.Sun Department of Energy Conversion and Storage Technical University of Denmark(DTU)Frederiksborgvej 399DK-4000 RoskildeDenmark Haldor Topsøe Haldor Topsøes Allé1DK-2800 Lyngby Department of Chemistry Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark DynElectro ApS DK-4621 GadstrupDenmark

This review gives first a brief view of the potential availability of sustainable *** is clear that over 100 times more solar photovoltaic energy than necessary is readily accessible and that practically available wind alone may deliver sufficient energy supply to the *** to the intermittency of these sources,effective and inexpensive energy-conversion and storage technology is *** for the possible electrolysis application of reversible solid-oxide cells(RSOCs),including a comparison of power-to-fuel/fuel-to-power to other energy-conversion and storage technologies is *** electrochemistry and chemistry of H_(2)O,CO_(2),H_(2),CO,CnHm(hydrocarbons)and NH3,including thermodynamics and cell performance,are *** mechanical strength of popular cell supports is outlined,and newly found stronger materials are *** cell-degradation mechanisms,including the effect of common impurities in gases and materials(such as S and Si),plus the deleterious effects of carbon deposition in the fuel electrode are described followed by explanations of how to avoid or ease the *** of how RSOCs powered by sustainable energy may be applied on a large scale for the transportation sector via power-to-fuel technology and for integration with the electrical grid together with seasonal storage are ***,a brief comparison of RSOCs to other electrolysis cells and an outlook with examples of actions necessary to commercialize RSOC applications are sketched.

关键词： electrolysis fuel cells solid-oxide cells power-to-fuel electrochemical syngas

An Overview about the brazilian Photovoltaic Market Development

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Journal of Power and Energy Engineering 2020年第8期8卷 73-84页

作者： Larissa Ananda hansen Diorge Alex báo Zambra Departamento Interdisciplinar Universidade Federal do Rio Grande do Sul Tramandaí Brazil

There are five main institutions that develop research and provide data regarding photovoltaic energy generation in brazil, they are: brazilian Electricity Regulatory Agency (ANEEL);Energy Research Office (EPE);International Renewable Energy Agency (IRENA);Institute for the Development of Alternative Energies in Latin America (IDEAL);and Greener (a research and consultancy company specialized in the photovoltaic solar energy sector). The reports provided by these institutions present a large volume of data and information, this factor makes hard task of understanding the brazilian photovoltaic market. Therefore, this paper purposes to present an overview about the development of photovoltaic generation in brazil, through of an unpublished compilation and analysis of the data provided by the institutions previously cited. For this, initially the factors that contributed to the implementation and expansion of this sector are presented. Following, it is presented the main resolutions for the implementation of distributed generation, as well as organizations responsible for the standardization, operation, testing and expected requirements for connection of renewable sources in the electrical system. Quantitative data about energy installed, number of installations approvals, distribution of installations by sector of society, number homologations by power range and cost distribution for the implementation of these systems are provided. Finally, the incentive policies, credit lines and future perspectives for the development of the photovoltaic sector in Brazil are presented.

关键词： Photovoltaic Systems Solar Power Generation Solar Energy Standardization Governmental Factors

Recent shifts in shade tolerance and disturbance traits in forests of the eastern United States

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Ecological Processes 2019年第1期8卷 391-401页

作者： brice b.Hanberry Rocky Mountain Research Station USDA Forest ServiceRapid CitySD 57702USA

background:Current forests of the eastern USA have the potential to succeed in composition to more shade-tolerant ***,long-term processes of transition from fire-tolerant tree species to fire-sensitive species and effects of current land use on forests may interfere with successional ***:I examined if forests in three regions have increased in shade tolerance and if life history strategy groups that represent response to disturbance(i.e.,fire-tolerance,early-successional species based on low shade tolerance,mid-successional species,late-successional species,and trees valued for traits related to short harvest rotations)have changed,using Forest Inventory and Analysis surveys,adjusted for comparison,and generalized linear mixed models to assess approximately 30 year trends,with adjustments to equalize different survey ***:Although statistically significant,a slight increase of 2 to 4%in regional mean shade tolerance may not be ecologically *** the central East,mid-successional species replaced early-successional species and early-successional species replaced fire-tolerant oaks,resulting in an overall shift from fire-tolerant oaks to mid-successional *** fire-tolerant pine species and increased planted pine species were the major changes in the northern Southeast and Coastal ***:The successional process of increased composition by shade-tolerant species over time was overshadowed by land use changes that resulted in decreased fire-tolerant species and increased planted ***,frequent land use disturbance may continue to prevent the slow progress of compositional succession to very shade-tolerant species.

关键词： Disturbance Eastern United States Fire Land use Mesophication Oak Pine Succession Traits

膜接触臭氧-紫外联用强化降解耐臭氧微量有机污染物

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环境工程学报 2022年第6期16卷 1807-1814页

作者：王颖李梦凯孙喆张会敏 HANS C.b.hansen 强志民中国科学院生态环境研究中心饮用水科学与技术重点实验室北京100085 哥本哈根大学植物与环境科学学院丹麦哥本哈根1871 中国科学院大学中丹学院北京100049 北京安力斯环境科技股份有限公司北京100085

臭氧(O_(3))已被广泛应用于水深度处理中,但其无法有效降解耐O_(3)微量有机污染物(OR-MOPs)。针对OR-MOPs的强化降解,搭建了由O_(3)膜接触器和细管流光反应系统组成的膜接触O_(3)-紫外(UV)实验装置,并对O_(3)膜接触器的处理效果进行评... 详细信息

臭氧(O_(3))已被广泛应用于水深度处理中,但其无法有效降解耐O_(3)微量有机污染物(OR-MOPs)。针对OR-MOPs的强化降解,搭建了由O_(3)膜接触器和细管流光反应系统组成的膜接触O_(3)-紫外(UV)实验装置,并对O_(3)膜接触器的处理效果进行评估。结果表明,随着气相O_(3)质量浓度增加、溶液流量和pH的降低,液相O_(3)质量浓度升高;磷酸盐对O_(3)溶解没有影响;测得细管流光反应系统的UV剂量率为4.56×10^(-4)Einstein·m^(-2)·s^(-1)。当液相O_(3)质量浓度为1.0和2.0 mg·L^(-1)时,膜接触O_(3)-UV联用对代表性OR-MOP—布洛芬的去除率分别为63.2%和82.9%,比单独O_(3)氧化增加了38.1%和44.5%,且O_(3)被完全利用。布洛芬的降解效果随pH升高而提升,当液相O_(3)质量浓度为1.0 mg·L^(-1)、pH=9.0时,布洛芬的整体去除率最高(77.2%);在布洛芬各主要降解途径中,羟基自由基(HO·)氧化的贡献比达90%以上。膜接触O_(3)-UV联用可强化OR-MOPs的降解并提高O_(3)利用率,可为O_(3)在水深度处理中的应用提供新方法。

关键词：膜接触臭氧紫外臭氧氧化高级氧化耐臭氧微量有机污染物

预期寿命估计对脊柱转移瘤手术选择与预后预测的临床意义

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癌症 2006年第11期25卷 1406-1410页

作者：邹学农 Anders Grejs 李海声 Kristian Hφy Ebbe S hansen Cody bünger 丹麦奥胡斯大学医院骨科

背景与目的:目前,临床上对脊柱转移瘤患者是否采取手术治疗以及如何选择手术仍然存在较大的争议。预期寿命的估计是手术选择的决定因素之一。本研究旨在评价Tokuhashi和Tomita评分系统这两种常用的预期寿命估计方法对硬膜外脊柱转移瘤... 详细信息

背景与目的:目前,临床上对脊柱转移瘤患者是否采取手术治疗以及如何选择手术仍然存在较大的争议。预期寿命的估计是手术选择的决定因素之一。本研究旨在评价Tokuhashi和Tomita评分系统这两种常用的预期寿命估计方法对硬膜外脊柱转移瘤患者手术选择与预后预测的临床价值。方法:对2001年1月至2004年4月丹麦奥胡斯大学医院脊柱外科中心收治的169例硬膜外脊柱转移瘤入组患者,术前用Tokuhashi与Tomita评分系统进行评分以及估计预期寿命,并结合Tomita脊柱肿瘤分型,选择实施手术分级治疗。术后6个月、12个月以及24个月分别进行前瞻性随访观察。对在预期寿命为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的患者通过Tokuhashi与Tomita评分系统绘制受试者作业特征曲线(receiveroperatingcharacteristiccurves,ROC曲线),比较两个评分系统对预期寿命估计的准确性。同时采用Kaplan-Meier生存曲线分析法,计算Tokuhashi和Tomita评分系统各分数段患者术后的实际平均生存时间。结果:预期寿命分别为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的病例ROC曲线分析显示,Tomita评分系统与Tokuhashi评分系统之间的差异均无显著性(各组P值分别为0.16、0.47与0.38)。Kaplan-Meier生存曲线分析显示,Tomita评分系统在4～7分之间对预后估计过高,Tokuhashi评分系统在0～8分之间对预后估计过低。结论:Tokuhashi和Tomita评分系统均可成功地预测脊柱转移瘤患者术后预后的情况。Tokuhashi评分系统可较为准确地预测生存期较短的患者,从而避免对这类患者做不必要的大手术。

关键词：脊柱肿瘤/继发性手术疗法预期寿命预后