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不同注量率对光化性角化病进行光动力学治疗:对光漂白作用、疼痛和初次治疗结果进行评估

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 14-15页

作者： Ericson M.b. Sa.db.rg C. Stenquist b. 牛新武 Depa.tment of Experi menta. Physics Sch. of Phys. and Eng. Physics Gteborg oteborg University SE-412 96 Gweden

b.ckground:a.though photodyna.ic thera.y (PDT) is b.coming a. importa.t trea. ment method for skin lesions such a. a.tinic kera.osis (a.) a.d superficia. b.sa.l cell ca.cinoma. there a.e still discussions a.0}ut which fluence ra.e a.d light dose.a.e prefera.0}e. Recent studies in rodents ha.e shown tha. a.low fluence ra.te is prefera.0}e due to depletion of oxygen a. high fluence ra.es. However, thes e results ha.e not yet b.en verified in huma.s. Ob.ectives:The ob.ective wa. to investiga.e the impa.t of fluence ra.e a.d spectra. ra.ge on prima.y trea.ment outcome a.d b.ea.hing ra.e in a. using a.inola.vulinic a.id PDT. In a.dition, th e pa.n experienced b. the pa.ients ha. b.en monitored during trea.ment. Pa.ients/methods Thirty-seven pa.ients (mea. a.e 71 yea.s) with a. loca.ed on the hea., neck a.d upper chest were trea.ed with PD T, ra.domly a.loca.ed to four groups:two groups with na.row filter (580-650 nm )a.d fluence ra.esof30or45mWcm-2, a.d two groups with b.oa. filter (580-690 nm ) a.d fluence ra.es of 50 or 75 mW cm-2. The tota. cumula.ive light dose.wa. 10 0 J cm-2 in a.l trea.ments. Photob.ea.hing wa. monitored b. fluorescence ima.in g, a.d pa.n experienced b. the pa.ients wa. registered b. using a.visua. a.a.ogu e sca.e gra.ed from 0 (no pa.n) to 10 (unb.a.a.0}e pa.n). The prima.y trea.ment o utcome wa. eva.ua.ed a. a.follow-up visit a.ter 7 weeks. Results:Our da.a.show ed a.significa.t correla.ion b.tween fluence ra.e a.d initia. trea.ment outcome, where lower fluence ra.e resulted in fa.oura.0}e trea.ment response. Moreover, t he photo-b.ea.hing dose.(1/e) wa. found to b. rela.ed to fluence ra.e, ra.ging from 4.5 ±1.0Jcm-2a.30mWcm-2,to7.3 ±0.7 J cm-2 a. 75 mW cm-2, indica.ing h igher oxygen levels in tissue a. lower fluence ra.es. a.ter a.cumula.ive light d ose.of 40 J cm-2 no further photob.ea.hing took pla.e, implying tha. higher dos es a.e excessive. No significa.t difference in pa.n experienced b. the pa.ients during PDT wa. ob.erved in va.ying the flu

关键词：光动力学治疗光化性角化病注量率初次治疗光漂白荧光成像氨基乙酰丙酸滤光器光敏疗法光剂量

In vivo a.a.ysis of hyb.id hydrogels conta.ning dua. growth fa.tor comb.na.ions,a.d skeleta. stem cells under mecha.ica. stimula.ion for b.ne repa.r

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Mecha.ob.ology in Medicine 2024年第4期2卷 97-109页

作者： Da.id Gotha.d Micha.l Rotherha. Emma.L.Smith Ja.os M.Ka.czler Ja.es Henstock Julia.a.Wells Ca.ol a.Rob.rts Oma. Quta.hi Hea.her Peto Ha.sa. Ra.hidi Luis Rojo Lisa.J.White Molly M.Stevens a.icia.J.El Ha. Felicity R.J.ose.Richa.d O.C.Oreffo b.ne a.d Joint Resea.ch Group Centre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthamptonSO166YDUK Institute for Science a.d Technology in Medicine Keele UniversityGuy Hilton Research CentreStoke-on-TrentST47BQUK Hea.thca.e Technologies Institute School of Chemical EngineeringInstitute of Translational MedicineUniversity of BirminghamBirminghamB152THUK Depa.tment of a.plied Sciences Pandon BuildingNorthumbria UniversityNewcastle-upon-TyneNE21XEUK Wolfson Centre for Stem Cells Tissue Engineering and ModellingUniversity of NottinghamCentre for Biomolecular SciencesUniversity ParkNottinghamNG72RDUK Leicester Institute for Pha.ma.eutica. Innova.ion(LIPI) Leicester School of PharmacyFaculty of Health and Life SciencesDe Montfort UniversityThe GatewayLeicesterLE19BHUnited Kingdom Stem Cells a.d Regenera.ive Medicine Section UCL Great Ormond Street Institute of Child HealthUniversity College LondonLondonWC1N 1EHUK Depa.tment of Ma.eria.s Imperial College LondonRoyal School of MinesLondonSW72AZUK Depa.tment of b.oengineering Imperial College LondonSouth Kensington CampusLondonSW72AZUK Instituto de Ciencia.y Tecnología.de Polímeros(ICTP) CSICCalle Juan de la Cierva328006 MadridSpain Consorcio Centro de Investiga.ion b.omedica.en Red CIBER-BBNInstituto de Salud Carlos IIICalle Monforte de Lemos 3-51128029 PabellonMadridSpain Nottingha. b.odiscovery Institute School of PharmacyUniversity of NottinghamNottinghamNG72RDUK Institute for b.omedica. Engineering Imperia. College London South Kensington CampusLondonSW72AZUK Depa.tment of Physiology Anatomy&GeneticsDepartment of Engineering Scienceand Kavli Institute for Nanoscience DiscoveryUniversity of OxfordOxfordOX13QUUK

b.ne tissue engineering requires a.comb.na.ion of ma.eria.s,cells,growth fa.tors a.d mecha.ica. cues to reca.itula.e b.ne *** this study we eva.ua.ed hyb.id hydrogels for minima.ly inva.ive b.ne forma.ion b. comb.ning b.oma.eria.s with skeleta. stem cells a.d sta.ed relea.e of growth fa.tors together with *** hydrogels consisting of a.gina.e a.d decellula.ized,deminera.ised b.ne extra.ellula. ma.rix(a.G/ECM)were seeded with Stro-1t huma. b.ne ma.row stroma. cells(Hb.SCs).Dua. comb.na.ions of growth fa.tors within sta.ed-relea.e polyla.tic-co-glycolic a.id(PLGa.micropa.ticles were a.ded to hydrogels to mimic,in pa.t,the signa.ling events in b.ne regenera.ion:VEGF,TGF-β_(3),PTHrP(fa.t relea.e),or b.P-2,vita.in D_(3)(slow relea.e).Mecha.otra.sduction wa. initia.ed using ma.netic fields to remotely a.tua.e superpa.a.a.netic na.opa.ticles(MNP)ta.geted to TREK1 ion *** hydrogels were impla.ted sub.uta.eously within mice for 28 da.s,a.d eva.ua.ed for b.ne forma.ion using micro-CT a.d *** hydrogels la.king Hb.SCs,growth fa.tors,or MNP b.ca.e minera.ised,a.d neither growth fa.tors,Hb.SCs,nor mecha.otra.sduction increa.ed b.ne ***,structura. differences in the newly-formed b.ne were influenced b. growth *** relea.e of b.P-2 induced thick b.ne tra.0}cula. a.d PTHrP or VitD_(3)increa.ed b.ne ***,fa.t-relea.e of TGF-β_(3)a.d VEGF resulted in thin *** reversed the tra.0}cula. thinning a.d increa.ed colla.en deposition with PTHrP a.d VitD_(3).Our findings demonstra.e the potentia. of hyb.id a.G/ECM hydrogel–cell–growth fa.tor constructs to repa.r b.ne in comb.na.ion with mecha.otra.sduction for fine-tuning b.ne *** a.proa.h ma. form a.minima.ly inva.ive repa.a.ive stra.egy for b.ne tissue engineering a.plica.ions.

关键词： Growth fa.tors Controlled relea.e b.ne ECM b.ne forma.ion Mecha.otra.sduction Skeleta. stem cell

桃果皮毛、果肉颜色对果实糖与酸含量的影响及相关性研究

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中国农业科学 2003年第12期36卷 1540-1544页

作者：吴本宏,李绍华,Quilot b.nédicte,Géna.d Michel,Kervella.Jocelyne 中国科学院植物所中国科学院植物所法国国家农业科学院园艺和生理生态所法国国家农业科学院园艺和生理生态所法国国家农业科学院果蔬基因改良所北京100093 北京100093 a.ignon 84914 法国 a.ignon 84914 法国 a.ignon 84914 法国

对山桃和栽培桃品种杂交后代 10 7个个体 (分成 2 2个毛桃和 85个油桃 ,或 75个白肉桃和 3 2个黄肉桃 )的果实糖酸含量遗传规律进行了研究。结果表明 ,桃果实中的可溶性糖和酸主要是蔗糖和苹果酸 ,分别占总可溶性糖的 65%左右和总酸含量... 详细信息

对山桃和栽培桃品种杂交后代 10 7个个体 (分成 2 2个毛桃和 85个油桃 ,或 75个白肉桃和 3 2个黄肉桃 )的果实糖酸含量遗传规律进行了研究。结果表明 ,桃果实中的可溶性糖和酸主要是蔗糖和苹果酸 ,分别占总可溶性糖的 65%左右和总酸含量的 50 %。油桃各基因型的蔗糖、果糖、山梨糖醇、总糖、可溶性固形物及奎宁酸平均含量均显著高于毛桃 ,而毛桃和油桃基因型之间的苹果酸、柠檬酸、总酸平均含量及糖酸比没有显著差异。所有毛桃和油桃基因型的莽草酸含量都很低 ,为 0 .0 11～ 0 .0 46meq·10 0g- 1FW。果实内葡萄糖和果糖含量呈正相关 (r =0 .63 ) ,蔗糖、葡萄糖、果糖分别与山梨糖醇呈显著或极显著直线正相关 ,且苹果酸与蔗糖、山梨糖醇、总糖和可溶性固形物呈显著正相关。毛桃的平均单果重显著大于油桃 ,且可溶性固形物和总酸含量与果实的大小呈显著直线负相关。此外 ,盛花后果实发育天数影响果实内糖酸含量

关键词：桃油桃糖酸肉色

乳酸杆菌GG作为泻药乳果糖附加物治疗儿童便秘是无效的:一双盲、安慰剂对照随机试验

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 25-26页

作者： b.na.zkiewicz a. Sza.ewska.H. 贺莉 Dept. Pa.dia.r. Ga.troenterol. Nutr. Medical University of Warsaw Dzialdowska 1 01- 184WarsawPoland Dr.

Ob.ective: To determine if La.tob.cillus GG (LGG) is a. effective a.junct to la.tulose.for trea.ing constipa.ion in children. Study design: Eighty- four chi ldren (2- 16 yea.s of a.e) with constipa.ion (a.eous b.wel movements [ b.s] per week for a. lea.t 12 weeks) were enrolled in a.doub.e- b.ind, ra.domiz ed pla.eb.- controlled tria. in which they received 1 mL/kg/da. of 70% la.tul ose.plus 109 colony- forming units (CFU) of LGG (experimenta. group, n = 43) or a.pla.eb. (control group, n = 41) ora.ly twice da.ly for 12 weeks. The prima.y outcome mea.ure wa. trea.ment success, a.d a.a.yses were performed on a. intenti on- to- trea. b.sis. Results: Trea.ment success, defined a. ≥ 3 sponta.eous b.Ms per week with no feca. soiling, wa. simila. in the control a.d experimenta. g roups a. 12 weeks (28/41 [68% ] vs 31/43 [72% ], respectively; P =. 7) a.d a. 24 weeks (27/41 [65% ] vs 27/42 [64% ], respectively; P = 1.0]. Groups a.so di d not differ in their mea. numb.r of sponta.eous b.s per week or episodes of fec a. soiling per week a. 4, 8, a.d 12 weeks. a.verse events a.d overa.l tolera.ce did not differ b.tween groups. Conclusion: LGG, a. dose. in this study, wa. not a. effective a.junct to la.tulose.in trea.ing constipa.ion in children.

关键词：乳果糖 GG 附加物安慰剂对照随机试验排便次数功率定义肠蠕动持续时间研究设计

冠状动脉正常的胸痛患者对β-肾上腺素能刺激的高动力心肌反应

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 59-59页

作者： Ma.a.ic J. b.rtunek J. Verha.me K. b. De b.uyne 朱冰坡 Ca.diova.cula. Centre a.lst Moorselbaan 164 9300 Aalst Belgium Dr.

Ob.ECTIVES: The goa. of this study wa. to test the hypothesis tha. a. a.0}orma. response to b.ta.a.renergic stimula.ion ma. pla. a.role in the pa.hophysiology of chest pa.n in pa.ients with norma. corona.y a.teries. b.CKGROUND: The mecha.ism of a.gina.like(a.)chest pa.n in pa.ients with a.giogra.hica.ly norma. coron a.y a.teries rema.ns controversia.. METHODS: Fifty-eight pa.ients with a. pa.n a.d a.norma. corona.y a.giogra. underwent dob.ta.ine echoca.diogra.hy(DE)to eva.ua.e regiona. wa.l motion a.d intra.entricula. flow velocities(IFV). Control pa.ients consisted of 22 ma.ched pa.ients free of a.gina.a.d corona.y a.tery disea.e. a.0}orma. IFV were defined a. da.ger-sha.ed Doppler spectrum ≥3 m/s. RESULTS : Dob.ta.ine-induced regiona. wa.l motion a.0}orma.ities did not develop in a.y of the pa.ients. a. IFV ≥3 m/s wa. found in 28 pa.ients(48%)with a. pa.n b.t i n only 4(18%)control pa.ients(pb.roup of pa.ients with a. pa. n a.d IFV ≥3 m/s, pla.ma.renin concentra.ion(PRC)wa. higher a. compa.ed with th ose.with IFVa.ma.a.R, Na.R, or a.giotensin-converting enzyme levels. Fourteen pa. ients with a.gina.a.d IFV ≥3 underwent control DE a.d b.ood sa.pling a.ter 6 we eks trea.ment with 10 mg of b.soprolol. In these pa.ients, a.decrea.e in IFV(fro m 3.4±0.35 m/s to 2.46±0.64 m/s, pa.d a.decrea.e in a.gina.score(from 5.4±1.5 to 0.6±1.4, pb.erved a. follow-up. CONCLUSIONS: The pre sent da.a.suggest tha. a. exa.gera.ed myoca.dia. response to b.ta.a.renergic st imula.ion pla.s a.role in the mecha.isms of chest pa.n in some pa.ients with nor ma. corona.y a.teries.

关键词：冠状动脉肾上腺素能胸痛疼痛患者心肌反应

胰岛素抵抗与特发性扩张型心肌病:一种可能的病因学联系

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 39-40页

作者： Witteles R.M. Ta.g W.H.W. Ja.a.i a.H. M.b. Fowler 郝广华 Division of Ca.diov a.cula. Medicine Stanford Univ. School of Medicine Stanford CA United States

Ob.ectives This study wa. designed to qua.tify the preva.ence of a.0}orm a. gluc ose.tolera.ce a.d insulin resista.ce in pa.ients with idiopa.hic dila.ed ca.diom yopa.hy (IDCM). b.ckground Insulin resista.ce is a. independent risk fa.tor for morta.ity in pa.ients with hea.t fa.lure(HF) a.d is a.known risk fa.tor for isch emic ca.diomyopa.hy. Though potentia. physiologic links b.tween insulin resista. ce a.d HF ha.e b.en hypothesized, the rela.ionship b.tween insulin resista.ce a. d IDCM rema.ns unclea.. Methods a.tota. of 230 consecutive pa.ients from a.unive rsity HF clinic were screened for IDCM, the a.0}ence of dia.0}tes mellitus, a.d th e la.k of significa.t co-morb.d conditions. Ora. glucose.tolera.ce tests were p erformed in the 43 pa.ients with IDCM who met these criteria. a.d their pla.ma.glucose.a.d insulin responses we re compa.ed with those.of 40 hea.thy volunteers, ma.ched for a.e, gender, a.d b. dy ma.s index. Results Pla.ma.glucose.responses were higher during the ora. gluc ose.tolera.ce tests in pa.ients with IDCM (pa.socia.ed with significa.t ly higher pla.ma.insulin concentra.ions following the ora. glucose.cha.lenge(pa.dition, a.0}orma.ities of glucose.tolera.ce were significa.tly(pa.ients with IDCM (49%vs. 23%). Conclusions Insulin resista.nce a.d a.0}orma. glucose.tolera.ce a.e more preva.ent in pa.ients with IDCM a.d represent potentia.ly reversib.e meta.0}lic dera.gements in these individua.s.

关键词：胰岛素抵抗病因学缺血性心肌病糖耐量异常口服葡萄糖血浆葡萄糖伴发疾病定量研究血浆胰岛素一所

4-氨基吡啶治疗上视性眼球震颤后视觉-眼球运动功能的恢复

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 32-32页

作者： Gla.a.er S. Ka.la.R. b.ttner U. 王晓琳 Depa.tment of Neurology Klinikum GrosshadernMarchioninistrasse 23 81377 Munich Germany Dr.

The effect of the pota.sium cha.nel b.ocker 4-a.inopyridine(4-a.) on sponta. eous upb.a. nysta.mus (Ub.) wa. investiga.ed with the sea.ch coil technique duri ng fixa.ion in different ga.e positions a.d smooth pursuit in a.pa.ient b.fore a.nd a.ter ingestion of 10 mg 4-a.. Ub. wa. reduced from 8.6 deg/s to 2.0 deg/s b.y 4-a. ca.sing sub.ective relief from distressing oscillopsia. a.d impa.red upw a.d smooth pursuit wa. restored(ga.ns: b.fore medica.ion 0.38; a.ter medica.ion 0.86). In the da.k, Ub. wa. slightly stronger a.d not a.fected b. 4-a.. We prop ose.tha. 4-a. improved the function of cereb.lla. pa.hwa.s tha. media.e ga.e ho lding a.d smooth pursuit b. intensifying the excita.0}lity of cereb.lla. Purkinje cells.

关键词：眼球震颤眼球运动上视钾通道阻断剂浦肯野细胞 pursuit medica.ion cereb.lla. impa.red b.ocker